Now showing items 1141-1160 of 3130

  • Petridis, Christos; Brook, Mark N; Shah, Vandna; Kohut, Kelly; Gorman, Patricia; Caneppele, Michele; Levi, Dina; Papouli, Efterpi; Orr, Nick; Cox, Angela; Cross, Simon S; dos-Santos-Silva, Isabel; Peto, Julian; Swerdlow, Anthony; Schoemaker, Minouk J; Bolla, Manjeet K; Wang, Qin; Dennis, Joe; Michailidou, Kyriaki; Benitez, Javier; González-Neira, Anna; Tessier, Daniel C; Vincent, Daniel; Li, Jingmei; Figueroa, Jonine; Kristensen, Vessela; Borresen-Dale, Anne-Lise; Soucy, Penny; Simard, Jacques; Milne, Roger L; Giles, Graham G; Margolin, Sara; Lindblom, Annika; Brüning, Thomas; Brauch, Hiltrud; Southey, Melissa C; Hopper, John L; Dörk, Thilo; Bogdanova, Natalia V; Kabisch, Maria; Hamann, Ute; Schmutzler, Rita K; Meindl, Alfons; Brenner, Hermann; Arndt, Volker; Winqvist, Robert; Pylkäs, Katri; Fasching, Peter A; Beckmann, Matthias W; Lubinski, Jan; Jakubowska, Anna; Mulligan, Anna M; Andrulis, Irene L; Tollenaar, Rob A E M; Devilee, Peter; Le Marchand, Loic; Haiman, Christopher A; Mannermaa, Arto; Kosma, Veli-Matti; Radice, Paolo; Peterlongo, Paolo; Marme, Frederik; Burwinkel, Barbara; van Deurzen, Carolien H M; Hollestelle, Antoinette; Miller, Nicola; Kerin, Michael J; Lambrechts, Diether; Floris, Giuseppe; Wesseling, Jelle; Flyger, Henrik; Bojesen, Stig E; Yao, Song; Ambrosone, Christine B; Chenevix-Trench, Georgia; Truong, Thérèse; Guénel, Pascal; Rudolph, Anja; Chang-Claude, Jenny; Nevanlinna, Heli; Blomqvist, Carl; Czene, Kamila; Brand, Judith S; Olson, Janet E; Couch, Fergus J; Dunning, Alison M; Hall, Per; Easton, Douglas F; Pharoah, Paul D P; Pinder, Sarah E; Schmidt, Marjanka K; Tomlinson, Ian; Roylance, Rebecca; García-Closas, Montserrat; Sawyer, Elinor J (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
    Background Ductal carcinoma in situ (DCIS) is a non-invasive form of breast cancer. It is often associated with invasive ductal carcinoma (IDC), and is considered to be a non-obligate precursor of IDC. It ...
  • Reppe, Sjur; Wang, Yunpeng; Thompson, WK; McEvoy, LK; Schork, AJ; Zuber, Verena; LeBlanc, Marissa; Bettella, Franscesco; Mills, Ian Geoffrey; Desikan, Rahul S.; Djurovic, Srdjan; Gautvik, Kaare M; Dale, AM; Andreassen, Ole Andreas; GEFOS, Consortium (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    Bone Mineral Density (BMD) is a highly heritable trait, but genome-wide association studies have identified few genetic risk factors. Epidemiological studies suggest associations between BMD and several traits and diseases, ...
  • Bjorland, Siri (Doctoral thesis / Doktoravhandling, 2019)
    Back pain is a common and major source of disability. Although the majority of patients recover, 10–20% develops persistent pain. Twin studies estimate the heritability regarding back pain to 30-40%. Such studies measure ...
  • Johnson, Nichola; Dudbridge, Frank; Orr, Nick; Gibson, Lorna; Jones, Michael E; Schoemaker, Minouk J; Folkerd, Elizabeth J; Haynes, Ben P; Hopper, John L; Southey, Melissa C; Dite, Gillian S; Apicella, Carmel; Schmidt, Marjanka K; Broeks, Annegien; Van’t Veer, Laura J; Atsma, Femke; Muir, Kenneth; Lophatananon, Artitaya; Fasching, Peter A; Beckmann, Matthias W; Ekici, Arif B; Renner, Stefan P; Sawyer, Elinor; Tomlinson, Ian; Kerin, Michael; Miller, Nicola; Burwinkel, Barbara; Marme, Frederik; Schneeweiss, Andreas; Sohn, Christof; Guénel, Pascal; Truong, Therese; Cordina, Emilie; Menegaux, Florence; Bojesen, Stig E; Nordestgaard, Børge G; Flyger, Henrik; Milne, Roger; Zamora, M P; Arias Perez, Jose I; Benitez, Javier; Bernstein, Leslie; Anton-Culver, Hoda; Ziogas, Argyrios; Clarke Dur, Christina; Brenner, Hermann; Müller, Heiko; Arndt, Volker; Dieffenbach, Aida K; Meindl, Alfons; Heil, Joerg; Bartram, Claus R; Schmutzler, Rita K; Brauch, Hiltrud; Justenhoven, Christina; Ko, Yon-Dschun; Nevanlinna, Heli; Muranen, Taru A; Aittomäki, Kristiina; Blomqvist, Carl; Matsuo, Keitaro; Dörk, Thilo; Bogdanova, Natalia V; Antonenkova, Natalia N; Lindblom, Annika; Mannermaa, Arto; Kataja, Vesa; Kosma, Veli-Matti; Hartikainen, Jaana M; Chenevix-Trench, Georgia; Beesley, Jonathan; Wu, Anna H; Van den Berg, David; Tseng, Chiu-Chen; Lambrechts, Diether; Smeets, Dominiek; Neven, Patrick; Wildiers, Hans; Chang-Claude, Jenny; Rudolph, Anja; Nickels, Stefan; Flesch-Janys, Dieter; Radice, Paolo; Peterlongo, Paolo; Bonanni, Bernardo; Pensotti, Valeria; Couch, Fergus J; Olson, Janet E; Wang, Xianshu; Fredericksen, Zachary; Pankratz, Vernon S; Giles, Graham G; Severi, Gianluca; Baglietto, Laura; Haiman, Chris; Simard, Jacques; Goldberg, Mark S; Labrèche, France; Dumont, Martine; Soucy, Penny; Teo, Soo; Yip, Cheng H; Phuah, Sze Y; Cornes, Belinda K; Kristensen, Vessela N; Grenaker Alnæs, Grethe; Børresen-Dale, Anne-Lise; Zheng, Wei; Winqvist, Robert; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Grip, Mervi; Andrulis, Irene L; Knight, Julia A; Glendon, Gord; Mulligan, Anna M; Devillee, Peter; Figueroa, Jonine; Chanock, Stephen J; Lissowska, Jolanta; Sherman, Mark E; Hall, Per; Schoof, Nils; Hooning, Maartje; Hollestelle, Antoinette; Oldenburg, Rogier A; Tilanus-Linthorst, Madeleine; Liu, Jianjun; Cox, Angie; Brock, Ian W; Reed, Malcolm W; Cross, Simon S; Blot, William; Signorello, Lisa B; Pharoah, Paul D; Dunning, Alison M; Shah, Mitul; Kang, Daehee; Noh, Dong-Young; Park, Sue K; Choi, Ji-Yeob; Hartman, Mikael; Miao, Hui; Lim, Wei Y; Tang, Anthony; Hamann, Ute; Försti, Asta; Rüdiger, Thomas; Ulmer, Hans U; Jakubowska, Anna; Lubinski, Jan; Jaworska-Bieniek, Katarzyna; Durda, Katarzyna; Sangrajrang, Suleeporn; Gaborieau, Valerie; Brennan, Paul; McKay, James; Slager, Susan; Toland, Amanda E; Vachon, Celine; Yannoukakos, Drakoulis; Shen, Chen-Yang; Yu, Jyh-Cherng; Huang, Chiun-Sheng; Hou, Ming-Feng; González-Neira, Anna; Tessier, Daniel C; Vincent, Daniel; Bacot, Francois; Luccarini, Craig; Dennis, Joe; Michailidou, Kyriaki; Bolla, Manjeet K; Wang, Jean; Easton, Douglas F; García-Closas, Montserrat; Dowsett, Mitch; Ashworth, Alan; Swerdlow, Anthony J; Peto, Julian; dos Santos Silva, Isabel; Fletcher, Olivia (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
    Introduction We have previously shown that a tag single nucleotide polymorphism (rs10235235), which maps to the CYP3A locus (7q22.1), was associated with a reduction in premenopausal urinary estrone ...
  • Stokowy, Tomasz; Polushina, Tatiana; Sønderby, Ida Elken; Karlsson, Robert; Giddaluru, Sudheer; Le Hellard, Stephanie; Bergen, Sarah E; Sullivan, Patrick F; Andreassen, Ole Andreas; Djurovic, Srdjan; Hultman, Christina M.; Steen, Vidar Martin (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Schizophrenia is a serious psychotic disorder with high heritability. Several common genetic variants, rare copy number variants and ultra-rare gene-disrupting mutations have been linked to disease susceptibility, but there ...
  • Kambur, Oleg; Kaunisto, Mari A; Winsvold, Bendik K S; Wilsgaard, Tom; Stubhaug, Audun; Zwart, John-Anker; Kalso, Eija; Nielsen, Christopher Sivert (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    P2X7 is a nonselective cation channel activated by extracellular ATP. P2X7 activation contributes to the proinflammatory response to injury or bacterial invasion and mediates apoptosis. Recently, P2X7 function has been ...
  • Rohde, Kerstin; Keller, Maria; La Cour Poulsen, Lars; Blüher, Matthias; Kovacs, Peter; Böttcher, Yvonne (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
    Obesity is among the most threatening health burdens worldwide and its prevalence has markedly increased over the last decades. Obesity maybe considered a heritable trait. Identifications of rare cases of monogenic obesity ...
  • Russell, Michael B (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
    This tutorial describes different methods and results of genetic studies of primary headaches. A positive family history is imprecise, because it does not specify the number of affected, family size or relation to the ...
  • Pihlstrøm, Lasse (Doctoral thesis / Doktoravhandling, 2015)
    Parkinson's disease is a common neurological disorder where the prevalence increases with age. The diagnosis is based on motor symptoms, namely slowness of movements, rigidity, tremor and balance problems, yet patients ...
  • Russell, Michael B (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
    The objective of this study was to investigate the importance of genetics in tension-type headache. A MEDLINE search from 1966 to December 2006 was performed for “tension-type headache and prevalence” and “tension-type ...
  • Eike, Morten Christoph (Doctoral thesis / Doktoravhandling, 2008)
    Type 1 diabetes (T1D) is a complex, autoimmune disease with a strong heritable component. The single most important genomic region for this and a large number of other diseases is the major histocompatibility complex (MHC), ...
  • Lazarevic, Bato (Doctoral thesis / Doktoravhandling, 2012)
  • Kanduri, Chakravarthi; Domanska, Diana; Hovig, Eivind; Sandve, Geir K (Journal article / Tidsskriftartikkel / PublishedVersion, 2017)
    Genomic locations are represented as coordinates on a specific genome build version, but the build information is frequently missing when coordinates are provided. We show that this information is essential to correctly ...
  • Diep, Chieu B; Teixeira, Manuel R; Thorstensen, Lin; Wiig, Johan N; Eknæs, Mette; Nesland, Jahn M; Giercksky, Karl-Erik; Johansson, Bertil; Lothe, Ragnhild A (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2004)
    Background Colorectal cancer (CRC) is one of the most common causes of cancer-related deaths in the Western world, and despite the fact that metastases are usually the ultimate cause of deaths, the knowledge ...
  • Ambur, Ole Herman; Davidsen, Tonje; Frye, Stephan Alfons; Balasingham, Seetha; Lagesen, Karin; Rognes, Torbjørn; Tønjum, Tone (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2009)
    Pathogenic bacteria continuously encounter multiple forms of stress in their hostile environments, which leads to DNA damage. With the new insight into biology offered by genome sequences, the elucidation of the gene content ...
  • Zayats, Tetyana; Athanasiu, Lavinia; Sønderby, Ida Elken; Djurovic, Srdjan; Westlye, Lars Tjelta; Tamnes, Christian Krog; Fladby, Tormod; Aase, Heidi; Zeiner, Pål; Reichborn-Kjennerud, Ted; Knappskog, Per; Knudsen, Gun Peggy; Andreassen, Ole Andreas; Johansson, Stefan; Haavik, Jan (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    Background: Attention deficit hyperactivity disorder (ADHD) is a highly heritable neuropsychiatric condition, but it has been difficult to identify genes underlying this disorder. This study aimed to explore genetics of ...
  • Pillai, Sreekumar G.; Ge, Dongliang; Zhu, Guohua; Kong, Xiangyang; Shianna, Kevin V.; Need, Anna C.; Feng, Sheng; Hersh, Craig P.; Bakke, Per S.; Gulsvik, Amund; Ruppert, Andreas; Carlsen, Karin Cecilie Lødrup; Roses, Allen; Anderson, Wayne; Rennard, Stephen I.; Lomas, David A.; Silverman, Edwin K.; Goldstein, David B. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2009)
    There is considerable variability in the susceptibility of smokers to develop chronic obstructive pulmonary disease (COPD). The only known genetic risk factor is severe deficiency of α1-antitrypsin, which is present in ...
  • Vojinovic, Dina; Adams, Hieab H.; Jian, Xueqiu; Yang, Qiong; Smith, Albert Vernon; Bis, Joshua C.; Teumer, Alexander; Scholz, Markus; Armstrong, Nicola J.; Hofer, Edith; Saba, Yasaman; Luciano, Michelle; Bernard, Manon; Trompet, Stella; Yang, Jingyun; Gillespie, Nathan A.; van der Lee, Sven J.; Neumann, Alexander; Ahmad, Shahzad; Andreassen, Ole Andreas; Ames, David; Amin, Najaf; Arfanakis, Konstantinos; Bastin, Mark E.; Becker, Diane M.; Beiser, Alexa S.; Beyer, Frauke; Brodaty, Henry; Bryan, R. Nick; Bülow, Robin; Dale, Anders; De Jager, Philip L.; Deary, Ian J.; DeCarli, Charles; Fleischman, Debra A.; Gottesman, Rebecca F.; van der Grond, Jeroen; Gudnason, Vilmundur; Harris, Tamara B.; Homuth, Georg; Knopman, David S.; Kwok, John B.; Lewis, Cora E.; Li, Shuo; Loeffler, Markus; Lopez, Oscar L.; Maillard, Pauline; El Marroun, Hanan; Mather, Karen A.; Mosley, Thomas H.; Muetzel, Ryan L.; Nauck, Matthias; Nyquist, Paul A.; Panizzon, Matthew S.; Pausova, Zdenka; Psaty, Bruce M.; Rice, Ken; Rotter, Jerome I.; Royle, Natalie; Satizabal, Claudia L.; Schmidt, Reinhold; Schofield, Peter R.; Schreiner, Pamela J.; Sidney, Stephen; Stott, David J.; Thalamuthu, Anbupalam; Uitterlinden, André G.; Valdés Hernández, Maria C.; Vernooij, Meike W.; Wen, Wei; White, Tonya; Witte, A. Veronica; Wittfeld, Katharina; Wright, Margaret J.; Yanek, Lisa R.; Tiemeier, Henning; Kremen, William S.; Bennett, David A.; Jukema, J. Wouter; Paus, Tomáš; Wardlaw, Joanna M.; Schmidt, Helena; Sachdev, Perminder S.; Villringer, Arno; Grabe, Hans Jörgen; Longstreth, William T.; van Duijn, Cornelia M.; Launer, Lenore J.; Seshadri, Sudha; Ikram, M. Arfan; Fornage, Myriam (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    The volume of the lateral ventricles (LV) increases with age and their abnormal enlargement is a key feature of several neurological and psychiatric diseases. Although lateral ventricular volume is heritable, a comprehensive ...
  • Reichborn-Kjennerud, Ted; Knudsen, Gun Peggy; Andreassen, Ole Andreas; Espeseth, Thomas; Lundervold, Astri; Reinvang, Ivar; Steen, Vidar Martin; Le Hellard, Stephanie; Mattingsdal, Morten; Boraske, V; Franklin, CS; Floyd, James A. B.; Thornton, Laura M; Huckins, L. M.; Southam, L; Rayner, NW; Tachmazidou, I; Klump, KL; Treasure, Jim; Lewis, C. M.; Schmidt, U; Tozzi, F; Kiezebrink, K; Hebebrand, J.; Gorwood, P.; Adan, R. A. H.; Kas, M. J. H.; Favaro, A; Santonastaso, P; Fernández-Aranda, Fernando; Gratacòs, Mònica; Rybakowski, Finn; Dmitrzak-Weglarz, M.; Kaprio, J; Keski-Rahkonen, A; Raevuori, A.; Van Furth, E. F.; Slof-Op 't Landt, M. C. T.; Hudson, JI; Monteleone, P.; Kaplan, AS; Karwautz, A; Hakonarson, H; Berrettini, W. H.; Guo, Y; Li, D; Schork, NJ; Komaki, G; Ando, T; Inoko, H. (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2014)
    Anorexia nervosa (AN) is a complex and heritable eating disorder characterized by dangerously low body weight. Neither candidate gene studies nor an initial genome-wide association study (GWAS) have yielded significant and ...
  • Witt, Stephanie H.; Streit, F; Jungkunz, M; Frank, J; Awasthi, S; Reinbold, CS; Treutlein, J; Degenhardt, F; Forstner, AJ; Heilmann-Heimbach, S; Dietl, L; Schwarze, CE; Schendel, D; Strohmaier, Jana; Abdellaoui, A; Adolfsson, Rolf; Air, TM; Akil, Huda; Alda, Martin; Alliey-Rodriguez, N; Andreassen, Ole Andreas; Babadjanova, Gulia; Bass, N; Bauer, M; Baune, Bernhard T.; Bellivier, Frank; Bergen, Sarah E; Bethell, A; Biernacka, Joanna M.; Blackwood, Douglas H.R.; Boks, Marco P; Boomsma, Dorret I.; Borglum, Anders D; Borrmann-Hassenbach, M; Brennan, P; Budde, M; Buttenschon, HN; Byrne, Enda M.; Cervantes, P; Clarke, TK; Craddock, N; Cruceanu, C; Curtis, David; Czerski, Piotr M.; Dannlowski, Udo; Davis, T; de Geus, Eco J C; Di Florio, A; Djurovic, Srdjan; Domenici, Enrico; Edenberg, Howard J; Etain, Bruno; Fischer, SB; Forty, L; Fraser, C; Frye, M; Fullerton, JM; Gershon, Elliot S.; Gieglin, I; Gordon, Scott D; Gordon-Smith, K; Grabe, Hans Jörgen; Green, EK; Greenwood, TA; Grigoroiu-Serbanescu, Maria; Guzman-Parra, J; Hall, L; Hamshere, Marian; Hauser, J; Hautzinger, Martin; Heilbronner, U; Herms, Stefan; Hitturlingappa, S; HOFFMANN, PAVEL; Holmans, P; Hottenga, Jouke Jan; Jamain, Stephane; Jones, I; Jones, L; Juréus, Anna; Kahn, René S; Kammerer-Ciernioch, Jutta; Kirov, George; Kittel-Schneider, Sarah; Kloiber, Stefan; Knott, SV; Kogevinas, Manolis; Landen, M; Leber, M; Leboyer, Marion; Li, Qingqin S.; Lissowska, Jolanta; Lucae, Susanne; Martin, NG; Mayoral-Cleries, F; McElroy, SL; McIntosh, Andrew M; McKay, James D; McQuilling, A; Medland, Sarah E; Middeldorp, Christel M.; Milaneschi, Y; Mitchell, Philip B; Montgomery, Grant W; Mors, O; Mühleisen, Thomas W.; Muller-Myshok, B; Myers, Richard M; Nievergelt, Caroline M.; Nurnberger, John I.; O'Donovan, Michael C; Loohuis, Loes M. Olde; Ophoff, R; Oruc, Liliana; Owen, Michael J; Paciga, SA; Penninx, Brenda W J H; Perry, A; Pfennig, Andrea; Potash, James B.; Preisig, Martin; Reif, A; Rivas, F; Rouleau, GA; Schofield, Peter R; Schulze, Thomas G; Schwarz, M; Scott, L; Sinnamon, GCB; Stahl, Eli A.; Strauss, J; Turecki, G; Van der Auwera, S; Vedder, Helmut; Vincent, John B; Willemsen, Gonneke; Witt, CC; Wray, Naomi R; Xi, HS; Tadic, A; Dahmen, Norbert; Schott, Björn H; Cichon, Sven; Nothen, Markus M; Ripke, Stephan; Mobascher, A; Rujescu, Dan; Lieb, K; Roepke, S; Schmal, Christine; Bohus, Martin; Rietschel, Marcella; Morken, Gunnar; Gade, K (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Borderline personality disorder (BOR) is determined by environmental and genetic factors, and characterized by affective instability and impulsivity, diagnostic symptoms also observed in manic phases of bipolar disorder ...