Now showing items 1141-1160 of 4480

  • Gill, Peter (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
    DNA analysis has revolutionised forensic science; helping to catch prolific murderers and shining a light on miscarriages of justice that have seen innocent people wrongfully convicted of serious crimes. Such is the power ...
  • Lindstedt, Bjørn-Arne; Heir, Even; Gjernes, Elisabet; Vardund, Traute; Kapperud, Georg (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2003)
    Background The ability to react early to possible outbreaks of Escherichia coli O157:H7 and to trace possible sources relies on the availability of highly discriminatory and reliable techniques. The ...
  • Page, Christian (Doctoral thesis / Doktoravhandling, 2016)
    Recent advances in biotechnology have led to an explosion in the amount of biological data available to researchers. Since the introduction of high-throughput technologies, a massive number of genetic markers can now be ...
  • Kular, Lara; Liu, Yun; Ruhrmann, Sabrina; Zheleznyakova, Galina; Marabita, Francesco; Gomez-Cabrero, David; James, Tojo; Ewing, Ewoud; Lindén, Magdalena; Górnikiewicz, Bartosz; Aeinehband, Shahin; Stridh, Pernilla; Link, Jenny; Andlauer, Till F.M.; Gasperi, Christiane; Wiendl, Heinz; Zipp, Frauke; Gold, Ralf; Tackenberg, Björn; Weber, Frank; Hemmer, Bernhard; Strauch, Konstantin; Heilmann-Heimbach, Stefanie; Rawal, Rajesh; Schminke, Ulf; Schmidt, Carsten O.; Kacprowski, Tim; Franke, Andre; Laudes, Matthias; Dilthey, Alexander T.; Celius, Elisabeth Gulowsen; Søndergaard, Helle Bach; Tegnér, Jesper; Harbo, Hanne Flinstad; Oturai, Annette B.; Olafsson, Sigurgeir; Eggertsson, Hannes P.; Halldorsson, Bjarni V.; Hjaltason, Haukur; Olafsson, Elias; Jonsdottir, Ingileif; Stefansson, Kari; Olsson, Tomas; Piehl, Fredrik; Ekström, Tomas J.; Kockum, Ingrid; Feinberg, Andrew P.; Jagodic, Maja (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    The human leukocyte antigen (HLA) haplotype DRB1*15:01 is the major risk factor for multiple sclerosis (MS). Here, we find that DRB1*15:01 is hypomethylated and predominantly expressed in monocytes among carriers of ...
  • Fleischer, Thomas; Tekpli, Xavier; Mathelier, Anthony; Wang, Shixiong; Nebdal, Daniel J.H.; Dhakal, Hari Prasad; Sahlberg, Kristine Kleivi; Schlichting, Ellen; Børresen-Dale, Anne-Lise; Borgen, Elin; Naume, Bjørn; Eskeland, Ragnhild; Frigessi, Arnoldo; Tost, Jörg; Rodriguez, Antoni Hurtado; Kristensen, Vessela N. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Breast cancers exhibit genome-wide aberrant DNA methylation patterns. To investigate how these affect the transcriptome and which changes are linked to transformation or progression, we apply genome-wide expression–methylation ...
  • Wikenius, Ellen; Moe, Vibeke; Smith, Lars; Heiervang, Einar; Berglund, Anders (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Infants undergo extensive developments during their frst year of life. Although the biological mechanisms involved are not yet fully understood, changes in the DNA methylation in mammals are believed to play a key role. ...
  • Xu, Cheng-Jian; Söderhäll, Cilla; Bustamante, Mariona; Baïz, Nour; Gruzieva, Olena; Gehring, Ulrike; Mason, Dan; Chatzi, Leda; Basterrechea, Mikel; Llop, Sabrina; Torrent, Maties; Forastiere, Francesco; Fantini, Maria Pia; Carlsen, Karin C. Lødrup; Haahtela, Tari; Morin, Andréanne; Kerkhof, Marjan; Merid, Simon Kebede; van Rijkom, Bianca; Jankipersadsing, Soesma A.; Bonder, Marc Jan; Ballereau, Stephane; Vermeulen, Cornelis J.; Aguirre-Gamboa, Raul; De Jongste, Johan C.; Smit, Henriëtte A.; Kumar, Ashish; Pershagen, Göran; Guerra, Stefano; Garcia-Aymerich, Judith; Greco, Dario; Reinius, Lovisa; McEachan, Rosemary R.C.; Azad, Raf; Hovland, Vegard; Mowinckel, Petter; Alenius, Harri; Fyhrquist, Nanna; Lemonnier, Nathanael; Pellet, Johann; Auffray, Charles; van der Vlies, Pieter; van Diemen, Cleo C.; Li, Yang; Wijmenga, Cisca; Netea, Mihai G.; Moffatt, Miriam F.; Cookson, William O.C.M; Anto, Josep M.; Bousquet, Jean; Laatikainen, Tiina; Laprise, Catherine; Carlsen, Kai-Håkon; Gori, Davide; Porta, Daniela; Iñiguez, Carmen; Bilbao, Jose Ramon; Kogevinas, Manolis; Wright, John; Brunekreef, Bert; Kere, Juha; Nawijn, Martijn C.; Annesi-Maesano, Isabella; Sunyer, Jordi; Melén, Erik; Koppelman, Gerard H. (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
    Background DNA methylation profiles associated with childhood asthma might provide novel insights into disease pathogenesis. We did an epigenome-wide association study to assess methylation profiles associated with ...
  • Johnson, Kevin C; Koestler, Devin C; Fleischer, Thomas; Chen, Panpan; Jenson, Erik G; Marotti, Jonathan D; Onega, Tracy; Kristensen, Vessela N; Christensen, Brock C (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    Background Ductal carcinoma in situ (DCIS) is a heterogeneous, pre-invasive lesion associated with an increased risk for future invasive ductal carcinoma. However, accurate risk stratification for development ...
  • Guo, Yichen; Zhang, Ruyang; Shen, Sipeng; Wei, Yongyue; Salama, Sebastian Moran; Fleischer, Thomas; Bjaanæs, Maria Moksnes; Karlsson, Anna; Planck, Maria; Su, Li; Zhu, Zhaozhong; Staaf, Johan; Helland, Åslaug; Esteller, Manel; Christiani, David C. (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
    Background: Previous studies support a tumor-suppressor role for LRRC3B across various types of cancers. We aimed to investigate the association between DNA methylation of LRRC3B and overall survival (OS) for patients with ...
  • Keller, Maria; Klos, Matthias; Rohde, Kerstin; Krüger, Jacqueline; Kurze, Tabea; Dietrich, Arne; Schön, Michael R.; Gärtner, Daniel; Lohmann, Tobias; Dressler, Miriam; Stumvoll, Michael; Bluher, Matthias; Kovacs, Peter; Böttcher, Yvonne (Journal article / Tidsskriftartikkel / SubmittedVersion, 2018)
    DNA methylation is a crucial epigenetic mechanism in obesity and fat distribution. We explored the Sarcospan (SSPN) gene locus by using genome-wide data sets comprising methylation and expression data, pyrosequencing ...
  • Narud, Birgitte; Stenseth, Else-Berit; Johannisson, Anders; Myromslien, Frøydis Deinboll; Gaustad, Ann Helen; Wilson, Robert Charles; Lyle, Robert; Morrell, Jane; Kommisrud, Elisabeth; Ahmad, Rafi (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Background Sperm DNA integrity is considered essential for successful transmission of the paternal genome, fertilization and normal embryo development. DNA fragmentation index (DFI, %) has become a key parameter in the ...
  • Dejeux, Emelyne; Rønneberg, Anders J; Solvang, Hiroko; Bukholm, Ida; Geisler, Stephanie; Aas, Turid; Gut, Ivo G; Børresen-Dale, Anne-Lise; Lønning, Per E; Kristensen, Vessela N; Tost, Jörg (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)
    Background Breast cancer is the most frequent cancer in women and consists of a heterogeneous collection of diseases with distinct histopathological, genetic and epigenetic characteristics. In this study, ...
  • Lauss, Martin; Ringnér, Markus; Karlsson, Anna; Harbst, Katja; Busch, Christian; Geisler, Jürgen; Lønning, Per E; Staaf, Johan; Jönsson, Göran (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    Background DNA methylation at CpG dinucleotides is modified in tumorigenesis with potential impact on transcriptional activity. Methods We used ...
  • Njølstad, Tormund Salvesen; Trovik, Jone; Hveem, Tarjei Sveinsgjerd; Kjæreng, Marna Lill; Kildal, Wanja; Pradhan, Manohar; Marcickiewicz, Janusz; Tingulstad, Solveig; Staff, Anne Cathrine; Haugland, Hans Kristian; Eraker, Runar; Oddenes, Klaus; Rokne, Jan Anders; Tjugum, Jostein; Lode, Margaret Sævik; Amant, Frédéric; Werner, Henrica Maria Johanna; Salvesen, Helga; Danielsen, Håvard Emil (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2015)
    Background: Preoperative risk stratification is essential in tailoring endometrial cancer treatment, and biomarkers predicting lymph node metastasis and aggressive disease are aspired in clinical practice. DNA ploidy ...
  • Andersen, Tor Kristian; Zhou, Fan; Cox, Rebecca Jane; Bogen, Bjarne; Grødeland, Gunnveig (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Zoonotic influenza H7 viral infections have a case fatality rate of about 40%. Currently, no or limited human to human spread has occurred, but we may be facing a severe pandemic threat if the virus acquires the ability ...
  • Løvås, Tom-Ole; Bruusgaard, Jo C.; Øynebråten, Inger; Gundersen, Kristian; Bogen, Bjarne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
    Vaccination with naked DNA holds great promise but immunogenicity needs to be improved. DNA constructs encoding bivalent proteins that bind antigen-presenting cells (APC) for delivery of antigen have been shown to enhance ...
  • Heuch, Ingrid; Heuch, Ivar; Hagen, Knut; Zwart, John-Anker (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
    Background: Cross-sectional studies suggest associations between abnormal lipid levels and prevalence of low back pain (LBP), but it is not known if there is any causal relationship. Objective: The objective was to ...
  • Åsberg, Anders Nikolai; Hagen, Knut; Stovner, Lars Jacob; Heuch, Ingrid; Zwart, John-Anker; Winsvold, Bendik K S (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Background Musculoskeletal complaints (MSC) are common in the general population, causing a major disease burden to the individual and society. The association between MSC and mortality is still unclear. To our knowledge, ...
  • Aas, Anne-Marie; Johansson, Lars; Bjerkan, Kirsti; Lorentsen, Nina; Mostad, Ingrid Løvold (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
    Objective: Review current knowledge about dietary habits among people with diabetes in Norway compared with the general population and nutrient- and food-based dietary recommendations. Method: Baseline dietary data from ...
  • Hage, Trine W; Rø, Øyvind; Moen, Anne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Background Eating disorders are psychiatric illnesses with potentially life-threatening consequences. Inpatient treatment is typically required for the most severely ill patients, who are often emaciated ...