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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
The tumor microenvironment is now widely recognized for its role in tumor progression, treatment response, and clinical outcome. The intratumoral immunological landscape, in particular, has been shown to exert both ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Background: Chemotherapeutic agents such as anthracyclines and taxanes are commonly used in the neoadjuvant setting. Bevacizumab is an antibody which binds to vascular endothelial growth factor A (VEGFA) and inhibits its ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background
Breast cancer is a heterogeneous disease at the clinical and molecular level. In this study we integrate classifications extracted from five different molecular levels in order to identify ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Long noncoding RNAs (lncRNAs) are emerging as regulators of gene expression in pathogenesis, including cancer. Recently, lncRNAs have been implicated in progression of specific subtypes of breast cancer. One aggressive, ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Background
Single-cell micro-metastases of solid tumors often occur in the bone marrow. These disseminated tumor cells (DTCs) may resist therapy and lay dormant or progress to cause overt bone and visceral ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2006)
Background
Gene expression profiling has been used to define molecular phenotypes of complex diseases such as breast cancer. The luminal A and basal-like subtypes have been repeatedly identified and validated ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2006)
Background
Previously, a total of five breast cancer subtypes have been identified based on variation in gene expression patterns. These expression profiles were also shown to be associated with different ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)
Background
A recent genome-wide association study (GWAS) has identified a single nucleotide polymorphism (SNP) rs11249433 in the 1p11.2 region as a novel genetic risk factor for breast cancer, and this ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Background
Alternate transcripts from a single gene locus greatly enhance the combinatorial flexibility of the human transcriptome. Different patterns of exon usage have been observed when comparing normal ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Background
Ductal carcinoma in situ (DCIS) of the breast is a precursor of invasive breast carcinoma. DNA methylation alterations are thought to be an early event in progression of cancer, and may prove ...