Now showing items 1-3 of 3
The carnitine-butyrobetaine-TMAO pathway after cardiac transplant: Impact on cardiac allograft vasculopathy and acute rejection
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
BACKGROUND Alterations in the partly microbiota-dependent carnitine–γ-butyrobetaine (γBB)–trimethylamine N-oxide (TMAO) pathway have been linked to the progression of heart failure and atherosclerotic disease. We evaluated ...
Design of the GutHeart-targeting gut microbiota to treat heart failure-trial: a Phase II, randomized clinical trial
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Aims: Heart failure (HF) is a multifactorial disease. Current treatments target only a fraction of the putative pathophysiological pathways. In patients with HF, reduced cardiac output and congestion cause increased gut ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
Objective: Bile acids (BAs) are now recognized as signaling molecules and emerging evidence suggests that BAs affect cardiovascular function. The gut microbiota has recently been linked to the severity of heart failure ...