Browsing Institutt for klinisk medisin by Author "Yaari, Gur"

Now showing items 1-7 of 7

  • Germline polymorphisms and alternative splicing of human immunoglobulin light chain genes 
    Mikocziova, Ivana; Peres, Ayelet; Gidoni, Moriah; Greiff, Victor; Yaari, Gur; Sollid, Ludvig Magne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Inference of germline polymorphisms in immunoglobulin genes from B cell receptor repertoires is complicated by somatic hypermutations, sequencing/PCR errors, and by varying length of reference alleles. The light chain ...
  • Inferred allelic variants of immunoglobulin receptor genes: A system for their evaluation, documentation, and naming 
    Ohlin, Mats; Scheepers, Cathrine; Corcoran, Martin; Lees, William D.; Busse, Christian E.; Bagnara, Davide; Thörnqvist, Linnea; Bürckert, Jean-Philippe; Jackson, Katherine J.L.; Ralph, Duncan; Schramm, Chaim A.; Marthandan, Nishanth; Breden, Felix; Scott, Jamie; Matsen, Frederick A.; Greiff, Victor; Yaari, Gur; Kleinstein, Steven H.; Christley, Scott; Sherkow, Jacob S.; Kossida, Sofia; Lefranc, Marie-Paule; van Zelm, Menno C.; Watson, Corey T.; Collins, Andrew M. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Immunoglobulins or antibodies are the main effector molecules of the B-cell lineage and are encoded by hundreds of variable (V), diversity (D), and joining (J) germline genes, which recombine to generate enormous IG ...
  • Machine Learning Analysis of Naïve B-Cell Receptor Repertoires Stratifies Celiac Disease Patients and Controls 
    Shemesh, Or; Polak, Pazit; Lundin, Knut Erik Aslaksen; Sollid, Ludvig M.; Yaari, Gur (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Celiac disease (CeD) is a common autoimmune disorder caused by an abnormal immune response to dietary gluten proteins. The disease has high heritability. HLA is the major susceptibility factor, and the HLA effect is mediated ...
  • Mosaic deletion patterns of the human antibody heavy chain gene locus shown by Bayesian haplotyping 
    Gidoni, Moriah; Snir, Omri; Peres, Ayelet; Polak, Pazit; Lindeman, Ida; Mikocziova, Ivana; Sarna, Vikas Kumar; Lundin, Knut Erik Aslaksen; Clouser, Christopher; Vigneault, Francois; Collins, Andrew M.; Sollid, Ludvig Magne; Yaari, Gur (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Analysis of antibody repertoires by high-throughput sequencing is of major importance in understanding adaptive immune responses. Our knowledge of variations in the genomic loci encoding immunoglobulin genes is incomplete, ...
  • Polymorphisms in human immunoglobulin heavy chain variable genes and their upstream regions 
    Mikocziova, Ivana; Gidoni, Moriah; Lindeman, Ida; Peres, Ayelet; Snir, Omri; Yaari, Gur; Sollid, Ludvig Magne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Abstract Germline variations in immunoglobulin genes influence the repertoire of B cell receptors and antibodies, and such polymorphisms may impact disease susceptibility. However, the knowledge of the genomic ...
  • simAIRR: simulation of adaptive immune repertoires with realistic receptor sequence sharing for benchmarking of immune state prediction methods 
    Kanduri, Chakravarthi; Scheffer, Lonneke; Pavlović, Milena; Rand, Knut Dagestad; Chernigovskaia, Maria; Pirvandy, Oz; Yaari, Gur; Greiff, Victor; Sandve, Geir Kjetil Ferkingstad (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Abstract Background Machine learning (ML) has gained significant attention for classifying immune states in adaptive immune receptor repertoires (AIRRs) to support the advancement of ...
  • Stereotyped antibody responses target posttranslationally modified gluten in celiac disease 
    Snir, Omri; Chen, Xi; Gidoni, Moriah; du Pré, Marie Fleur; Zhao, Yuguang; Steinsbø, Øyvind; Lundin, Knut Erik Aslaksen; Yaari, Gur; Sollid, Ludvig Magne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    The role of B cells and posttranslational modifications in pathogenesis of organ-specific immune diseases is increasingly envisioned but remains poorly understood, particularly in human disorders. In celiac disease, ...