Browsing Institutt for klinisk medisin by Author "Vaage, Ingvar Jarle"

Now showing items 1-12 of 12

  • A Novel Ex Vivo Model of Aortic Valve Calcification. A Preliminary Report 
    Zabirnyk, Arsenii; Perez, Maria del Mar; Blasco, Marc; Stensløkken, Kåre-Olav; Ferrer, Miguel D.; Salcedo, Carolina; Vaage, Ingvar Jarle (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Background: No pharmacological treatment exists to prevent or stop the calcification process of aortic valves causing aortic stenosis. The aim of this study was to develop a robust model of induced calcification in whole ...
  • Complement activation is associated with poor outcome after out-of-hospital cardiac arrest 
    Chaban, Viktoriia; Nakstad, Espen R.; Stær-Jensen, Henrik; Schjalm, Camilla; Seljeflot, Ingebjørg; Vaage, Ingvar Jarle; Lundqvist, Christofer; Saltyte Benth, Jurate; Sunde, Kjetil; Mollnes, Tom Eirik; Andersen, Geir Øystein; Pischke, Soeren (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Background Cardiopulmonary resuscitation after cardiac arrest initiates a whole-body ischemia-reperfusion injury, which may activate the innate immune system, including the complement system. We hypothesized that ...
  • Escherichia coli-induced inflammatory responses are temperature-dependent in human whole blood ex vivo 
    Chaban, Viktoriia; de Boer, Eline; Ekholt, Karin; Vaage, Ingvar Jarle; Mollnes, Tom Eirik; Nilsson, Per; Pischke, Soeren; Islam, Rakibul (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Systemic inflammatory conditions are often associated with hypothermia or hyperthermia. Therapeutic hypothermia is used in post-cardiac arrest and some other acute diseases. There is a need for more knowledge concerning ...
  • Inflammation and Mechanical Stress Stimulate Osteogenic Differentiation of Human Aortic Valve Interstitial Cells 
    Bogdanova, Mariia; Kostina, Aleksandra; Zihlavnikova, Katarina; Malashicheva, Anna; Stensløkken, Kåre-Olav; Sullivan, Gareth; Kaljusto, Mari-Liis; Kvitting, John Peder Escobar; Kostareva, Anna; Vaage, Ingvar Jarle; Rutkovskiy, Arkady (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Background: Aortic valve calcification is an active proliferative process, where interstitial cells of the valve transform into either myofibroblasts or osteoblast-like cells causing valve deformation, thickening of cusps ...
  • Intracellular Complement Component 3 Attenuated Ischemia-Reperfusion Injury in the Isolated Buffer-Perfused Mouse Heart and Is Associated With Improved Metabolic Homeostasis 
    Torp, May-Kristin; Ranheim, Trine; Schjalm, Camilla; Hjorth, Marit; Heiestad, Christina Mathisen; Dalen, Knut Tomas; Nilsson, Per; Mollnes, Tom Eirik; Pischke, Soeren; Lien, Egil; Vaage, Ingvar Jarle; Yndestad, Arne; Stensløkken, Kåre-Olav (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    The innate immune system is rapidly activated during myocardial infarction and blockade of extracellular complement system reduces infarct size. Intracellular complement, however, appears to be closely linked to metabolic ...
  • Life without Oxygen: Gene Regulatory Responses of the Crucian Carp (Carassius carassius) Heart Subjected to Chronic Anoxia 
    Stensløkken, Kåre-Olav; Ellefsen, Stian; Vasieva, Olga; Fang, Youhan; Farrell, Anthony P.; Olohan, Lisa; Vaage, Ingvar Jarle; Nilsson, Göran Erik; Cossins, Andrew R. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
    Crucian carp are unusual among vertebrates in surviving extended periods in the complete absence of molecular oxygen. During this time cardiac output is maintained though these mechanisms are not well understood. Using a ...
  • Mitochondria-derived damage-associated molecular patterns and inflammation in the ischemic-reperfused heart 
    Torp, May-Kristin; Vaage, Ingvar Jarle; Stensløkken, Kåre-Olav (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Cardiac cell death after myocardial infarction release endogenous structures termed damage-associated molecular patterns (DAMPs) that trigger the innate immune system and initiate a sterile inflammation in the myocardium. ...
  • Models and Techniques to Study Aortic Valve Calcification in Vitro, ex Vivo and in Vivo. An Overview 
    Bogdanova, Mariia; Zabirnyk, Arsenii; Malashicheva, Anna; Semenova, Daria; Kvitting, John-Peder; Kaljusto, Mari-Liis; Perez, Maria del Mar; Kostareva, Anna; Stensløkken, Kåre-Olav; Sullivan, Gareth John; Rutkovskiy, Arkady; Vaage, Ingvar Jarle (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Aortic valve stenosis secondary to aortic valve calcification is the most common valve disease in the Western world. Calcification is a result of pathological proliferation and osteogenic differentiation of resident valve ...
  • Plin2 deletion increases cholesteryl ester lipid droplet content and disturbs cholesterol balance in adrenal cortex 
    Li, Yuchuan; Khanal, Prabhat; Norheim, Frode; Hjorth, Marit; Bjellaas, Thomas; Drevon, Christian A; Vaage, Ingvar Jarle; kimmel, Alan; Dalen, Knut Tomas (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Cholesteryl esters (CEs) are the water-insoluble transport and storage form of cholesterol. Steroidogenic cells primarily store CEs in cytoplasmic lipid droplet (LD) organelles, as contrasted to the majority of mammalian ...
  • Serglycin in Quiescent and Proliferating Primary Endothelial Cells 
    Reine, Trine M.; Vuong, Tram Thu; Rutkovskiy, Arkady; Meen, Astri Jeanette; Vaage, Ingvar Jarle; Jenssen, Trond Geir; Kolset, Svein Olav (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    Proteoglycans are fundamental components of the endothelial barrier, but the functions of the proteoglycan serglycin in endothelium are less described. Our aim was to describe the roles of serglycin in processes relevant ...
  • SNF472, a novel anti-crystallization agent, inhibits induced calcification in an in vitro model of human aortic valve calcification 
    Zabirnyk, Arsenii; Ferrer, Miguel David; Bogdanova, Maria A; Perez, MM; Salcedo, C; Kaljusto, Mari-Liis; Kvitting, John Peder Escobar; Stensløkken, Kåre-Olav; Perello, Joan; Vaage, Ingvar Jarle (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    The purpose of the present study was to investigate whether SNF472, the hexasodium salt of myo-inositol hexaphosphate (IP6 or phytate): 1. Inhibits induced calcification in cultured aortic valve interstitial cells (VIC) ...
  • Toll-like receptor 9 signaling after myocardial infarction: Role of p66ShcA adaptor protein 
    Baysa, Anton; Maghazachi, Azzam; Sand, Kristin Larsen; Campesan, Marika; Zaglia, Tania; Mongillo, Marco; Giorgio, Marco; Di Lisa, Fabio; Gullestad, Lars; Mariero, Lars Henrik; Vaage, Ingvar Jarle; Valen, Guro; Stensløkken, Kåre-Olav (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    During myocardial infarction, cellular debris is released, causing a sterile inflammation via pattern recognition receptors. These reactions amplify damage and promotes secondary heart failure. The pattern recognition ...