Browsing Institutt for klinisk medisin by Author "Tadele, Dagim Shiferaw"

Now showing items 1-4 of 4

  • Clinical forecasting of acute myeloid leukemia using ex vivo drug-sensitivity profiling 
    Andersen, Aram Nikolai; Brodersen, Andrea M; Ayuda Duran, Pilar; Piechaczyk, Laure Isabelle; Tadele, Dagim Shiferaw; Baken, Lizet; Fredriksen, Julie; Stoksflod, Mia; Lenartova, Andrea; Fløisand, Yngvar; Skånland, Sigrid S; Enserink, Jorrit (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Current treatment selection for acute myeloid leukemia (AML) patients depends on risk stratification based on cytogenetic and genomic markers. However, the forecasting accuracy of treatment response remains modest, with ...
  • Drug-screening and genomic analyses of HER2-positive breast cancer cell lines reveal predictors for treatment response 
    Jernström, Sandra Johanna; Hongisto, Vesa; Leivonen, Suvi-Katri; Due, Eldri Undlien; Tadele, Dagim Shiferaw; Edgren, Henrik; Kallioniemi, Olli; Perälä, Merja; Mælandsmo, Gunhild; Sahlberg, Kristine Kleivi (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Background: Approximately 15%–20% of all diagnosed breast cancers are characterized by amplified and overexpressed HER2 (= ErbB2). These breast cancers are aggressive and have a poor prognosis. Although improvements in ...
  • Early response evaluation by single cell signaling profiling in acute myeloid leukemia 
    Tislevoll, Benedicte Sjo; Hellesøy, Monica; Fagerholt, Oda Helen Eck; Gullaksen, Stein-Erik; Srivastava, Aashish; Birkeland, Even; Kleftogiannis, Dimitrios; Ayuda Duran, Pilar; Piechaczyk, Laure Isabelle; Tadele, Dagim Shiferaw; Skavland, Jørn; Panagiotis, Baliakas; Hovland, Randi; Andresen, Vibeke; Seternes, Ole Morten; Tvedt, Tor Henrik Anderson; Aghaeepour, Nima; Gavasso, Sonia; Porkka, Kimmo; Jonassen, Inge; Fløisand, Yngvar; Enserink, Jorrit; Blaser, Nello; Gjertsen, Bjørn Tore (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Abstract Aberrant pro-survival signaling is a hallmark of cancer cells, but the response to chemotherapy is poorly understood. In this study, we investigate the initial signaling response to standard induction chemotherapy ...
  • Phenotypic deconvolution in heterogeneous cancer cell populations using drug screen data 
    Köhn-Luque, Alvaro; Myklebust, Even Moa; Tadele, Dagim Shiferaw; Giliberto, Mariaserena; Schmiester, Leonard; Noory, Jasmine; Harivel, Elise; Arsenteva, Polina; Mumenthaler, Shannon M.; Schjesvold, Fredrik Hellem; Tasken, Kjetil; Enserink, Jorrit; Leder, Kevin; Frigessi, Arnoldo; Foo, Jasmine (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Tumor heterogeneity is an important driver of treatment failure in cancer since therapies often select for drug-tolerant or drug-resistant cellular subpopulations that drive tumor growth and recurrence. Profiling the ...