Browsing Institutt for klinisk medisin by Author "Taavela, Juha"

Now showing items 1-3 of 3

  • A Randomized Trial of a Transglutaminase 2 Inhibitor for Celiac Disease 
    Schuppan, Detlef; Maki, Markku; Lundin, Knut Erik Aslaksen; Isola, Jorma; Friesing-Sosnik, Tina; Taavela, Juha; Popp, Alina; Koskenpato, Jari; Langhorst, Jost; Hovde, Øistein; Lähdeaho, Marja-Leena; Fucso, Stefano; Schumann, Michael; Török, Helga-Paula; Kupcinskas, Jouzas; Zopf, Yurdagul; Lohse, Ansgar W.; Scheinin, Mika; Kull, Karin; Biedermann, Luc; Byrnes, Valerie; Stellmach, Andreas; Jahnsen, Jørgen; Zeitz, Jonas; Mohrbacher, Ralf; Greinwald, Roland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Background: In celiac disease, small intestinal transglutaminase 2 causes deamidation of glutamine residues in gluten peptides, which enhances stimulation of T cells and leads to mucosal injury. Inhibition of transglutaminase ...
  • Epitope-specific immunotherapy targeting CD4-positive T cells in coeliac disease: two randomised, double-blind, placebo-controlled phase 1 studies 
    Goel, Gautam; King, Tim; Daveson, A. James; Andrews, Jane M.; Krishnarajah, Janakan; Krause, Richard; Brown, Gregor J.E.; Fogel, Ronald; Barish, Charles F.; Epstein, Roger; Kinney, Timothy P.; Miner, Philip B.; Tye-Din, Jason A.; Girardin, Adam; Taavela, Juha; Popp, Alina; Sidney, John; Mäki, Markku; Goldstein, Kaela E.; Griffin, Patrick H.; Wang, Suyue; Dzuris, John L.; Williams, Leslie J.; Sette, Alessandro; Xavier, Ramnik J.; Sollid, Ludvig Magne; Jabri, Bana; Anderson, Robert P. (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
    Background: A gluten-free diet is the only means to manage coeliac disease, a permanent immune intolerance to gluten. We developed a therapeutic vaccine, Nexvax2, designed to treat coeliac disease. Nexvax2 is an adjuvant-free ...
  • Outcome measures in coeliac disease trials: The Tampere recommendations 
    Ludvigsson, Jonas F.; Ciacci, Carolina; Green, Peter H.R.; Kaukinen, Katri; Korponay-Szabó, Ilma R.; Kurppa, Kalle; Murray, Joseph A.; Lundin, Knut Erik Aslaksen; Mäki, Markku J.; Popp, Alina; Reilly, Norelle R.; Rodríguez-Herrera, Alfonso; Sanders, David; Schuppan, Detlef; Sleet, Sarah; Taavela, Juha; Voorhees, Kristin; Walker, Marjorie M.; Leffler, Daniel A. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Objective: A gluten-free diet is the only treatment option of coeliac disease, but recently an increasing number of trials have begun to explore alternative treatment strategies. We aimed to review the literature on coeliac ...