Browsing Institutt for klinisk medisin by Author "O'Connell, Kevin S."

Now showing items 1-6 of 6

  • Association between complement component 4A expression, cognitive performance and brain imaging measures in UK Biobank 
    O'Connell, Kevin S.; Sønderby, Ida Elken; Frei, Oleksandr; van der Meer, Dennis; Athanasiu, Lavinia; Smeland, Olav Bjerkehagen; Alnæs, Dag; Kaufmann, Tobias; Westlye, Lars Tjelta; Steen, Vidar Martin; Andreassen, Ole Andreas; Hughes, Timothy; Djurovic, Srdjan (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Background Altered expression of the complement component C4A gene is a known risk factor for schizophrenia. Further, predicted brain C4A expression has also been associated with memory function highlighting that altered ...
  • Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation 
    Frei, Oleksandr; Holland, Dominic; Smeland, Olav Bjerkehagen; Shadrin, Alexey A.; Fan, Chun Chieh; Maeland, Steffen; O'Connell, Kevin S.; Wang, Yunpeng; Djurovic, Srdjan; Thompson, Wesley Kurt; Andreassen, Ole Andreas; Dale, Anders (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Accumulating evidence from genome wide association studies (GWAS) suggests an abundance of shared genetic influences among complex human traits and disorders, such as mental disorders. Here we introduce a statistical tool, ...
  • Extensive bidirectional genetic overlap between bipolar disorder and cardiovascular disease phenotypes 
    Rødevand, Linn; Bahrami, Shahram; Frei, Oleksandr; Chu, Yunhan; Shadrin, Alexey A.; O'Connell, Kevin S.; Smeland, Olav Bjerkehagen; Elvsåshagen, Torbjørn; Hindley, Guy Frederick Lanyon; Djurovic, Srdjan; Dale, Anders; Lagerberg, Trine Vik; Steen, Nils Eiel; Andreassen, Ole Andreas (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Abstract Patients with bipolar disorder (BIP) have a high risk of cardiovascular disease (CVD), despite considerable individual variation. The mechanisms underlying comorbid CVD in BIP remain largely unknown. We investigated ...
  • Population-based body–brain mapping links brain morphology with anthropometrics and body composition 
    Gurholt, Tiril Pedersen; Kaufmann, Tobias; Frei, Oleksandr; Alnæs, Dag; Haukvik, Unn Kristin H.; van der Meer, Dennis; Moberget, Torgeir; O'Connell, Kevin S.; Leinhard, Olof Dahlqvist; Linge, Jennifer; Simon, Rozalyn; Smeland, Olav Bjerkehagen; Sønderby, Ida Elken; Winterton, Adriano; Steen, Nils Eiel; Westlye, Lars Tjelta; Andreassen, Ole Andreas (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Abstract Understanding complex body–brain processes and the interplay between adipose tissue and brain health is important for understanding comorbidity between psychiatric and cardiometabolic disorders. We investigated ...
  • Quantifying the polygenic architecture of the human cerebral cortex: Extensive genetic overlap between cortical thickness and surface area 
    van der Meer, Dennis; Frei, Oleksandr; Kaufmann, Tobias; Chen, Chi-Hua; Thompson, Wesley K.; O'Connell, Kevin S.; Monereo Sanchez, Jennifer; Linden, David E.J.; Westlye, Lars Tjelta; Dale, Anders; Andreassen, Ole Andreas (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    The thickness of the cerebral cortical sheet and its surface area are highly heritable traits thought to have largely distinct polygenic architectures. Despite large-scale efforts, the majority of their genetic determinants ...
  • Using iPSC Models to Understand the Role of Estrogen in Neuron–Glia Interactions in Schizophrenia and Bipolar Disorder 
    de Assis, Denis; Szabo, Attila; Osete, Jordi Requena; Puppo, Francesca; O'Connell, Kevin S.; Akkouh, Ibrahim; Hughes, Timothy; Frei, Evgeniia; Andreassen, Ole Andreas; Djurovic, Srdjan (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Schizophrenia (SCZ) and bipolar disorder (BIP) are severe mental disorders with a considerable disease burden worldwide due to early age of onset, chronicity, and lack of efficient treatments or prevention strategies. ...