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Now showing items 1-100 of 308
Turning off autophagy: Investigation of the role of TOR and the Ubiquitin Proteasome System. Restricted Access
(Master thesis / Masteroppgave, 2023)
Transcriptional regulation of histone variants in breast cancer Restricted Access
(Master thesis / Masteroppgave, 2023)
(Master thesis / Masteroppgave, 2023)
The role of GCN2 in prostate cancer Restricted Access
(Master thesis / Masteroppgave, 2023)
Characterizing the role of transcriptional cyclin-dependent kinases, CDK12 and CDK13 in regulating RNA Polymerase II phosphorylation and cell cycle Restricted Access
(Master thesis / Masteroppgave, 2023)
(Master thesis / Masteroppgave, 2023)
(Master thesis / Masteroppgave, 2023)
The emergence of multi-antibacterial resistant pathogens worldwide has become a crisis and new therapies are needed to combat this threat. One potential solution is the use of bacteriocins: bacterially produced polypeptides ...
(Master thesis / Masteroppgave, 2023)
Natural killer (NK) cells in the human body play a critical role in immunosurveillance and the control of cancer metastasis, mainly due to their capacity to respond spontaneously to targets without the need for prior antigen ...
AI Selected Therapeutics and Targets Increase Longevity in Both Normal and Accelerated Aging Populations Restricted Access
(Master thesis / Masteroppgave, 2023)
(Master thesis / Masteroppgave, 2023)
(Master thesis / Masteroppgave, 2023)
(Master thesis / Masteroppgave, 2023)
Ex vivo tumor tissue cultures, such as organoids or explants, hold promise as a drug screening platform for functional precision diagnostics. In this project, we have employed such cultures to investigate functional and ...
(Master thesis / Masteroppgave, 2023)
(Master thesis / Masteroppgave, 2023)
Characterization of the substrate interaction sites in factor seven activating protease (FSAP) Restricted Access
(Master thesis / Masteroppgave, 2022)
Screening for Compounds that Can Alter Unfolded Protein Response Activity in Prostate Cancer Cells Restricted Access
(Master thesis / Masteroppgave, 2022)
(Master thesis / Masteroppgave, 2022)
Investigations of Developing T-cells in Human Thymus Restricted Access
(Master thesis / Masteroppgave, 2022)
Identification and characterization of a novel Invariant Chain-interacting protein Restricted Access
(Master thesis / Masteroppgave, 2022)
Characterisation of the role of CYRI-B in immune cells Restricted Access
(Master thesis / Masteroppgave, 2022)
“String-of-Beads” DNA Vaccine Encoding T cell Epitopes Targeted towards Antigen Presenting Cells for Protection Against Multiple Myeloma in MOPC315 Mouse Model Restricted Access
(Master thesis / Masteroppgave, 2022)
Study of the membrane protein SLC38A9 and the Rag-Ragulator complex, key effectors of mTOR Complex 1 signaling Restricted Access
(Master thesis / Masteroppgave, 2022)
Palladium nanoparticles in copper transport mutants of Escherichia coli Restricted Access
(Master thesis / Masteroppgave, 2022)
(Master thesis / Masteroppgave, 2022)
(Master thesis / Masteroppgave, 2022)
(Master thesis / Masteroppgave, 2022)
(Master thesis / Masteroppgave, 2022)
Germ cells are responsible for the delivery of genetic information from one generation to the next and thus provide a physical chain of inheritance. When fertilized, the female gamete, the oocyte, initiates the transition ...
(Master thesis / Masteroppgave, 2022)
(Master thesis / Masteroppgave, 2022)
Pancreatic ductal adenocarcinoma (PDAC), often referred to as pancreatic cancer is one of the most aggressive and deadliest cancer types, with a 5-year survival rate of less than 10%. PDAC is characterized by vague, ...
(Master thesis / Masteroppgave, 2021)
In this study, we assessed the potential synergistic effects of XBP1 and ATF4 on cell growth in two different PCa cell lines. Through simultaneous siRNA-mediated knockdown of ATF4 and total XBP1, we analyzed effects on ...
(Master thesis / Masteroppgave, 2021)
Macrophages are essential innate immune cells which have increasingly become attractive manipulable targets in designing therapies, given their significant involvement in the pathophysiology of several diseases, including ...
(Master thesis / Masteroppgave, 2021)
Validation of KAT6A and Menin as therapeutic targets for TKI resistant Philadelphia positive leukemia Restricted Access
(Master thesis / Masteroppgave, 2021)
(Master thesis / Masteroppgave, 2021)
(Master thesis, Group thesis / Masteroppgave, Gruppeoppgave, 2021)
Tuberculosis (TB), one of the oldest recorded diseases of mankind, remains a major health threat to the global population to date. Its causative agent, Mycobacterium tuberculosis (M.tb), has survived numerous public health ...
(Master thesis / Masteroppgave, 2021)
(Master thesis / Masteroppgave, 2021)
Blocking the Inhibitory Prostaglandin E2 Signaling Pathway with Small Molecules to Restore T Cell Function Restricted Access
(Master thesis / Masteroppgave, 2021)
(Master thesis / Masteroppgave, 2021)
(Master thesis / Masteroppgave, 2021)
Analyses of the molecular mechanisms involved in controlling the connexin 43 ubiquitination status and protein level in cervical cancer cells Restricted Access
(Master thesis / Masteroppgave, 2021)
(Master thesis / Masteroppgave, 2021)
(Master thesis / Masteroppgave, 2021)
Important drug delivery discoveries have been made in the field of drug carrying NPs. The penetration and accumulation of nanoparticles (NPs) at the granulomatous area was shown in a zebrafish and mice study conducted by ...
Novel function of GCN2 in directional migration Restricted Access
(Master thesis / Masteroppgave, 2021)
GCN2 is a protein kinase, which is implicated in several diseases, including cancer. The only well-characterized role of GCN2 is a translational reprogramming of cells when challenged by several types of stress. Since ...
Regulatory mechanisms behind muscle memory Restricted Access
(Master thesis / Masteroppgave, 2021)
Establishment of a CRISPR/Cas9 β2m knockout cell line for production of recombinant FcRn Restricted Access
(Master thesis / Masteroppgave, 2021)
A study of a genetic variant identified in FRMD6 in a patient with oral-facial-digital syndrome Restricted Access
(Master thesis / Masteroppgave, 2021)
(Master thesis / Masteroppgave, 2021)
(Master thesis / Masteroppgave, 2020)
The purpose of this study was to find whether exosomes can function as biomarkers for acute leukemia in children, with the long-term goal to assess whether exosomes can be used to predict risk of relapse.
(Master thesis / Masteroppgave, 2020)
The surface of Gram-negative bacteria is perforated by β-barrel proteins called outer membrane proteins (OMPs). These β-barrels are integral to the outer membrane (OM) and are essential for the viability of the bacterial ...
Synergia PRR-fecta: Harnessing pathogen-recognition receptor synergy to produce high levels of IL-12p70 & prime dendritic cells for use in cancer immunotherapy Restricted Access
(Master thesis / Masteroppgave, 2020)
Progress in the production of consistent, viable anti-cancer vaccines has been hampered by the lack of a fitting adjuvant capable of eliciting a targeted, cytotoxic response against tumours. The cytokine interleukin 12p70 ...
Characterization of human and chicken PGM2 and PGM5 Restricted Access
(Master thesis / Masteroppgave, 2020)
The proteins of the α-D-phosphohexomutase superfamily are important in several metabolic processes in all kingdoms of life. Many of the superfamily members are, however, severely understudied. Two of the less studied human ...
In Vitro Sensitivity to Targeted Therapies in Mantle Cell Lymphoma and Chronic Lymphocytic Leukemia Restricted Access
(Master thesis / Masteroppgave, 2020)
(Master thesis / Masteroppgave, 2020)
The Gram-negative bacterium, Acinetobacter baumannii, is one of the leading causes of drug resistant hospital-acquired infections in humans. Owing to its ability to easily acquire resistance genes and to survive in the ...
(Master thesis / Masteroppgave, 2020)
A novel trimeric APC targeted DNA vaccine against influenza Restricted Access
(Master thesis / Masteroppgave, 2020)
Antibody-targeted photodynamic therapy to kill cancer cells Restricted Access
(Master thesis / Masteroppgave, 2020)
An imaging-based study of the dynamical behavior of Rab proteins during endosomal maturation Restricted Access
(Master thesis / Masteroppgave, 2020)
Idiotype-specific Th cells as a drive for the expansion of malignant B cells in chronic lymphocytic leukemia Restricted Access
(Master thesis / Masteroppgave, 2020)
(Master thesis / Masteroppgave, 2020)
Aquaculture is an important industry in Norway, particularly the production of Atlantic salmon (Salmo salar L.). Health problems and environmental impacts during the seawater stage are limiting factors for the industry. ...
Increasing the efficacy of influenza vaccination in obese individuals Restricted Access
(Master thesis / Masteroppgave, 2020)
(Master thesis / Masteroppgave, 2020)
(Master thesis / Masteroppgave, 2020)
An investigation of different factors that affect mapping accuracy
(Master thesis / Masteroppgave, 2019)
Production of autoantibodies by TG2-specific gut plasma cells is a hallmark of celiac disease. Previous studies have revealed biased selection of IGHV and IGKV gene segments, low number of mutations and preferential targeting ...
(Master thesis / Masteroppgave, 2019)
microRNAs (miRNAs) are short RNA molecules, which post-transcriptionally regulate other genes. They are generated from genome-encoded single-stranded hairpin structures, by a set of RNA-processing enzymes. miRNAs are highly ...
Effects of the mycotoxin Deoxynivalenol and grain components on intestinal in vitro model systems Restricted Access
(Master thesis / Masteroppgave, 2019)
Characterization of eIF2α kinases in prostate cancer cells Restricted Access
(Master thesis / Masteroppgave, 2019)
Cancer is the second leading cause of death worldwide. In Norwegian men, prostate cancer (PCa) was the most commonly diagnosed cancer and second most frequent cause of cancer death in 2017. The tumor microenvironment (TME), ...
(Master thesis / Masteroppgave, 2019)
Whole exome sequencing was performed to identify putative disease-causing variants in a girl with macrocephaly, epilepsy and severe mental retardation, who had an unknown molecular diagnosis. Compound heterozygous SZT2 ...
(Master thesis / Masteroppgave, 2019)
Sarcomas arise in patients of all ages and account for approximately 1% of new cancer diagnoses in Norway and the United States. Osteosarcoma is a subtype of sarcoma that typically affects children and adolescents and ...
Development of Novel Treatments for Drug-Resistant Candida Infections Restricted Access
(Master thesis / Masteroppgave, 2019)
Small molecule c-Myc modulator as a potential compound for immunotherapeutic treatment of cancers Restricted Access
(Master thesis / Masteroppgave, 2019)
(Master thesis / Masteroppgave, 2019)
(Master thesis / Masteroppgave, 2019)
(Master thesis / Masteroppgave, 2019)
Gram-negative bacteria use different protein secretion systems, ranging from type I through type IX, to invade the host and cause infections. Proteins of the type V secretion system, called autotransporters, can autonomously ...
(Master thesis / Masteroppgave, 2019)
Acute myeloid leukemia (AML) is one of the subtypes of leukemia that is genetically and medically heterogeneous. The FLT3-ITD mutant variant is one of its form of leukemia, that constitutes 30% of the occurrences. This ...
(Master thesis / Masteroppgave, 2019)
Identification of a novel interacting partner of Rab33b: a potential link to cell migration Restricted Access
(Master thesis / Masteroppgave, 2019)
Characterization of the role of a Rab protein in cell migration through novel interactors Restricted Access
(Master thesis / Masteroppgave, 2019)
Endoplasmic reticulum stress downregulates c-MYC expression through proteasomal degradation in prostate cancer cells Restricted Access
(Master thesis / Masteroppgave, 2019)
Prostate cancer (PCa) is the most prevalent non-cutaneous cancer and second leading cause of cancer-related death among men in Western countries. Knowledge of its underlying molecular mechanism is necessary to characterise ...
Molecular heterogeneity in multifocal primary prostate cancer Restricted Access
(Master thesis / Masteroppgave, 2019)
Improved biomarker potential of long non-coding RNAs in multisampled primary prostate cancer Restricted Access
(Master thesis / Masteroppgave, 2019)
Characterization of a Drosophila model of MLL-rearranged leukemia Restricted Access
(Master thesis / Masteroppgave, 2019)
Studying the Impact of Drugs on LINE-1 Retrotransposition Restricted Access
(Master thesis / Masteroppgave, 2019)
(Master thesis / Masteroppgave, 2019)
(Master thesis / Masteroppgave, 2019)
(Master thesis / Masteroppgave, 2019)
A proteomics-based approach to identify interactors of the IDA-HAE/HSL2 signaling pathway Restricted Access
(Master thesis / Masteroppgave, 2019)
Emblica officinalis as a therapeutic supplement in Alzheimer’s disease Restricted Access
(Master thesis / Masteroppgave, 2019)
Alzheimer’s disease (AD) is the most common form of dementia, currently affecting 50 million people worldwide. While plaques of misfolded protein amyloid-beta (Aβ) are a hallmark of the disease, drugs targeted to reduce ...
Repeated social defeat induces changes in splenic myeloid cells: downregulation of β-arrestin-2 and upregulation of IL-6 Restricted Access
(Master thesis / Masteroppgave, 2019)
Identification and pre-clinical assessment of patient-derived TCRs for solid tumor immunotherapy Restricted Access
(Master thesis / Masteroppgave, 2019)
(Master thesis / Masteroppgave, 2019)
(Master thesis / Masteroppgave, 2019)
Targeting of FGFR overexpressing cancer cells by PCI of FGF-SAP Restricted Access
(Master thesis / Masteroppgave, 2019)
(Master thesis / Masteroppgave, 2019)
Background: Increased plasma glucose levels in pregnancy or gestational diabetes may have implications for future maternal health, such as increased risk of type 2 diabetes mellitus (T2DM) developing within 10 years. ...
TREM2: A potential target for treatment of Alzheimer’s Disease Restricted Access
(Master thesis / Masteroppgave, 2019)
(Master thesis / Masteroppgave, 2019)
(Master thesis / Masteroppgave, 2019)
The ability of neurons to encode information and communicate with each other is vital for the normal functioning of our brain and body. The large pyramidal cells of the hippocampus have been of particular interest, due to ...
(Master thesis / Masteroppgave, 2019)
Role of NEIL DNA glycosylases in G4 dynamics Restricted Access
(Master thesis / Masteroppgave, 2019)