Lyme borreliosis (LB) is the most frequent human tick-borne disease in Scandinavia. This master thesis is focusing on the Borrelia burgdorferi sensu lato (s.l.) complex, which is the causative agent of LB. Today, the B. ...

The c-Myb transcription factor is a key regulator of haematopoiesis. Its activity is regulated by a large network of protein interactions and post-translational modifications. ATF7IP is a transcriptional cofactor previously ...

Protein methylation is a post-translational modification best studied in regards to histones and the histone code. In recent years, more studies have begun to unearth non-histone protein methylation, in most cases however, ...

Aberrant DNA methylation is one of the most common alterations in cancer, and a vast diversity of methods for its investigation exists. Quantitative methylation-specific PCR (qMSP) is frequently used to estimate the amounts ...

Transcription of genes is controlled by a highly tuned machinery regulated by transcription factors, histone modifications and chromatin remodelers. CHD3, as a member of the chromatin remodelers, has an important role in ...

Chondroitin Sulfate (CS) glycosaminoglycan (GAG) is a modification carried by proteoglycans (PGs) that have important physiological functions in cartilage and bone formation, the immune system and the central nervous system. ...

Ectoine is a small compound synthesized in the cytoplasm of halophilic and halotolerant bacteria in response to salt stress. The compound has been found to behave as a compatible solute counterweighing osmotic imbalance ...

The goal of this work was to express the three enzymes that catalyse the synthesis of ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid) in the chloroplast of Chlamydomonas reinhardtii. Ectoine is an amino ...