Earlier observations show that social stress has a strong effect on the autonomic nervous system. Moreover, exposure to social stress may be associated with low-grade systemic inflammation and hyperalgesia. In the present ...

The effects of resistance exercise have shown to be long-lasting. This was previously attributed solely to motor learning, but more recently a memory mechanism residing in the muscle cell itself has been proposed, based ...

The reciprocally connected entorhinal cortex and hippocampal formation (HF) are pivotal in spatial navigation and episodic memory. Principal neurons in these regions show spatially modulated activity with grid cells in the ...

Low back pain and sciatica after disc herniation may be caused by mechanical compression of the nerve roots, but also by the release of pro-inflammatory agents and growth factors from the nucleus pulposus (NP) of the ...

Defensive behaviours are vital for survival. Animals portray a range of context specific defensive behaviours when faced with a threat. Previous studies have shown that electrical stimulation of the hypothalamus induces ...

Lumbar disc herniation may affect the spinal nerve roots through mechanical pressure, but may also induce a local inflammatory response. Therefore, in an animal model mimicking the clinical situation after intervertebral ...

Hippocampus is a brain region known to be important for memory and learning which requires a high level of plasticity throughout life. Perineuronal nets (PNNs) are specialized extracellular matrix structures found to ...

Lumbar radicular pain after intervertebral disc herniation may be associated with mechanical compression of the nerve roots, but also release of pro-inflammatory cytokines from nucleus pulposus (NP) tissue. In an animal ...

Chronic stress is the principal component to many human and animal disorders. As stress responses are remarkably conserved between mammals and teleosts, the use of teleosts in comparative models has been a useful tool in ...

Cardiac pathology related to stress and life-style is a major cause of death in humans. It is also an emerging problem for the salmon aquaculture industry. This industry produces semi-domesticated fish in very intensive ...

Tuberculosis (TB) is a disease caused by the bacterium Mycobacterium tuberculosis, a pathogen that has accompanied mankind throughout its far and recent history. Current TB-therapy consists of two treatment phases, one ...

A unique characteristic of skeletal muscle is its heterogeneous nature and ability to acquire new functional characteristics to keep up with changing demands. These plastic properties are mainly regulated by activity. ...

Perineuronal nets (PNNs) are a specialized form of extracellular matrix in the CNS, embodying parvalbumin expressing inhibitory neurons. The PNN assembles towards the end of the period of heightened plasticity, the critical ...