Browsing Institutt for biovitenskap by Author "Dal, Nils-Jørgen Knudsen"

Now showing items 1-5 of 5

  • Biodistribution of surfactant-free poly(lactic-acid) nanoparticles and uptake by endothelial cells and phagocytes in zebrafish: Evidence for endothelium to macrophage transfer 
    Resseguier, Julien; Levraud, Jean-Pierre; Dal, Nils-Jørgen Knudsen; Fenaroli, Federico; Primard, Charlotte; Wohlmann, Jens; Carron, Gabrielle; Griffiths, Gareth Wyn; Le Guellec, Dominique; Verrier, Bernard (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    In the development of therapeutic nanoparticles (NP), there is a large gap between in vitro testing and in vivo experimentation. Despite its prominence as a model, the mouse shows severe limitations for imaging NP and the ...
  • End group dye-labeled polycarbonate block copolymers for micellar (immuno-)drug delivery 
    Czysch, Christian; Medina-Montano, Carolina; Dal, Nils-Jørgen Knudsen; Dinh, Thi; Fröder, Yannick; Winterwerber, Pia; Maxeiner, Konrad; Räder, Hans-Joachim; Schuppan, Detlef; Schild, Hansjörg; Bros, Matthias; Biersack, Bernhard; Fenaroli, Federico; Grabbe, Stephan; Nuhn, Lutz (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Defined conjugation of functional molecules to block copolymer end groups is a powerful strategy to enhance the scope of micellar carriers for drug delivery. In this study, an approach to access well-defined polycarbonate-based ...
  • Real-time imaging of polymersome nanoparticles in zebrafish embryos engrafted with melanoma cancer cells: Localization, toxicity and treatment analysis 
    Kocere, Agnese; Resseguier, Julien; Wohlmann, Jens; Skjeldal, Frode Miltzow; Khan, Shanawaz; Speth, Martin; Dal, Nils-Jørgen Knudsen; Ng, Matthew Yoke Wui; Alonso Rodriguez, Noelia; Scarpa, Edoardo; Rizzello, Loris; Battaglia, Giuseppe; Griffiths, Gareth Wyn; Fenaroli, Federico (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Background The developing zebrafish is an emerging tool in nanomedicine, allowing non-invasive live imaging of the whole animal at higher resolution than is possible in the more commonly used mouse models. In addition, ...
  • The zebrafish embryo as an in vivo model for screening nanoparticle-formulated lipophilic anti-tuberculosis compounds 
    Dal, Nils-Jørgen Knudsen; Speth, Martin Tobias; Johann, Kerstin; Barz, Matthias; Beauvineau, Claire; Wohlmann, Jens; Fenaroli, Federico; Gicquel, Brigitte; Griffiths, Gareth Wyn; Alonso Rodriguez, Noelia (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    ABSTRACT With the increasing emergence of drug-resistant Mycobacterium tuberculosis strains, new and effective antibiotics against tuberculosis (TB) are urgently needed. However, the high frequency of poorly ...
  • Zebrafish Embryos Allow Prediction of Nanoparticle Circulation Times in Mice and Facilitate Quantification of Nanoparticle–Cell Interactions 
    Dal, Nils-Jørgen Knudsen; Kocere, Agnese; Wohlmann, Jens; Van Herck, Simon; Bauer, Tobias A; Resseguier, Julien; Bagheri Fam, Shahla; Hyldmo, Hilde C Bergvin; Barz, Matthias; De Geest, Bruno G.; Fenaroli, Federico (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    The zebrafish embryo is a vertebrate well suited for visualizing nanoparticles at high resolution in live animals. Its optical transparency and genetic versatility allow noninvasive, real‐time observations of vascular flow ...