Now showing items 152-171 of 1306

  • Bengtsen, Mads; Klepper, Kjetil; Gundersen, Sveinung; Cuervo, Ignacio; Drabløs, Finn; Hovig, Johannes Eivind; Sandve, Geir Kjetil F.; Gabrielsen, Odd Stokke; Eskeland, Ragnhild (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    Strict control of tissue-specific gene expression plays a pivotal role during lineage commit- ment. The transcription factor c-Myb has an essential role in adult haematopoiesis and func- tions as an oncogene when rearranged ...
  • Fuglerud, Bettina Maria; Lemma, Roza Berhanu; Wanichawan, Pimthanya; Sundaram, Arvind; Eskeland, Ragnhild; Gabrielsen, Odd Stokke (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    The transcription factor c-Myb is involved in early differentiation and proliferation of haematopoietic cells, where it operates as a regulator of self-renewal and multi-lineage differentiation. Deregulated c-Myb plays ...
  • Barfeld, Stefan Jörg; Urbanucci, Alfonso; Itkonen, Harri; Fazli, Ladan; Hicks, Jessica L.; Thiede, Bernd; Rennie, Paul S.; Yegnasubramanian, Srinivasan; DeMarzo, Angelo M.; Mills, Ian Geoffrey (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Prostate cancer (PCa) is the most common non-cutaneous cancer in men. The androgen receptor (AR), a ligand-activated transcription factor, constitutes the main drug target for advanced cases of the disease. However, a ...
  • Fusser, Markus; Øverbye, Anders; Pandya, Abhilash D.; Mørch, Ýrr Asbjørg; Borgos, Sven Even F.; Kildal, Wanja; Snipstad, Sofie; Sulheim, Einar; Fleten, Karianne Giller; Askautrud, Hanne Arenberg; Engebraaten, Olav; Flatmark, Kjersti; Iversen, Tore Geir; Sandvig, Kirsten; Skotland, Tore; Mælandsmo, Gunhild Mari (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    The effect of poly(2-ethyl-butyl cyanoacrylate) nanoparticles containing the cytotoxic drug cabazitaxel was studied in three breast cancer cell lines and one basal-like patient-derived xenograft model grown in the mammary ...
  • Øverbye, Anders; Torgersen, Maria Lyngaas; Sønstevold, Tonje; Iversen, Tore Geir; Mørch, Ýrr Asbjørg; Skotland, Tore; Sandvig, Kirsten (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2021)
    Nanoparticles composed of poly(alkyl cyanoacrylate) (PACA) have shown great promise due to their biodegradability and high drug loading capacity. Development of optimal PACA nanocarriers requires detailed analysis of the ...
  • Brydegaard, Mikkel; Jansson, Samuel; Schulz, Marcus; Runemark, Anna (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Despite numerous studies of selection on position and number of spectral vision bands, explanations to the function of narrow spectral bands are lacking. We investigate dragonflies (Odonata), which have the narrowest ...
  • Jorde, Per Erik; Synnes, Ann-Elin; Espeland, Sigurd Heiberg; Sodeland, Marte; Knutsen, Halvor (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    The use of genetic markers under putative selection in population studies carries the potential for erroneous identification of populations and misassignment of individuals to population of origin. Selected markers are ...
  • Mazagão Guerreiro, Eduarda; Øvstebø, Reidun; Thiede, Bernd; Costea, Daniela Elena; Søland, Tine Merete; Galtung, Hilde (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Extracellular vesicles (EVs), are important for intercellular communication in both physiological and pathological processes. To explore the potential of cancer derived EVs as disease biomarkers for diagnosis, monitoring, ...
  • Filbee-Dexter, Karen; Pedersen, Morten Foldager; Fredriksen, Stein; Norderhaug, Kjell Magnus; Rinde, Eli; Kristiansen, Trond; Albretsen, Jon; Wernberg, Thomas (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
    With the increasing imperative for societies to act to curb climate change by increasing carbon stores and sinks, it has become critical to understand how organic carbon is produced, released, transformed, transported, and ...
  • Langangen, Øystein; Ohlberger, Jan; Stige, Leif C.; Durant, Joel M.; Ravagnan, Elisa; Stenseth, Nils C.; Hjermann, Dag Ø. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Mass mortality events caused by pulse anthropogenic or environmental perturbations (e.g., extreme weather, toxic spills or epizootics) severely reduce the abundance of a population in a short time. The frequency and impact ...
  • Sguotti, Camilla; Otto, Saskia A; Frelat, Romain; Langbehn, Tom; Plambech Ryberg, M; Lindegren, Martin; Durant, Joel Marcel; Stenseth, Nils Christian; Möllmann, Christian (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Collapses and regime changes are pervasive in complex systems (such as marine ecosystems) governed by multiple stressors. The demise of Atlantic cod (Gadus morhua) stocks constitutes a text book example of the consequences ...
  • Ferter, Keno; Klaas, Hartmann; Kleiven, Alf Ring; Moland, Even; Olsen, Esben Moland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
    Studying the sublethal effects of catch-and-release (C&R) is challenging, as there are several potential sources of bias. For example, if behavioural alterations immediately after the release event are to be studied, ...
  • Hatlem, Daniel; Trunk, Thomas; Linke, Dirk; Leo, Jack Christopher (Chapter / Bokkapittel / PublishedVersion; Peer reviewed, 2020)
    The SpyCatcher-SpyTag system was developed seven years ago as a method for protein ligation. It is based on a modified domain from a Streptococcus pyogenes surface protein (SpyCatcher), which recognizes a cognate 13-amino-acid ...
  • Hatlem, Daniel; Trunk, Thomas; Linke, Dirk; Leo, Jack Christopher (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    The SpyCatcher-SpyTag system was developed seven years ago as a method for protein ligation. It is based on a modified domain from a Streptococcus pyogenes surface protein (SpyCatcher), which recognizes a cognate 13-amino-acid ...
  • Rusch, Johannes C; Hansen, Haakon; Strand, David A; Markussen, Turhan; Hytterød, Sigurd; Vrålstad, Trude (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Background Environmental DNA (eDNA) monitoring is growing increasingly popular in aquatic systems as a valuable complementary method to conventional monitoring. However, such tools have not yet been ...
  • Frank, Matthias Johannes; Walter, Martin Sebastian; Rubert, Marina; Thiede, Bernd; Monjo Cabrer, Marta; Reseland, Janne Elin; Haugen, Håvard Jostein; Lyngstadaas, Ståle Petter (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
    The idea of a bioactive surface coating that enhances bone healing and bone growth is a strong focus of on-going research for bone implant materials. Enamel matrix derivate (EMD) is well documented to support bone regeneration ...
  • Hannisdal, Bjarte; Liow, Lee Hsiang (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    As custodians of deep time, palaeontologists have an obligation to seek the causes and consequences of long‐term evolutionary trajectories and the processes of ecosystem assembly and collapse. Building explicit process ...
  • Haabeth, Ole Audun; Hennig, Kjartan; Fauskanger, Marte; Løset, Geir Åge; Bogen, Bjarne; Tveita, Anders Aune (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Abstract CD4+ T cells may induce potent antitumor immune responses through interaction with antigen-presenting cells within the tumor microenvironment. Using a murine model of multiple myeloma, we demonstrated ...
  • Herrera, Maria Carmen; Chymkowitch, Pierre; Robertson, Joseph; Eriksson, Jens; Bøe, Stig Ove; Alseth, Ingrun; Enserink, Jorrit (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    tRNA genes are transcribed by RNA polymerase III (RNAPIII). During recent years it has become clear that RNAPIII activity is strictly regulated by the cell in response to environmental cues and the homeostatic status of ...
  • Skedsmo, Fredrik S; Tranulis, Michael A; Espenes, Arild; Prydz, Kristian; Matiasek, Kaspar; Gunnes, Gjermund; Hermansen, Lene C; Jäderlund, Karin H (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Background Mutations in the N-myc downstream-regulated gene 1 (NDRG1) can cause degenerative polyneuropathy in humans, dogs, and rodents. In humans, this motor and sensory neuropathy is known as Charcot-Marie-Tooth ...