Search
Now showing items 1-100 of 1489
(Master thesis / Masteroppgave, 2019)
Acute myeloid leukemia (AML) is one of the subtypes of leukemia that is genetically and medically heterogeneous. The FLT3-ITD mutant variant is one of its form of leukemia, that constitutes 30% of the occurrences. This ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Air pollution is the most important environmental risk factor for disease and premature death, and exposure to combustion particles from vehicles is a major contributor. Human epidemiological studies combined with experimental ...
(Master thesis / Masteroppgave, 2019)
Sarcomas arise in patients of all ages and account for approximately 1% of new cancer diagnoses in Norway and the United States. Osteosarcoma is a subtype of sarcoma that typically affects children and adolescents and ...
Development of Novel Treatments for Drug-Resistant Candida Infections Restricted Access
(Master thesis / Masteroppgave, 2019)
Small molecule c-Myc modulator as a potential compound for immunotherapeutic treatment of cancers Restricted Access
(Master thesis / Masteroppgave, 2019)
Characterization of eIF2α kinases in prostate cancer cells Restricted Access
(Master thesis / Masteroppgave, 2019)
Cancer is the second leading cause of death worldwide. In Norwegian men, prostate cancer (PCa) was the most commonly diagnosed cancer and second most frequent cause of cancer death in 2017. The tumor microenvironment (TME), ...
(Master thesis / Masteroppgave, 2019)
Whole exome sequencing was performed to identify putative disease-causing variants in a girl with macrocephaly, epilepsy and severe mental retardation, who had an unknown molecular diagnosis. Compound heterozygous SZT2 ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Objective
Earlier studies documenting the effect of candidate genes on recovery have seldom taken into consideration the impact of emotional distress. Thus, we aimed to assess the modifying effect of emotional ...
(Doctoral thesis / Doktoravhandling, 2019)
In this work Ignacio Cuervo and co-workers have studied different aspects of the transcriptional regulating processes implicated in embryonic stem cell differentiation and in the regulation and dysregulation of cancer ...
(Master thesis / Masteroppgave, 2019)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background
Mutations in the N-myc downstream-regulated gene 1 (NDRG1) can cause degenerative polyneuropathy in humans, dogs, and rodents. In humans, this motor and sensory neuropathy is known as Charcot-Marie-Tooth ...
(Master thesis / Masteroppgave, 2019)
(Doctoral thesis / Doktoravhandling, 2019)
Targeted Thorium-227 Conjugates (TTCs) represent a novel class of cancer therapy currently in preclinical and clinical development. The TTCs consist of the alpha emitter thorium-227 (227Th) complexed to a 3,2-HOPO chelator ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background
Mononuclear cell infiltration of exocrine glands, production of Ro/SSA and La/SSB autoantibodies, along with oral and ocular dryness, are characteristic features of primary Sjögren’s syndrome ...
The endangered Dracocephalum ruyschiana: a study of factors affecting reproduction and recruitment in Norwegian populations Restricted Access
(Master thesis / Masteroppgave, 2019)
Dracocephalum ruyschiana is a rare species in Europe and its conservation is considered a priority by the Norwegian Environment Agency. Specialist species in fragmented and rare habitats such as dry, calcareous grasslands ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
On 3 August 1900, bubonic plague (Yersinia pestis) broke out in Glasgow for the first time during the Third Pandemic. The local sanitary authorities rigorously tracked the spread of the disease and they found that nearly ...
(Master thesis / Masteroppgave, 2019)
(Journal article / Tidsskriftartikkel; Peer reviewed, 2019)
Puwainaphycins (PUWs) and minutissamides (MINs) are structurally analogous cyclic lipopeptides possessing cytotoxic activity. Both types of compound exhibit high structural variability, particularly in the fatty acid (FA) ...
(Doctoral thesis / Doktoravhandling, 2019)
Fungi are crucial components in all ecosystems, as decomposers and recyclers of organic matter, as pathogens and as beneficial symbionts with plants. Several recent studies indicate that the borders between these ecological ...
(Master thesis / Masteroppgave, 2019)
Gram-negative bacteria use different protein secretion systems, ranging from type I through type IX, to invade the host and cause infections. Proteins of the type V secretion system, called autotransporters, can autonomously ...
(Master thesis / Masteroppgave, 2019)
Production of autoantibodies by TG2-specific gut plasma cells is a hallmark of celiac disease. Previous studies have revealed biased selection of IGHV and IGKV gene segments, low number of mutations and preferential targeting ...
(Master thesis / Masteroppgave, 2019)
Human activities have historically influenced the evolution of other species. Dramatic modifications in land-use and extreme urbanization have increased not only the amount of species associated with human environments, ...
(Master thesis / Masteroppgave, 2019)
The INFLORESCENCE DEFICIENT IN ABSCISSION (IDA)/IDA-LIKE gene family encodes peptides hypothesized to be involved in different cell-separation events in plants. A phylogenetic analysis was performed to elucidate the ...
(Master thesis / Masteroppgave, 2019)
microRNAs (miRNAs) are short RNA molecules, which post-transcriptionally regulate other genes. They are generated from genome-encoded single-stranded hairpin structures, by a set of RNA-processing enzymes. miRNAs are highly ...
Effects of the mycotoxin Deoxynivalenol and grain components on intestinal in vitro model systems Restricted Access
(Master thesis / Masteroppgave, 2019)
(Doctoral thesis / Doktoravhandling, 2019)
(Doctoral thesis / Doktoravhandling, 2019)
Friend or foe? Bacteria are often recognized for causing illness and fatal diseases, but many bacteria are harmless and can even serve beneficial roles in their hosts. In this doctoral work, Nelson Wang investigated both ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background and Objectives: The oxidative potential (OP) of particulate matter (PM) in cell-free/abiotic systems have been suggested as a possible measure of their biological reactivity and a relevant exposure metric for ...
Endoplasmic reticulum stress downregulates c-MYC expression through proteasomal degradation in prostate cancer cells Restricted Access
(Master thesis / Masteroppgave, 2019)
Prostate cancer (PCa) is the most prevalent non-cutaneous cancer and second leading cause of cancer-related death among men in Western countries. Knowledge of its underlying molecular mechanism is necessary to characterise ...
(Master thesis / Masteroppgave, 2019)
Identification of a novel interacting partner of Rab33b: a potential link to cell migration Restricted Access
(Master thesis / Masteroppgave, 2019)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
In recent decades, the freshwater alga Gonyostomum semen (Ehrenberg) Diesing has increased in abundance and distribution, which has created problems regarding the use of lakes for drinking water and recreation. Increases ...
Characterization of the role of a Rab protein in cell migration through novel interactors Restricted Access
(Master thesis / Masteroppgave, 2019)
(Doctoral thesis / Doktoravhandling, 2019)
The aim of this thesis was to combine computational and experimental methods to engineer high affinity gluten pMHC specific antibodies, validate them, and use them to study peptide presentation in CeD patients and explore ...
(Doctoral thesis / Doktoravhandling, 2019)
Marine coastal areas are among the most productive ecosystems in the world. Protists are an extremely diverse group of mostly unicellular microeukaryotes and includes the microalgae. They are the basis for the majority of ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Wild animal populations experience selection pressures from both natural and anthropogenic sources. The availability of extensive pedigrees is increasing along with our ability to quantify the heritability and evolvability ...
(Master thesis / Masteroppgave, 2019)
(Master thesis / Masteroppgave, 2019)
The use of remote video traps is a popular method of studying animal behavior in nature. It is an efficient, inexpensive and non-invasive way of obtaining samples from the field. In this study, I built and used video traps ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Objectives
We report a transcriptome acquisition for the bath sponge Spongia officinalis, a non-model marine organism that hosts rich symbiotic microbial communities. To this end, a pipeline was developed to efficiently ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
The taxonomy of Protomerulius and Heterochaetella is revised based on DNA data and morphological evidence, and their type species, P. brasiliensis and H. dubia, are proved to be congeneric. As a consequence, H. dubia and ...
(Master thesis / Masteroppgave, 2019)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Premise of the Study Fungal diversity (richness) trends at large scales are in urgent need of investigation, especially through novel situations that combine long‐term observational with environmental and remotely sensed ...
(Doctoral thesis / Doktoravhandling, 2019)
In their natural environment, marine organisms are exposed to a wide range of chemical and physical factors that can damage their genetic material. Polycyclic aromatic hydrocarbons (PAHs) and trace metals (e.g. copper) are ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Satellite telemetry is an increasingly utilized technology in wildlife research, and current devices can track individual animal movements at unprecedented spatial and temporal resolutions. However, as we enter the golden ...
(Master thesis / Masteroppgave, 2019)
(Doctoral thesis / Doktoravhandling, 2019)
Well-functioning mating systems are perceived as vital for population growth rate and resilience to environmental change, but we know surprisingly little about the interplay between human-induced mortality and the mating ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Abyssal plains are among the most biodiverse yet least explored marine ecosystems on our planet, and they are increasingly threatened by human impacts, including future deep seafloor mining. Recovery of abyssal populations ...
(Master thesis / Masteroppgave, 2019)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
The presence of a multitude of bioactive organic pollutants collectively classified as pharmaceuticals and personal care products (PPCPs) in freshwaters is of concern, considering that ecological assessments of their ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Cope's Rule describes increasing body size in evolutionary lineages through geological time. This pattern has been documented in unitary organisms but does it also apply to module size in colonial organisms? We address ...
(Master thesis / Masteroppgave, 2019)
In the Arctic tundra several different species of herbivores co-exist, with potentially large effects on tundra ecosystem functions and dynamics. Understanding the herbivores trophic interactions therefore provides essential ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
The importance of survival and growth variations early in life for population dynamics depends on the degrees of compensatory density dependence and size dependence in survival at later life stages. Quantifying density‐ ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Here, Diaporthe myracrodruonis is introduced as new species from Brazil, isolated as endophyte from Myracrodruon urundeuva. Asterina mandaquiensis is epitypified and ilustrated for the first time. Serpula similis is reported ...
(Master thesis / Masteroppgave, 2019)
The nanomaterial industry is currently expanding, driven by the diversity and versatility of applications in which they can be found. Nanomaterials (NMs) can have a variety of uses ranging from solar cells and pigments to ...
(Master thesis / Masteroppgave, 2019)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Complement component 5 (C5) is an essential factor of the defensive complement system in all vertebrates. We report the characterization of C5 cDNA and protein from Atlantic salmon (Salmo salar), a teleost fish species of ...
(Doctoral thesis / Doktoravhandling, 2019)
Sea cage production of salmonid fish delivers a large amount of waste products to the marine environment including dissolved nutrients, organic particles, and chemicals. Recent developments in the Norwegian aquaculture ...
(Master thesis / Masteroppgave, 2019)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Atmospheric N pollution may shift nutrient limitations in aquatic autotrophs from N to P or cause an intensification of P limitation in formerly pristine areas. Small changes in nutrient supply in oligotrophic lakes and ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Plants both generate and shed organs throughout their lifetime. Cell separation is in function during opening of anthers to release pollen; floral organs are detached after pollination when they have served their purpose; ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Cervids are keystone species in ecosystems and are associated with enormous cultural and economic value. Chronic wasting disease (CWD) is a fatal prion disease spreading in North American cervid populations. The 2016 ...
(Master thesis / Masteroppgave, 2019)
Studying the Impact of Drugs on LINE-1 Retrotransposition Restricted Access
(Master thesis / Masteroppgave, 2019)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
The Fungi are a diverse kingdom, dominating terrestrial environments and driving important ecologies. Although fungi, and the related Opisthosporidia, interact with photosynthetic organisms on land and in freshwater as ...
(Master thesis / Masteroppgave, 2019)
Characterization of a Drosophila model of MLL-rearranged leukemia Restricted Access
(Master thesis / Masteroppgave, 2019)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Hydrurus foetidus is a freshwater alga belonging to the phylum Heterokonta. It thrives in cold rivers in polar and high alpine regions. It has several morphological traits reminiscent of single-celled eukaryotes, but can ...
(Master thesis / Masteroppgave, 2019)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
The Helvellaceae encompasses taxa that produce some of the most elaborate apothecial forms, as well as hypogeous ascomata, in the class Pezizomycetes (Ascomycota). While the circumscription of the Helvellaceae is clarified, ...
(Master thesis / Masteroppgave, 2019)
The seasonal cycle of phytoplankton with emphasis on Pseudo-nitzschia was studied at Elle, Drøbak from September 2016 to August 2017. Vertical (1 m) and horizontal net hauls (20 – 0 m), and water samples (1 m) were collected ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Reductions in Arctic sea ice affect marine food webs through a multitude of direct and indirect effects. We here analysed direct, indirect, and delayed associations between winter sea ice cover and year-to-year changes in ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Impact assessments for sonar operations typically use received sound levels to predict behavioural disturbance in marine mammals. However, there are indications that cetaceans may learn to associate exposures from distant ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Genetic divergence among populations arises through natural selection or drift and is counteracted by connectivity and gene flow. In sympatric populations, isolating mechanisms are thus needed to limit the homogenizing ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Climate variability, fishing and predation are the main factors affecting fish population dynamics. In this study, the drivers of population growth variability were investigated for 7 fish stocks (2 cod, 4 herring and 1 ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
An inherent problem with microfluidic filters is the tendency to clog, especially when applied to cells due to their geometrical complexity, deformability, and tendency to adhere to surfaces. In this work, we handle live ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
The European autophagy consortium Driving next-generation autophagy researchers towards translation (DRIVE) held its kick-off meeting in Groningen on the 14th and 15th of June 2018. This Marie Skłodowska-Curie Early Training ...
(Master thesis / Masteroppgave, 2019)
Den teknologiske eksplosjonen i næringslivet har vore med på å skape eit behov for teknologisk kompetanse. Utdanningsinstitusjonane og grunnopplæringa har som fylje av dette innført programmering i utdannings- og skuleløp ...
(Master thesis / Masteroppgave, 2019)
Programmering får en stadig sterkere rolle i de ulike realfagene. Dette ser vi gjennom fagfornyelsen i norsk grunn- og videregående skole, og på behovet i næringslivet. Universitetet i Oslo er blant de første i Norge til ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
The successful use of chimeric antigen receptor (CAR) for hematological cancer treatment has influenced the direction taken in translational research toward an increasing focus on personalized targeted immunotherapy. Thus, ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
To understand the consequences of underwater noise exposure for cetaceans, there is a need for assessments of behavioural responses over increased spatial and temporal scales. Bottom-moored acoustic recorders and satellite ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Atlantic cod (Gadus morhua) represents a unique immune system among teleost fish, making it a species of interest for immunological studies, and especially for investigating the evolutionary history of immune gene families. ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Autotransporters, or type 5 secretion systems, are widespread surface proteins of Gram-negative bacteria often associated with virulence functions. Autotransporters consist of an outer membrane β-barrel domain and an ...
(Master thesis / Masteroppgave, 2019)
(Master thesis / Masteroppgave, 2019)
Molecular phylogeny and morphological variation of the genus Thymus (Lamiaceae) and its allies Restricted Access
(Master thesis / Masteroppgave, 2019)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
We investigated the interactions between styrene–maleic acid (SMA) copolymers and phospholipid bilayers, using confocal microscopy and surface acoustic wave resonance (SAR) sensing. For the first time we experimentally ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Recent climate change has led to advanced spring phenology in many temperate regions. The phenological response to variation in the local environment, such as the habitat characteristics of the territories birds occupy, ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Various studies have demonstrated that the two leaflets of cellular membranes interact, potentially through so-called interdigitation between the fatty acyl groups. While the molecular mechanism underlying interleaflet ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Ricin can be isolated from the seeds of the castor bean plant (Ricinus communis). It belongs to the ribosome-inactivating protein (RIP) family of toxins classified as a bio-threat agent due to its high toxicity, stability ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Recent theories in evolutionary medicine have suggested that behavioural outputs associated with depression-like states (DLS) could be an adaptation to unpredictable and precarious situations. In animal models, DLS are ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Yersinia ruckeri is the causative agent of enteric redmouth disease, a bacterial infection of marine and freshwater fish. The disease mainly affects salmonids, and outbreaks have significant economic impact on fish farms ...
Determination of 3´, 5´- Cyclic adenosine monophosphate in HT-29 epithelial cells by liquid chromatography and tandem mass spectrometry Restricted Access
(Master thesis / Masteroppgave, 2019)
Repeated social defeat induces changes in splenic myeloid cells: downregulation of β-arrestin-2 and upregulation of IL-6 Restricted Access
(Master thesis / Masteroppgave, 2019)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background
Studying variation in life-history traits and correlated behaviours, such as boldness and foraging (i.e., pace-of-life syndrome), allows us to better understand how these traits evolve in a ...
A proteomics-based approach to identify interactors of the IDA-HAE/HSL2 signaling pathway Restricted Access
(Master thesis / Masteroppgave, 2019)
(Master thesis / Masteroppgave, 2019)
Black-headed Gulls are in rapid decline in Norway and is categorized as VU (Vulnerable) on the national Red List. The Norwegian population has decreased from 30 000 pairs around 1990 to just 7000 pairs in 2011. In the study ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
With climate change, the effect of global warming on snow cover is expected to cause range expansion and enhance habitat suitability for species at their northern distribution limits. However, how this depends on landscape ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Antibodies are essential components of an adaptive immune response. Immunoglobulin G (IgG) is the most common type of antibody found in circulation and extracellular fluids. Although IgG alone can directly protect the body ...
(Master thesis / Masteroppgave, 2019)