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(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
The neonatal crystallizable fragment receptor (FcRn) is responsible for maintaining the long half-life and high levels of the two most abundant circulating proteins, albumin and IgG. In the latter case, the protective ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Eculizumab is a humanized IgG2/4 chimeric anti-complement C5 antibody used to treat patients with paroxysmal nocturnal hemoglobinuria (PNH) or atypical hemolytic uremic syndrome. The aim of this study was to evaluate whether ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Albumin and IgG have remarkably long serum half-lives due to pH-dependent FcRn-mediated cellular recycling that rescues both ligands from intracellular degradation. Furthermore, increase in half-lives of IgG and albumin-based ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Phage display screening readily allows for the identification of a multitude of antibody specificities, but to identify optimal lead candidates remains a challenge. Here, we direct the antibody-capsid fusion away from the ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Antibodies are key molecules in the fight against infections. Although previously thought to mediate protection solely in the extracellular environment, recent research has revealed that antibody-mediated protection extends ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
The remarkable clinical success of Fc-fusion proteins has driven intense investigation for even more potent replacements. Using quality-by-design (QbD) approaches, we generated hexameric-Fc (hexa-Fc), a ~20 nm oligomeric ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
During infection with non-enveloped viruses, antibodies stimulate immunity from inside cells by activating the cytosolic Fc receptor TRIM21. This intracellular humoral response relies on opsonized viral particles reaching ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Cancer immunotherapy has finally come of age, demonstrated by recent progress in strategies that engage the endogenous adaptive immune response in tumor killing. Occasionally, significant and durable tumor regression has ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
Albumin has a serum half-life of 3 weeks in humans. This has been utilized to extend the serum persistence of biopharmaceuticals that are fused to albumin. In light of the fact that the neonatal Fc receptor (FcRn) is a key ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
We here report a novel phage display selection strategy enabling fast and easy selection of thermostabilized proteins. The approach is illustrated with stabilization of an aggregation-prone soluble single chain T cell ...