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dc.date.accessioned2013-08-08T10:01:45Z
dc.date.available2013-08-08T10:01:45Z
dc.date.issued2013en_US
dc.date.submitted2013-06-13en_US
dc.identifier.citationKolstad, Terje R Selnes. Development of biodegradable nanobeads as a novel drug delivery system for the treatment of tuberculosis using the zebrafish model. Masteroppgave, University of Oslo, 2013en_US
dc.identifier.urihttp://hdl.handle.net/10852/36328
dc.description.abstractTuberculosis (TB) is a disease caused by the bacterium Mycobacterium tuberculosis, a pathogen that has accompanied mankind throughout its far and recent history. Current TB-therapy consists of two treatment phases, one initial phase where a cocktail of four frontline anti-tubercular drugs are administered daily for a minimum of two months followed by a continuation phase where two or more drugs are taken for a minimum of four months. The extensiveness of the treatment is a problem as it becomes very costly and hampers patient lifestyle. In turn, this may lead to patient non-compliance and an increased probability of the emergence of drug resistant strains. There is thus a great need for developing new drugs and to improve the efficiency of current drugs. Our group has developed a method for encapsulating one of the frontline anti-TB drugs, rifampicin (RIF), in the biodegradable polymer Poly-Lactic-co-Glycolic-Acid (PLGA). The idea behind encapsulating the drug is to promote its gradual release, increase its residence time in the body, to promote a natural co-localization between drug and pathogen and by doing so, enhance the therapeutic effect of the drug. The main goal of my master project has been to develop and apply methods for measuring the effect of these PLGA-RIF-nanoparticles on zebrafish challenged with mycobacterial infection. The experiments reveal a decrease in bacterial burden accompanied by a significant increase in the survival of zebrafish larvae treated with these nanoparticles compared to their free-drug counterparts. This thesis therefore substantiates the claim that nanoparticle-based therapy holds real promise for the successful treatment of TB.eng
dc.language.isoengen_US
dc.titleDevelopment of biodegradable nanobeads as a novel drug delivery system for the treatment of tuberculosis using the zebrafish modelen_US
dc.typeMaster thesisen_US
dc.date.updated2013-08-06en_US
dc.creator.authorKolstad, Terje R Selnesen_US
dc.subject.nsiVDP::473en_US
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft.au=Kolstad, Terje R Selnes&rft.title=Development of biodegradable nanobeads as a novel drug delivery system for the treatment of tuberculosis using the zebrafish model&rft.inst=University of Oslo&rft.date=2013&rft.degree=Masteroppgaveen_US
dc.identifier.urnURN:NBN:no-37265
dc.type.documentMasteroppgaveen_US
dc.identifier.duo182940en_US
dc.contributor.supervisorFederico Fenaroli, Gareth Griffithsen_US
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/36328/1/Kolstad-Master.pdf


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