The synthesis of cholene derivatives hold many intriguing possibilities for modulation of lipogenesis. Compounds derived from a have been widely studied in our group.
Successful synthesis of b1 and b2 was achieved in this project through elegant use of Mukaiyama Aldol Addition (Scheme 1, compound b1) and direct alkylation of aldehyde a (Scheme 1, compound b2). Structure of compounds b1 and b2 was confirmed by X-ray crystal structure.
All intermediates were synthesized successfully and characterized. A new synthetic route was applied for the synthesis of achieving pure compound a.
All aims for this thesis were met.