Objective and method: The study investigates how comprehensive assessment of executive function in adults with Spina Bifida (SB) can provide information of executive dysfunction. In total, 38 patients with SB registered at The National Resource centre for Rare disorders (TRS) participated in the study. As a part of the PhD study ”Cognitive rehabilitation in patients with Spina Bifida: Effects of executive functions, psychological and health related factors” (Stubberud, 2010), the participants completed a number of neuropsychological tests, including the Hotel task, as well as self-report questionnaires like the Behaviour Rating Inventory of Executive Function – Adult version (BRIEF-A) and the Hopkins Symptom Checklist -25 (HSCL-25). Pearsons correlational analyses were performed in order to investigate whether the self-report questionnaires and Hotel task could add information on executive dysfunction to the information retrieved from the neuropsychological measures. Results: Non-significant correlations between BRIEF-A and the neuropsychological tests were found. When controlling for psychological disstress measured by HSCL-25, the correlations were nonexistent. This implies that BRIEF-A could provide valuable information on a patient’s challenges in daily life, not captured by neuropsychological measures. There were several significant correlations between the Hotel task and the neuropsychological tests, indicating that the Hotel task probably measures some of the same concepts as the neuropsychological tests employed. However, the assessments are not highly correlated. Thus, the implication of the study is that the Hotel task should be included in a comprehensive assessment of executive dysfunction. Conclusion: The results demonstrated that BRIEF-A and the Hotel task are measures that could be considered for inclusion in a comprehensive assessment of executive function in patients with Spina Bifida.