Browsing CRIStin høstingsarkiv by Author "Saatcioglu, Fahri"

Now showing items 1-15 of 15

  • A Nutraceutical Formula Is Effective in Raising the Circulating Vitamin and Mineral Levels in Healthy Subjects: A Randomized Trial 
    Nenseth, Hatice Zeynep; Sahu, Aparna; Saatcioglu, Fahri; Osguthorpe, Steven (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Low levels of nutrient intake are common in industrialized countries. This has negative implications on health and is associated with chronic diseases. Supplementation of vitamins, minerals, and key nutrients to optimal ...
  • Androgen receptor deregulation drives bromodomain-mediated chromatin alterations in prostate cancer 
    Urbanucci, Alfonso; Barfeld, Stefan Jörg; Kytölä, Ville; Itkonen, Harri; Coleman, Ilsa M.; Vodák, Daniel; Sjöblom, Liisa; Sheng, Xia; Minner, Sarah; Burdelski, Christoph; Kivinummi, Kati K.; Kohvakka, Annika; Kregel, Steven; Takhar, Mandeep; Alshalalfa, Mohammed; Davicioni, Elai; Erho, Nicholas; Lloyd, Paul; Karnes, R. Jeffrey; Ross, Ashley E.; Schaeffer, Edward M.; Vander Griend, Donald J; Knapp, Stefan; Corey, Eva; Feng, Felix Y.; Nelson, Peter S.; Saatcioglu, Fahri; Knudsen, Karen E.; Tammela, Teuvo L.J.; Sauter, Guido; Schlomm, Thorsten; Nykter, Matti; Visakorpi, Tapio; Mills, Ian Geoffrey (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Global changes in chromatin accessibility may drive cancer progression by reprogramming transcription factor (TF) binding. In addition, histone acetylation readers such as bromodomain-containing protein 4 (BRD4) have been ...
  • Differential Expression and Function of Stamp Family Proteins in Adipocyte Differentiation 
    Sikkeland, Jørgen; Saatcioglu, Fahri (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
    Six transmembrane protein of prostate (Stamp) proteins play an important role in prostate cancer cell growth. Recently, we found that Stamp2 has a critical role in the integration of inflammatory and metabolic signals in ...
  • Distinctly different dynamics and kinetics of two steroid receptors at the same response elements in living cells 
    Saatcioglu, Fahri (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
    Closely related transcription factors (TFs) can bind to the same response elements (REs) with similar affinities and activate transcription. However, it is unknown whether transcription is similarly orchestrated by different ...
  • Divergent androgen regulation of unfolded protein response pathways drives prostate cancer 
    Sheng, Xia; Arnoldussen, Yke Jildouw; Storm, Margrethe Larsdatter; Tesikova, Martina; Nenseth, Hatice Zeynep; Zhao, Sen; Fazli, Ladan; Rennie, Paul S.; Risberg, Bjørn Åke; Wæhre, Haakon; Danielsen, Håvard Emil; Mills, Ian Geoffrey; Jin, Yang; Hotamisligil, Gökhan S; Saatcioglu, Fahri (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    The unfolded protein response (UPR) is a homeostatic mechanism to maintain endoplasmic reticulum (ER) function. The UPR is activated by various physiological conditions as well as in disease states, such as cancer. As ...
  • Identification and Validation of Leucine-rich alpha-2-glycoprotein 1 as a Noninvasive Biomarker for Improved Precision in Prostate Cancer Risk Stratification. 
    Guldvik, Ingrid J.; Zuber, Verena; Braadland, Peder R.; Grytli, Helene H.; Ramberg, Håkon; Lilleby, Wolfgang; Thiede, Bernd; Zucknick, Manuela; Saatcioglu, Fahri; Gislefoss, Randi Elin; Kvåle, Rune; George, Anne; Grönberg, Henrik; Wiklund, Fredrik; Neal, David E.; Gnanapragasam, Vincent J.; Tasken, Kristin Austlid; Mills, Ian G (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Background More accurate risk assessments are needed to improve prostate cancer management. Objective To identify blood-based protein biomarkers that provided prognostic information for risk stratification. Design, ...
  • Inflammation and ER stress differentially regulate STAMP2 expression and localization in adipocytes 
    Sikkeland, Jørgen; Lindstad, Torstein; Nenseth, Hatice Zeynep; Dezitter, Xavier Gabriel M; Qu, Su; Mohamed Muhumed, Ridhwan; Erikei, Meric; Gregor, Margaret F.; Saatcioglu, Fahri (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Background Chronic ER stress and dysfunction is a hallmark of obesity and a critical contributor to metaflammation, abnormal hormone action and altered substrate metabolism in metabolic tissues, such as liver and adipocytes. ...
  • IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling 
    Sheng, Xia; Nenseth, Hatice Zeynep; Qu, Su; Kuzu, Ömer Faruk; Frahnow, Turid; Simon, Lukas; Greene, Stephanie; Zeng, Qingping; Fazli, Ladan; Rennie, Paul S.; Mills, Ian Geoffrey; Danielsen, Håvard Emil; Theis, Fabian; Patterson, John B.; Jin, Yang; Saatcioglu, Fahri (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Activation of endoplasmic reticulum (ER) stress/the unfolded protein response (UPR) has been linked to cancer, but the molecular mechanisms are poorly understood and there is a paucity of reagents to translate this for ...
  • Prostate cancer and the unfolded protein response 
    Storm, Margrethe Larsdatter; Sheng, Xia; Arnoldussen, Yke Jildouw; Saatcioglu, Fahri (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
    The endoplasmic reticulum (ER) is an essential organelle that contributes to several key cellular functions, including lipogenesis, gluconeogenesis, calcium storage, and organelle biogenesis. The ER also serves as the major ...
  • Regulation of the unfolded protein response through ATF4 and FAM129A in prostate cancer 
    Pällmann, Nora; Livgård, Marte; Tesikova, Martina; Nenseth, Hatice Zeynep; Akkus, Erman; Sikkeland, Jørgen; Jin, Yixin; Koc, Dogukan; Kuzu, Ömer Faruk; Pradhan, Manohar; Danielsen, Håvard Emil; Kahraman, Nermin; Mokhlis, Hamada M.; Ozpolat, Bulent; Banerjee, Partha P.; Uren, Aykut; Fazli, Ladan; Rennie, Paul S.; Jin, Yang; Saatcioglu, Fahri (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
    Cancer cells exploit many of the cellular adaptive responses to support their survival needs. One such critical pathway in eukaryotic cells is the unfolded protein response (UPR) that is important in normal physiology as ...
  • Stamp2 expression mediated by cytokines attenuates their growth-limiting effects in prostate cancer cells 
    Pihlstrøm, Nicklas; Jin, Yang; Nenseth, Hatice Zeynep; Kuzu, Omer Faruk; Saatcioglu, Fahri (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Inflammatory events and dysregulated cytokine expression are implicated in prostate cancer (PCa), but the underlying molecular mechanisms are poorly understood at present. We have previously identified six transmembrane ...
  • STAMP2 increases oxidative stress and is critical for prostate cancer 
    Jin, Yang; Wang, Ling; Qu, Su; Sheng, Xia; Kristian, Alexandr; Mælandsmo, Gunhild M.; Pällmann, Nora; Yuca, Erkan; Tekedereli, Ibrahim; Gorgulu, Kivanc; Alpay, Neslihan; Sood, Anil; Lopez-Berestein, Gabriel; Fazli, Ladan; Rennie, Paul; Risberg, Bjørn; Wæhre, Håkon; Danielsen, Håvard E.; Ozpolat, Bulent; Saatcioglu, Fahri (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    The six transmembrane protein of prostate 2 (STAMP2) is an androgen‐regulated gene whose mRNA expression is increased in prostate cancer (PCa). Here, we show that STAMP2 protein expression is increased in human PCa compared ...
  • STAMP2 suppresses autophagy in prostate cancer cells by modulating the integrated stress response pathway 
    Sikkeland, Jørgen; Ng, Matthew; Nenseth, Hatice Zeynep; Ünal, Bilal; Qu, Su; Jin, Yang; Simonsen, Anne Gjøen; Saatcioglu, Fahri (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2022)
    Six Transmembrane Protein of Prostate 2 (STAMP2) is critical for prostate cancer (PCa) growth. We previously showed that STAMP2 regulates the expression of stress induced transcription factor ATF4, which is implicated in ...
  • TCTP is an androgen-regulated gene implicated in prostate cancer 
    Kaarbø, Mari; Storm, Margrethe; Qu, Su; Wæhre, Haakon; Risberg, Bjørn Åke; Danielsen, Håvard Emil; Saatcioglu, Fahri (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
    TCTP has been implicated in a plethora of important cellular processes related to cell growth, cell cycle progression, malignant transformation and inhibition of apoptosis. In addition to these intracellular functions, ...
  • The Promise of Well-Being Interventions to Mitigate Physician Burnout During the COVID-19 Pandemic and Beyond 
    Saatcioglu, Fahri; Cirit, Burcu; Koprucu Suzer, Gayem (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2022)
    The high degree of burnout in physicians, including oncologists, is detrimental to physicians themselves, their families, patients, health care organizations, and the health care systems as a whole. This dire situation has ...