Browsing CRIStin høstingsarkiv by Author "La Cour Poulsen, Lars"

Now showing items 1-6 of 6

  • 3PO inhibits inflammatory NFκB and stress-activated kinase signaling in primary human endothelial cells independently of its target PFKFB3 
    Wik, Jonas Aakre; Lundbäck, Peter; La Cour Poulsen, Lars; Haraldsen, Guttorm; Skålhegg, Bjørn Steen; Hol, Johanna (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Inhibition of the key glycolytic activator 6-phosphofructokinase 2/fructose-2,6-bisphosphatase-3 (PFKFB3) by 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one (3PO) strongly attenuates pathological angiogenesis in cancer and ...
  • Endothelial IL-33 expression is augmented by adenoviral activation of the DNA damage machinery 
    Stav-Noraas, Tor Espen; Edelmann, Reidunn Jetne; La Cour Poulsen, Lars; Sundnes, Olav; Phung, Danh; Kuchler, Axel Matthias; Müller, Fredrik; Kamen, Amine A.; Haraldsen, Guttorm; Kaarbø, Mari; Hol, Johanna (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
    IL-33, required for viral clearance by cytotoxic T cells, is generally expressed in vascular endothelial cells in healthy human tissues. We discovered that endothelial IL-33 expression was stimulated as a response to ...
  • (Epi)genetic regulation of CRTC1 in human eating behaviour and fat distribution 
    Rohde, Kerstin; Keller, Maria; La Cour Poulsen, Lars; Rønningen, Torunn; Stumvoll, Michael; Tonjes, Anke; Kovacs, Peter; Horstmann, Annette; Villringer, Arno; Bluher, Matthias; Böttcher, Yvonne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Background In brain, CREB-regulated transcription co-activator 1 (CRTC1) is involved in metabolic dysregulation. In humans a SNP in CRTC1 was associated to body fat percentage and two SNPs affected RNA Pol II binding ...
  • Genetics and epigenetics in obesity 
    Rohde, Kerstin; Keller, Maria; La Cour Poulsen, Lars; Blüher, Matthias; Kovacs, Peter; Böttcher, Yvonne (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
    Obesity is among the most threatening health burdens worldwide and its prevalence has markedly increased over the last decades. Obesity maybe considered a heritable trait. Identifications of rare cases of monogenic obesity ...
  • Inhibition of Endothelial NOTCH1 Signaling Attenuates Inflammation by Reducing Cytokine-Mediated Histone Acetylation at Inflammatory Enhancers 
    La Cour Poulsen, Lars; Edelmann, Reidunn Jetne; Krüger, Stig; Diéguez-Hurtado, Rodrigo; Shah, Akshay; Stav-Noraas, Tor Espen; Renzi, Anastasia; Szymanska, Monika; Wang, Junbai; Ehling, Manuel; Benedito, Rui; Kasprzycka, Monika; Bækkevold, Espen Sønderaal; Sundnes, Olav; Midwood, Kim S.; Scott, Helge; Collas, Philippe; Siebel, Christian W.; Adams, Ralf H.; Haraldsen, Guttorm; Sundlisæter, Eirik; Hol, Johanna (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
    Objective: Endothelial upregulation of adhesion molecules serves to recruit leukocytes to inflammatory sites and appears to be promoted by NOTCH1; however, current models based on interactions between active NOTCH1 and ...
  • Role of the DNA repair genes H2AX and HMGB1 in human fat distribution and lipid profiles 
    Rohde, Kerstin; Rønningen, Torunn; La Cour Poulsen, Lars; Keller, Maria; Blüher, Matthias; Böttcher, Yvonne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Introduction Regional fat distribution strongly relates to metabolic comorbidities. We identified the DNA repair genes H2AX and HMGB1 to be differentially expressed between human subcutaneous (SAT) and omental visceral ...