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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2006)
Background
Complex traits, which are under the influence of multiple and possibly interacting genes, have become a subject of new statistical methodological research. One of the greatest challenges facing ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2006)
Background
The tumor suppressor gene p53 (TP53) controls numerous signaling pathways and is frequently mutated in human cancers. Novel p53 isoforms suggest alternative splicing as a regulatory feature of ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2006)
Background
Previous studies demonstrated breast cancer tumor tissue samples could be classified into different subtypes based upon DNA microarray profiles. The most recent study presented evidence for the ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2006)
Background
Previously, a total of five breast cancer subtypes have been identified based on variation in gene expression patterns. These expression profiles were also shown to be associated with different ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2006)
Background
Individuals heterozygous for germline ATM mutations have been reported to have an increased risk for breast cancer but the role for ATM genetic variants for breast cancer risk has remained unclear. ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2006)
Background
Gene expression profiling has been used to define molecular phenotypes of complex diseases such as breast cancer. The luminal A and basal-like subtypes have been repeatedly identified and validated ...