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Blocking FcRn in humans reduces circulating IgG levels and inhibits IgG immune complex-mediated immune responses.
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
The neonatal crystallizable fragment receptor (FcRn) functions as an intracellular protection receptor for immunoglobulin G (IgG). Recently, several clinical studies have reported the lowering of circulating monomeric IgG ...