ABSTRACTWomen with epilepsy (WWE) are faced with a variety of problems related to fertility, contraception, pregnancy and delivery. Some of the problems are related to epilepsy itself, others to the treatment with antiepileptic drugs (AEDs), and some specifically to the use of enzyme inducing antiepileptic drugs (EIAEDs). It has been assumed that the latter drugs may affect the vitamin K dependent coagulation factors in the fetus’ immature liver and thereby causing an increased risk of neonatal hemorrhage. For prevention of this, the guidelines for WWE suggest prenatal vitamin K supplementation during the last month of pregnancy to all women taking EIAEDs. There are few studies in this field, and those that exist have shown little or no evidence of any increased risk of neonatal hemorrhage in children born to mothers taking EIAEDs. ObjectiveAlthough there have been studies pointing out other maternal and obstetric outcomes in WWE, risks related to hemorrhage in the mother taking EIAEDs has not been in major focus in the litterature. In this study, I aim to take a closer look on whether WWE have a higher frequency of large post partum hemorrhage, whether this is more severe in women taking EIAEDs, and whether those receiving prenatal vitamin K supplementation have a less pronounced risk.MethodsAll patiens, 109 in all, with the diagnosis of epilepsy giving birth at OUS Rikshospitalet from 2006 to 2011 were selected to be in the epilepsy group. One control for each of the WWE were chosen based on age, time of delivery and delivery method, resulting in a total of 218 subjects in the study. All information was gathered from delivery charts and patient charts at OUS. Through statistic analysis the different groups were compared in regards to the amount of post partum hemorrhage, gestational age for the mother, and birth weight and APGAR score in the newborns.Results and conclusionsThere was no significant difference between the groups for either post partum hemorrhage, birthweight, APGAR or gestational age. More specifically, there were no significant difference in post partum hemorrhage between WWE treated with EIAED who received prenatal vitamin K, and those who did not receive vitamin K. These findings along with further studies in this field, may contribute to an altering of the guidelines concerning WWE and prenatal vitamin K supplementation.