The study examined the nature of compulsory land acquisition and compensation, the right to property within Ghanaian context from human rights perspectives. This study was to find out whether the conditions that are required before interference with peoples’ rights to property in compulsory land acquisition are satisfied in the protection of their rights since the constitution guarantees protection of property rights. It further seek to find out whether the legal framework on compulsory land acquisition contradict with relevant sections of mining act (Act 703) which might facilitate human right violation. In addition, its seek to find how best the laws can cohere and harmonised with international human rights law to bring protection of peoples’ rights to propertyA case study from rural mining communities was analyse based on the legal framework in Ghana simply because of ambiguity within the laws when it comes to compulsory land acquisition and issues of compensation in such communities in which much preference is given mining companies than property owners. The analysis draw inference from international human rights on how best a fair balance can be determined among competing interest in ensuring protection of rights of vulnerable within mining communities.