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dc.date.accessioned2013-03-12T13:30:37Z
dc.date.available2013-03-12T13:30:37Z
dc.date.issued2008en_US
dc.date.submitted2008-10-10en_US
dc.identifier.citationAbdul-Majeed, Nibras A.. AI-2 signaling in the Streptococcus anginosus group. Doktoravhandling, University of Oslo, 2008en_US
dc.identifier.urihttp://hdl.handle.net/10852/33169
dc.description.abstractBacteria employ various signaling systems to communicate and sense their environment. The autoinducer type II (AI-2) signaling system is, however, unique in its widespread presence across the bacterial kingdom, allowing communication within and across bacterial species. The S. anginosus bacterial group is commensal to humans but may also be associated with several life threatening diseases including abscesses and cancer. We identified the presence of AI-2 signal production in the S. anginosus group and several other oral streptococci. To investigate the role of AI-2 production in biofilm formation and antibiotic susceptibility, the luxS gene which encodes the enzyme catalyzing AI-2 synthesis was inactivated in S. anginosus and S. intermedius. The resultant S. anginosus and S. intermedius luxS mutants displayed significant reduction in biofilm formation compared to their wild type counterparts. S. anginosus luxS mutant was significantly more susceptible to several subinhibitory concentrations of ampicillin and erythromycin. Supplementation of AI-2 signals significantly restored biofilm formation in S. intermedius and antibiotic susceptibility in S. anginosus to their wild type levels. Targeting AI-2 signaling in bacteria may provide novel and valuable clinical applications in the future.eng
dc.language.isoengen_US
dc.relation.haspartPaper I: Fernanda C. Petersen, Nibras A.M. Ahmed, Alioddin Naemi and Anne Aamdal Scheie. 2006. LuxS-mediated signalling in Streptococcus anginosus and its role in biofilm formation. The paper is not available in DUO. The published version is available at: http://dx.doi.org/10.1007/s10482-006-9065-y
dc.relation.haspartPaper II: Nibras A.M. Ahmed, Fernanda C. Petersen and Anne Aamdal Scheie. 2008. Biofilm formation and AI-2 signaling in Streptococcus intermedius: role of thermal and pH factors. Oral Microbiology and Immunology. In press. The paper is not available in DUO.
dc.relation.haspartPaper III: Nibras A.M. Ahmed, Fernanda C. Petersen and Anne Aamdal Scheie. 2007. AI-2 quorum sensing affects antibiotic susceptibility in Streptococcus anginosus. Journal of Antimicrobial Chemotherapy. 60: 49–53. The paper is not available in DUO. The published version is available at: http://dx.doi.org/10.1093/jac/dkm124
dc.relation.urihttp://dx.doi.org/10.1007/s10482-006-9065-y
dc.relation.urihttp://dx.doi.org/10.1093/jac/dkm124
dc.titleAI-2 signaling in the Streptococcus anginosus groupen_US
dc.typeDoctoral thesisen_US
dc.date.updated2010-01-29en_US
dc.creator.authorAbdul-Majeed, Nibras A.en_US
dc.subject.nsiVDP::710en_US
cristin.unitcode160000en_US
cristin.unitnameOdontologisk fakulteten_US
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft.au=Abdul-Majeed, Nibras A.&rft.title=AI-2 signaling in the Streptococcus anginosus group&rft.inst=University of Oslo&rft.date=2008&rft.degree=Doktoravhandlingen_US
dc.identifier.urnURN:NBN:no-20551en_US
dc.type.documentDoktoravhandlingen_US
dc.identifier.duo85735en_US
dc.contributor.supervisorAnne Aamdal Scheie, Fernanda Petersenen_US
dc.identifier.bibsys082603057en_US
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/33169/1/DUO_14_AbdulMajeed.pdf


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