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Now showing items 1-10 of 10
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Obesity and associated disorders such as metabolic syndrome and type 2 diabetes (T2D) have reached epidemic proportions. Several natural products have been reported as Peroxisome Proliferator-Activated Receptor (PPAR) ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
The resolution of inflammation is an active process orchestrated by specialized proresolving lipid mediators (SPM) that limit the host response within the affected tissue; failure of effective resolution may lead to tissue ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
A stereodivergent total synthesis has been executed based on the plausibly misassigned structure of the unusual marine hydrindane mucosin (1). The topological connectivity of the four contiguous all-carbon stereocenters ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
Resolvins, protectins and maresins are individual families of specialized pro-resolving mediators biosynthesized from the dietary n-3 polyunsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid. These ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
PD1n-3 DPA is a specialized pro-resolving lipid mediator that displays potent anti-inflammatory properties and pro-resolving bioactivities. Such naturally occurring compounds are of current interest in biomolecular chemistry ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
Several novel oxygenated polyunsaturated lipid mediators biosynthesized from n-3 docosapentaenoic acid were recently isolated from murine inflammatory exudates and human primary cells. These compounds belong to a distinct ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
The regioselective synthesis of estrogens and their derivatives continues to be of interest. Most reported syntheses require multistep protocols associated with poor overall yield and lack of regioselectivity. New preparative ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Aim: Interleukin-27 (IL-27) is involved in different inflammatory diseases; however, its role in atherosclerosis is unclear. In this study we investigated the expression of IL-27 and its receptor in patients with carotid ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Specialized pro-resolving lipid mediators are biosynthesized during the resolution phase of acute inflammation from n-3 polyunsaturated fatty acids. Recently, the isolation and identification of the four novel mediators ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
A novel C1-symmetric dinitrogen ligand was synthesized in high yield from commercially available (1R,2R,3R,5S)-(−)-isopinocampheylamine and 1-methyl-2- imidazolecarboxaldehyde. In combination with Cu(OAc)2∙H2O, this new ...