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Effects of a human-based mixture of persistent organic pollutants on the in vivo exposed cerebellum and cerebellar neuronal cultures exposed in vitro 
Berntsen, Hanne Friis; Duale, Nur; Bjørklund, Cesilie Granum; Rangel-Huerta, Oscar Daniel; Dyrberg, Kine; Hofer, Tim; Rakkestad, Kirsten Eline; Østby, Gunn Charlotte; Halsne, Ruth; Boge, Gudrun Seeberg; Paulsen, Ragnhild Elisabeth; Myhre, Oddvar; Ropstad, Erik (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Exposure to persistent organic pollutants (POPs), encompassing chlorinated (Cl), brominated (Br) and perfluoroalkyl acid (PFAA) compounds is associated with adverse neurobehaviour in humans and animals, and is observed to ...
Exposure to human relevant mixtures of halogenated persistent organic pollutants (POPs) alters neurodevelopmental processes in human neural stem cells undergoing differentiation 
Davidsen, Nichlas; Lauvås, Anna Jacobsen; Myhre, Oddvar; Ropstad, Erik; Carpi, Donatella; Mendoza-de Gyves, Emilio; Berntsen, Hanne Friis; Dirven, Hubert; Paulsen, Ragnhild Elisabeth; Bal-Price, Anna; Pistollato, Francesca (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Halogenated persistent organic pollutants (POPs) like perfluorinated alkylated substances (PFASs), brominated flame retardants (BFRs), organochlorine pesticides and polychlorinated biphenyls (PCBs) are known to cause cancer, ...
Interactions of natural deep eutectic solvents (NADES) with artificial and natural membranes 
Nystedt, Helene Liepelt; Grønlien, Krister Gjestvang; Tønnesen, Hanne Hjorth (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Natural deep eutectic solvents (NADES) are a third type of liquids, apart from water and lipids. NADES show promise as drug carriers in dermal formulations or formulations for local administration in the oral cavity due ...
A mouth rinse based on a tea solution of Salvia officinalis for oral discomfort in palliative cancer care: A randomized controlled trial 
Monsen, Ragnhild Elisabeth; Herlofson, Bente Brokstad; Gay, Caryl; Fjeld, Katrine Gahre; Hove, Lene Hystad; Malterud, Karl Egil; Saghaug, Elisabeth; Slaaen, Joran; Sundal, Tone; Tollisen, Anita; Lerdal, Anners (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background: Few clinical studies evaluate interventions to reduce oral discomfort among patients in palliative care. Aim: This study examines the efficacy of a Salvia officinalis (SO) based herbal mouth rinse compared to ...
The effect of a pharmacist consultation on pregnant women’s quality of life with a special focus on nausea and vomiting: an intervention study 
Truong, Maria B; Ngo, Elin; Ariansen, Hilde; Tsuyuki, Ross T; Nordeng, Hedvig (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Maternal wellbeing and quality of life (QOL) are increasingly being recognized as important for healthy pregnancies. The aim of this study was to investigate the impact of a pharmacist consultation ...
Medication-related problems among hospitalized pregnant women in a tertiary teaching hospital in Ethiopia: a prospective observational study 
Ahmed, Seid M; Sundby, Johanne; Aragaw, Yesuf A; Nordeng, Hedvig (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Studies on medication-related problems (MRPs) among pregnant women are scarce, despite the potential consequences for both mother and child. This study aimed to describe the prevalence, clinical significance, ...
Identifying targets for antibiotic stewardship interventions through analysis of the antibiotic prescribing process in hospitals - a multicentre observational cohort study 
Wathne, Jannicke S; Skodvin, Brita; Charani, Esmita; Harthug, Stig; Blix, Hege S; Nilsen, Roy M; Kleppe, Lars K S; Vukovic, Marta; Smith, Ingrid (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background In order to change antibiotic prescribing behaviour, we need to understand the prescribing process. The aim of this study was to identify targets for antibiotic stewardship interventions in ...
Measured GFR by Utilizing Population Pharmacokinetic Methods to Determine Iohexol Clearance 
Åsberg, Anders; Bjerre, Anna Kristina; Almaas, Runar; Luis-Lima, Sergio; Robertsen, Ida; Salvador, Cathrin Lytomt; Porrini, Esteban; Schwartz, George; Hartmann, Anders; Bergan, Stein (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Introduction There is an increasing demand for accurately measured glomerular filtration rate (GFR). Iohexol serum clearance has become a new gold standard, but it is challenging when GFR is low and 24-hour sampling is ...
Phenotypic Characterization of Larval Zebrafish (Danio rerio) with Partial Knockdown of the cacna1a Gene 
Gawel, Kinga Aurelia; Turski, Waldemar A.; van der Ent, Wietske; Mathai, Benan John; Kirstein-Smardzewska, Karolina Joanna; Simonsen, Anne; Esguerra, Camila V. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The CACNA1A gene encodes the pore-forming α1 subunit of voltage-gated P/Q type Ca2+ channels (Cav2.1). Mutations in this gene, among others, have been described in patients and rodents suffering from absence seizures and ...
Sleep problems and depressive symptoms in toddlers and 8-year-old children: A longitudinal study 
Sivertsen, Børge; Harvey, Allison G.; Reichborn-Kjennerud, Ted; Ystrøm, Eivind; Hysing, Mari (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Sleep and depression are interlinked throughout the lifespan, but very few studies have examined the directionality of the sleep–depression link in children. The aim of the current study was to prospectively examine the ...
The cure model in perinatal epidemiology 
Stoltenberg, Emil Aas; Nordeng, Hedvig Marie Egeland; Ystrøm, Eivind; Samuelsen, Sven Ove (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
In the statistical literature, the class of survival analysis models known as cure models has received much attention in recent years. Cure models seem not, however, to be part of the statistical toolbox of perinatal ...
Preterm birth and risk for language delays before school entry: A sibling-control study 
Zambrana, Imac Maria; Vollrath, Margarete Erika Maria Torgerse; Jacobsson, Bo; Sengpiel, Verena; Ystrøm, Eivind (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
We investigated whether children born preterm are at risk for language delay using a sibling-control design in the Norwegian Mother and Child Cohort Study (MoBa), conducted by the Norwegian Institute of Public Health. ...
Prenatal exposure to methadone or buprenorphine alters µ-opioid receptor binding and downstream signaling in the rat brain 
Kongstorp, Mette; Bogen, Inger Lise; Steinsland, Synne; Nerem, Elisabeth; Salih, Triske Woshyar; Stiris, Tom; Andersen, Jannike Mørch (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
There is a growing concern related to the use of opioid maintenance treatment during pregnancy. Studies in both humans and animals have reported reduced cognitive functioning in offspring prenatally exposed to methadone ...
Association of coincident self-reported mental health problems and alcohol intake with all-cause and cardiovascular disease mortality: A Norwegian pooled population analysis 
Degerud, Eirik Magnus Meek; Høiseth, Gudrun; Mørland, Jørg Gustav; Ariansen, Inger; Graff-Iversen, Sidsel; Ystrøm, Eivind; Zuccolo, Luisa; Næss, Øyvind (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background The disease burden attributable to mental health problems and to excess or harmful alcohol use is considerable. Despite a strong relationship between these 2 important factors in population health, there are ...
Comparing Two Methods of Tablet Manipulation to Adjust the Warfarin Dose in Paediatric Care 
Brustugun, Jørgen; Aas, Elisabeth Birkedal; Tho, Ingunn; Bjerknes, Kathrin (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Tablets containing prescribed doses are not always available, and this is of particular importance in paediatric care where suitable age-appropriate formulations are generally lacking. To obtain a child-adjusted dose, ...
ZN148 Is a Modular Synthetic Metallo-beta-Lactamase Inhibitor That Reverses Carbapenem Resistance in Gram-Negative Pathogens In Vivo 
Samuelsen, Ørjan; Åstrand, Ove Alexander Høgmoen; Frøhlich, Christopher; Heikal, Adam; Skagseth, Susann; Carlsen, Trine Josefine Olsen; Leiros, Hanna-Kirsti S.; Bayer, Annette; Schnaars, Christian; Kildahl-andersen, Geir; Lauksund, Silje; Finke, Sarah; Huber, Sandra; Gjøen, Tor; Andresen, Adriana Magalhaes Santos; Økstad, Ole Andreas; Rongved, Pål (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Carbapenem-resistant Gram-negative pathogens are a critical public health threat and there is an urgent need for new treatments. Carbapenemases (β-lactamases able to inactivate carbapenems) have been identified in both ...
Synthesis and Biological Evaluation of Analogs of Didehydroepiandrosterone as Potential New Anticancer Agents 
J Solum, Eirik; Liekens, Sandra; Hansen, Trond Vidar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The synthesis, cytotoxicity and inhibition of CDK8 by thirteen analogs of cortistatin A are reported. These efforts revealed that the analogs with either a 6- or 7-isoquinoline or 5-indole side chain in the 17-position are ...
How important are parents in the development of child anxiety and depression? A genomic analysis of parent-offspring trios in the Norwegian Mother Father and Child Cohort Study (MoBa) 
Cheesman, Rosa; Eilertsen, Espen M; Ahmadzadeh, Yasmin I; Gjerde, Line C; Hannigan, Laurie J; Havdahl, Alexandra; Young, Alexander I; Eley, Thalia C; Njølstad, Pål R; Magnus, Per; Andreassen, Ole A; Ystrom, Eivind; McAdams, Tom A (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Many studies detect associations between parent behaviour and child symptoms of anxiety and depression. Despite knowledge that anxiety and depression are influenced by a complex interplay of genetic and environmental ...
Extending balance assessment for the generalized propensity score under multiple imputation 
Frank, Anna-Simone; Matteson, David S.; Solvang, Hiroko Kato; Lupattelli, Angela; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
This manuscript extends the definition of the Absolute Standardized Mean Difference (ASMD) for binary exposure (M = 2) to cases for M > 2 on multiple imputed data sets. The Maximal Maximized Standardized Difference (MMSD) ...
Pharmacological Validation of the Prepulse Inhibition of Startle Response in Larval Zebrafish using a Commercial Automated System and Software 
Banono, Nancy Saana; Esguerra, Camila (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
While there is an abundance of commercial and standardized automated systems and software for performing the prepulse inhibition (PPI) assay in rodents, to the best of our knowledge, all PPI assays performed in the zebrafish ...
Non-prescription purchase of antibiotics during travel abroad among a general adult population in Norway: Findings from the seventh Tromsø Study 
Gravningen, Kirsten Midttun; Field, Nigel; Blix, Hege Salvesen; Asfeldt, anne mette; Småbrekke, Lars (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Non-prescription purchase of antibiotics is undesirable and has not recently been investigated in a representative population in a high-income low-use country during travel abroad. This study examined ...
Mechanisms linking parental educational attainment with child ADHD, depression, and academic problems: a study of extended families in The Norwegian Mother, Father and Child Cohort Study 
Torvik, Fartein Ask; Eilertsen, Espen Moen; McAdams, Tom A.; Gustavson, Kristin; Zachrisson, Henrik Daae; Brandlistuen, Ragnhild Eek; Gjerde, Line C.; Havdahl, Alexandra; Stoltenberg, Camilla; Ask, Helga; Ystrøm, Eivind (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Low educational attainment in parents is associated with child psychopathology. It is not clear whether the associations are due to risk factors that family members share or due to effects of maternal or ...
Y-site physical compatibility of Numeta G13E with drugs frequently used at Neonatal Intensive Care 
Nezvalova-henriksen, Katerina; Østerberg, Camilla Tomine; Nilsson, Niklas; Staven Berge, Vigdis; Tho, Ingunn (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Preterm neonates require parenteral nutrition (PN) in addition to intravenous drug therapy. Due to limited venous access, drugs are often co-administered with PN via the same lumen. If incompatible, precipitation and ...
Legumain is upregulated in acute cardiovascular events and associated with improved outcome – potentially related to anti-inflammatory effects on macrophages 
Lunde, Ngoc Dieu Nguyen; Gregersen, Ida; Ueland, Thor; Shetelig, Christian; Holm, Sverre; Kong, Xiang Yi; Michelsen, Annika; Otterdal, Kari; Yndestad, Arne; Broch, Kaspar; Gullestad, Lars; Nyman, Tuula Anneli; Bendz, Bjørn; Eritsland, Jan; Hoffmann, Pavel; Skagen, Karolina Ryeng; Gonçalves, Isabel; Nilsson, Jan; Grenegård, Magnus; Poreba, Marcin; Drag, Marcin; Seljeflot, Ingebjørg; Sporsheim, Bjørnar; Espevik, Terje; Skjelland, Mona; Johansen, Harald Thidemann; Solberg, Rigmor; Aukrust, Pål; Björbacka, Harry; Andersen, Geir Øystein; Halvorsen, Bente (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background and aims We have previously found increased levels of the cysteine protease legumain in plasma and plaques from patients with carotid atherosclerosis. This study further investigated legumain during acute ...
The PPAR Ω Pocket: Renewed Opportunities for Drug Development 
Kaupang, Åsmund; Hansen, Trond Vidar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The past decade of PPARγ research has dramatically improved our understanding of the structural and mechanistic bases for the diverging physiological effects of different classes of PPARγ ligands. The discoveries that lie ...
Blood-based epigenetic estimators of chronological age in human adults using DNA methylation data from the Illumina MethylationEPIC array 
Lee, Yunsung; Haftorn, Kristine L; Denault, William R P; Nustad, Haakon E; Page, Christian M; Lyle, Robert; Lee-Ødegård, Sindre; Moen, Gunn-Helen; Prasad, Rashmi B; Groop, Leif C; Sletner, Line; Sommer, Christine; Magnus, Maria C; Gjessing, Håkon K; Harris, Jennifer R; Magnus, Per; Håberg, Siri E; Jugessur, Astanand; Bohlin, Jon (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Epigenetic clocks have been recognized for their precise prediction of chronological age, age-related diseases, and all-cause mortality. Existing epigenetic clocks are based on CpGs from the ...
Perfluoroalkyl acids potentiate glutamate excitotoxicity in rat cerebellar granule neurons 
Berntsen, Hanne Friis; Moldes-Anaya, Angel; Bjørklund, Cesilie Granum; Ragazzi, Lorenzo; Haug, Trude M; Strandabø, Rønnaug; Verhaegen, Steven; Paulsen, Ragnhild Elisabeth; Ropstad, Erik; Tasker, Andrew (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Perfluoroalkyl acids (PFAAs) are persistent man-made chemicals, ubiquitous in nature and present in human samples. Although restrictions are being introduced, they are still used in industrial processes as well as in ...
Substrate oxidation in primary human skeletal muscle cells is influenced by donor age 
Aas, Vigdis; Thoresen, G. Hege; Rustan, Arild; Lund, Jenny (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Abstract Primary human myotubes represent an alternative system to intact skeletal muscle for the study of human diseases related to changes in muscle energy metabolism. This work aimed to study if fatty acid and glucose ...
Potentially inappropriate prescribing to older patients receiving multidose drug dispensing 
Josendal, Anette V; Bergmo, Trine S; Granas, Anne G (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Multidose drug dispensing (MDD) is an adherence aid that provides patients with machine-dispensed medicines in disposable unit bags, usually for a 14 day period. Previous studies have suggested that the quality ...
Prescribed Doses of CYP2D6-Metabolized Drugs and Hemodynamic Responses in Relation to CYP2D6 Genotype Among Older Patients Exposed to Polypharmacy 
Romskaug, Rita; Wyller, Torgeir Bruun; Straand, Jørund; Kersten, Hege; Molden, Espen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background: Many drugs with dose-dependent effects on hemodynamic variables are metabolized by cytochrome P450 2D6 (CYP2D6). The aim of this study was to compare prescribed dosages and hemodynamic responses of such drugs ...
New CDK8 inhibitors as potential anti-leukemic agents – Design, synthesisand biological evaluation 
Solum, Eirik Johansson; Hansen, Trond Vidar; Aesoy, Reidun; Herfindal, Lars (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Cyclin-dependent kinase 8 (CDK8) plays a vital role in regulating cell transcription either through its association with the mediator complex or by the phosphorylation of transcription factors. CDK8-mediated activation of ...
Determination of anticoagulant rodenticides in faeces of exposed dogs and in a healthy dog population 
Seljetun, Kristin O; Vindenes, Vigdis; Øiestad, Elisabeth L; Brochmann, Gerd-Wenche; Eliassen, Elin; Moe, Lars (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Exposure to anticoagulant rodenticides (ARs) in dogs is among the most common causes of poisoning in small animal practice, but information about toxicokinetic of these rodenticides in dogs is lacking. We ...
A natural deep eutectic solvent (NADES) as potential excipient in collagen-based products 
Grønlien, Krister Gjestvang; Pedersen, Mona Elisabeth; Tønnesen, Hanne Hjorth (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Natural deep eutectic solvents (NADES) have previously shown antibacterial properties alone or in combination with photosensitizers and light. In this study, we investigated the behavior of the structural protein collagen ...
Use of Antidepressants in Older People during a 10-Year Period: An Observational Study on Prescribed Doses and Serum Levels 
Tveit, Kristine; Hermann, Monica; Waade, Ragnhild Birkeland; Nilsen, Roy Miodini; Wallerstedt, Susanna M.; Molden, Espen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background According to previous studies, older patients frequently have serum concentrations of antidepressant medication above the recommended reference range. Objective The aim of this study was to investigate ...
Impact of mucin on drug diffusion: Development of a straightforward in vitro method for the determination of drug diffusivity in the presence of mucin 
Falavigna, Margherita; Stein, Paul C.; Flaten, Gøril Eide; Di Cagno, Massimiliano Pio (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Mucosal drug delivery accounts for various administration routes (i.e., oral, vaginal, ocular, pulmonary, etc.) and offers a vast surface for the permeation of drugs. However, the mucus layer which shields and lubricates ...
Correlation of body weight and composition with hepatic activities of cytochrome P450 enzymes 
Krogstad, Veronica; Peric, Alexandra; Robertsen, Ida; Kringen, Marianne K.; Vistnes, Maria; Hjelmesæth, Jøran; Sandbu, Rune; Johnson, Line Kristin; Angeles, Philip Carlo Soriano; Jansson-Löfmark, Rasmus; Karlsson, Cecilia; Andersson, Shalini; Åsberg, Anders; Andersson, Tommy B.; Christensen, Hege Staaland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Obesity is associated with comorbidities of which pharmacological treatment is needed. Physiological changes associated with obesity may influence the pharmacokinetics of drugs, but the effect of body weight on drug ...
Complex Temperature and Concentration Dependent Self-Assembly of Poly(2-oxazoline) Block Copolymers 
Che, Loan Trinh; Hiorth, Marianne; Hoogenboom, Richard; Kjøniksen, Anna-Lena (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The effect of polymer concentration on the temperature-induced self-association of a block copolymer comprising a poly(2-ethyl-2-oxazoline) block and a random copolymer block consisting of 2-ethyl-2-oxazoline and ...
Solid lipid nanoparticle-loaded mucoadhesive buccal films – Critical quality attributes and in vitro safety & efficacy 
Tzanova, Martina; Hagesaether, Ellen; Tho, Ingunn (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The objective of this work was to develop and characterize solid lipid nanoparticle (SLN)-loaded mucoadhesive films to reveal their potential as successful drug formulations. SLNs based on lipid (Lipoid S100) and surfactant ...
Proteomics‐informed prediction of rosuvastatin plasma profiles in patients with a wide range of body weight 
Wegler, Christine; Garcia, Luna Prieto; Klinting, Signe; Robertsen, Ida; Wisniewski, Jacek R.; Hjelmesæth, Jøran; Åsberg, Anders; Jansson-Löfmark, Rasmus; Andersson, Tommy B.; Artursson, Per (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Pharmacists’ experience of a diabetes risk-assessment service and analytical quality control in community pharmacies : a focus-group study 
Risøy, Aslaug Johanne; Kjome, Reidun Lisbet Skeide; Svensberg, Karin; Råheim, Målfrid; Sølvik, Una Ørvim (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Healthcare services such as diabetes risk-assessment are increasingly common in community pharmacies. Knowledge of community pharmacists’ experiences of such services could ease the implementation of a larger-scale ...
Identification of a novel polymorphism associated with reduced clozapine concentration in schizophrenia patients—a genome-wide association study adjusting for smoking habits 
Smith, Robert Løvsletten; O’Connell, Kevin; Athanasiu, Lavinia; Djurovic, Srdjan; Kringen, Marianne K.; Andreassen, Ole Andreas; Molden, Espen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Abstract Clozapine (CLZ) is the superior antipsychotic drug for treatment of schizophrenia, but exhibits an extensive interpatient pharmacokinetic variability. Here, we conducted a genome-wide association study ...
Impact of age and CYP2D6 genotype on exposure of zuclopenthixol in patients using long-acting injectable versus oral formulation-an observational study including 2044 patients 
Tveito, Marit; Smith, Robert Løvsletten; Molden, Espen; Høiseth, Gudrun (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Purpose Zuclopenthixol is an antipsychotic available as oral and long-acting injectable (LAI) formulations. The aim of this study was to investigate the effect of age on zuclopenthixol exposure during oral and LAI ...
Fertility treatment and oral contraceptive discontinuation for identification of pregnancy planning in routinely collected health data – an application to analgesic and antibiotic utilisation 
Hjorth, Sarah; Wood, Mollie; Tauqeer, Fatima; Nordeng, Hedvig (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Women with unplanned pregnancies use folic acid less frequently, and more often use potentially teratogenic medications in the first trimester. Yet most studies based on routinely collected data lack information ...
Effect of medicines management versus standard care on readmissions in multimorbid patients: a randomised controlled trial 
Lea, Marianne; Mowe, Morten; Molden, Espen; Kvernrød, Kristin; Skovlund, Eva; Mathiesen, Liv (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Objective To investigate the effect of pharmacist-led medicines management in multimorbid, hospitalised patients on long-term hospital readmissions and survival. Design Parallel-group, randomised controlled trial. Setting ...
Degradative behavior and toxicity of alkylated imidazoles 
Evjen, Sigvart; Åstrand, Ove Alexander Høgmoen; Gaarder, Mona; Paulsen, Ragnhild Elisabeth; Fiksdahl, Anne; Knuutila, Hanna K (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
The thermal and oxidative degradation behavior and the corrosiveness of imidazole (Im), 2-methylimidazole (2MIm), 2-ethyl-4-methylimidazole (2E4MIm), 2,4,5-trimethylimidazole (2,4,5MIm), and 1,2,4,5-tetramethylimidazole ...
Evaluation of a eukaryote phylogenetic microarray for environmental monitoring of marine sediments 
Lekang, Katrine; Lanzén, Anders; Jonassen, Inge; Thompson, Eric; Troedsson, Christofer (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Increased exploitation of resources in sensitive marine ecosystems emphasizes the importance of knowledge regarding ecological impacts. However, current bio-monitoring practices are limited in terms of target-organisms and ...
Global variability analysis of mRNA and protein concentrations across and within human tissues 
Wegler, Christine; Ölander, Magnus; Wisniewski, JR; Lundquist, Patrick; Zettl, K; Åsberg, Anders; Hjelmesæth, Jøran; Andersson, Tommy B; Artursson, Per (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Abstract Genes and proteins show variable expression patterns throughout the human body. However, it is not clear whether relative differences in mRNA concentrations are retained on the protein level. Furthermore, ...
Diagnostic tests and treatment procedures performed prior to cardiovascular death in individuals with severe mental illness 
Heiberg, Ina Heidi; Nesvåg, Ragnar; Balteskard, Lise; Bramness, Jørgen Gustav; Hultman, Christina M.; Næss, Øyvind; Reichborn-Kjennerud, Ted; Ystrøm, Eivind; Jacobsen, Bjarne K.; Høye, Anne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Objective To examine whether severe mental illnesses (i.e., schizophrenia or bipolar disorder) affected diagnostic testing and treatment for cardiovascular diseases in primary and specialized health care. Methods We ...
Thyroid hormone replacement therapy in pregnancy and motor function, communication skills, and behavior of preschool children: The Norwegian Mother, Father, and Child Cohort Study 
van den Broek, Sophie; Lupattelli, Angela; Frank, Anna-Simone; Haug, Line Småstuen; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Purpose Limited research has focused on the association between prenatal thyroid hormone replacement therapy (THRT) and motor function, communication skills, and behavior in preschool children. Here, we estimated the ...
Undetectable or subtherapeutic serum levels of antipsychotic drugs preceding switch to clozapine 
Kyllesø, Lennart; Smith, Robert Løvsletten; Karlstad, Øystein; Andreassen, Ole Andreas; Molden, Espen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Abstract Adequate antipsychotic treatment intensity is required for defining treatment-resistant schizophrenia (TRS) and justifying clozapine treatment. We investigated the occurrence of undetectable or subtherapeutic serum ...
Prenatal exposure to methadone or buprenorphine impairs cognitive performance in young adult rats 
Kongstorp, Mette; Bogen, Inger Lise; Stiris, Tom; Andersen, Jannike Mørch (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Concerns have been raised about the use of opioid maintenance treatment (OMT) during pregnancy and negative effects for the offspring. While neonatal outcomes and short-term effects are relatively well ...
Fuel oil desulfurization with dual functionalized imidazolium based ionic liquids 
Butt, Hussain Shakeel; Chellappan, Lethesh Kallidanthiyil; Fiksdahl, Anne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
A series of 36 dual functionalized N-(poly)ethylen glycol N-allyl-/N-benzyl imidazolium and benzimidazolium ILs were synthesized for extractive desulfurization studies (EDS). The novel ILs were readily prepared from imidazole ...
Prevalence of multiple sclerosis in rural and urban districts in Telemark county, Norway 
Flemmen, Heidi Øyen; Simonsen, Cecilia Smith; Berg-Hansen, Pål; Moen, Stine Marit; Kersten, Hege; Heldal, Kristian; Celius, Elisabeth Gulowsen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Objective: To explore the trends in prevalence and incidence of multiple sclerosis (MS) in Telemark, Norway (latitude 58.7-60.3˚N), over the past two decades, with focus on differences between rural and urban areas. Methods: ...
An engineered human albumin enhances half-life and transmucosal delivery when fused to protein-based biologics 
Bern, Malin C.; Nilsen, Jeannette; Ferrarese, Mattia; Sand, Kine Marita Knudsen; Tollefsrud Gjølberg, Torleif; Lode, Heidrun Elisabeth; Davidson, Robert J.; Camire, Rodney M.; Bækkevold, Espen Sønderaal; Foss, Stian; Grevys, Algirdas; Dalhus, Bjørn; Wilson, John; Høydahl, Lene; Christianson, Gregory J.; Roopenian, Derry C.; Schlothauer, Tilman; Michaelsen, Terje Einar; Moe, Morten Carsten; Lombardi, Silvia; Pinotti, Mirko; Sandlie, Inger; Branchini, Alessio; Andersen, Jan Terje (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Needle-free uptake across mucosal barriers is a preferred route for delivery of biologics, but the efficiency of unassisted transmucosal transport is poor. To make administration and therapy efficient and convenient, ...
Impact of genotype-predicted CYP2D6 metabolism on clinical effects and tolerability of metoprolol in patients after myocardial infarction – a prospective observational study 
Anstensrud, Anne Kristine; Molden, Espen; Haug, Hans Jørgen; Qazi, Rehman; Muriq, Hysen; Fosshaug, Linn Elisabeth Lillerud; Spigset, Olav; Øie, Erik (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Purpose The β-1 adrenergic receptor blocker metoprolol is primarily metabolized by the polymorphic enzyme cytochrome P 450 2D6 (CYP2D6), an enzyme with substantial genetic heterogeneity. Our purpose was to investigate the ...
A human relevant mixture of persistent organic pollutants (POPs) and perfluorooctane sulfonic acid (PFOS) enhance nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells 
Yadav, Ajay; Amber, Mazia; Zosen, Denis; Labba, Nils Anders; Huiberts, Eva Henriette Willemijn; Samulin-Erdem, Johanna Maria; Haugen, Fred; Berntsen, Hanne Friis; Zienolddiny, Shanbeh; Paulsen, Ragnhild Elisabeth; Ropstad, Erik; Connolly, Lisa; Verhaegen, Steven (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Disruption of neurite outgrowth is a marker for neurotoxicity. Persistent organic pollutants (POPs) are potential developmental neurotoxicants. We investigated their effect on neurite outgrowth in PC12 rat pheochromocytoma ...
3D cell culture models and organ-on-a-chip: Meet separation science and mass spectrometry 
Lin, Ann; Skottvoll, Frøydis Sved; Rayner, Simon; Pedersen-Bjergaard, Stig; Sullivan, Gareth; Krauss, Stefan; Wilson, Steven Ray Haakon; Harrison, Sean (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
In vitro derived simplified 3D representations of human organs or organ functionalities are predicted to play a major role in disease modeling, drug development, and personalized medicine, as they complement traditional ...
Comparison of anticoagulant rodenticide concentrations in liver and feces from apparently healthy red foxes 
Seljetun, Kristin Opdal; Sandvik, Morten; Vindenes, Vigdis; Eliassen, Elin; Øiestad, Elisabeth Leere; Madslien, Knut Ivar Engesæter; Moe, Lars (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Exposure of wildlife and domestic animals to anticoagulant rodenticides (ARs) is a worldwide concern, but few methods exist to determine residue levels in live animals. Traditional liver detection methods preclude determining ...
Legumain in Acute Coronary Syndromes: A Substudy of the PLATO (Platelet Inhibition and Patient Outcomes) Trial 
Gregersen, Ida; Michelsen, Annika; Lunde, Ngoc Nguyen; Åkerblom, Axel; Lakic, Tatevik G.; Skjelland, Mona; Skagen, Karolina Ryeng; Becker, Richard C.; Lindbäck, Johan; Himmelmann, Anders; Solberg, Rigmor; Johansen, Harald Thidemann; James, Stefan K.; Siegbahn, Agneta; Storey, Robert F.; Kontny, Frederic; Aukrust, Pål; Ueland, Thor; Wallentin, Lars; Halvorsen, Bente (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background The cysteine protease legumain is increased in patients with atherosclerosis, but its causal role in atherogenesis and cardiovascular disease is still unclear. The aim of the study was to investigate the ...
Thyroid hormone replacement therapy patterns in pregnant women and perinatal outcomes in the offspring 
Frank, Anna-Simone; Lupattelli, Angela; Matteson, David S.; Meltzer, Helle Margrete; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Purpose It remains unknown to what degree thyroid hormone replacement therapy (THRT) during and initiation after pregnancy determines pregnancy outcomes. The present study primarily aimed to quantify the impact of THRT ...
Treatment of human skeletal muscle cells with inhibitors of diacylglycerol acyltransferases 1 and 2 to explore isozyme-specific roles on lipid metabolism. 
Thoresen, Hege; Kase, Eili Tranheim; Skagen, Christine (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Diacylglycerol acyltransferases (DGAT) 1 and 2 catalyse the final step in triacylglycerol (TAG) synthesis, the esterification of fatty acyl-CoA to diacylglycerol. Despite catalysing the same reaction and being present in ...
Rheumatoid Arthritis Patients, Both Newly Diagnosed and Methotrexate Treated, Show More DNA Methylation Differences in CD4+ Memory Than in CD4+ Naïve T Cells 
Guderud, Kari; Sunde, Line Hagen; Flåm, Siri Tennebø; Mæhlen, Marthe Thoresen; Mjaavatten, Maria Dahl; Lillegraven, Siri; Aga, Anna-Birgitte; Evenrød, Ida Marie; Norli, Ellen Sauar; Andreassen, Bettina Kulle; Franzenburg, Sören; Franke, Andre; Haavardsholm, Espen Andre; Rayner, Simon; Gervin, Kristina; Lie, Benedicte Alexandra (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background: Differences in DNA methylation have been reported in B and T lymphocyte populations, including CD4+ T cells, isolated from rheumatoid arthritis (RA) patients when compared to healthy controls. CD4+ T cells are ...
Dendritic localization and exocytosis of NAAG in the rat hippocampus 
Nordengen, Kaja; Morland, C; Slusher, B.S.; Gundersen, V (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
While a lot is known about classical, anterograde neurotransmission, less is known about the mechanisms and molecules involved in retrograde neurotransmission. Our hypothesis is that N-acetylaspartylglutamate (NAAG), the ...
Drug Use and Cancer Risk: A Drug-Wide Association Study (DWAS) in Norway 
Støer, Nathalie Charlotte; Botteri, Edoardo; Thoresen, G. Hege; Karlstad, Øystein; Weiderpass, Elisabete; Friis, Søren; Pottegård, Anton; Kulle, Bettina (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Background: Population-based pharmaco-epidemiologic studies are used to assess postmarketing drug safety and discover beneficial effects of off-label drug use. We conducted a drug-wide association study (DWAS) to screen ...
Enzymatic studies with 3-oxa n-3 DPA 
Pangopoulos, Maria Kant; Nolsøe, Jens Mortansson Jelstrup; Antonsen, Simen Gjelseth; Colas, Romain; Dalli, Jesmond; Aursnes, Marius; Stenstrøm, Yngve H.; Hansen, Trond Vidar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Cyclooxygenase-2 and several lipoxygenases convert polyunsaturated fatty acids into a large variety of products. During inflammatory processes, these enzymes form several distinct families of specialized pro-resolving lipid ...
Photodynamic Efficacy of Cercosporin in 3D Tumor Cell Cultures 
Grigalavicius, Mantas; Mastrangelopoulou, Maria; Arous, Delmon; Juzeniene, Asta; Ménard, Mathilde; Skarpen, Ellen; Berg, Kristian; Theodossiou, Theodossis (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
In the present work, we study the photodynamic action of cercosporin (cerco), a naturally occurring photosensitizer, on human cancer multicellular spheroids. U87 spheroids exhibit double the uptake of cerco than T47D and ...
The Lactate Receptor HCA1 Is Present in the Choroid Plexus, the Tela Choroidea, and the Neuroepithelial Lining of the Dorsal Part of the Third Ventricle 
Hadzic, Alena; Nguyen, Teresa Dang; Hosoyamada, Makoto; Tomioka, Naoko H.; Bergersen, Linda Hildegard; Storm-Mathisen, Jon; Morland, Cecilie (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The volume, composition, and movement of the cerebrospinal fluid (CSF) are important for brain physiology, pathology, and diagnostics. Nevertheless, few studies have focused on the main structure that produces CSF, the ...
Alternative Biosynthetic Starter Units Enhance the Structural Diversity of Cyanobacterial Lipopeptides 
Mareš, Jan; Hájek, Jan; Urajová, Petra; Kust, Andreja; Jokela, Jouni; Saurav, Kumar; Galica, Tomáš; Čapková, Kateřina; Mattila, Antti; Haapaniemi, Esa; Permi, Perttu; Mysterud, Ivar; Skulberg, Olav M.; Karlsen, Jan; Fewer, David P.; Sivonen, Kaarina; Tønnesen, Hanne Hjort; Hrouzek, Pavel (Journal article / Tidsskriftartikkel; Peer reviewed, 2019)
Puwainaphycins (PUWs) and minutissamides (MINs) are structurally analogous cyclic lipopeptides possessing cytotoxic activity. Both types of compound exhibit high structural variability, particularly in the fatty acid (FA) ...
Validation of diagnostic utility of fasting plasma glucose and HbA1c in stable renal transplant recipients one year after transplantation 
Ussif, Amin M; Åsberg, Anders; Halden, Thea A S; Nordheim, Espen; Hartmann, Anders; Jenssen, Trond (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background The use of HbA1c ≥6.5% for diagnosis of diabetes has been challenged for post-transplantation diabetes mellitus (PTDM) also known as new onset diabetes after transplantation (NODAT) due to a low ...
The hypotonic environmental changes affect liposomal formulations for nose-to-brain targeted drug delivery 
Wu, Iren Yeeling; Nikolaisen, Trygg Einar; Skalko-Basnet, Natasa; Di Cagno, Massimiliano Pio (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Systemic administration of drugs is ineffective in the treatment of central nervous system disorders because of the blood-brain barrier. Nasal administration has been suggested as an alternative administration route as ...
Association of Maternal Use of Benzodiazepines and Z-Hypnotics During Pregnancy With Motor and Communication Skills and Attention-Deficit/Hyperactivity Disorder Symptoms in Preschoolers 
Lupattelli, Angela; Chambers, Christina D.; Bandoli, Gretchen; Handal, Marte; Skurtveit, Svetlana; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Importance The reproductive safety of benzodiazepine/z-hypnotic exposure on child longer-term developmental risks remains unresolved. Objective To quantify the association of motor, communication, and attention-defi ...
Climate change and epilepsy: Time to take action 
Sisodiya, Sanjay M.; Fowler, Hayley J.; Lake, Iain; Nanji, Rosemary O.; Gawel, Kinga Aurelia; Esguerra, Camila Vicencio; Newton, Charles; Foley, Aideen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Climate change is the biggest challenge facing humanity today. The associated global warming and humidification, increases in the severity and frequency of extreme climate events, extension of the ranges of vector‐borne ...
Interpreting non-linear drug diffusion data: Utilizing Korsmeyer-Peppas model to study drug release from liposomes 
Wu, Iren Yeeling; Bala, Sonali; Skalko-Basnet, Natasa; Di Cagno, Massimiliano Pio (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
The aim of this work was to clarify the dynamics behind the influence of ionic strength on the changes in drug release from large unilamellar vesicles (LUVs). For this purpose, we have investigated the transport of two ...
Studying the effect of solubilizing agents on drug diffusion through the unstirred water layer (UWL) by localized spectroscopy 
Di Cagno, Massimiliano Pio; Stein, Paul C (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
An experimental/computational approach has been successfully applied in order to study the effect of solubilizing vehicles (cyclodextrins and liposomes) on the passive diffusion of four active pharmaceutical ingredients ...
Undiagnosed cardiovascular disease prior to cardiovascular death in individuals with severe mental illness 
Heiberg, Ina Heidi; Jacobsen, Bjarne K.; Balteskard, Lise; Bramness, Jørgen Gustav; Næss, Øyvind; Ystrøm, Eivind; Reichborn-Kjennerud, Ted; Hultman, Christina M.; Nesvåg, Ragnar; Høye, Anne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Objective To examine whether individuals with schizophrenia (SCZ) or bipolar disorder (BD) had equal likelihood of not being diagnosed with cardiovascular disease (CVD) prior to cardiovascular death, compared to individuals ...
Perceived sensitivity to medicines: a study among chronic medicine users in Norway 
Svensberg, Karin; Nordeng, Hedvig Marie Egeland; Gaffari, Sahar; Faasse, Kate; Horne, Rob; Lupattelli, Angela (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Background Little is known about patients’ Perceived Sensitivity to Medicines (PSM), “the belief that one is especially sensitive to the actions and side effects of medicines”. Objective (i) To explore the extent of and ...
Impact of prenatal exposure to benzodiazepines and z-hypnotics on behavioral problems at 5 years of age: A study from the Norwegian Mother and Child Cohort Study 
Sundbakk, Lene Maria; Wood, Mollie; Gran, Jon Michael; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Many women experience anxiety or sleep disorders during pregnancy and require pharmacological treatment with benzodiazepines (BZDs) or z-hypnotics. Limited information is currently available on how prenatal exposure to ...
Efficacy and Safety of Empagliflozin in Renal Transplant Recipients With Posttransplant Diabetes Mellitus 
Strøm Halden, Thea Anine; Kvitne, Kine Eide; Midtvedt, Karsten; Rajakumar, Laavanyaah; Robertsen, Ida; Brox, Jan; Bollerslev, Jens; Hartmann, Anders; Åsberg, Anders; Jenssen, Trond Geir (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
OBJECTIVE Sodium–glucose cotransporter 2 (SGLT2) inhibitors have lately become the recommended treatment in patients with type 2 diabetes and high cardiovascular risk. Patients with posttransplant diabetes mellitus (PTDM) ...
Design, synthesis and biological evaluation of 6‐substituted quinolines derived from cabozantinib as c‐Met inhibitors 
Lien, Vegard Torp; Pettersen, Solveig; Haugen, Mads Haugland; Olberg, Dag Erlend; Mælandsmo, Gunhild Mari; Klaveness, Jo (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Based on the cabozantinib scaffold, novel c‐Met inhibitors were rationalized from the limited knowledge of structure‐activity relationships for the quinoline 6‐position. Emphasis was given to modifications capable of ...
Matrix assisted ionization mass spectrometry in targeted protein analysis – an initial evaluation 
Skjærvø, Øystein; Trimpin, Sarah; Halvorsen, Trine Grønhaug (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Rationale Matrix‐assisted ionization (MAI) is a relatively new ionization technique for analysis by mass spectrometry (MS). The technique is simple and has been shown to be less influenced by matrix effects than e.g. ...
Immunocapture sample clean-up in determination of low abundant protein biomarkers-a feasibility study of peptide capture by anti-protein antibodies 
Levernæs, Maren Christin Stillesby; Farhat, Bassem; Oulie, Inger; Abdullah, Sazan S.; Paus, Elisabeth; Reubsaet, Leon; Halvorsen, Trine Grønhaug (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Immunocapture in mass spectrometry based targeted protein analysis using a bottom-up workflow is nowadays mainly performed by target protein extraction using anti-protein antibodies followed by tryptic digestion. Already ...
Mucoadhesive buccal films based on a graft co-polymer – A mucin-retentive hydrogel scaffold 
Alopaeus, Julia Fredrika; Hellfritzsch, Marie; Gutowski, Tobias; Scherließ, Regina; Almeida, Andreia F; Sarmento, Bruno; Skalko-Basnet, Natasa; Tho, Ingunn (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
From a patient-centric perspective, oromucosal drug delivery is highly attractive due to the ease of administration without the need of swallowing, and improved patient safety. The aim of the presented work was to prepare ...
NIPSNAP1 and NIPSNAP2 act as “eat-me signal” for mitophagy 
Abudu, Yakubu Princely; Pankiv, Serhiy; Mathai, Benan John; Lystad, Alf Håkon; Bindesbøll, Christian; Brenne, Hanne Britt; Ng, Matthew Yoke Wui; Thiede, Bernd; Yamamoto, Ai; Nthiga, Thaddaeus Mutugi; Lamark, Trond; Esguerra, Camila Vicencio; Johansen, Terje; Simonsen, Anne (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
The clearance of damaged or dysfunctional mitochondria by selective autophagy (mitophagy) is important for cellular homeostasis and prevention of disease. Our understanding of the mitochondrial signals that trigger their ...
Increased glycolysis and higher lactate production in hyperglycemic myotubes 
Lund, Jenny; Ouwens, DM; Wettergreen, Marianne; Bakke, Siril Skaret; Thoresen, G. Hege; Aas, Vigdis (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Previous studies have shown that chronic hyperglycemia impairs glucose and fatty acid oxidation in cultured human myotubes. To further study the hyperglycemia-induced suppression of oxidation, lactate oxidation, mitochondrial ...
Cyclopropanation–ring expansion of 3-chloroindoles with α-halodiazoacetates: novel synthesis of 4-quinolone-3-carboxylic acid and norfloxacin 
Peeters, Sara; Berntsen, Linn Neerbye; Rongved, Pål; Bonge-Hansen, Tore (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
We present a short and efficient way of synthesizing two synthetically versatile 4-quinolone-3-carboxylate building blocks by cyclopropanation-ring expansion of 3-chloroindoles with α-halodiazoacetates as the key step. ...
A mitochondria-targeted fatty acid analogue influences hepatic glucose metabolism and reduces the plasma insulin/glucose ratio in male Wistar rats 
Lindquist, Carine; Bjørndal, Bodil; Bakke, Hege Gilbø; Slettom, Grete; Karoliussen, Marie; Rustan, Arild; Thoresen, G. Hege; Skorve, Jon; Nygård, Ottar; Berge, Rolf Kristian (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
A fatty acid analogue, 2-(tridec-12-yn-1-ylthio)acetic acid (1-triple TTA), was previously shown to have hypolipidemic effects in rats by targeting mitochondrial activity predominantly in liver. This study aimed to determine ...
Identification of potential carcinogenic and chemopreventive effects of prescription drugs: A protocol for a Norwegian registry-based study 
Kulle, Bettina; Støer, Nathalie Charlotte; Martinsen, Jan Ivar; Ursin, Giske; Weiderpass, Elisabete; Thoresen, G. Hege; Debernard, Karen A. Boldingh; Karlstad, Øystein; Pottegard, Anton; Friis, Søren (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Surveillance of unintended effects of pharmaceuticals (pharmacovigilance or drug safety) is crucial, as knowledge of rare or late side effects is limited at the time of the introduction of new medications into the market. ...
Experiences of Kurdish immigrants with the management of type 2 diabetes: a qualitative study from Norway 
Abuelmagd, Walaa Metwally Ali Abdalaah; Osman, Bavi Botan; Håkonsen, Helle; Jenum, Anne Karen; Toverud, Else-Lydia (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Objective: To explore the experiences of immigrant Kurdish patients in Oslo, Norway, related to the management of type 2 diabetes mellitus (T2DM). Design: A qualitative study with focus group interviews. Setting: ...
Emulsion Stability of Different Intravenous Propofol Formulations in Simulated Co-Administration with Remifentanil Hydrochloride 
Niklas, Nilsson; Katerina, Nezvalova-Henriksen; Tho, Ingunn (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background Propofol and remifentanil often need to be co-administered via the same intravenous catheter line, which predisposes to potential compatibility issues. Our aim was to determine and compare the emulsion stability ...
Synthesis of both enantiomers of the docosahexaenoic acid ester of 13-hydroxyoctadecadienoic acid (13-DHAHLA) 
Vik, Anders; Hansen, Trond Vidar; Kuda, Ondrej (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Recently, several different classes of endogenous lipids have been reported that display antidiabetic and anti-inflammatory effects. Due to their minute presence in human samples, access to synthetic material of each ...
Upregulated PDK4 expression is a sensitive marker of increased fatty acid oxidation 
Pettersen, Ina Katrine Nitschke; Tusubira, Deusdedit; Ashrafi, Hanan; Dyrstad, Sissel Elisabeth; Hansen, Lena; Liu, Xiao-Zheng; Hodneland, Linn I.; Løvsletten, Nils Gunnar; Berge, Kjetil; Wergedahl, Hege; Bjørndal, Bodil; Fluge, Øystein; Bruland, Ove; Rustan, Arild; Halberg, Nils; Røsland, Gro Vatne; Berge, Rolf Kristian; Tronstad, Karl Johan (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Fatty acid oxidation is a central fueling pathway for mitochondrial ATP production. Regulation occurs through multiple nutrient- and energy-sensitive molecular mechanisms. We explored if upregulated mRNA expression of the ...
Analyzing Missing Data in Perinatal Pharmacoepidemiology Research: Methodological Considerations to Limit the Risk of Bias 
Lupattelli, Angela; Wood, Mollie; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Pharmacoepidemiological studies on the safety of medication during pregnancy are all susceptible to missing data (ie, data that should have been recorded but for some reason were not). Missing data are ubiquitous, irrespective ...
Sepsis causes right ventricular myocardial inflammation independent of pulmonary hypertension in a porcine sepsis model 
Pischke, Søren; Hestenes, Siv Merete; Johansen, Harald Thidemann; Fure, Hilde; Bugge, Jan F; Espinoza, Andreas Westenvik; Skulstad, Helge; Edvardsen, Thor; Fosse, Erik; Mollnes, Tom Eirik; Halvorsen, Per Steinar; Nielsen, Erik Waage (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Introduction Right ventricular (RV) myocardial dysfunction is a common feature in septic shock. It can worsen outcome, but the etiology is poorly understood. Pulmonary artery hypertension (PAH) plays a part in the ...
Collagen from Turkey (Meleagris gallopavo) tendon: A promising sustainable biomaterial for pharmaceutical use 
Grønlien, Krister Gjestvang; Pedersen, Mona Elisabeth; Sanden, Karen Wahlstrøm; Høst, Vibeke; Karlsen, Jan; Tønnesen, Hanne Hjorth (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Collagen is the major fibrillar component and protein in both human and animal connective tissue. It is applied in medical preparations, e.g. wound dressings and tissue engineering. Meat and poultry production industries ...
Bacillus cereus biofilm formation on central venous catheters of hospitalised cardiac patients 
Ikram, Samman; Heikal, Adam; Finke, Sarah; Hofgaard, Antje; Rehman, Yasir; Sabri, Anjum Nasim; Økstad, Ole Andreas (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Formation of bacterial biofilms is a risk with many in situ medical devices. Biofilm-forming Bacillus species are associated with potentially life-threatening catheter-related blood stream infections in immunocompromised ...
A twin study of cigarette and snus initiation and quantity of use in Norwegian Adult Twins 
Kendler, Kenneth S.; Aggen, Steven H.; Gillespie, Nathan; Czajkowski, Nikolai Olavi; Ystrøm, Eivind; Reichborn-Kjennerud, Ted (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
While snus has been the focus of increasing public health interest, twin studies have examined neither sources of individual variation for its use nor the sources of resemblance between snus and cigarette use. Twins from ...
Paternal antidepressant use as a negative control for maternal use: assessing familial confounding on gestational length and anxiety traits in offspring 
Cohen, Jacqueline Mallory; Wood, Mollie; Hernandez-Diaz, Sonia; Ystrøm, Eivind; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Background Maternal antidepressant use in pregnancy has been associated with both shorter gestational length and child anxiety. We employed paternal antidepressant use as a negative-control exposure to indirectly assess ...
Bacillus thuringiensis CbpA is a collagen binding cell surface protein under c-di-GMP control 
Finke, Sarah; Fagerlund, Annette; Smith, Veronika; Krogstad, Veronica; Zhang, Mimmi; Saragliadis, Athanasios; Linke, Dirk; Nielsen-Leroux, Christina; Økstad, Ole Andreas (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Cyclic diguanylate (c-di-GMP) signalling affects several cellular processes in Bacillus cereus group bacteria including biofilm formation and motility, and CdgF was previously identified as a diguanylate cyclase promoting ...
Vitamin D as a risk factor for patient survival after kidney transplantation: A prospective observational cohort study 
Thorsen, Inga Strand; Bleskestad, Inger Hjørdis; Åsberg, Anders; Hartmann, Anders; Skadberg, Øyvind; Brede, Cato; Ueland, Thor; Pasch, Andreas; Reisæter, Anna Varberg; Gøransson, Lasse (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Background Short‐term survival after kidney transplantation is excellent, but long‐term survival remains low and is equivalent to non‐end‐stage renal disease patients with many invasive malignancies. The aim of the study ...
Micellisation Mechanism and Behaviour of Soluplus®–Furosemide Micelles: Preformulation Studies of an Oral Nanocarrier-Based System 
Alopaeus, Julia Fredrika; Hagesæther, Ellen; Tho, Ingunn (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
In this study, self-assembling Soluplus® micelles were examined for inherent properties. Through calorimetric analysis, the critical micelle concentration (CMC) could be determined at 25 and 37 °C, and the influence of ...
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