Search
Now showing items 1-100 of 135
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Exposure to persistent organic pollutants (POPs), encompassing chlorinated (Cl), brominated (Br) and perfluoroalkyl acid (PFAA) compounds is associated with adverse neurobehaviour in humans and animals, and is observed to ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Halogenated persistent organic pollutants (POPs) like perfluorinated alkylated substances (PFASs), brominated flame retardants (BFRs), organochlorine pesticides and polychlorinated biphenyls (PCBs) are known to cause cancer, ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background: Few clinical studies evaluate interventions to reduce oral discomfort among patients in palliative care. Aim: This study examines the efficacy of a Salvia officinalis (SO) based herbal mouth rinse compared to ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Natural deep eutectic solvents (NADES) are a third type of liquids, apart from water and lipids. NADES show promise as drug carriers in dermal formulations or formulations for local administration in the oral cavity due ...
(Doctoral thesis / Doktoravhandling, 2021)
The bacterium Bacillus cereus is increasingly recognized as a major source of food-borne disease, as well as other severe infections. Biofilms are a common multicellular mode of growth, where bacteria can be protected ...
(Doctoral thesis / Doktoravhandling, 2020)
Legumain is an enzyme present in most cells but its dysregulation is associated with several diseases. During stem cell differentiation, legumain stimulates fat cell and inhibits osteoblast differentiation. This thesis ...
(Doctoral thesis / Doktoravhandling, 2020)
Main research findings
In the field of bioanalysis, drug molecules and endogenous compounds can be determined and quantified from biological samples such as blood and urine. However, the complexity of such biological ...
Effekt av fotodynamisk terapi på cysteinproteasen legumain og hemmeren cystatin E/M Restricted Access
(Master thesis / Masteroppgave, 2020)
(Doctoral thesis / Doktoravhandling, 2020)
Paper-based sample collection has gained increased attention during the past few decades for its simplicity and applicability to a wide range of matrices and analytes. Particularly for sampling of blood. Compared to ...
Circadisk påvirkning på farmakokinetikken til mykofenolat og mykofenolatglukuronid i nyretransplanterte pasienter Restricted Access
(Master thesis / Masteroppgave, 2020)
Bakgrunn: Etter en nyretransplantasjon er immunsupprimerende behandling helt nødvendig, og mykofenolatmofetil (MMF) inngår som en del av behandlingen og doseres morgen og kveld. Mykofenolat (MPA) glukuronideres til ...
Effects of feeding mice with different Plin genotypes a methionine-choline-deficient (MCD) diet - a model of nonalcoholic steatohepatitis (NASH) disease. Restricted Access
(Master thesis / Masteroppgave, 2020)
(Doctoral thesis / Doktoravhandling, 2020)
Livelong immunosuppressive treatment is needed after renal transplantation. Tacrolimus has been the cornerstone in most transplant centers. Its narrow therapeutic window and large inter- and intra-individual variability ...
(Master thesis / Masteroppgave, 2020)
(Doctoral thesis / Doktoravhandling, 2020)
Extracellular vesicles are small round bodies secreted from the membranes of most living cells, including bacteria. The bacterial vesicles contain many of the same components as the mother bacteria and play numerous roles ...
(Master thesis / Masteroppgave, 2020)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background
Maternal wellbeing and quality of life (QOL) are increasingly being recognized as important for healthy pregnancies. The aim of this study was to investigate the impact of a pharmacist consultation ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background
Studies on medication-related problems (MRPs) among pregnant women are scarce, despite the potential consequences for both mother and child. This study aimed to describe the prevalence, clinical significance, ...
(Doctoral thesis / Doktoravhandling, 2020)
Inonotus obliquus (Chaga) is a strange-looking fungus growing on birch trees in the Northern Hemisphere. Chaga is perhaps best known for its use in traditional medicine, where the fungus is used as an herbal tea against ...
(Doctoral thesis / Doktoravhandling, 2020)
After transplantation patients receive individualized immunosuppressive treatment based on drug concentrations to hinder rejection of the transplant. This thesis aimed to develop and apply alternative methods of measuring ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background
Many studies detect associations between parent behaviour and child symptoms of anxiety and depression. Despite knowledge that anxiety and depression are influenced by a complex interplay of genetic and environmental ...
(Master thesis, Group thesis / Masteroppgave, Gruppeoppgave, 2020)
(Master thesis / Masteroppgave, 2020)
Elektromembranekstraksjon (EME) har siden den første publiserte artikkelen i 2006, vist seg å være en effektiv prøveopparbeidelsesmetode til ekstraksjon av blant annet sure og basiske legemidler, hvor det foreligger flest ...
(Master thesis / Masteroppgave, 2020)
Hensikt: Fremstille bioadhesive liposomer med innkapslet glyserol for fukting av slimhinnene i munnhulen. Metode: Liposomer med ulike lipidsammensetninger ble tillaget ved to like metoder og med to nøytrale polymerer hvor ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background
In order to change antibiotic prescribing behaviour, we need to understand the prescribing process. The aim of this study was to identify targets for antibiotic stewardship interventions in ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
While a lot is known about classical, anterograde neurotransmission, less is known about the mechanisms and molecules involved in retrograde neurotransmission. Our hypothesis is that N-acetylaspartylglutamate (NAAG), the ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
This manuscript extends the definition of the Absolute Standardized Mean Difference (ASMD) for binary exposure (M = 2) to cases for M > 2 on multiple imputed data sets. The Maximal Maximized Standardized Difference (MMSD) ...
(Master thesis / Masteroppgave, 2020)
Psykofarmaka omfatter antipsykotika, antidepressiva, anxiolytika (angstdempende legemidler), sedativa (beroligende legemidler) og hypnotika (sovemidler). Det er vanskelig å vurdere effekt av psykofarmaka, og behandlingen ...
Pediatrisk dosetilpasning av prednisolon – manipulering av tablett eller apotekfremstilt mikstur? Restricted Access
(Master thesis / Masteroppgave, 2020)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background: Differences in DNA methylation have been reported in B and T lymphocyte populations, including CD4+ T cells, isolated from rheumatoid arthritis (RA) patients when compared to healthy controls. CD4+ T cells are ...
Apotekets intervensjoner under reseptekspedisjonen Restricted Access
(Master thesis / Masteroppgave, 2020)
Bakgrunn: Apotekfarmasøytene bidrar til riktig legemiddelbruk i befolkningen og er siste skanse før pasienten mottar legemidlene sine. Før utlevering av legemidlene utføres farmasøytkontroll der det kan avdekkes feil eller ...
Medication use challenges among immigrants originating from Syria living in Norway - with focus on antibiotics Restricted Access
(Master thesis / Masteroppgave, 2020)
(Master thesis / Masteroppgave, 2020)
Bakgrunn: Økende antibiotikaresistens er i dag en velkjent utfordring og en alvorlig trussel for global helse. Forekomsten av antibiotikaresistens er foreløpig relativt lavt i Norge, men for å unngå økning har de norske ...
(Doctoral thesis / Doktoravhandling, 2020)
In this thesis, it has been shown that the management of Type 2 diabetes mellitus (T2DM) in the immigrant women in Norway and the native Emirati women in the United Arab Emirates was largely suboptimal in terms of lifestyle ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Objective
To examine whether severe mental illnesses (i.e., schizophrenia or bipolar disorder) affected diagnostic testing and treatment for cardiovascular diseases in primary and specialized health care.
Methods
We ...
(Master thesis / Masteroppgave, 2020)
Molecularly Imprinted Polymers (MIPs) are tailor-made polymers with high affinity for a specific target. They can be used for selective sample preparation prior to liquid chromatography mass spectrometry determination of ...
Akutte effekter av kuldeeksponering på smertemodulering Restricted Access
(Master thesis / Masteroppgave, 2020)
(Doctoral thesis / Doktoravhandling, 2020)
Pathogenic Escherichia coli, such as EPEC and EHEC, remain a global threat, responsible for millions of acute diseases worldwide. The dissertation by Julia Weikum investigates two E. coli proteins, which are involved with ...
Impact of the deletion of syntrophins and AQP4 on the prevalence of astrocytic gap junctions Restricted Access
(Master thesis / Masteroppgave, 2020)
Forlikelighet av TPN og legemidler som parallellinfusjon til nyfødte Restricted Access
(Master thesis / Masteroppgave, 2020)
Kritisk syke nyfødte og prematurt fødte spedbarn innlagt på nyfødtintensivavdeling trenger ofte kontinuerlig tilførsel av total parenteral næring (TPN) og mange legemidler. De fleste legemidlene må gis intravenøst, og på ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Sleep and depression are interlinked throughout the lifespan, but very few studies have examined the directionality of the sleep–depression link in children. The aim of the current study was to prospectively examine the ...
(Master thesis / Masteroppgave, 2020)
Bakgrunn: Klozapin er det mest effektive legemiddelet for behandling av schizofreni, men er samtidig assosiert med alvorlig bivirkningsrisiko. Hos pasienter med bipolare tilleggssymptomer, såkalt schizoaffektiv lidelse, ...
(Master thesis / Masteroppgave, 2020)
3D printing of pharmaceuticals: From printed product variability study to direct powder 3D printing Restricted Access
(Master thesis / Masteroppgave, 2020)
This study aims to investigate the variation of the 3D printers Ultimaker 3 and ZMorph VX by printing 80 cylindrical products from the same model on different positions on the build plate and comparing the diameter, height ...
(Master thesis / Masteroppgave, 2020)
The focus of this thesis has been to develop a total synthesis of benzo-RvD1n-3 DPA, which is an analog of the specialized pro-resolving lipid mediator (SPM) named RvD1n-3 DPA. The synthetic methods towards the α-fragment ...
(Master thesis / Masteroppgave, 2020)
Electromembrane extraction (EME) is a principle for sample preparation, evolved from the principle of liquid-liquid extraction. In EME an electrical field facilitates the extraction of target analytes from an aqueous sample, ...
(Master thesis / Masteroppgave, 2020)
Innledning: Helsekompetanse beskriver personers evne til å ta kunnskapsbaserte beslutninger om egen helse. Når pasienter skrives ut fra sykehus pålegges de et ansvar å mestre egen sykdom og legemiddelinformasjonen må derfor ...
Studier av teriparatid på differensiering av stamceller til osteoblaster og regulering av cysteinproteasene legumain og cathepsin B Restricted Access
(Master thesis / Masteroppgave, 2020)
Osteoporose er en sykdom i skjelettet hvor nedbrytningen av bein går raskere enn nydannelsen. De viktigste cellene som inngår i beinhomeostasen er osteoklaster som bryter ned bein og osteoblaster som bygger opp bein. ...
The lactate receptor HCAR1 in the regulation of neurogenesis and angiogenesis during stroke Restricted Access
(Master thesis / Masteroppgave, 2020)
Millions of people suffer from stroke every year, being a leading cause of morbidity and mortality worldwide. The current pharmacological and endovascular therapies in stroke aim to restore cerebral blood flow, but are not ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Exposure of wildlife and domestic animals to anticoagulant rodenticides (ARs) is a worldwide concern, but few methods exist to determine residue levels in live animals. Traditional liver detection methods preclude determining ...
(Master thesis / Masteroppgave, 2020)
(Master thesis / Masteroppgave, 2020)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Purpose
It remains unknown to what degree thyroid hormone replacement therapy (THRT) during and initiation after pregnancy determines pregnancy outcomes. The present study primarily aimed to quantify the impact of THRT ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Diacylglycerol acyltransferases (DGAT) 1 and 2 catalyse the final step in triacylglycerol (TAG) synthesis, the esterification of fatty acyl-CoA to diacylglycerol. Despite catalysing the same reaction and being present in ...
(Master thesis / Masteroppgave, 2020)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background
The cysteine protease legumain is increased in patients with atherosclerosis, but its causal role in atherogenesis and cardiovascular disease is still unclear. The aim of the study was to investigate the ...
Plantebaserte legemidler og doping: En litteraturundersøkelse om plantebaserte legemidler kan inneholde forbudte stoffer i idretten Restricted Access
(Master thesis / Masteroppgave, 2020)
Sammendrag Bakgrunn: Hovedhensikten med denne studien var å utføre en litteraturstudie for å undersøke om plantene fra de plantebaserte legemidlene som er markedsført i Norge har kjent innhold av stoffer som står på ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background
The disease burden attributable to mental health problems and to excess or harmful alcohol use is considerable. Despite a strong relationship between these 2 important factors in population health, there are ...
(Journal article / Tidsskriftartikkel / SubmittedVersion, 2020)
We have previously demonstrated that heroin's first metabolite, 6‐acetylmorphine (6‐AM), is an important mediator of heroin's acute effects. However, the significance of 6‐AM to the rewarding properties of heroin still ...
(Master thesis / Masteroppgave, 2020)
Motilitetsrepressoren MogR i Bacillus cereus-gruppen – Ekspresjonsanalyser og kloning av mogR-FLAG for global kartlegging av DNA-bindingsseter Restricted Access
(Master thesis / Masteroppgave, 2020)
Medlemmer av Bacillus cereus-gruppen (B. cereus sensu lato) er Gram-positive, stavformede, aerobe eller fakultativt anaerobe, sporedannende bakterier med en vid utbredelse i det naturlige miljøet. Alle etablerte arter i ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
There is a growing concern related to the use of opioid maintenance treatment during pregnancy. Studies in both humans and animals have reported reduced cognitive functioning in offspring prenatally exposed to methadone ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
In the statistical literature, the class of survival analysis models known as cure models has received much attention in recent years. Cure models seem not, however, to be part of the statistical toolbox of perinatal ...
Effekten av høy-dose omega-3-fettsyrer på farmakokinetikken til takrolimus og mykofenolat i nyretransplanterte pasienter Restricted Access
(Master thesis / Masteroppgave, 2020)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Introduction
There is an increasing demand for accurately measured glomerular filtration rate (GFR). Iohexol serum clearance has become a new gold standard, but it is challenging when GFR is low and 24-hour sampling is ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The CACNA1A gene encodes the pore-forming α1 subunit of voltage-gated P/Q type Ca2+ channels (Cav2.1). Mutations in this gene, among others, have been described in patients and rodents suffering from absence seizures and ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
We investigated whether children born preterm are at risk for language delay using a sibling-control design in the Norwegian Mother and Child Cohort Study (MoBa), conducted by the Norwegian Institute of Public Health. ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Carbapenem-resistant Gram-negative pathogens are a critical public health threat and there is an urgent need for new treatments. Carbapenemases (β-lactamases able to inactivate carbapenems) have been identified in both ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The synthesis, cytotoxicity and inhibition of CDK8 by thirteen analogs of cortistatin A are reported. These efforts revealed that the analogs with either a 6- or 7-isoquinoline or 5-indole side chain in the 17-position are ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Tablets containing prescribed doses are not always available, and this is of particular importance in paediatric care where suitable age-appropriate formulations are generally lacking. To obtain a child-adjusted dose, ...
(Master thesis / Masteroppgave, 2020)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background and aims
We have previously found increased levels of the cysteine protease legumain in plasma and plaques from patients with carotid atherosclerosis. This study further investigated legumain during acute ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background
Low educational attainment in parents is associated with child psychopathology. It is not clear whether the associations are due to risk factors that family members share or due to effects of maternal or ...
(Master thesis / Masteroppgave, 2020)
(Master thesis / Masteroppgave, 2020)
Innledning: Studier har vist at bare 50 prosent av kronisk syke pasienter etterlever legemiddelbehandlingen. I følge WHO sin modell for etterlevelse påvirkes etterlevelse av fem faktorer: pasientrelaterte, sosioøkonomiske, ...
Paracetamol og mulige nevrotoksiske effekter - in vitro studier i kyllingkornceller og optimalisering av studier i humane cellelinjemodeller; SH-SY5Y og NTERA2 Restricted Access
(Master thesis / Masteroppgave, 2020)
Paracetamol er førstevalget ved behov for smertestillende og/eller febernedsettende effekt hos gravide. Legemiddelet har vært brukt i 70 år og har vært ansett som trygt å bruke under svangerskap. Nyere epidemiologiske ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
While there is an abundance of commercial and standardized automated systems and software for performing the prepulse inhibition (PPI) assay in rodents, to the best of our knowledge, all PPI assays performed in the zebrafish ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Preterm neonates require parenteral nutrition (PN) in addition to intravenous drug therapy. Due to limited venous access, drugs are often co-administered with PN via the same lumen. If incompatible, precipitation and ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The past decade of PPARγ research has dramatically improved our understanding of the structural and mechanistic bases for the diverging physiological effects of different classes of PPARγ ligands. The discoveries that lie ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background
Non-prescription purchase of antibiotics is undesirable and has not recently been investigated in a representative population in a high-income low-use country during travel abroad. This study examined ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Cyclin-dependent kinase 8 (CDK8) plays a vital role in regulating cell transcription either through its association with the mediator complex or by the phosphorylation of transcription factors. CDK8-mediated activation of ...
Antibiotikabruk hos pasienter som legges inn på sykehus med samfunnservervet pneumoni og KOLS-eksaserbasjon Restricted Access
(Master thesis / Masteroppgave, 2020)
(Master thesis / Masteroppgave, 2020)
(Master thesis / Masteroppgave, 2020)
Hensikt Hensikten med denne studien var å kartlegge antibiotikabruk hos pasienter i sykehus med samfunnservervet pneumoni eller KOLS eksaserbasjon, samt å undersøke hvorvidt gjeldende retningslinje for behandling følges. ...
(Master thesis / Masteroppgave, 2020)
Hensikt: Hensikten med denne studien var å kartlegge oppfølgingen av anbefalte legemiddelintervensjoner etter legemiddelgjennomgang i sykehus når pasienten var tilbake i kommunehelsetjenesten, herunder hvilke legemiddelrelaterte ...
Studie av hvordan barn aksepterer medisiner Restricted Access
(Master thesis / Masteroppgave, 2020)
Phytochemical analysis of Tragopogon floccosus (Compositae) Restricted Access
(Master thesis / Masteroppgave, 2020)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background
Exposure to anticoagulant rodenticides (ARs) in dogs is among the most common causes of poisoning in small animal practice, but information about toxicokinetic of these rodenticides in dogs is lacking. We ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background
Multidose drug dispensing (MDD) is an adherence aid that provides patients with machine-dispensed medicines in disposable unit bags, usually for a 14 day period. Previous studies have suggested that the quality ...
Effekten av SENP2 på glukose- og oljesyremetabolismen i humane myotuber Restricted Access
(Master thesis / Masteroppgave, 2020)
Bakgrunn: Overvekt, fedme og diabetes mellitus type 2 er et voksende problem i det globale perspektiv. Økt fettvevsmasse er sterkt assosiert med utvikling av insulinresistens og diabetes mellitus type 2. I mus er ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background
Women with unplanned pregnancies use folic acid less frequently, and more often use potentially teratogenic medications in the first trimester. Yet most studies based on routinely collected data lack information ...
(Master thesis / Masteroppgave, 2020)
Gravide kvinner i legemiddelassistert rehabilitering (LAR) anbefales å opprettholde behandlingen i svangerskapet på tross av manglende kunnskap om mulige negative korttids- og langtidseffekter i deres fostre og barn. En ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Natural deep eutectic solvents (NADES) have previously shown antibacterial properties alone or in combination with photosensitizers and light. In this study, we investigated the behavior of the structural protein collagen ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Obesity is associated with comorbidities of which pharmacological treatment is needed. Physiological changes associated with obesity may influence the pharmacokinetics of drugs, but the effect of body weight on drug ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Abstract
Clozapine (CLZ) is the superior antipsychotic drug for treatment of schizophrenia, but exhibits an extensive interpatient pharmacokinetic variability. Here, we conducted a genome-wide association study ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background
According to previous studies, older patients frequently have serum concentrations of antidepressant medication above the recommended reference range.
Objective
The aim of this study was to investigate ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Mucosal drug delivery accounts for various administration routes (i.e., oral, vaginal, ocular, pulmonary, etc.) and offers a vast surface for the permeation of drugs. However, the mucus layer which shields and lubricates ...
Maternal characteristics and use of medications in pregnant women that sought medical help due to infertility – a European, cross-sectional web-based study Restricted Access
(Master thesis / Masteroppgave, 2020)
The lactate receptor HCAR1 at the brain-cerebrospinal fluid interface and its role in stroke Restricted Access
(Master thesis / Masteroppgave, 2020)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The objective of this work was to develop and characterize solid lipid nanoparticle (SLN)-loaded mucoadhesive films to reveal their potential as successful drug formulations. SLNs based on lipid (Lipoid S100) and surfactant ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Abstract
Primary human myotubes represent an alternative system to intact skeletal muscle for the study of human diseases related to changes in muscle energy metabolism. This work aimed to study if fatty acid and glucose ...