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Measured GFR by Utilizing Population Pharmacokinetic Methods to Determine Iohexol Clearance 
Åsberg, Anders; Bjerre, Anna Kristina; Almaas, Runar; Luis-Lima, Sergio; Robertsen, Ida; Salvador, Cathrin Lytomt; Porrini, Esteban; Schwartz, George; Hartmann, Anders; Bergan, Stein (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Introduction There is an increasing demand for accurately measured glomerular filtration rate (GFR). Iohexol serum clearance has become a new gold standard, but it is challenging when GFR is low and 24-hour sampling is ...
Proteomics‐informed prediction of rosuvastatin plasma profiles in patients with a wide range of body weight 
Wegler, Christine; Garcia, Luna Prieto; Klinting, Signe; Robertsen, Ida; Wisniewski, Jacek R.; Hjelmesæth, Jøran; Åsberg, Anders; Jansson-Löfmark, Rasmus; Andersson, Tommy B.; Artursson, Per (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Correlation of body weight and composition with hepatic activities of cytochrome P450 enzymes 
Krogstad, Veronica; Peric, Alexandra; Robertsen, Ida; Kringen, Marianne K.; Vistnes, Maria; Hjelmesæth, Jøran; Sandbu, Rune; Johnson, Line Kristin; Angeles, Philip Carlo Soriano; Jansson-Löfmark, Rasmus; Karlsson, Cecilia; Andersson, Shalini; Åsberg, Anders; Andersson, Tommy B.; Christensen, Hege Staaland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Obesity is associated with comorbidities of which pharmacological treatment is needed. Physiological changes associated with obesity may influence the pharmacokinetics of drugs, but the effect of body weight on drug ...
Global variability analysis of mRNA and protein concentrations across and within human tissues 
Wegler, Christine; Ölander, Magnus; Wisniewski, JR; Lundquist, Patrick; Zettl, K; Åsberg, Anders; Hjelmesæth, Jøran; Andersson, Tommy B; Artursson, Per (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Abstract Genes and proteins show variable expression patterns throughout the human body. However, it is not clear whether relative differences in mRNA concentrations are retained on the protein level. Furthermore, ...
Validation of diagnostic utility of fasting plasma glucose and HbA1c in stable renal transplant recipients one year after transplantation 
Ussif, Amin M; Åsberg, Anders; Halden, Thea A S; Nordheim, Espen; Hartmann, Anders; Jenssen, Trond (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background The use of HbA1c ≥6.5% for diagnosis of diabetes has been challenged for post-transplantation diabetes mellitus (PTDM) also known as new onset diabetes after transplantation (NODAT) due to a low ...
Pharmacokinetics of a novel, approved, 1.4-mg intranasal naloxone formulation for reversal of opioid overdose—a randomized controlled trial 
Skulberg, Arne Kristian; Åsberg, Anders; Zare, Hasse Khiabani; Røstad, Hilde; Tylleskär, Ida; Dale, Ola (Journal article / Tidsskriftartikkel / SubmittedVersion, 2019)
Background and aims Intranasal (i.n.) naloxone is an established treatment for opioid overdose. Anyone likely to witness an overdose should have access to the antidote. We aimed to determine whether an i.n. formulation ...
Efficacy and Safety of Empagliflozin in Renal Transplant Recipients With Posttransplant Diabetes Mellitus 
Strøm Halden, Thea Anine; Kvitne, Kine Eide; Midtvedt, Karsten; Rajakumar, Laavanyaah; Robertsen, Ida; Brox, Jan; Bollerslev, Jens; Hartmann, Anders; Åsberg, Anders; Jenssen, Trond Geir (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
OBJECTIVE Sodium–glucose cotransporter 2 (SGLT2) inhibitors have lately become the recommended treatment in patients with type 2 diabetes and high cardiovascular risk. Patients with posttransplant diabetes mellitus (PTDM) ...
Vitamin D as a risk factor for patient survival after kidney transplantation: A prospective observational cohort study 
Thorsen, Inga Strand; Bleskestad, Inger Hjørdis; Åsberg, Anders; Hartmann, Anders; Skadberg, Øyvind; Brede, Cato; Ueland, Thor; Pasch, Andreas; Reisæter, Anna Varberg; Gøransson, Lasse (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Background Short‐term survival after kidney transplantation is excellent, but long‐term survival remains low and is equivalent to non‐end‐stage renal disease patients with many invasive malignancies. The aim of the study ...
The influence of bariatric surgery on oral drug bioavailability in patients with obesity: A systematic review 
Angeles, Philip Carlo Soriano; Robertsen, Ida; Seeberg, Lars Thomas; Krogstad, Veronica; Skattebu, Julie; Sandbu, Rune; Åsberg, Anders; Hjelmesæth, Jøran (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Anatomical changes in the gastrointestinal tract and subsequent weight loss may influence drug disposition and thus drug dosing following bariatric surgery. This review systematically examines the effects of bariatric ...
Impact of body weight, low energy diet and gastric bypass on drug bioavailability, cardiovascular risk factors and metabolic biomarkers: protocol for an open, non-randomised, three-armed single centre study (COCKTAIL) 
Hjelmesæth, Jøran; Åsberg, Anders; Andersson, Shalini; Sandbu, Rune; Robertsen, Ida; Johnson, Line Kristin; Angeles, Philip Carlo Soriano; Hertel, Jens Kristoffer; Skovlund, Eva; Heijer, Maria; Ek, Anna-Lena; Krogstad, Veronica; Karlsen, Tor-Ivar; Christensen, Hege Staaland; Andersson, Tommy B; Karlsson, Cecilia (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Introduction Roux-en-Y gastric bypass (GBP) is associated with changes in cardiometabolic risk factors and bioavailability of drugs, but whether these changes are induced by calorie restriction, the weight loss or surgery ...
Outcomes in pancreas transplantation with exocrine drainage through a duodenoduodenostomy versus duodenojejunostomy 
Lindahl, Jørn Petter Hanto; Horneland, Rune; Nordheim, Espen; Hartmann, Anders; Aandahl, Einar Martin; Grzyb, Krzysztof; Haugaa, Håkon; Kjøsen, Gisle; Åsberg, Anders; Jenssen, Trond Geir (Journal article / Tidsskriftartikkel / SubmittedVersion, 2018)
Until recently, pancreas transplantation has mostly been performed with exocrine drainage via duodenojejunostomy (DJ). Since 2012, DJ was substituted with duodenoduodenostomy (DD) in our hospital, allowing endoscopic access ...
The European Renal Association - European Dialysis and Transplantation Association (ERA-EDTA) registry Annual Report 2015: a summary 
Kramer, Anneke; Pippias, Maria; Noordzij, Marlies; Stel, VS; Afentakis, Nikolaos; Ambühl, Patrice M; Andrusev, AM; Fuster, EA; Monzon, Federico E; Åsberg, Anders; Barbullushi, M; Bonthius, Marjolein; Caskey, Fergus J; De La Nuez, Pablo Castro; Cernevskis, Harijs; des Grottes, Jean-Marin; Garneata, Liliana; Golan, Eliezer; Hemmelder, Marc H.; Ioannou, Kyriakos; Jarraya, Facial; Kolesnyk, Mykola; Komissarov, Kirill; Lassalle, Mathilde; Macário, Fernando; Mahillo-Duran, Beatriz; de Francisco, A; Pálsson, Runólfur; Pechter, Ülle; Resic, Halima; Rutkowski, Boleslaw; De Pablos, Carmen Santiuste; Seyahi, Nurhan; Ogrizovic, Sanja Simic; Roblero, María Fernanda Slon; Spustová, Viera; Stojceva-Taneva, Olivera; Traynor, Jamie P.; Massy, Ziad A.; Jager, Kitty J (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Background: This article summarizes the European Renal Association – European Dialysis and Transplant Association (ERA-EDTA) Registry’s 2015 Annual Report. It describes the epidemiology of renal replacement therapy (RRT) ...
Small effort, high impact: Focus on physical activity improves oxygen uptake (VO2peak), quality of life, and mental health after pediatric renal transplantation 
Thorsteinsdottir, Hjørdis; Diseth, Trond H; Lie, Anine; Tangeraas, Trine; Matthews, Iren; Åsberg, Anders; Bjerre, Anna Kristina (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
This study estimates the effects on peak oxygen uptake (VO2 peak), QoL, and mental health after the introduction of an adjusted post‐transplant follow‐up program, that is, early physiotherapy and focus on the importance ...
Paricalcitol supplementation during the first year after kidney transplantation does not affect calcification propensity score 
Ussif, Amin; Pihlstrøm, Hege; Pasch, Andreas; Holdaas, Hallvard; Hartmann, Anders; Smerud, Knut; Åsberg, Anders (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Background Cardiovascular complications are common in kidney transplant patients and calcification propensity of blood, measured as T50, is associated with cardiovascular outcomes. Paricalcitol supplementation ...
Exposure to mycophenolate and fatherhood 
Midtvedt, Karsten; Bergan, Stein; Reisæter, Anna Varberg; Vikse, Bjørn Egil; Åsberg, Anders (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background: Mycophenolic acid (MPA) is the active immunosuppressive substance in both mycophenolate mofetil and mycophenolate sodium, and it is widely used after organ transplantation. In women, taking MPA is teratogenic ...
Risk factors for exertional rhabdomyolysis with renal stress 
Apeland, Terje; Danielsen, Tore; Staal, Eva Marianne; Åsberg, Anders; Thorsen, Inga Strand; Dalsrud, Tom Ole; Ørn, Stein (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background: Exercise-induced rhabdomyolysis denotes the exertional damage of myocytes with leakage of sarcoplasmic content into the circulation. The purpose of this study was to determine important risk factors for the ...
Inflammation in early kidney allograft surveillance biopsies and its relationship with de novo donor specific antibodies 
Garcia-Carro, Clara; Dörje, Christina; Åsberg, Anders; Midtvedt, Karsten; Reinholdt, Finn; Strøm, Erik Heyerdahl; Holdaas, Hallvard (Journal article / Tidsskriftartikkel / SubmittedVersion, 2017)
Interstitial fibrosis and tubular atrophy (IFTA) associated with interstitial inflammation in non scarred areas (IFTA+i) is associated with poorer graft outcome than inflammation without IFTA or IFTA without inflammation. ...
Haptoglobin 2-2 Genotype, Patient, and Graft Survival in Renal Transplant Recipients 
Dupont, Laust; Eide, Ivar Anders; Hartmann, Anders; Christensen, Jeppe Hagstrup; Åsberg, Anders; Jenssen, Trond Geir; Krarup, Henrik; Svensson, My Hanna Sofia (Journal article / Tidsskriftartikkel / SubmittedVersion, 2017)
Background: Cardiovascular disease is the leading cause of death in renal transplant recipients. An association between haptoglobin genotype 2-2 and cardiovascular disease has been found in patients with diabetes mellitus ...
Novel decay dynamics revealed for virus-mediated drug activation in cytomegalovirus infection 
Rose, J; Emery, Vincent C; Kumar, Deepali; Åsberg, Anders; Hartmann, Anders; Jardine, Alan G.; Bignamini, Angelo A; Humar, Atul; Neumann, Avidan U (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Human cytomegalovirus (CMV) infection is a substantial cause of morbidity and mortality in immunocompromised hosts and globally is one of the most important congenital infections. The nucleoside analogue ganciclovir (GCV), ...
High Tacrolimus Clearance Is a Risk Factor for Acute Rejection in the Early Phase After Renal Transplantation 
Egeland, Erlend Johannessen; Robertsen, Ida; Hermann, Monica; Midtvedt, Karsten; Størset, Elisabet; Gustavsen, Marte Theie; Reisæter, Anna Varberg; Klaasen, Rolf; Bergan, Stein; Holdaas, Hallvard; Hartmann, Anders; Åsberg, Anders (Journal article / Tidsskriftartikkel / SubmittedVersion, 2017)
Background: Patients with high tacrolimus clearance eliminate more drug within a dose interval compared to those with low clearance. Delays in dosing time will result in transient periods of lower concentrations in high- ...
Tacrolimus and mycophenolate regimen and subclinical tubulo-interstitial inflammation in low immunological risk renal transplants 
Torres, Irina B; Reisæter, Anna Varberg; Moreso, Francesc; Åsberg, Anders; Vidal, Marta; Garcia-Carro, Clara; Midtvedt, Karsten; Reinholt, Finn P.; Scott, Helge; Castellà, Eva; Salcedo, Maite; Dörje, Christina; Sellarés, Joana; Azancot, Maria A; Perello, Manel; Holdaas, Hallvard; Serón, Daniel (Journal article / Tidsskriftartikkel / SubmittedVersion, 2017)
The aim was to evaluate the relationship between maintenance immunosuppression, subclinical tubulo-interstital inflammation and interstitial fibrosis/tubular atrophy (IF/TA) in surveillance biopsies performed in low ...
Estimating Glomerular Filtration Rate in Kidney Transplant Recipients: Comparing a Novel Equation With Commonly Used Equations in this Population 
Salvador, Cathrin Lytomt; Hartmann, Anders; Åsberg, Anders; Bergan, Stein; Rowe, Alexander D.; Mørkrid, Lars (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background: Assessment of glomerular filtration rate (GFR) is important in kidney transplantation. The aim was to develop a kidney transplant specific equation for estimating GFR and evaluate against published equations ...
The CYP3A biomarker 4β-hydroxycholesterol does not improve tacrolimus dose predictions early after kidney transplantation 
Størset, Elisabet; Hole, Kristine; Midtvedt, Karsten; Bergan, Stein; Molden, Espen; Åsberg, Anders (Journal article / Tidsskriftartikkel / SubmittedVersion, 2017)
Aims: Tacrolimus is a cornerstone in modern immunosuppressive therapy after kidney transplantation. Tacrolimus dosing is challenged by considerable pharmacokinetic variability, both between patients and over time after ...
A rapid and sustained improvement of calcification propensity score (serum T50) after successful kidney transplantation: Reanalysis of a randomized controlled trial of ibandronate 
Smerud, Knut Terje; Åsberg, Anders; Kile, Håkon; Pasch, Andreas; Dahle, Dag Olav; Bollerslev, Jens; Godang, Kristin; Hartmann, Anders (Journal article / Tidsskriftartikkel / SubmittedVersion, 2017)
A serum test called T50 assesses the overall propensity for calcification of the blood and is associated with cardiovascular outcomes. We aimed to examine T50 over time in kidney transplant recipients and also address any ...
Plasma levels of marine n-3 fatty acids and cardiovascular risk markers in renal transplant recipients 
Eide, Ivar A.; Dahle, Dag O.; Svensson, My; Hartmann, Anders; Åsberg, Anders; Bjerve, Kristian S.; Christensen, Jeppe H.; Schmidt, Erik B.; Lauritsen, ME; Lund, K; Jenssen, Trond (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2016)
Background/Objectives: Cardiovascular (CV) disease is the leading cause of death after renal transplantation. Marine n-3 polyunsaturated fatty acids (PUFAs) exert potential cardio-protective metabolic effects and might ...
Visceral fat is strongly associated with post-transplant diabetes mellitus and glucose metabolism 1 year after kidney transplantation 
Von Düring, Marit Elizabeth; Jenssen, Trond Geir; Bollerslev, Jens; Åsberg, Anders; Godang, Kristin; Hartmann, Anders (Journal article / Tidsskriftartikkel / SubmittedVersion, 2016)
Body composition after kidney transplantation is linked to glucose metabolism, and impaired glucose metabolism is associated with increased risk of cardiovascular events and death. One year after transplantation, we examined ...
Improved prediction of tacrolimus concentrations early after kidney transplantation using theory-based pharmacokinetic modelling 
Størset, Elisabet; Holford, Nick; Hennig, Stefanie; Bergmann, Troels K.; Bergan, Stein; Bremer, Sara; Åsberg, Anders; Midtvedt, Karsten; Staatz, Christine E. (Journal article / Tidsskriftartikkel / Published version; Peer reviewed, 2014)
Aims The aim was to develop a theory-based population pharmacokinetic model of tacrolimus in adult kidney transplant recipients and to externally evaluate this model and two previous empirical models. Methods Data were ...
Importance of hematocrit for a tacrolimus target concentration strategy 
Størset, Elisabet; Holford, Nick; Midtvedt, Karsten; Bremer, Sara; Bergan, Stein; Åsberg, Anders (Journal article / Tidsskriftartikkel / Published version; Peer reviewed, 2014)
Purpose To identify patient characteristics that influence tacrolimus individual dose requirement in kidney transplant recipients. Methods Data on forty-four 12-h pharmacokinetic profiles from 29 patients and trough ...
Endomyocardial, intralymphocyte, and whole blood concentrations of ciclosporin A in heart transplant recipients 
Robertsen, Ida; Falck, Pål; Andreassen, Arne K; Næss, Nina K; Lunder, Niclas; Christensen, Hege; Gullestad, Lars; Åsberg, Anders (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
Background In the early phases following heart transplantation a main challenge is to reduce the impact of acute rejections. Previous studies indicate that intracellular ciclosporin A (CsA) concentration ...
Urinary proteomic shotgun approach for identification of potential acute rejection biomarkers in renal transplant recipients 
Loftheim, Håvard; Midtvedt, Karsten; Hartmann, Anders; Reisæter, Anna V; Falck, Pål; Holdaas, Hallvard; Jenssen, Trond; Reubsaet, Leon; Åsberg, Anders (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
Background Acute rejection (AR) episodes in renal transplant recipients are suspected when plasma creatinine is elevated and other potential causes out ruled. Graft biopsies are however needed for definite ...
 
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