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Bioadhesive Mini-Tablets for Vaginal Drug Delivery 
Hiorth, Marianne; Nilsen, Susanne; Tho, Ingunn (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Different non-ionic cellulose ethers (methyl cellulose, MC; hydroxyethyl cellulose, HEC; hydroxypropyl cellulose, HPC; hydroxypropylmethyl cellulose, HPMC) and microcrystalline cellulose (MCC) were investigated as matrix ...
Chitosan in Mucoadhesive Drug Delivery: Focus on Local Vaginal Therapy 
Andersen, Toril; Bleher, Stefan; Flaten, Gøril Eide; Tho, Ingunn; Mattsson, Sofia; Skalko-Basnet, Natasa (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Mucoadhesive drug therapy destined for localized drug treatment is gaining increasing importance in today’s drug development. Chitosan, due to its known biodegradability, bioadhesiveness and excellent safety profile offers ...
Development and evaluation of a test program for Y-site compatibility testing of total parenteral nutrition and intravenous drugs 
Staven, Vigdis; Wang, Siri; Grønlie, Ingrid; Tho, Ingunn (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Background There is no standardized procedure or consensus to which tests should be performed to judge compatibility/incompatibility of intravenous drugs. The purpose of this study was to establish and ...
Chitosan-Based Nanomedicine to Fight Genital Candida Infections: Chitosomes 
Andersen, Toril; Mishchenko, Ekatarina; Flaten, Gøril Eide; Sollid, Johanna U Ericson; Mattsson, Sofia; Tho, Ingunn; Skalko-Basnet, Natasa (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Vaginal infections are associated with high recurrence, which is often due to a lack of efficient treatment of complex vaginal infections comprised of several types of pathogens, especially fungi and bacteria. Chitosan, a ...
Micellisation Mechanism and Behaviour of Soluplus®–Furosemide Micelles: Preformulation Studies of an Oral Nanocarrier-Based System 
Alopaeus, Julia Fredrika; Hagesæther, Ellen; Tho, Ingunn (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
In this study, self-assembling Soluplus® micelles were examined for inherent properties. Through calorimetric analysis, the critical micelle concentration (CMC) could be determined at 25 and 37 °C, and the influence of ...
Gellan Gum/Laponite Beads for the Modified Release of Drugs: Experimental and Modeling Study of Gastrointestinal Release 
Adrover, Alessandra; Paolicelli, Patrizia; Petralito, Stefania; Di Muzio, Laura; Trilli, Jordan; Cesa, Stefania; Tho, Ingunn; Casadei, Maria Antonietta (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
In this study, gellan gum (GG), a natural polysaccharide, was used to fabricate spherical porous beads suitable as sustained drug delivery systems for oral administration. GG was cross-linked with calcium ions to prepare ...
Adjusting the dose in paediatric care: dispersing four different aspirin tablets and taking a proportion 
Brustugun, Jørgen; Notaker, Nikolai; Paetz, Lasse Holtan; Tho, Ingunn; Bjerknes, Kathrin (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Objectives: When caring for children in a hospital setting, tablets are often manipulated at the ward to obtain the right dose. One example is manipulation of tablets containing the slightly water-soluble substance aspirin, ...
Mucoadhesive buccal films based on a graft co-polymer – A mucin-retentive hydrogel scaffold 
Alopaeus, Julia Fredrika; Hellfritzsch, Marie; Gutowski, Tobias; Scherließ, Regina; Almeida, Andreia F; Sarmento, Bruno; Skalko-Basnet, Natasa; Tho, Ingunn (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
From a patient-centric perspective, oromucosal drug delivery is highly attractive due to the ease of administration without the need of swallowing, and improved patient safety. The aim of the presented work was to prepare ...
Comparing Two Methods of Tablet Manipulation to Adjust the Warfarin Dose in Paediatric Care 
Brustugun, Jørgen; Aas, Elisabeth Birkedal; Tho, Ingunn; Bjerknes, Kathrin (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Tablets containing prescribed doses are not always available, and this is of particular importance in paediatric care where suitable age-appropriate formulations are generally lacking. To obtain a child-adjusted dose, ...
Emulsion Stability of Different Intravenous Propofol Formulations in Simulated Co-Administration with Remifentanil Hydrochloride 
Niklas, Nilsson; Katerina, Nezvalova-Henriksen; Tho, Ingunn (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background Propofol and remifentanil often need to be co-administered via the same intravenous catheter line, which predisposes to potential compatibility issues. Our aim was to determine and compare the emulsion stability ...
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