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Membrane vesicles from Piscirickettsia salmonis induce protective immunity and reduce development of salmonid rickettsial septicemia in an adult zebrafish model 
Tandberg, Julia Isabel; Oliver, Cristian; Lagos, Leidy; Gaarder, Mona; Yáñez, Alejandro J.; Ropstad, Erik; Winther-Larsen, Hanne Cecilie (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Infections caused by the facultative intracellular bacterial pathogen Piscirickettsia salmonis remains an unsolved problem for the aquaculture as no efficient treatments have been developed. As a result, substantial amounts ...
Nordic Pharmacy Schools’ Experience in Communication Skills Training 
Svensberg, Karin Anna Evelina; Björnsdottir, Ingunn; Wallman, Andy; Sporrong, Sofia K (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
Objective: To assess communication skills training at Nordic pharmacy schools and explore ways for improvement. Methods: E-mail questionnaires were developed and distributed with the aim to explore current practice and ...
Long-term prenatal exposure to paracetamol is associated with DNA methylation differences in children diagnosed with ADHD 
Gervin, Kristina; Nordeng, Hedvig; Ystrom, Eivind; Reichborn-Kjennerud, Ted; Lyle, Robert (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background Epidemiological studies have shown that long-term exposure to paracetamol during pregnancy is associated with attention-deficit/hyperactivity disorder (ADHD). The mechanism by which paracetamol ...
Nurses’ and pharmacists’ learning experiences from participating in interprofessional medication reviews for elderly in primary health care - a qualitative study 
Bell, H. T; Granas, A. G; Enmarker, I.; Omli, R.; Steinsbekk, A. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background Traditionally, drug prescription and follow up have been the sole responsibility of physicians. However, interprofessional medication reviews (IMRs) have been developed to prevent drug discrepancies ...
Antidepressants have anti-inflammatory effects that may be relevant to dermatology: A systematic review 
Eskeland, Shirin; Halvorsen, Jon Anders; Tanum, Lars (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
There is increasing evidence of clinically relevant antiinflammatory effects of monoaminergic antidepressants. PubMed and Ovid databases were searched systematically for the use and efficacy of antidepressants in association ...
Determinants of psychosocial health in psoriatic patients: A multinational study 
Lesner, Karolina; Reich, Adam; Szepietowski, Jacek C.; Dalgard, Florence; Gieler, Uwe; Tomasaragones, Lucia; Lien, Lars; Poot, Francoise; Jemec, Gregor B.; Misery, Laurent; Szabó, Csanád; Linder, Dennis; Sampogna, Francesca; Evers, Andrea W.M.; Halvorsen, Jon Anders; Balieva, Flora Nicol; Lvov, Andrey; Marrón, Servando E.; Altunay, Ilknur K.; Finlay, Andrew Y.; Salek, Sam S.; Kupfer, Jörg (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
There are limited data on the differences in the impact of psoriasis between various countries with respect to quality of life (QoL). The aim of this study was to explore the psychosocial health of patients with psoriasis ...
Factors associated with pharmacy students' attitudes towards learning communication skills – A study among Nordic pharmacy students 
Svensberg, Karin Anna Evelina; Brandlistuen, Ragnhild Eek; Björnsdottir, Ingunn; Sporrong, Sofia K (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
Introduction: Good communication skills are essential for pharmacy students to help patients with their medicines. Students' attitudes towards communication skills learning will influence their willingness to engage in ...
Structural review of PPARγ in complex with ligands: Cartesian- and dihedral angle principal component analyses of X-ray crystallographic data 
Kaupang, Åsmund; Laitinen, Tuomo; Poso, Antti; Hansen, Trond Vidar (Journal article / Tidsskriftartikkel / SubmittedVersion, 2017)
Two decades of research into the ligand‐dependent modulation of the activity of the peroxisome proliferator‐activated receptor γ (PPARγ) have demonstrated the heterogeneous modes of action of PPARγ ligands, in terms of ...
Stereopermutation on the Putative Structure of the Marine Natural Product Mucosin 
Antonsen, Simen Gjelseth; Gallantree-Smith, Harrison Christopher; Görbitz, Carl Henrik; Hansen, Trond Vidar; Stenstrøm, Yngve H.; Nolsøe, Jens Mortansson Jelstrup (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
A stereodivergent total synthesis has been executed based on the plausibly misassigned structure of the unusual marine hydrindane mucosin (1). The topological connectivity of the four contiguous all-carbon stereocenters ...
Protectin D1n-3 DPA and resolvin D5n-3 DPA are effectors of intestinal protection 
Gobbetti, Thomas; Dalli, Jesmond; Colas, Romain A.; Canova, Donata Federici; Aursnes, Marius; Bonnet, Delphine; Alric, Laurent; Vergnolle, Nathalie; Deraison, Celine; Hansen, Trond Vidar; Serhan, Charles N.; Perretti, Mauro (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
The resolution of inflammation is an active process orchestrated by specialized proresolving lipid mediators (SPM) that limit the host response within the affected tissue; failure of effective resolution may lead to tissue ...
Exploring the peptide retention mechanism in molecularly imprinted polymers 
Rossetti, Cecilia; Ore, Odd Gøran; Sellergren, Börje; Halvorsen, Trine Grønhaug; Reubsaet, Leon (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
Molecularly imprinted polymers (MIPs) have been used as useful sorbents in solid-phase extraction for a wide range of molecules and sample matrices. Their unique selectivity can be fine-tuned in the imprinting process and ...
Instant on-paper protein digestion during blood spot sampling 
Skjærvø, Øystein; Rosting, Cecilie; Halvorsen, Trine Grønhaug; Reubsaet, Leon (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
A concept integrating sampling and protein digestion is introduced here combining fast and simple fabrication by wax printing on filter paper with trypsin immobilized polymer beads. The paper reactors showed promising ...
Loss of perilipin 2 in cultured myotubes enhances lipolysis and redirects the metabolic energy balance from glucose oxidation towards fatty acid oxidation 
Feng, Yuan Zeng; Lund, Jenny; Li, Yuchuan; Knabenes, Irlin K; Bakke, Siril Skaret; Kase, Eili Tranheim; Lee, Yun K; Kimmel, Alan R; Thoresen, G. Hege; Rustan, Arild; Dalen, Knut Tomas (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Lipid droplet (LD) coating proteins are essential for the formation and stability of intracellular LDs. Plin2 is an abundant LD coating protein in skeletal muscle, but its importance for muscle function is unclear. We show ...
Causal Drivers of Barents Sea Capelin(Mallotus villosus) Population Dynamics on Different Time Scales 
Subbey, Sam; Solvang, Hiroko Kato; Frank, Anna-Simone Josefine (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
The dynamics of marine populations are usually forced by biotic and abiotic factors occurring at different intensity levels and time scales. Deriving the time frame within which each factor has a causal influence is important ...
To elute or not to elute in immunocapture bottom-up LC–MS 
Levernæs, Maren Christin Stillesby; Nordlund, Marianne Sparby; Reubsaet, Leon; Halvorsen, Trine Grønhaug (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
Immunocapture-based bottom-up LC–MS is a promising technique for the quantification of low abundant proteins. Magnetic immunocapture beads provide efficient enrichment from complex samples through the highly specific ...
Effect of Phenolic Compounds from Elderflowers on Glucose- and Fatty Acid Uptake in Human Myotubes and HepG2-Cells 
Ho, Giang Thanh Thi; Kase, Eili Tranheim; Wangensteen, Helle; Barsett, Hilde (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Type 2 diabetes (T2D) is manifested by progressive metabolic impairments in tissues such as skeletal muscle and liver, and these tissues become less responsive to insulin, leading to hyperglycemia. In the present study, ...
Elderberry and Elderflower Extracts, Phenolic Compounds, and Metabolites and Their Effect on Complement, RAW 264.7 Macrophages and Dendritic Cells 
Ho, Giang Thanh Thi; Wangensteen, Helle; Barsett, Hilde (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Modulation of complement activity and inhibition of nitric oxide (NO) production by macrophages and dendritic cells may have therapeutic value in inflammatory diseases. Elderberry and elderflower extracts, constituents, ...
The burden of nausea and vomiting during pregnancy: severe impacts on quality of life, daily life functioning and willingness to become pregnant again – results from a cross-sectional study 
Heitmann, Kristine; Nordeng, Hedvig; Havnen, Gro C; Solheimsnes, Anja; Holst, Lone (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background Though nausea and vomiting is very common during pregnancy, no studies have investigated the impact of this condition on the women’s daily lives in a Scandinavian population. The aim of this study ...
More Use of Peritoneal Dialysis Gives Significant Savings: A Systematic Review and Health Economic Decision Model 
Pike, Eva; Hamidi, Vida; Ringerike, Tove; Wisløff, Torbjørn; Klemp, Marianne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background: Patients with end-stage renal disease (ESRD) are in need of renal replacement therapy as dialysis and/or transplantation. The prevalence of ESRD and, thus, the need for dialysis are constantly growing. The ...
Cooperation between geriatricians and general practitioners for improved pharmacotherapy in home-dwelling elderly people receiving polypharmacy – the COOP Study: study protocol for a cluster randomised controlled trial 
Romskaug, Rita; Molden, Espen; Straand, Jørund; Kersten, Hege; Skovlund, Eva; Pitkala, Kaisu H; Wyller, Torgeir B (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background Polypharmacy and inappropriate drug use is associated with negative health outcomes among older people. Various interventions for improving drug treatment have been evaluated, but the majority ...
Risk of preeclampsia after gestational exposure to selective serotonin reuptake inhibitors and other antidepressants: A study from The Norwegian Mother and Child Cohort Study 
Lupattelli, Angela; Wood, Mollie; Lapane, Kate L; Spigset, Olav; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Purpose: To describe the risk of early- and late-onset preeclampsia across pregnancies exposed to antidepressants and to evaluate the impact of timing and length of gestational exposure to antidepressants, particularly ...
1H, 13C, 15N backbone assignment of the human heat-labile enterotoxin B-pentamer and chemical shift mapping of neolactotetraose binding 
Hatlem, Daniel; Heggelund, Julie Elisabeth; Burschowsky, Daniel; Krengel, Ute; Kristiansen, Per Eugen (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
The major virulence factor of enterotoxigenic Escherichia coli is the heat-labile enterotoxin (LT), an AB5 toxin closely related to the cholera toxin. LT consists of six subunits, the catalytically active A-subunit and ...
The novel lipid mediator PD1n-3 DPA: An overview of the structural elucidation, synthesis, biosynthesis and bioactions 
Hansen, Trond Vidar; Dalli, Jesmond; Serhan, Charles N. (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
Resolvins, protectins and maresins are individual families of specialized pro-resolving mediators biosynthesized from the dietary n-3 polyunsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid. These ...
Automated Protein Biomarker Analysis: on-line extraction of clinical samples by Molecularly Imprinted Polymers 
Rossetti, Cecilia; Świtnicka-Plak, Magdalena A.; Halvorsen, Trine Grønhaug; Cormack, Peter A.G.; Sellergren, Börje; Reubsaet, Léon (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Robust biomarker quantification is essential for the accurate diagnosis of diseases and is of great value in cancer management. In this paper, an innovative diagnostic platform is presented which provides automated molecularly ...
High-throughput liquid-liquid extraction in 96-well format: Parallel artificial liquid membrane extraction 
Gjelstad, Astrid; Andresen, Alf Terje; Dahlgren, Anders; Gundersen, Thomas Erik; Pedersen-Bjergaard, Stig (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Parallel artificial liquid membrane extraction (PALME) is a miniaturized version of liquid–liquid extraction (LLE) and is based on two 96-well plates in a sandwich-like configuration. With a very simple workflow, 96 samples ...
Chitosan-Based Nanomedicine to Fight Genital Candida Infections: Chitosomes 
Andersen, Toril; Mishchenko, Ekatarina; Flaten, Gøril Eide; Sollid, Johanna U Ericson; Mattsson, Sofia; Tho, Ingunn; Skalko-Basnet, Natasa (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Vaginal infections are associated with high recurrence, which is often due to a lack of efficient treatment of complex vaginal infections comprised of several types of pathogens, especially fungi and bacteria. Chitosan, a ...
Polymer coated mucoadhesive liposomes intended for the management of xerostomia 
Adamczak, Malgorzata Iwona; Martinsen, Ørjan Grøttem; Smistad, Gro; Hiorth, Marianne (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
The aim of this work was to prepare and test different pharmaceutical formulations in respect of their potential in relieving dry mouth symptom. Since many of the products available on the market provide only temporary ...
Patterns and predictors of analgesic use in pregnancy: a longitudinal drug utilization study with special focus on women with migraine 
Harris, Gerd-Marie E; Wood, Mollie; Eberhard-Gran, Malin; Lundqvist, Christofer; Nordeng, Hedvig (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background Few studies have investigated the drug utilization patterns and factors predicting drug use in pregnant women with migraine. This longitudinal drug utilization study aimed to describe patterns ...
Hypnotics use in children 0–18 months: moderate agreement between mother-reported survey data and prescription registry data 
Holdø, Ingvild; Bramness, Jørgen G; Handal, Marte; Torgersen, Leila; Reichborn-Kjennerud, Ted; Ystrøm, Eivind; Nordeng, Hedvig; Skurtveit, Svetlana (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background Different methods in pharmacoepidemiology can be used to study hypnotic use in children. But neither questionnaire-based data nor prescription records can be considered a “gold standard”. This ...
Characterization and Vaccine Potential of Membrane Vesicles Produced by Francisella noatunensis subsp. orientalis in an Adult Zebrafish Model. 
Lagos, Leidy; Tandberg, Julia Isabel; Repnik, Urska; Boysen, Preben; Ropstad, Erik; Varkey, Deepa Ruth; Paulsen, Ian T.; Winther-Larsen, Hanne Cecilie (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Vaccine development against extracellular bacteria has been important for the sustainability of the aquaculture industry. In contrast, infections with intracellular pathogens remain largely an unresolved problem. Francisella ...
Metabolic and performance effects of Yerba Mate on well-trained cyclists 
Areta, José; Austarheim, Ingvild; Wangensteen, Helle; Capelli, Carlo (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
Introduction: Yerba Mate (YM) is a South American plant, rich in polyphenols, saponins, and xanthines, of growing scientific interest because of its metabolic effects. YM has been shown to increase fat utilization during ...
Predictability of Marine Population Trajectories–the effect of delays and resource availability 
Frank, Anna-Simone Josefine (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
This paper studies the dynamics and stability of a stage-structured (immature/mature) population. The emphasis is on how resource available to the immature stage indirectly regulates the dynamics of the mature stage, where ...
Uncovering human METTL12 as a mitochondrial methyltransferase that modulates citrate synthase activity through metabolite-sensitive lysine methylation 
Malecki, Jedrzej Mieczyslaw; Jakobsson, Magnus; Ho, Angela Yeuan Yen; Moen, Anders; Rustan, Arild; Falnes, Pål (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Lysine methylation is an important and much-studied posttranslational modification of nuclear and cytosolic proteins but is present also in mitochondria. However, the responsible mitochondrial lysine-specific methyltransferases ...
Stereocontrolled synthesis and investigation of the biosynthetic transformations of 16(S),17(S)-epoxy-PDn-3 DPA 
Primdahl, Karoline Gangestad; Tungen, Jørn Eivind; De Souza, Patricia R; Colas, Romain A.; Dalli, Jesmond; Hansen, Trond Vidar; Vik, Anders (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
PD1n-3 DPA is a specialized pro-resolving lipid mediator that displays potent anti-inflammatory properties and pro-resolving bioactivities. Such naturally occurring compounds are of current interest in biomolecular chemistry ...
Liposomes coated with hydrophobically modified hydroxyethyl cellulose: Influence of hydrophobic chain length and degree of modification 
Smistad, Gro; Nyström, Bo; Zhu, Kaizheng; Grønvold, Marthe Karoline; Røv-Johnsen, Anne; Hiorth, Marianne (Journal article / Tidsskriftartikkel / SubmittedVersion, 2017)
Nanoparticulate systems with an uncharged hydrophilic surface may have a great potential in mucosal drug delivery. In the present study liposomes were coated with hydrophobically modified hydroxyethyl cellulose (HM-HEC) ...
Isolation and Characterization of Serum Extracellular Vesicles (EVs) from Atlantic Salmon Infected with Piscirickettsia Salmonis 
Lagos, Leidy; Tandberg, Julia Isabel; Kashulin, Alexander; Colquhoun, Duncan John; Sørum, Henning; Winther-Larsen, Hanne Cecilie (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Secretion of extracellular vesicles (EVs) is a common feature of both eukaryotic and prokaryotic cells. Isolated EVs have been shown to contain different types of molecules, including proteins and nucleic acids, and are ...
Francisella noatunensis subspecies noatunensis clpB deletion mutant impairs development of francisellosis in a zebrafish model 
Lampe, Elisabeth Opsjøn; Zingmark, Carl; Tandberg, Julia Isabel; Thrane, Ida Marie; Brudal, Espen; Sjöstedt, Anders; Winther-Larsen, Hanne Cecilie (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Keywords: Atlantic cod, Francisella noatunensis, Francisellosis, ClpB, Immunization, Zebrafish
Recent advances in the chemistry and biology of anti-inflammatory and specialized pro-resolving mediators biosynthesized from n-3 docosapentaenoic acid 
Vik, Anders; Dalli, Jesmond; Hansen, Trond Vidar (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
Several novel oxygenated polyunsaturated lipid mediators biosynthesized from n-3 docosapentaenoic acid were recently isolated from murine inflammatory exudates and human primary cells. These compounds belong to a distinct ...
Regioselective monoalkylation of 17β-estradiol for the synthesis of cytotoxic estrogens 
Van Gansbeke, Koen; Solum, Eirik Johansson; Liekens, Sandra; Vik, Anders; Hansen, Trond Vidar (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
The regioselective synthesis of estrogens and their derivatives continues to be of interest. Most reported syntheses require multistep protocols associated with poor overall yield and lack of regioselectivity. New preparative ...
Polysaccharides from the South African medicinal plant Artemisia afra: Structure and activity studies 
Bräunlich, Paula Marie; Inngjerdingen, Kari Tvete; Inngjerdingen, Marit; Johnson, Quinton; Paulsen, Berit Smestad; Mabusela, Wilfred (Journal article / Tidsskriftartikkel / SubmittedVersion, 2017)
Artemisia afra (Jacq. Ex. Willd), is an indigenous plant in South Africa and other parts of the African continent, where it is used as traditional medicine mostly for respiratory conditions. The objective of this study was ...
Treatment with antipsychotics in pregnancy: changes in drug disposition 
Westin, Andreas; Brekke, Malin; Molden, Espen; Skogvoll, Eirik; Castberg, Ingrid Mehli; Spigset, Olav (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Although pregnancy is known to cause changes in drug pharmacokinetics, little is known about its impact on serum levels of antipsychotics. In this study we retrospectively assessed 201 routine serum antipsychotic therapeutic ...
Maternal alcohol use during pregnancy and offspring attention-deficit hyperactivity disorder (ADHD): a prospective sibling control study 
Eilertsen, Espen Moen; Gjerde, Line C.; Reichborn-Kjennerud, Ted; Ørstavik, Ragnhild; Knudsen, Gun Peggy; Stoltenberg, Camilla; Czajkowski, Nikolai Olavi; Røysamb, Espen; Kendler, Kenneth S; Ystrøm, Eivind (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
Background Maternal alcohol use during pregnancy has repeatedly been associated with development of attention-deficit hyperactivity disorder (ADHD) in the offspring. It is, however not known whether this reflects a ...
Immunomodulatory properties of Concholepas concholepas hemocyanin against francisellosis in a zebrafish model 
Lagos, Leidy; Tandberg, Julia Isabel; Becker, María Inés; Winther-Larsen, Hanne Cecilie (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
The development of vaccines for aquaculture has been an important milestone in providing a continuous and sustainable production. Most of the vaccines currently on the market for aquaculture include oil as adjuvant. ...
Exposure to mycophenolate and fatherhood 
Midtvedt, Karsten; Bergan, Stein; Reisæter, Anna Varberg; Vikse, Bjørn Egil; Åsberg, Anders (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background: Mycophenolic acid (MPA) is the active immunosuppressive substance in both mycophenolate mofetil and mycophenolate sodium, and it is widely used after organ transplantation. In women, taking MPA is teratogenic ...
A rapid and sustained improvement of calcification propensity score (serum T50) after successful kidney transplantation: Reanalysis of a randomized controlled trial of ibandronate 
Smerud, Knut Terje; Åsberg, Anders; Kile, Håkon; Pasch, Andreas; Dahle, Dag Olav; Bollerslev, Jens; Godang, Kristin; Hartmann, Anders (Journal article / Tidsskriftartikkel / SubmittedVersion, 2017)
A serum test called T50 assesses the overall propensity for calcification of the blood and is associated with cardiovascular outcomes. We aimed to examine T50 over time in kidney transplant recipients and also address any ...
Sick leave and medication use in pregnancy: A European web-based study 
Truong, Bich Thuy Ha; Lupattelli, Angela; Kristensen, Petter; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background and objective: A comparison of sick leave in pregnancy between countries is difficult as most studies have been conducted in single countries in Scandinavia. The objective of this study was to explore patterns ...
Inflammation in early kidney allograft surveillance biopsies and its relationship with de novo donor specific antibodies 
Garcia-Carro, Clara; Dörje, Christina; Åsberg, Anders; Midtvedt, Karsten; Reinholdt, Finn; Strøm, Erik Heyerdahl; Holdaas, Hallvard (Journal article / Tidsskriftartikkel / SubmittedVersion, 2017)
Interstitial fibrosis and tubular atrophy (IFTA) associated with interstitial inflammation in non scarred areas (IFTA+i) is associated with poorer graft outcome than inflammation without IFTA or IFTA without inflammation. ...
Haptoglobin 2-2 Genotype, Patient, and Graft Survival in Renal Transplant Recipients 
Dupont, Laust; Eide, Ivar Anders; Hartmann, Anders; Christensen, Jeppe Hagstrup; Åsberg, Anders; Jenssen, Trond Geir; Krarup, Henrik; Svensson, My Hanna Sofia (Journal article / Tidsskriftartikkel / SubmittedVersion, 2017)
Background: Cardiovascular disease is the leading cause of death in renal transplant recipients. An association between haptoglobin genotype 2-2 and cardiovascular disease has been found in patients with diabetes mellitus ...
Estimating Glomerular Filtration Rate in Kidney Transplant Recipients: Comparing a Novel Equation With Commonly Used Equations in this Population 
Salvador, Cathrin Lytomt; Hartmann, Anders; Åsberg, Anders; Bergan, Stein; Rowe, Alexander D.; Mørkrid, Lars (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background: Assessment of glomerular filtration rate (GFR) is important in kidney transplantation. The aim was to develop a kidney transplant specific equation for estimating GFR and evaluate against published equations ...
Physical stability of moisture-sensitive tablets stored in a canister or as unit-dose 
Bjerknes, Kathrin; Helmizadeh, Zahra; Brustugun, Jørgen; Smistad, Gro (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
Background: Knowledge about the long-term stability of tablets outside the original container, e.g. as unit-doses, is limited. This leaves the pharmacist with the dilemma of seeking improved patient safety by use of ...
Making fair comparisons in pregnancy medication safety studies: An overview of advanced methods for confounding control 
Wood, Mollie; Lapane, Kate L; van Gelder, Marleen MHJ; Rai, Dheeraj; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
Understanding the safety of medication use during pregnancy relies on observational studies: However, confounding in observational studies poses a threat to the validity of estimates obtained from observational data. Newer ...
Risk factors for exertional rhabdomyolysis with renal stress 
Apeland, Terje; Danielsen, Tore; Staal, Eva Marianne; Åsberg, Anders; Thorsen, Inga Strand; Dalsrud, Tom Ole; Ørn, Stein (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background: Exercise-induced rhabdomyolysis denotes the exertional damage of myocytes with leakage of sarcoplasmic content into the circulation. The purpose of this study was to determine important risk factors for the ...
Structural characterization of bioactive heteropolysaccharides from the medicinal fungus Inonotus obliquus (Chaga). 
Wold, Christian Winther; Kjeldsen, Christian; Corthay, Alexandre; Rise, Frode; Christiansen, Bjørn E.; Duus, Jens Øllgaard; Inngjerdingen, Kari Tvete (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
The aim of this paper was to perform a comprehensive characterization of polysaccharides isolated from the interior (IOI) and exterior (IOE) parts of the fungus Inonotus obliquus. Pre-extraction with DCM and MeOH, followed ...
High Tacrolimus Clearance Is a Risk Factor for Acute Rejection in the Early Phase After Renal Transplantation 
Egeland, Erlend Johannessen; Robertsen, Ida; Hermann, Monica; Midtvedt, Karsten; Størset, Elisabet; Gustavsen, Marte Theie; Reisæter, Anna Varberg; Klaasen, Rolf; Bergan, Stein; Holdaas, Hallvard; Hartmann, Anders; Åsberg, Anders (Journal article / Tidsskriftartikkel / SubmittedVersion, 2017)
Background: Patients with high tacrolimus clearance eliminate more drug within a dose interval compared to those with low clearance. Delays in dosing time will result in transient periods of lower concentrations in high- ...
The impact of nondifferential exposure misclassification on the performance of propensity scores for continuous and binary outcomes: a simulation study 
Wood, Mollie; Chrysanthopoulou, Stavroula; Nordeng, Hedvig Marie Egeland; Lapane, Kate L. (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
Purpose: To investigate the ability of the propensity score (PS) to reduce confounding bias in the presence of nondifferential misclassification of treatment, using simulations. Methods: Using an example from the pregnancy ...
Legumain regulates differentiation fate of human bone marrow stromal cells and is altered in postmenopausal osteoporosis 
Jafari, Abbas; Qanie, Diyako; Andersen, Thomas L.; Zhang, Yuxi; Chen, Li; Postert, Benno; Parsons, Stuart; Ditzel, Nicholas; Khosla, Sundeep; Johansen, Harald Thidemann; Kjærsgaard-Andersen, Per; Delaissé, Jean-Marie; Abdallah, Basem M.; Hesselson, Daniel; Solberg, Rigmor; Kassem, Moustapha (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Secreted factors are a key component of stem cell niche and their dysregulation compromises stem cell function. Legumain is a secreted cysteine protease involved in diverse biological processes. Here, we demonstrate that ...
Novel decay dynamics revealed for virus-mediated drug activation in cytomegalovirus infection 
Rose, J; Emery, Vincent C; Kumar, Deepali; Åsberg, Anders; Hartmann, Anders; Jardine, Alan G.; Bignamini, Angelo A; Humar, Atul; Neumann, Avidan U (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Human cytomegalovirus (CMV) infection is a substantial cause of morbidity and mortality in immunocompromised hosts and globally is one of the most important congenital infections. The nucleoside analogue ganciclovir (GCV), ...
Electromembrane extraction – Recent trends and where to go 
Pedersen-Bjergaard, Stig; Huang, Chuixiu; Gjelstad, Astrid (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Electromembrane extraction (EME) is an analytical microextraction technique, where charged analytes (such as drug substances) are extracted from an aqueous sample (such as a biological fluid), through a supported liquid ...
Tacrolimus and mycophenolate regimen and subclinical tubulo-interstitial inflammation in low immunological risk renal transplants 
Torres, Irina B; Reisæter, Anna Varberg; Moreso, Francesc; Åsberg, Anders; Vidal, Marta; Garcia-Carro, Clara; Midtvedt, Karsten; Reinholt, Finn P.; Scott, Helge; Castellà, Eva; Salcedo, Maite; Dörje, Christina; Sellarés, Joana; Azancot, Maria A; Perello, Manel; Holdaas, Hallvard; Serón, Daniel (Journal article / Tidsskriftartikkel / SubmittedVersion, 2017)
The aim was to evaluate the relationship between maintenance immunosuppression, subclinical tubulo-interstital inflammation and interstitial fibrosis/tubular atrophy (IF/TA) in surveillance biopsies performed in low ...
The CYP3A biomarker 4β-hydroxycholesterol does not improve tacrolimus dose predictions early after kidney transplantation 
Størset, Elisabet; Hole, Kristine; Midtvedt, Karsten; Bergan, Stein; Molden, Espen; Åsberg, Anders (Journal article / Tidsskriftartikkel / SubmittedVersion, 2017)
Aims: Tacrolimus is a cornerstone in modern immunosuppressive therapy after kidney transplantation. Tacrolimus dosing is challenged by considerable pharmacokinetic variability, both between patients and over time after ...
Recent Development of Non-Peptide GnRH Antagonists 
Tukun, Feng-Ling; Olberg, Dag Erlend; Riss, Patrick; Haraldsen, Ira Hebold; Kåss, Anita Anjali Suri; Klaveness, Jo (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
The decapeptide gonadotropin-releasing hormone, also referred to as luteinizing hormone-releasing hormone with the sequence (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) plays an important role in regulating the reproductive ...
Interleukin 27 is increased in carotid atherosclerosis and promotes NLRP3 inflammasome activation. 
Gregersen, Ida; Sandanger, Øystein; Askevold, Erik Tandberg; Sagen, Ellen Lund; Yang, Kuan; Holm, Sverre; Pedersen, Turid Margrethe; Skjelland, Mona; Krohg-Sørensen, Kirsten; Hansen, Trond Vidar; Dahl, Tuva Børresdatter; Otterdal, Kari; Espevik, Terje; Aukrust, Pål; Yndestad, Arne; Halvorsen, Bente (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Aim: Interleukin-27 (IL-27) is involved in different inflammatory diseases; however, its role in atherosclerosis is unclear. In this study we investigated the expression of IL-27 and its receptor in patients with carotid ...
Elderly users of fall-risk-increasing drug perceptions of fall risk and the relation to their drug use?a qualitative study 
Bell, Hege Therese; Steinsbekk, Aslak; Granås, Anne Gerd (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Objective: The aim of the study was to explore how home-dwelling elderly who use fall-risk-increasing drugs (FRIDs) perceive their fall risk and how they relate this to their drug use. Design, setting and subjects: A ...
The putative drug efflux systems of the Bacillus cereus group 
Hassan, Karl A.; Fagerlund, Annette; Elbourne, Liam D.H.; Vörös, Aniko; Kroeger, Jasmin Kaori; Simm, Roger; Tourasse, Nicolas Jacques; Finke, Sarah; Henderson, Peter J.F.; Økstad, Ole Andreas Løchen; Paulsen, Ian T.; Kolstø, Anne-Brit (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
The Bacillus cereus group of bacteria includes seven closely related species, three of which, B. anthracis, B. cereus and B. thuringiensis, are pathogens of humans, animals and/or insects. Preliminary investigations into ...
Changes in drug disposition of lithium during pregnancy: A retrospective observational study of patient data from two routine therapeutic drug monitoring services in Norway 
Westin, Andreas; Brekke, Malin; Molden, Espen; Skogvoll, Eirik; Aadal, Marianne; Spigset, Olav (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Objectives: Pregnancy may cause changes in drug disposition, dose requirements and clinical response. For lithium, changes in disposition during pregnancy have so far been explored in a single-dose study on 4 participants ...
Exercise in vivo marks human myotubes in vitro: Training-induced increase in lipid metabolism 
Lund, Jenny; Rustan, Arild; Løvsletten, Nils Gunnar; Mudry, Jonathan M.; Langleite, Torgrim Mikal; Feng, Yuan Zeng; Stensrud, Camilla; Brubak, Mari G; Drevon, Christian A; Birkeland, Kåre I.; Kolnes, Kristoffer Jensen; Johansen, Egil Ivar; Tangen, Daniel S.; Stadheim, Hans Kristian; Gulseth, Hanne Løvdal; Krook, Anna; Kase, Eili Tranheim; Jensen, Jørgen; Thoresen, G. Hege (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background and aims Physical activity has preventive as well as therapeutic benefits for overweight subjects. In this study we aimed to examine effects of in vivo exercise on in vitro metabolic adaptations by studying ...
Use of medicines, adherence and attitudes to medicines among persons with chronic spinal cord injury 
Høgholen, Anna Helene; Storhaug, Anette; Kvernrød, Kristin; Kostovski, Emil; Viktil, Kirsten Kilvik; Mathiesen, Liv (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
Objectives: To describe the use of medicines and adherence among persons with spinal cord injury (SCI). Further, to examine the influence of pain, spasms and beliefs about medicines on adherence. Methods: Persons (18 ...
Multiple treatment comparison of seven new drugs for patients with advanced malignant melanoma: a systematic review and health economic decision model in a Norwegian setting 
Pike, Eva; Hamidi, Vida; Sæterdal, Ingvil Von Mehren; Odgaard-Jensen, Jan; Klemp, Marianne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Objective: To assess the relative effectiveness and cost-effectiveness of seven new drugs (cobimetinib, dabrafenib, ipilimumab, nivolumab, pembrolizumab, trametinib and vemurafenib) used for treatment of patients with ...
Does progestin-only contraceptive use after pregnancy affect recovery from pelvic girdle pain? A prospective population study 
Bjelland, Elisabeth Krefting; Owe, Katrine Mari; Nordeng, Hedvig Marie Egeland; Engdahl, Bo Lars; Kristiansson, Per; Vangen, Siri; Eberhard-Gran, Malin (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Objective: To estimate associations of progestin-only contraceptives with persistent pelvic girdle pain 18 months after delivery. Methods Prospective population based cohort study during the years 2003–2011. We included ...
Fluoride loaded polymeric nanoparticles for dental delivery 
Nguyen, Sanko; Escudero, Carlos; Sediqi, Nadia; Smistad, Gro; Hiorth, Marianne (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
The overall aim of the present paper was to develop fluoride loaded nanoparticles based on the biopolymers chitosan, pectin, and alginate, for use in dental delivery. First, the preparation of nanoparticles in the presence ...
Formulation of polysaccharide-based nanoparticles for local administration into the oral cavity 
Pistone, Sara; Goycoolea, Francisco M.; Young, Alix; Smistad, Gro; Hiorth, Marianne (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
The efficacy of treatments for oral ailments is often challenged by a low residence time of the conventional pharmaceutical formulations in the oral cavity. The residence time in the oral cavity could be improved by using ...
Polysaccharide-coated liposomal formulations for dental targeting 
Pistone, Sara; Rykke, Morten; Smistad, Gro; Hiorth, Marianne (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
The efficacy of treatments of oral ailments is often challenged by a low residence time of the conventional pharmaceutical formulations in the oral cavity, which could be improved by using bioadhesive formulations. This ...
Underestimated impact of novel psychoactive substances: laboratory confirmation of recreational drug toxicity in Oslo, Norway 
Vallersnes, Odd Martin; Persett, Per Sverre; Øiestad, Elisabeth Leere; Karinen, Ritva Anneli; Heyerdahl, Fridtjof; Hovda, Knut Erik (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
Context: Recreational drug toxicity is frequent. Availability of new psychoactive substances is steadily increasing. However, data with verified analyses from clinical settings are limited. To evaluate the impact of novel ...
Administrative Claims Data Versus Augmented Pregnancy Data for the Study of Pharmaceutical Treatments in Pregnancy 
Wood, Mollie; Nordeng, Hedvig Marie Egeland; Andrade, Susan; Toh, Sengwee; Berard, Anick; van Gelder, Marlene (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Purpose of Review: Administrative claims databases, which collect reimbursement-related information generated from healthcare encounters, are increasingly used to evaluate medication safety in pregnancy. We reviewed the ...
Erratum to: Natural products from Zanthoxylum heitzii with potent activity against the malaria parasite 
Goodman, Christopher D; Austarheim, Ingvild; Mollard, Vanessa; Mikolo, Bertin; Malterud, Karl E; McFadden, Geoffrey I; Wangensteen, Helle (Journal article / Tidsskriftartikkel / PublishedVersion, 2016)
Safety classification of herbal medicines used in pregnancy in a multinational study 
Kennedy, D. A; Lupattelli, A.; Koren, G.; Nordeng, H. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Background The use of herbal medicines for health prevention and ailments is an increasing trend worldwide. Women in pregnancy are no exception; the reported prevalence of herbal medicine use in pregnancy ...
Development and evaluation of a test program for Y-site compatibility testing of total parenteral nutrition and intravenous drugs 
Staven, Vigdis; Wang, Siri; Grønlie, Ingrid; Tho, Ingunn (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Background There is no standardized procedure or consensus to which tests should be performed to judge compatibility/incompatibility of intravenous drugs. The purpose of this study was to establish and ...
Synthesis of 13(R)‐Hydroxy‐7Z,10Z,13R,14E,16Z,19Z Docosapentaenoic Acid (13R‐HDPA) and Its Biosynthetic Conversion to the 13-Series Resolvins 
Primdahl, Karoline Gangestad; Aursnes, Marius; Walker, Mary E.; Colas, Romain A.; Serhan, Charles N.; Dalli, Jesmond; Hansen, Trond Vidar; Vik, Anders (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Specialized pro-resolving lipid mediators are biosynthesized during the resolution phase of acute inflammation from n-3 polyunsaturated fatty acids. Recently, the isolation and identification of the four novel mediators ...
Intra-individual changes in DNA methylation not mediated by cell-type composition are correlated with aging during childhood 
Gervin, Kristina; Andreassen, Bettina K; Hjorthaug, Hanne S; Carlsen, Karin C L; Carlsen, Kai-Håkon; Undlien, Dag E; Lyle, Robert; Munthe-Kaas, Monica C (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Background Several studies have reported age-associated changes in DNA methylation in the first few years of life and in adult populations, but the extent of such changes during childhood is less well ...
Plasma levels of marine n-3 fatty acids and cardiovascular risk markers in renal transplant recipients 
Eide, Ivar A.; Dahle, Dag O.; Svensson, My; Hartmann, Anders; Åsberg, Anders; Bjerve, Kristian S.; Christensen, Jeppe H.; Schmidt, Erik B.; Lauritsen, ME; Lund, K; Jenssen, Trond (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2016)
Background/Objectives: Cardiovascular (CV) disease is the leading cause of death after renal transplantation. Marine n-3 polyunsaturated fatty acids (PUFAs) exert potential cardio-protective metabolic effects and might ...
Proteomics tools reveal startlingly high amounts of oxytocin in plasma and serum 
Brandtzaeg, Ole Kristian; Johnsen, Elin Follaug; Røberg-Larsen, Hanne; Seip, Knut Fredrik; MacLean, Evan L.; Gesquiere, Laurence R.; Leknes, Siri; Lundanes, Elsa; Wilson, Steven Ray Haakon (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
The neuropeptide oxytocin (OT) is associated with a plethora of social behaviors, and is a key topic at the intersection of psychology and biology. However, tools for measuring OT are still not fully developed. We describe ...
Natural products from Zanthoxylum heitzii with potent activity against the malaria parasite 
Goodman, Christopher D; Austarheim, Ingvild; Mollard, Vanessa; Mikolo, Bertin; Malterud, Karl E; McFadden, Geoffrey I; Wangensteen, Helle (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Background Zanthoxylum heitzii (Rutaceae) (olon) is used in traditional medicine in Central and West Africa to treat malaria. To identify novel compounds with anti-parasitic ...
Mood, anxiety, and alcohol use disorders and later cause-specific sick leave in young adult employees 
Torvik, Fartein Ask; Reichborn-Kjennerud, Ted; Gjerde, Line C.; Knudsen, Gun Peggy; Ystrøm, Eivind; Tambs, Kristian; Røysamb, Espen; Østby, Kristian Amundsen; Ørstavik, Ragnhild (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Background Mental disorders strongly influence work capability in young adults, but it is not clear which disorders that are most strongly associated with sick leave, and which diagnoses that are stated on the sick leave ...
Longitudinal changes in neurodevelopmental outcomes between 18 and 36 months in children with prenatal triptan exposure: findings from the Norwegian Mother and Child Cohort Study 
Wood, Mollie; Frazier, Jean A; Nordeng, Hedvig Marie Egeland; Lapane, Kate L (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Objective This study sought to determine whether changes in neurodevelopmental outcomes between 18 and 36 months of age were associated with prenatal exposure to triptan medications, a class of 5-HT receptor agonists used ...
Social inequalities in reception of social welfare support: A population based twin study 
Ystrøm, Eivind; Ørstavik, Ragnhild; Reichborn-Kjennerud, Ted; Torvik, Fartein Ask (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Social welfare support runs in families. Recent studies using Nordic registry data have found individual differences in genetic factors to be of substantial importance for medical benefits. However, to date there has been ...
Survival-associated heterogeneity of marker-defined perivascular cells in colorectal cancer 
Mezheyeuski, Artur; Lindh, Maja Bradic; Guren, Tormod Kyrre; Dragomir, Anca; Pfeiffer, Per; Kure, Elin H.; Ikdahl, Tone; Skovlund, Eva; Corvigno, Sara; Strell, Carina; Pietras, Kristian; Pontén, Fredrik; Mulder, Jan; Qvortrup, Camilla; Portyanko, Anna; Tveit, Magne Kjell; Glimelius, Bengt; Sorbye, Halfdan; Ostman, Arne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Perivascular cells (PC) were recently implied as regulators of metastasis and immune cell activity. Perivascular heterogeneity in clinical samples, and associations with other tumor features and outcome, remain largely ...
Bradykinin-Induced Shock Increase Exhaled Nitric Oxide, Complement Activation and Cytokine Production in Pigs 
Seip, Knut Fredrik; Evjenth, Bjørg; Hovland, Anders; Dybwik, Knut Gustav; Johansen, Harald Thidemann; Fure, Hilde; Mollnes, Tom Eirik; Nielsen, Erik Waage (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Bradykinin is an important mediator in blood pressure regulation, ischemic precondition and capillary leakage, allergy, anaphylaxis, inflammation, and nociception, at least partly via the generation of nitric oxide (NO). ...
India’s scientific publication in predatory journals: need for regulating quality of Indian science and education 
Gopalakrishnan Saroja, Seethapathy; Santhosh Kumar, J. U.; Hareesha, A. S. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Nature Index analysis 2014 rates India at the 13th place for its high-quality scientific publications. Despite this achievement, several studies have revealed that India is also among the major contrib-utors of articles ...
Isolation and mass spectrometry analysis of urinary extraexosomal proteins 
Hildonen, Siri; Skarpen, Ellen; Halvorsen, Trine Grønhaug; Reubsaet, Leon (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
The aim of the present study was to develop a LC-MS/MS-based proteomic analysis method of urinary exosomal proteins that has the potential to discover disease biomarkers. In short, urinary exosomes from healthy subjects ...
Multivalent pIX phage display selects for distinct and improved antibody properties 
Høydahl, Lene Støkken; Nilssen, Nicolay Rustad; Gunnarsen, Kristin Støen; du Pré, Marie Fleur; Iversen, Rasmus; Roos, Norbert; Chen, Xi; Michaelsen, Terje Einar; Sollid, Ludvig Magne; Sandlie, Inger; Løset, Geir Åge (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Phage display screening readily allows for the identification of a multitude of antibody specificities, but to identify optimal lead candidates remains a challenge. Here, we direct the antibody-capsid fusion away from the ...
Association of Prenatal Ibuprofen Exposure with Birth Weight and Gestational Age: A Population-Based Sibling Study 
Nezvalova-Henriksen, Katerina; Wood, Mollie; Spigset, Olav; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Objectives Three studies so far have investigated the effect of prenatal non-steroidal anti-inflammatory drug (NSAID) exposure on birth weight and gestational age. The aim in this study was to evaluate the association of ...
Water sorption properties of HM-pectin and liposomes intended to alleviate dry mouth 
Adamczak, Malgorzata Iwona; Martinsen, Ørjan Grøttem; Smistad, Gro; Hiorth, Marianne (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2016)
Pharmaceutical formulations intended for treatment of xerostomia (dry mouth) should be able to keep the oral mucosa hydrated for a prolonged period of time. The products already existing on the market contain water-soluble ...
An in vitro study of mucoadhesion and biocompatibility of polymer coated liposomes on HT29-MTX mucus-producing cells 
Adamczak, Malgorzata Iwona; Hagesæther, Ellen; Smistad, Gro; Hiorth, Marianne (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2016)
Drug delivery to the oral cavity poses a significant challenge due to the short residence time of the formulations at the site of action. From this point of view, nanoparticulate drug delivery systems with ability to adhere ...
Comparative Analysis of Membrane Vesicles from Three Piscirickettsia salmonis Isolates Reveals Differences in Vesicle Characteristics. 
Tandberg, Julia Isabel; Lagos Rojas, Leidy Ximena; Langlete, Petter; Berger, Eva Kathrin; Rishovd, Anne-Lise; Roos, Norbert; Varkey, Deepa Ruth; Paulsen, Ian T.; Winther-Larsen, Hanne Cecilie (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Membrane vesicles (MVs) are spherical particles naturally released from the membrane of Gram-negative bacteria. Bacterial MV production is associated with a range of phenotypes including biofilm formation, horizontal gene ...
Visceral fat is strongly associated with post-transplant diabetes mellitus and glucose metabolism 1 year after kidney transplantation 
Von Düring, Marit Elizabeth; Jenssen, Trond Geir; Bollerslev, Jens; Åsberg, Anders; Godang, Kristin; Hartmann, Anders (Journal article / Tidsskriftartikkel / SubmittedVersion, 2016)
Body composition after kidney transplantation is linked to glucose metabolism, and impaired glucose metabolism is associated with increased risk of cardiovascular events and death. One year after transplantation, we examined ...
Determination of very low-abundance diagnostic proteins in serum using immuno-capture LC-MS-MS 
Reubsaet, Leon; Halvorsen, Trine Grønhaug (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
The use of antibodies in “bottom-up “LC-MS workflows to determine low abundant biological active proteins in complex human samples has increased in recent years: immuno-capture analysis combines the workflow of conventional ...
Treatment with tacrolimus and sirolimus reveals no additional adverse effects on human islets in vitro compared to each drug alone but they are reduced by adding glucocorticoids 
Kloster-Jensen, Kristine; Sahraoui, Afaf; Vethe, Nils Tore; Korsgren, Olle; Bergan, Stein; Foss, Aksel; Scholz, Hanne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Tacrolimus and sirolimus are important immunosuppressive drugs used in human islet transplantation; however, they are linked to detrimental effects on islets and reduction of long-term graft function. Few studies investigate ...
Perception of the Professional Knowledge of and Education on the Medical Technology Products among the Pharmacists in the Baltic and Nordic Countries—A Cross-Sectional Exploratory Study 
Volmer, Daisy; Sokirskaja, Aleksandra; Laaksonen, Raisa; Vainio, Kirsti; Sandler, Niklas; Halvorsen, Kjell H.; Kjome, Reidun Lisbet Skeide; Gizurarson, Sveinbjørn; Muceniece, Ruta; Maurina, Baiba; Dauksiene, Jurgita; Ruuben, Lilian; Björnsdottir, Ingunn; Ratassepp, Tagne; Heinämäki, Jyrki (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
With increased development of medical technology (MT), new challenges emerge related to education and training of pharmacists and other healthcare specialists. Currently, only a few universities in the EU promote MT education ...
Chitosan in Mucoadhesive Drug Delivery: Focus on Local Vaginal Therapy 
Andersen, Toril; Bleher, Stefan; Flaten, Gøril Eide; Tho, Ingunn; Mattsson, Sofia; Skalko-Basnet, Natasa (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Mucoadhesive drug therapy destined for localized drug treatment is gaining increasing importance in today’s drug development. Chitosan, due to its known biodegradability, bioadhesiveness and excellent safety profile offers ...
Identification and characterization of small molecular NPR-B receptor antagonists 
Andresen, Henriette; Moltzau, Lise R; Fagerheim, Steffen; Gloriam, David; Bach, Trond; Levy, Finn O (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
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