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Underestimated impact of novel psychoactive substances: laboratory confirmation of recreational drug toxicity in Oslo, Norway 
Vallersnes, Odd Martin; Persett, Per Sverre; Øiestad, Elisabeth Leere; Karinen, Ritva Anneli; Heyerdahl, Fridtjof; Hovda, Knut Erik (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
Context: Recreational drug toxicity is frequent. Availability of new psychoactive substances is steadily increasing. However, data with verified analyses from clinical settings are limited. To evaluate the impact of novel ...
Multiple treatment comparison of seven new drugs for patients with advanced malignant melanoma: a systematic review and health economic decision model in a Norwegian setting 
Pike, Eva; Hamidi, Vida; Sæterdal, Ingvil Von Mehren; Odgaard-Jensen, Jan; Klemp, Marianne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Objective: To assess the relative effectiveness and cost-effectiveness of seven new drugs (cobimetinib, dabrafenib, ipilimumab, nivolumab, pembrolizumab, trametinib and vemurafenib) used for treatment of patients with ...
Does progestin-only contraceptive use after pregnancy affect recovery from pelvic girdle pain? A prospective population study 
Bjelland, Elisabeth Krefting; Owe, Katrine Mari; Nordeng, Hedvig Marie Egeland; Engdahl, Bo Lars; Kristiansson, Per; Vangen, Siri; Eberhard-Gran, Malin (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Objective: To estimate associations of progestin-only contraceptives with persistent pelvic girdle pain 18 months after delivery. Methods Prospective population based cohort study during the years 2003–2011. We included ...
Fluoride loaded polymeric nanoparticles for dental delivery 
Nguyen, Sanko; Escudero, Carlos; Sediqi, Nadia; Smistad, Gro; Hiorth, Marianne (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
The overall aim of the present paper was to develop fluoride loaded nanoparticles based on the biopolymers chitosan, pectin, and alginate, for use in dental delivery. First, the preparation of nanoparticles in the presence ...
Formulation of polysaccharide-based nanoparticles for local administration into the oral cavity 
Pistone, Sara; Goycoolea, Francisco M.; Young, Alix; Smistad, Gro; Hiorth, Marianne (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
The efficacy of treatments for oral ailments is often challenged by a low residence time of the conventional pharmaceutical formulations in the oral cavity. The residence time in the oral cavity could be improved by using ...
Polysaccharide-coated liposomal formulations for dental targeting 
Pistone, Sara; Rykke, Morten; Smistad, Gro; Hiorth, Marianne (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
The efficacy of treatments of oral ailments is often challenged by a low residence time of the conventional pharmaceutical formulations in the oral cavity, which could be improved by using bioadhesive formulations. This ...
The novel lipid mediator PD1n-3 DPA: An overview of the structural elucidation, synthesis, biosynthesis and bioactions 
Hansen, Trond Vidar; Dalli, Jesmond; Serhan, Charles N. (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
Resolvins, protectins and maresins are individual families of specialized pro-resolving mediators biosynthesized from the dietary n-3 polyunsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid. These ...
High-throughput liquid-liquid extraction in 96-well format: Parallel artificial liquid membrane extraction 
Gjelstad, Astrid; Andresen, Alf Terje; Dahlgren, Anders; Gundersen, Thomas Erik; Pedersen-Bjergaard, Stig (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Parallel artificial liquid membrane extraction (PALME) is a miniaturized version of liquid–liquid extraction (LLE) and is based on two 96-well plates in a sandwich-like configuration. With a very simple workflow, 96 samples ...
Automated Protein Biomarker Analysis: on-line extraction of clinical samples by Molecularly Imprinted Polymers 
Rossetti, Cecilia; Świtnicka-Plak, Magdalena A.; Halvorsen, Trine Grønhaug; Cormack, Peter A.G.; Sellergren, Börje; Reubsaet, Léon (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Robust biomarker quantification is essential for the accurate diagnosis of diseases and is of great value in cancer management. In this paper, an innovative diagnostic platform is presented which provides automated molecularly ...
Characterization and Vaccine Potential of Membrane Vesicles Produced by Francisella noatunensis subsp. orientalis in an Adult Zebrafish Model. 
Lagos, Leidy; Tandberg, Julia Isabel; Repnik, Urska; Boysen, Preben; Ropstad, Erik; Varkey, Deepa Ruth; Paulsen, Ian T.; Winther-Larsen, Hanne Cecilie (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Vaccine development against extracellular bacteria has been important for the sustainability of the aquaculture industry. In contrast, infections with intracellular pathogens remain largely an unresolved problem. Francisella ...
Legumain regulates differentiation fate of human bone marrow stromal cells and is altered in postmenopausal osteoporosis 
Jafari, Abbas; Qanie, Diyako; Andersen, Thomas L.; Zhang, Yuxi; Chen, Li; Postert, Benno; Parsons, Stuart; Ditzel, Nicholas; Khosla, Sundeep; Johansen, Harald Thidemann; Kjærsgaard-Andersen, Per; Delaissé, Jean-Marie; Abdallah, Basem M.; Hesselson, Daniel; Solberg, Rigmor; Kassem, Moustapha (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Secreted factors are a key component of stem cell niche and their dysregulation compromises stem cell function. Legumain is a secreted cysteine protease involved in diverse biological processes. Here, we demonstrate that ...
High Tacrolimus Clearance Is a Risk Factor for Acute Rejection in the Early Phase After Renal Transplantation 
Egeland, Erlend Johannessen; Robertsen, Ida; Hermann, Monica; Midtvedt, Karsten; Størset, Elisabet; Gustavsen, Marte Theie; Reisæter, Anna Varberg; Klaasen, Rolf; Bergan, Stein; Holdaas, Hallvard; Hartmann, Anders; Åsberg, Anders (Journal article / Tidsskriftartikkel / SubmittedVersion, 2017)
Background: Patients with high tacrolimus clearance eliminate more drug within a dose interval compared to those with low clearance. Delays in dosing time will result in transient periods of lower concentrations in high- ...
Isolation and Characterization of Serum Extracellular Vesicles (EVs) from Atlantic Salmon Infected with Piscirickettsia Salmonis 
Lagos, Leidy; Tandberg, Julia Isabel; Kashulin, Alexander; Colquhoun, Duncan John; Sørum, Henning; Winther-Larsen, Hanne Cecilie (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Secretion of extracellular vesicles (EVs) is a common feature of both eukaryotic and prokaryotic cells. Isolated EVs have been shown to contain different types of molecules, including proteins and nucleic acids, and are ...
Electromembrane extraction – Recent trends and where to go 
Pedersen-Bjergaard, Stig; Huang, Chuixiu; Gjelstad, Astrid (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Electromembrane extraction (EME) is an analytical microextraction technique, where charged analytes (such as drug substances) are extracted from an aqueous sample (such as a biological fluid), through a supported liquid ...
A rapid and sustained improvement of calcification propensity score (serum T50) after successful kidney transplantation: Reanalysis of a randomized controlled trial of ibandronate 
Smerud, Knut Terje; Åsberg, Anders; Kile, Håkon; Pasch, Andreas; Dahle, Dag Olav; Bollerslev, Jens; Godang, Kristin; Hartmann, Anders (Journal article / Tidsskriftartikkel / SubmittedVersion, 2017)
A serum test called T50 assesses the overall propensity for calcification of the blood and is associated with cardiovascular outcomes. We aimed to examine T50 over time in kidney transplant recipients and also address any ...
Physical stability of moisture-sensitive tablets stored in a canister or as unit-dose 
Bjerknes, Kathrin; Helmizadeh, Zahra; Brustugun, Jørgen; Smistad, Gro (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
Background: Knowledge about the long-term stability of tablets outside the original container, e.g. as unit-doses, is limited. This leaves the pharmacist with the dilemma of seeking improved patient safety by use of ...
Estimating Glomerular Filtration Rate in Kidney Transplant Recipients: Comparing a Novel Equation With Commonly Used Equations in this Population 
Salvador, Cathrin Lytomt; Hartmann, Anders; Åsberg, Anders; Bergan, Stein; Rowe, Alexander D.; Mørkrid, Lars (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background: Assessment of glomerular filtration rate (GFR) is important in kidney transplantation. The aim was to develop a kidney transplant specific equation for estimating GFR and evaluate against published equations ...
The impact of nondifferential exposure misclassification on the performance of propensity scores for continuous and binary outcomes: a simulation study 
Wood, Mollie; Chrysanthopoulou, Stavroula; Nordeng, Hedvig Marie Egeland; Lapane, Kate L. (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
Purpose: To investigate the ability of the propensity score (PS) to reduce confounding bias in the presence of nondifferential misclassification of treatment, using simulations. Methods: Using an example from the pregnancy ...
Structural characterization of bioactive heteropolysaccharides from the medicinal fungus Inonotus obliquus (Chaga). 
Wold, Christian Winther; Kjeldsen, Christian; Corthay, Alexandre; Rise, Frode; Christiansen, Bjørn E.; Duus, Jens Øllgaard; Inngjerdingen, Kari Tvete (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
The aim of this paper was to perform a comprehensive characterization of polysaccharides isolated from the interior (IOI) and exterior (IOE) parts of the fungus Inonotus obliquus. Pre-extraction with DCM and MeOH, followed ...
Francisella noatunensis subspecies noatunensis clpB deletion mutant impairs development of francisellosis in a zebrafish model 
Lampe, Elisabeth Opsjøn; Zingmark, Carl; Tandberg, Julia Isabel; Thrane, Ida Marie; Brudal, Espen; Sjöstedt, Anders; Winther-Larsen, Hanne Cecilie (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Keywords: Atlantic cod, Francisella noatunensis, Francisellosis, ClpB, Immunization, Zebrafish
Immunomodulatory properties of Concholepas concholepas hemocyanin against francisellosis in a zebrafish model 
Lagos, Leidy; Tandberg, Julia Isabel; Becker, María Inés; Winther-Larsen, Hanne Cecilie (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
The development of vaccines for aquaculture has been an important milestone in providing a continuous and sustainable production. Most of the vaccines currently on the market for aquaculture include oil as adjuvant. ...
Risk factors for exertional rhabdomyolysis with renal stress 
Apeland, Terje; Danielsen, Tore; Staal, Eva Marianne; Åsberg, Anders; Thorsen, Inga Strand; Dalsrud, Tom Ole; Ørn, Stein (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background: Exercise-induced rhabdomyolysis denotes the exertional damage of myocytes with leakage of sarcoplasmic content into the circulation. The purpose of this study was to determine important risk factors for the ...
Inflammation in early kidney allograft surveillance biopsies and its relationship with de novo donor specific antibodies 
Garcia-Carro, Clara; Dörje, Christina; Åsberg, Anders; Midtvedt, Karsten; Reinholdt, Finn; Strøm, Erik Heyerdahl; Holdaas, Hallvard (Journal article / Tidsskriftartikkel / SubmittedVersion, 2017)
Interstitial fibrosis and tubular atrophy (IFTA) associated with interstitial inflammation in non scarred areas (IFTA+i) is associated with poorer graft outcome than inflammation without IFTA or IFTA without inflammation. ...
Sick leave and medication use in pregnancy: A European web-based study 
Truong, Bich Thuy Ha; Lupattelli, Angela; Kristensen, Petter; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background and objective: A comparison of sick leave in pregnancy between countries is difficult as most studies have been conducted in single countries in Scandinavia. The objective of this study was to explore patterns ...
Haptoglobin 2-2 Genotype, Patient, and Graft Survival in Renal Transplant Recipients 
Dupont, Laust; Eide, Ivar Anders; Hartmann, Anders; Christensen, Jeppe Hagstrup; Åsberg, Anders; Jenssen, Trond Geir; Krarup, Henrik; Svensson, My Hanna Sofia (Journal article / Tidsskriftartikkel / SubmittedVersion, 2017)
Background: Cardiovascular disease is the leading cause of death in renal transplant recipients. An association between haptoglobin genotype 2-2 and cardiovascular disease has been found in patients with diabetes mellitus ...
Exposure to mycophenolate and fatherhood 
Midtvedt, Karsten; Bergan, Stein; Reisæter, Anna Varberg; Vikse, Bjørn Egil; Åsberg, Anders (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background: Mycophenolic acid (MPA) is the active immunosuppressive substance in both mycophenolate mofetil and mycophenolate sodium, and it is widely used after organ transplantation. In women, taking MPA is teratogenic ...
Novel decay dynamics revealed for virus-mediated drug activation in cytomegalovirus infection 
Rose, J; Emery, Vincent C; Kumar, Deepali; Åsberg, Anders; Hartmann, Anders; Jardine, Alan G.; Bignamini, Angelo A; Humar, Atul; Neumann, Avidan U (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Human cytomegalovirus (CMV) infection is a substantial cause of morbidity and mortality in immunocompromised hosts and globally is one of the most important congenital infections. The nucleoside analogue ganciclovir (GCV), ...
Making fair comparisons in pregnancy medication safety studies: An overview of advanced methods for confounding control 
Wood, Mollie; Lapane, Kate L; van Gelder, Marleen MHJ; Rai, Dheeraj; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
Understanding the safety of medication use during pregnancy relies on observational studies: However, confounding in observational studies poses a threat to the validity of estimates obtained from observational data. Newer ...
Use of medicines, adherence and attitudes to medicines among persons with chronic spinal cord injury 
Høgholen, Anna Helene; Storhaug, Anette; Kvernrød, Kristin; Kostovski, Emil; Viktil, Kirsten Kilvik; Mathiesen, Liv (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
Objectives: To describe the use of medicines and adherence among persons with spinal cord injury (SCI). Further, to examine the influence of pain, spasms and beliefs about medicines on adherence. Methods: Persons (18 ...
Exercise in vivo marks human myotubes in vitro: Training-induced increase in lipid metabolism 
Lund, Jenny; Rustan, Arild; Løvsletten, Nils Gunnar; Mudry, Jonathan M.; Langleite, Torgrim Mikal; Feng, Yuan Zeng; Stensrud, Camilla; Brubak, Mari G; Drevon, Christian A; Birkeland, Kåre I.; Kolnes, Kristoffer Jensen; Johansen, Egil Ivar; Tangen, Daniel S.; Stadheim, Hans Kristian; Gulseth, Hanne Løvdal; Krook, Anna; Kase, Eili Tranheim; Jensen, Jørgen; Thoresen, G. Hege (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background and aims Physical activity has preventive as well as therapeutic benefits for overweight subjects. In this study we aimed to examine effects of in vivo exercise on in vitro metabolic adaptations by studying ...
Maternal alcohol use during pregnancy and offspring attention-deficit hyperactivity disorder (ADHD): a prospective sibling control study 
Eilertsen, Espen Moen; Gjerde, Line C.; Reichborn-Kjennerud, Ted; Ørstavik, Ragnhild; Knudsen, Gun Peggy; Stoltenberg, Camilla; Czajkowski, Nikolai Olavi; Røysamb, Espen; Kendler, Kenneth S; Ystrøm, Eivind (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
Background Maternal alcohol use during pregnancy has repeatedly been associated with development of attention-deficit hyperactivity disorder (ADHD) in the offspring. It is, however not known whether this reflects a ...
The CYP3A biomarker 4β-hydroxycholesterol does not improve tacrolimus dose predictions early after kidney transplantation 
Størset, Elisabet; Hole, Kristine; Midtvedt, Karsten; Bergan, Stein; Molden, Espen; Åsberg, Anders (Journal article / Tidsskriftartikkel / SubmittedVersion, 2017)
Aims: Tacrolimus is a cornerstone in modern immunosuppressive therapy after kidney transplantation. Tacrolimus dosing is challenged by considerable pharmacokinetic variability, both between patients and over time after ...
Tacrolimus and mycophenolate regimen and subclinical tubulo-interstitial inflammation in low immunological risk renal transplants 
Torres, Irina B; Reisæter, Anna Varberg; Moreso, Francesc; Åsberg, Anders; Vidal, Marta; Garcia-Carro, Clara; Midtvedt, Karsten; Reinholt, Finn P.; Scott, Helge; Castellà, Eva; Salcedo, Maite; Dörje, Christina; Sellarés, Joana; Azancot, Maria A; Perello, Manel; Holdaas, Hallvard; Serón, Daniel (Journal article / Tidsskriftartikkel / SubmittedVersion, 2017)
The aim was to evaluate the relationship between maintenance immunosuppression, subclinical tubulo-interstital inflammation and interstitial fibrosis/tubular atrophy (IF/TA) in surveillance biopsies performed in low ...
Interleukin 27 is increased in carotid atherosclerosis and promotes NLRP3 inflammasome activation. 
Gregersen, Ida; Sandanger, Øystein; Askevold, Erik Tandberg; Sagen, Ellen Lund; Yang, Kuan; Holm, Sverre; Pedersen, Turid Margrethe; Skjelland, Mona; Krohg-Sørensen, Kirsten; Hansen, Trond Vidar; Dahl, Tuva Børresdatter; Otterdal, Kari; Espevik, Terje; Aukrust, Pål; Yndestad, Arne; Halvorsen, Bente (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Aim: Interleukin-27 (IL-27) is involved in different inflammatory diseases; however, its role in atherosclerosis is unclear. In this study we investigated the expression of IL-27 and its receptor in patients with carotid ...
The putative drug efflux systems of the Bacillus cereus group 
Hassan, Karl A.; Fagerlund, Annette; Elbourne, Liam D.H.; Vörös, Aniko; Kroeger, Jasmin Kaori; Simm, Roger; Tourasse, Nicolas Jacques; Finke, Sarah; Henderson, Peter J.F.; Økstad, Ole Andreas Løchen; Paulsen, Ian T.; Kolstø, Anne-Brit (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
The Bacillus cereus group of bacteria includes seven closely related species, three of which, B. anthracis, B. cereus and B. thuringiensis, are pathogens of humans, animals and/or insects. Preliminary investigations into ...
Changes in drug disposition of lithium during pregnancy: A retrospective observational study of patient data from two routine therapeutic drug monitoring services in Norway 
Westin, Andreas; Brekke, Malin; Molden, Espen; Skogvoll, Eirik; Aadal, Marianne; Spigset, Olav (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Objectives: Pregnancy may cause changes in drug disposition, dose requirements and clinical response. For lithium, changes in disposition during pregnancy have so far been explored in a single-dose study on 4 participants ...
Elderly users of fall-risk-increasing drug perceptions of fall risk and the relation to their drug use?a qualitative study 
Bell, Hege Therese; Steinsbekk, Aslak; Granås, Anne Gerd (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Objective: The aim of the study was to explore how home-dwelling elderly who use fall-risk-increasing drugs (FRIDs) perceive their fall risk and how they relate this to their drug use. Design, setting and subjects: A ...
Recent Development of Non-Peptide GnRH Antagonists 
Tukun, Feng-Ling; Olberg, Dag Erlend; Riss, Patrick; Haraldsen, Ira Hebold; Kåss, Anita Anjali Suri; Klaveness, Jo (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
The decapeptide gonadotropin-releasing hormone, also referred to as luteinizing hormone-releasing hormone with the sequence (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) plays an important role in regulating the reproductive ...
Predictability of Marine Population Trajectories–the effect of delays and resource availability 
Frank, Anna-Simone Josefine (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
This paper studies the dynamics and stability of a stage-structured (immature/mature) population. The emphasis is on how resource available to the immature stage indirectly regulates the dynamics of the mature stage, where ...
Metabolic and performance effects of Yerba Mate on well-trained cyclists 
Areta, José; Austarheim, Ingvild; Wangensteen, Helle; Capelli, Carlo (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
Introduction: Yerba Mate (YM) is a South American plant, rich in polyphenols, saponins, and xanthines, of growing scientific interest because of its metabolic effects. YM has been shown to increase fat utilization during ...
Hypnotics use in children 0–18 months: moderate agreement between mother-reported survey data and prescription registry data 
Holdø, Ingvild; Bramness, Jørgen G; Handal, Marte; Torgersen, Leila; Reichborn-Kjennerud, Ted; Ystrøm, Eivind; Nordeng, Hedvig; Skurtveit, Svetlana (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Background Different methods in pharmacoepidemiology can be used to study hypnotic use in children. But neither questionnaire-based data nor prescription records can be considered a “gold standard”. This ...
Administrative Claims Data Versus Augmented Pregnancy Data for the Study of Pharmaceutical Treatments in Pregnancy 
Wood, Mollie; Nordeng, Hedvig Marie Egeland; Andrade, Susan; Toh, Sengwee; Berard, Anick; van Gelder, Marlene (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Purpose of Review: Administrative claims databases, which collect reimbursement-related information generated from healthcare encounters, are increasingly used to evaluate medication safety in pregnancy. We reviewed the ...
Regioselective monoalkylation of 17β-estradiol for the synthesis of cytotoxic estrogens 
Van Gansbeke, Koen; Solum, Eirik Johansson; Liekens, Sandra; Vik, Anders; Hansen, Trond Vidar (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
The regioselective synthesis of estrogens and their derivatives continues to be of interest. Most reported syntheses require multistep protocols associated with poor overall yield and lack of regioselectivity. New preparative ...
Recent advances in the chemistry and biology of anti-inflammatory and specialized pro-resolving mediators biosynthesized from n-3 docosapentaenoic acid 
Vik, Anders; Dalli, Jesmond; Hansen, Trond Vidar (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
Several novel oxygenated polyunsaturated lipid mediators biosynthesized from n-3 docosapentaenoic acid were recently isolated from murine inflammatory exudates and human primary cells. These compounds belong to a distinct ...
Stereocontrolled synthesis and investigation of the biosynthetic transformations of 16(S),17(S)-epoxy-PDn-3 DPA 
Primdahl, Karoline Gangestad; Tungen, Jørn Eivind; De Souza, Patricia R; Colas, Romain A.; Dalli, Jesmond; Hansen, Trond Vidar; Vik, Anders (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
PD1n-3 DPA is a specialized pro-resolving lipid mediator that displays potent anti-inflammatory properties and pro-resolving bioactivities. Such naturally occurring compounds are of current interest in biomolecular chemistry ...
Liposomes coated with hydrophobically modified hydroxyethyl cellulose: Influence of hydrophobic chain length and degree of modification 
Smistad, Gro; Nyström, Bo; Zhu, Kaizheng; Grønvold, Marthe Karoline; Røv-Johnsen, Anne; Hiorth, Marianne (Journal article / Tidsskriftartikkel / SubmittedVersion, 2017)
Nanoparticulate systems with an uncharged hydrophilic surface may have a great potential in mucosal drug delivery. In the present study liposomes were coated with hydrophobically modified hydroxyethyl cellulose (HM-HEC) ...
Uncovering human METTL12 as a mitochondrial methyltransferase that modulates citrate synthase activity through metabolite-sensitive lysine methylation 
Malecki, Jedrzej Mieczyslaw; Jakobsson, Magnus; Ho, Angela Yeuan Yen; Moen, Anders; Rustan, Arild; Falnes, Pål (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Lysine methylation is an important and much-studied posttranslational modification of nuclear and cytosolic proteins but is present also in mitochondria. However, the responsible mitochondrial lysine-specific methyltransferases ...
Treatment with antipsychotics in pregnancy: changes in drug disposition 
Westin, Andreas; Brekke, Malin; Molden, Espen; Skogvoll, Eirik; Castberg, Ingrid Mehli; Spigset, Olav (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Although pregnancy is known to cause changes in drug pharmacokinetics, little is known about its impact on serum levels of antipsychotics. In this study we retrospectively assessed 201 routine serum antipsychotic therapeutic ...
Polysaccharides from the South African medicinal plant Artemisia afra: Structure and activity studies 
Bräunlich, Paula Marie; Inngjerdingen, Kari Tvete; Inngjerdingen, Marit; Johnson, Quinton; Paulsen, Berit Smestad; Mabusela, Wilfred (Journal article / Tidsskriftartikkel / SubmittedVersion, 2017)
Artemisia afra (Jacq. Ex. Willd), is an indigenous plant in South Africa and other parts of the African continent, where it is used as traditional medicine mostly for respiratory conditions. The objective of this study was ...
Safety classification of herbal medicines used in pregnancy in a multinational study 
Kennedy, D. A; Lupattelli, A.; Koren, G.; Nordeng, H. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Background The use of herbal medicines for health prevention and ailments is an increasing trend worldwide. Women in pregnancy are no exception; the reported prevalence of herbal medicine use in pregnancy ...
Development and evaluation of a test program for Y-site compatibility testing of total parenteral nutrition and intravenous drugs 
Staven, Vigdis; Wang, Siri; Grønlie, Ingrid; Tho, Ingunn (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Background There is no standardized procedure or consensus to which tests should be performed to judge compatibility/incompatibility of intravenous drugs. The purpose of this study was to establish and ...
Erratum to: Natural products from Zanthoxylum heitzii with potent activity against the malaria parasite 
Goodman, Christopher D; Austarheim, Ingvild; Mollard, Vanessa; Mikolo, Bertin; Malterud, Karl E; McFadden, Geoffrey I; Wangensteen, Helle (Journal article / Tidsskriftartikkel / PublishedVersion, 2016)
Isolation and mass spectrometry analysis of urinary extraexosomal proteins 
Hildonen, Siri; Skarpen, Ellen; Halvorsen, Trine Grønhaug; Reubsaet, Leon (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
The aim of the present study was to develop a LC-MS/MS-based proteomic analysis method of urinary exosomal proteins that has the potential to discover disease biomarkers. In short, urinary exosomes from healthy subjects ...
India’s scientific publication in predatory journals: need for regulating quality of Indian science and education 
Gopalakrishnan Saroja, Seethapathy; Santhosh Kumar, J. U.; Hareesha, A. S. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Nature Index analysis 2014 rates India at the 13th place for its high-quality scientific publications. Despite this achievement, several studies have revealed that India is also among the major contrib-utors of articles ...
Association of Prenatal Ibuprofen Exposure with Birth Weight and Gestational Age: A Population-Based Sibling Study 
Nezvalova-Henriksen, Katerina; Wood, Mollie; Spigset, Olav; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Objectives Three studies so far have investigated the effect of prenatal non-steroidal anti-inflammatory drug (NSAID) exposure on birth weight and gestational age. The aim in this study was to evaluate the association of ...
Multivalent pIX phage display selects for distinct and improved antibody properties 
Høydahl, Lene Støkken; Nilssen, Nicolay Rustad; Gunnarsen, Kristin Støen; du Pré, Marie Fleur; Iversen, Rasmus; Roos, Norbert; Chen, Xi; Michaelsen, Terje Einar; Sollid, Ludvig Magne; Sandlie, Inger; Løset, Geir Åge (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Phage display screening readily allows for the identification of a multitude of antibody specificities, but to identify optimal lead candidates remains a challenge. Here, we direct the antibody-capsid fusion away from the ...
Proteomics tools reveal startlingly high amounts of oxytocin in plasma and serum 
Brandtzaeg, Ole Kristian; Johnsen, Elin Follaug; Røberg-Larsen, Hanne; Seip, Knut Fredrik; MacLean, Evan L.; Gesquiere, Laurence R.; Leknes, Siri; Lundanes, Elsa; Wilson, Steven Ray Haakon (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
The neuropeptide oxytocin (OT) is associated with a plethora of social behaviors, and is a key topic at the intersection of psychology and biology. However, tools for measuring OT are still not fully developed. We describe ...
Natural products from Zanthoxylum heitzii with potent activity against the malaria parasite 
Goodman, Christopher D; Austarheim, Ingvild; Mollard, Vanessa; Mikolo, Bertin; Malterud, Karl E; McFadden, Geoffrey I; Wangensteen, Helle (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Background Zanthoxylum heitzii (Rutaceae) (olon) is used in traditional medicine in Central and West Africa to treat malaria. To identify novel compounds with anti-parasitic ...
Mood, anxiety, and alcohol use disorders and later cause-specific sick leave in young adult employees 
Torvik, Fartein Ask; Reichborn-Kjennerud, Ted; Gjerde, Line C.; Knudsen, Gun Peggy; Ystrøm, Eivind; Tambs, Kristian; Røysamb, Espen; Østby, Kristian Amundsen; Ørstavik, Ragnhild (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Background Mental disorders strongly influence work capability in young adults, but it is not clear which disorders that are most strongly associated with sick leave, and which diagnoses that are stated on the sick leave ...
Longitudinal changes in neurodevelopmental outcomes between 18 and 36 months in children with prenatal triptan exposure: findings from the Norwegian Mother and Child Cohort Study 
Wood, Mollie; Frazier, Jean A; Nordeng, Hedvig Marie Egeland; Lapane, Kate L (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Objective This study sought to determine whether changes in neurodevelopmental outcomes between 18 and 36 months of age were associated with prenatal exposure to triptan medications, a class of 5-HT receptor agonists used ...
Survival-associated heterogeneity of marker-defined perivascular cells in colorectal cancer 
Mezheyeuski, Artur; Lindh, Maja Bradic; Guren, Tormod Kyrre; Dragomir, Anca; Pfeiffer, Per; Kure, Elin H.; Ikdahl, Tone; Skovlund, Eva; Corvigno, Sara; Strell, Carina; Pietras, Kristian; Pontén, Fredrik; Mulder, Jan; Qvortrup, Camilla; Portyanko, Anna; Tveit, Magne Kjell; Glimelius, Bengt; Sorbye, Halfdan; Ostman, Arne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Perivascular cells (PC) were recently implied as regulators of metastasis and immune cell activity. Perivascular heterogeneity in clinical samples, and associations with other tumor features and outcome, remain largely ...
Social inequalities in reception of social welfare support: A population based twin study 
Ystrøm, Eivind; Ørstavik, Ragnhild; Reichborn-Kjennerud, Ted; Torvik, Fartein Ask (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Social welfare support runs in families. Recent studies using Nordic registry data have found individual differences in genetic factors to be of substantial importance for medical benefits. However, to date there has been ...
Bradykinin-Induced Shock Increase Exhaled Nitric Oxide, Complement Activation and Cytokine Production in Pigs 
Seip, Knut Fredrik; Evjenth, Bjørg; Hovland, Anders; Dybwik, Knut Gustav; Johansen, Harald Thidemann; Fure, Hilde; Mollnes, Tom Eirik; Nielsen, Erik Waage (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Bradykinin is an important mediator in blood pressure regulation, ischemic precondition and capillary leakage, allergy, anaphylaxis, inflammation, and nociception, at least partly via the generation of nitric oxide (NO). ...
Synthesis of 13(R)‐Hydroxy‐7Z,10Z,13R,14E,16Z,19Z Docosapentaenoic Acid (13R‐HDPA) and Its Biosynthetic Conversion to the 13-Series Resolvins 
Primdahl, Karoline Gangestad; Aursnes, Marius; Walker, Mary E.; Colas, Romain A.; Serhan, Charles N.; Dalli, Jesmond; Hansen, Trond Vidar; Vik, Anders (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Specialized pro-resolving lipid mediators are biosynthesized during the resolution phase of acute inflammation from n-3 polyunsaturated fatty acids. Recently, the isolation and identification of the four novel mediators ...
Intra-individual changes in DNA methylation not mediated by cell-type composition are correlated with aging during childhood 
Gervin, Kristina; Andreassen, Bettina K; Hjorthaug, Hanne S; Carlsen, Karin C L; Carlsen, Kai-Håkon; Undlien, Dag E; Lyle, Robert; Munthe-Kaas, Monica C (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Background Several studies have reported age-associated changes in DNA methylation in the first few years of life and in adult populations, but the extent of such changes during childhood is less well ...
Plasma levels of marine n-3 fatty acids and cardiovascular risk markers in renal transplant recipients 
Eide, Ivar A.; Dahle, Dag O.; Svensson, My; Hartmann, Anders; Åsberg, Anders; Bjerve, Kristian S.; Christensen, Jeppe H.; Schmidt, Erik B.; Lauritsen, ME; Lund, K; Jenssen, Trond (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2016)
Background/Objectives: Cardiovascular (CV) disease is the leading cause of death after renal transplantation. Marine n-3 polyunsaturated fatty acids (PUFAs) exert potential cardio-protective metabolic effects and might ...
Water sorption properties of HM-pectin and liposomes intended to alleviate dry mouth 
Adamczak, Malgorzata Iwona; Martinsen, Ørjan Grøttem; Smistad, Gro; Hiorth, Marianne (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2016)
Pharmaceutical formulations intended for treatment of xerostomia (dry mouth) should be able to keep the oral mucosa hydrated for a prolonged period of time. The products already existing on the market contain water-soluble ...
An in vitro study of mucoadhesion and biocompatibility of polymer coated liposomes on HT29-MTX mucus-producing cells 
Adamczak, Malgorzata Iwona; Hagesæther, Ellen; Smistad, Gro; Hiorth, Marianne (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2016)
Drug delivery to the oral cavity poses a significant challenge due to the short residence time of the formulations at the site of action. From this point of view, nanoparticulate drug delivery systems with ability to adhere ...
Comparative Analysis of Membrane Vesicles from Three Piscirickettsia salmonis Isolates Reveals Differences in Vesicle Characteristics. 
Tandberg, Julia Isabel; Lagos Rojas, Leidy Ximena; Langlete, Petter; Berger, Eva Kathrin; Rishovd, Anne-Lise; Roos, Norbert; Varkey, Deepa Ruth; Paulsen, Ian T.; Winther-Larsen, Hanne Cecilie (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Membrane vesicles (MVs) are spherical particles naturally released from the membrane of Gram-negative bacteria. Bacterial MV production is associated with a range of phenotypes including biofilm formation, horizontal gene ...
Determination of very low-abundance diagnostic proteins in serum using immuno-capture LC-MS-MS 
Reubsaet, Leon; Halvorsen, Trine Grønhaug (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
The use of antibodies in “bottom-up “LC-MS workflows to determine low abundant biological active proteins in complex human samples has increased in recent years: immuno-capture analysis combines the workflow of conventional ...
Treatment with tacrolimus and sirolimus reveals no additional adverse effects on human islets in vitro compared to each drug alone but they are reduced by adding glucocorticoids 
Kloster-Jensen, Kristine; Sahraoui, Afaf; Vethe, Nils Tore; Korsgren, Olle; Bergan, Stein; Foss, Aksel; Scholz, Hanne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Tacrolimus and sirolimus are important immunosuppressive drugs used in human islet transplantation; however, they are linked to detrimental effects on islets and reduction of long-term graft function. Few studies investigate ...
Visceral fat is strongly associated with post-transplant diabetes mellitus and glucose metabolism 1 year after kidney transplantation 
Von Düring, Marit Elizabeth; Jenssen, Trond Geir; Bollerslev, Jens; Åsberg, Anders; Godang, Kristin; Hartmann, Anders (Journal article / Tidsskriftartikkel / SubmittedVersion, 2016)
Body composition after kidney transplantation is linked to glucose metabolism, and impaired glucose metabolism is associated with increased risk of cardiovascular events and death. One year after transplantation, we examined ...
Perception of the Professional Knowledge of and Education on the Medical Technology Products among the Pharmacists in the Baltic and Nordic Countries—A Cross-Sectional Exploratory Study 
Volmer, Daisy; Sokirskaja, Aleksandra; Laaksonen, Raisa; Vainio, Kirsti; Sandler, Niklas; Halvorsen, Kjell H.; Kjome, Reidun Lisbet Skeide; Gizurarson, Sveinbjørn; Muceniece, Ruta; Maurina, Baiba; Dauksiene, Jurgita; Ruuben, Lilian; Björnsdottir, Ingunn; Ratassepp, Tagne; Heinämäki, Jyrki (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
With increased development of medical technology (MT), new challenges emerge related to education and training of pharmacists and other healthcare specialists. Currently, only a few universities in the EU promote MT education ...
Chitosan in Mucoadhesive Drug Delivery: Focus on Local Vaginal Therapy 
Andersen, Toril; Bleher, Stefan; Flaten, Gøril Eide; Tho, Ingunn; Mattsson, Sofia; Skalko-Basnet, Natasa (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Mucoadhesive drug therapy destined for localized drug treatment is gaining increasing importance in today’s drug development. Chitosan, due to its known biodegradability, bioadhesiveness and excellent safety profile offers ...
Identification and characterization of small molecular NPR-B receptor antagonists 
Andresen, Henriette; Moltzau, Lise R; Fagerheim, Steffen; Gloriam, David; Bach, Trond; Levy, Finn O (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Women's perception of risks of adverse fetal pregnancy outcomes: a large-scale multinational survey 
Petersen, Irene; Mccrea, Rachel; Lupattelli, Angela; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Objective To determine pregnant women and new mothers’ perception of risks in pregnancy. Design, settings and participants This was a large-scale multinational survey including 9113 pregnant women and new mothers from 18 ...
Medication Use before, during, and after Pregnancy among Women with Eating Disorders: A Study from the Norwegian Mother and Child Cohort Study 
Lupattelli, Angela; Spigset, Olav; Torgersen, Leila; Zerwas, Stephanie; Hatle, Marianne; Reichborn-Kjennerud, Ted; Bulik, Cynthia M.; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Introduction Little is known about medication use among women with eating disorders in relation to pregnancy. Aims To explore patterns of and associations between use of psychotropic, gastrointestinal and analgesic ...
Effects of low-dose clonidine on cardiovascular and autonomic variables in adolescents with chronic fatigue: a randomized controlled trial 
Fagermoen, Even; Sulheim, Dag; Winger, Anette; Andersen, Anders M; Gjerstad, Johannes; Godang, Kristin; Rowe, Peter C; Saul, J. P; Skovlund, Eva; Wyller, Vegard B (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Background Chronic Fatigue Syndrome (CFS) is a common and disabling condition in adolescence with few treatment options. A central feature of CFS is orthostatic intolerance and abnormal autonomic cardiovascular ...
Rheological characterization of an injectable alginate gel system 
Larsen, Benjamin E; Bjørnstad, Jorunn; Pettersen, Erik O; Tønnesen, Hanne H; Melvik, Jan E (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Background This work investigates a general method for producing alginate gel matrices using an internal mode of gelation that depends solely on soluble alginate and alginate/gelling ion particles. The ...
Myotubes from Severely Obese Type 2 Diabetic Subjects Accumulate Less Lipids and Show Higher Lipolytic Rate than Myotubes from Severely Obese Non-Diabetic Subjects 
Bakke, Siril Skaret; Feng, Yuan Zeng; Nikolic, Natasa; Kase, Eili Tranheim; Moro, Cedric; Stensrud, Camilla; Damlien, Lisbeth; Ludahl, Marianne Odnakk; Sandbu, Rune; Solheim, Brita Marie; Rustan, Arild; Hjelmesæth, Jøran; Thoresen, G. Hege; Aas, Vigdis (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
About 80% of patients with type 2 diabetes are classified as overweight. However, only about 1/3 of severely obese subjects have type 2 diabetes. This indicates that several severely obese individuals may possess certain ...
Treatment of nausea in pregnancy: a cross-sectional multinational web-based study of pregnant women and new mothers 
Heitmann, Kristine; Holst, Lone; Lupattelli, Angela; Maltepe, Caroline; Nordeng, Hedvig (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Background The factors related to the treatment of nausea during pregnancy have not yet been investigated in several countries simultaneously. The present study aimed to describe differences in self-reported ...
Attitudes and use of medicinal plants during pregnancy among women at health care centers in three regions of Mali, West-Africa 
Nergard, Cecilie S; Ho, Thi P T; Diallo, Drissa; Ballo, Ngolo; Paulsen, Berit S; Nordeng, Hedvig (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Background Although, medicinal plants have been important for women’s health historically, the knowledge about such use during pregnancy in developing countries is limited. This is the first quantitative, ...
The protocol of the Oslo Study of Clonidine in Elderly Patients with Delirium; LUCID: a randomised placebo-controlled trial 
Neerland, Bjørn E; Hov, Karen R; Bruun Wyller, Vegard; Qvigstad, Eirik; Skovlund, Eva; MacLullich, Alasdair M; Bruun Wyller, Torgeir (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Background Delirium affects 15% of hospitalised patients and is linked with poor outcomes, yet few pharmacological treatment options exist. One hypothesis is that delirium may in part result from exaggerated ...
Identification of chemical constituents of Zanthoxylum heitzii stem bark and their insecticidal activity against the malaria mosquito Anopheles gambiae 
Moussavi, Nastaran; Malterud, Karl E; Mikolo, Bertin; Dawes, Dag; Chandre, Fabrice; Corbel, Vincent; Massamba, Daniel; Overgaard, Hans J; Wangensteen, Helle (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Background Zanthoxylum heitzii bark extracts have insecticidal properties and have been reported to be used against malaria in Western Africa. Previously, it has been shown ...
Palliative pelvic radiotherapy for symptomatic incurable prostate cancer – A prospective multicenter study 
Cameron, Marte; Kersten, Christian; Vistad, Ingvild; van Helvoirt, Rene; Weyde, Kjetil; Undseth, Christine; Mjaaland, Ingvil; Skovlund, Eva; Fosså, Sophie Dorothea; Guren, Marianne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Background and purpose Radiotherapy is used to palliate pelvic symptoms of castration resistant prostate cancer (CRPC). However, magnitude and time course of effects and toxicities are poorly documented. Study aims were ...
Photochemical activation of MH3-B1/rGel: a HER2-targeted treatment approach for ovarian cancer 
Bull-Hansen, Bente; Berstad, Maria B.; Berg, Kristian; Cao, Yu; Skarpen, Ellen; Fremstedal, Ane Sofie; Rosenblum, Michael G.; Peng, Qian; Weyergang, Anette (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
HER2-targeted therapy has been shown to have limited efficacy in ovarian cancer despite frequent overexpression of this receptor. Photochemical internalization (PCI) is a modality for cytosolic drug delivery, currently ...
Cu (II)-Catalyzed Asymmetric Henry Reaction with a Novel C1-Symmetric Aminopinane-Derived Ligand 
Filippova, Liudmila; Stenstrøm, Yngve H.; Hansen, Trond Vidar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
A novel C1-symmetric dinitrogen ligand was synthesized in high yield from commercially available (1R,2R,3R,5S)-(−)-isopinocampheylamine and 1-methyl-2- imidazolecarboxaldehyde. In combination with Cu(OAc)2∙H2O, this new ...
Lack of the lysosomal membrane protein, GLMP, in mice results in metabolic dysregulation in liver 
Kong, Xiang Yi; Kase, Eili Tranheim; Herskedal, Anette; Schjalm, Camilla; Damme, Markus; Nesset, Cecilie Kåsi; Thoresen, G. Hege; Rustan, Arild; Eskild, Winnie (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Ablation of glycosylated lysosomal membrane protein (GLMP, formerly known as NCU-G1) has been shown to cause chronic liver injury which progresses into liver fibrosis in mice. Both lysosomal dysfunction and chronic liver ...
Crystal structure of (S)-2-[(3S,8S,9S,10R,13S,14S,-17R)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,-12,13,14,15,16,17-tetradecahydro-1 H-cyclopenta-[a]phenanthren-17-yl]-N-methoxy-N-methylpro-panamide (Fernholz Weinreb amide) 
Viktorsson, Elvar Örn; Åstrand, Ove Alexander Høgmoen; Haseeb, Rasha Sabah; Gorbitz, Carl Henrik; Rongved, Pål (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
The literature compound 3[beta]-hy­droxy-bis­nor-5-cholenic aldehyde is an important inter­mediate for the synthesis of new modulators of the nuclear oxysterol receptor Liver X. As part of our ongoing search for new LXR ...
FCGR2A and FCGR3A polymorphisms and clinical outcome in metastatic colorectal cancer patients treated with first-line 5-fluorouracil/folinic acid and oxaliplatin +/- cetuximab 
Kjersem, Janne Beathe; Skovlund, Eva; Ikdahl, Tone; Guren, Tormod Kyrre; Kersten, Christian; Dalsgaard, Astrid Marie; Yilmaz, Mette Karen; Fokstuen, Tone; Tveit, Magne Kjell; Kure, Elin H. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Background Polymorphisms of genes encoding the Fcy receptors (Fc fragment of IgG receptor 2A (FCGR2A) and 3A (FCGR3A)), which influence their affinity for the Fc fragment, have been linked to the pharmacodynamics of ...
Bioadhesive Mini-Tablets for Vaginal Drug Delivery 
Hiorth, Marianne; Nilsen, Susanne; Tho, Ingunn (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Different non-ionic cellulose ethers (methyl cellulose, MC; hydroxyethyl cellulose, HEC; hydroxypropyl cellulose, HPC; hydroxypropylmethyl cellulose, HPMC) and microcrystalline cellulose (MCC) were investigated as matrix ...
Medication safety in pregnancy : results from the MoBa study 
Nordeng, Hedvig Marie Egeland; Ystrøm, Eivind; Eberhard-Gran, Malin (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
This article summarizes the results of several of our studies on medication safety in pregnancy based on the Norwegian Mother and Child Cohort Study (MoBa). Medications investigated include antidepressants, NSAIDs, codeine, ...
The effect of a pre- and postoperative orthogeriatric service on cognitive function in patients with hip fracture: Randomized controlled trial (Oslo Orthogeriatric Trial) 
Watne, Leiv Otto; Torbergsen, Anne Cathrine; Conroy, Simon; Engedal, Knut; Frihagen, Frede; Hjorthaug, Geir Aasmund; Juliebø, Vibeke; Ræder, Johan; Saltvedt, Ingvild; Skovlund, Eva; Wyller, Torgeir Bruun (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Background Delirium is a common complication in patients with hip fractures and is associated with an increased risk of subsequent dementia. The aim of this trial was to evaluate the effect of a pre- and postoperative ...
Loss of lysosomal membrane protein NCU-G1 in mice results in spontaneous liver fibrosis with accumulation of lipofuscin and iron in Kupffer cells 
Kong, Xiang Yi; Nesset, Cecilie Kåsi; Damme, Markus; Løberg, Else Marit; Lübke, Torben; Mæhlen, Jan; Andersson, Kristin Brevik; Lorenzo, Petra Isabel O.; Roos, Norbert; Thoresen, G. Hege; Rustan, Arild; Kase, Eili Tranheim; Eskild, Winnie (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Human kidney predominant protein, NCU-G1, is a highly conserved protein with an unknown biological function. Initially described as a nuclear protein, it was later shown to be a bona fide lysosomal integral membrane protein. ...
Characteristics of women who continue smoking during pregnancy: A cross-sectional study of pregnant women and new mothers in 15 European countries 
Smedberg, Janne; Lupattelli, Angela; Mårdby, Ann-Charlotte; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Background: Some women continue smoking during pregnancy despite the extensive information available on the dangers smoking poses to their fetus. This study aimed to examine the prevalence and determinants of smoking before ...
Insecticidal activities of bark, leaf and seed extracts of Zanthoxylum heitzii against the African malaria vector Anopheles gambiae 
Overgaard, Hans; Sirisopa, Patcharawan; Mikolo, Bertin; Malterud, Karl Egil; Wangensteen, Helle; Zou, Yuan-Feng; Paulsen, Berit Smestad; Massamba, Daniel; Duchon, Stephane; Corbel, Vincent; Chandre, Fabrice (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
The olon tree, Zanthoxylum heitzii (syn. Fagara heitzii) is commonly found in the central-west African forests. In the Republic of Congo (Congo-Brazzaville) its bark is anecdotally reported to provide human protection ...
Importance of hematocrit for a tacrolimus target concentration strategy 
Størset, Elisabet; Holford, Nick; Midtvedt, Karsten; Bremer, Sara; Bergan, Stein; Åsberg, Anders (Journal article / Tidsskriftartikkel / Published version; Peer reviewed, 2014)
Purpose To identify patient characteristics that influence tacrolimus individual dose requirement in kidney transplant recipients. Methods Data on forty-four 12-h pharmacokinetic profiles from 29 patients and trough ...
Improved prediction of tacrolimus concentrations early after kidney transplantation using theory-based pharmacokinetic modelling 
Størset, Elisabet; Holford, Nick; Hennig, Stefanie; Bergmann, Troels K.; Bergan, Stein; Bremer, Sara; Åsberg, Anders; Midtvedt, Karsten; Staatz, Christine E. (Journal article / Tidsskriftartikkel / Published version; Peer reviewed, 2014)
Aims The aim was to develop a theory-based population pharmacokinetic model of tacrolimus in adult kidney transplant recipients and to externally evaluate this model and two previous empirical models. Methods Data were ...
Medication use in pregnancy: a cross-sectional, multinational web-based study 
Lupattelli, Angela; Spigset, Olav; Twigg, MJ; Zagorodnikova, Ksenia; Mårdby, Ann-Charlotte; Moretti, M.E.; Drozd, Mariola; Panchaud, Alice; Hameen-Antilla, Katri; Rieutord, Andre; Gjergia Jurasky, Romana; Odalovic, Marina; Kennedy, Debra; Rudolf, Gorazd; Juch, Herbert; Passier, Anneke; Björnsdottir, Ingunn; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Objectives: Intercountry comparability between studies on medication use in pregnancy is difficult due to dissimilarities in study design and methodology. This study aimed to examine patterns and factors associated with ...
Bioactive flavone-C-glycosides of the African medicinal plant Biophytum umbraculum 
Pham, Anh Thu; Nguyen, Celine; Malterud, Karl Egil; Diallo, Drissa; Wangensteen, Helle (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
Three flavone-C-glycosides—cassiaoccidentalin A (1), isovitexin (2) and isoorientin (3)—were isolated from the ethyl acetate (EtOAc) soluble fraction of the methanol crude extract of the African medicinal plant Biophytum ...
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