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Now showing items 201-274 of 274
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Specialized pro-resolving lipid mediators are biosynthesized during the resolution phase of acute inflammation from n-3 polyunsaturated fatty acids. Recently, the isolation and identification of the four novel mediators ...
(Journal article / Tidsskriftartikkel / PublishedVersion, 2016)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
The neuropeptide oxytocin (OT) is associated with a plethora of social behaviors, and is a key topic at the intersection of psychology and biology. However, tools for measuring OT are still not fully developed. We describe ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Background
Mental disorders strongly influence work capability in young adults, but it is not clear which disorders that are most strongly associated with sick leave, and which diagnoses that are stated on the sick leave ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Background
Zanthoxylum heitzii (Rutaceae) (olon) is used in traditional medicine in Central and West Africa to treat malaria. To identify novel compounds with anti-parasitic ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Background
The use of herbal medicines for health prevention and ailments is an increasing trend worldwide. Women in pregnancy are no exception; the reported prevalence of herbal medicine use in pregnancy ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Background
Several studies have reported age-associated changes in DNA methylation in the first few years of life and in adult populations, but the extent of such changes during childhood is less well ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Objective This study sought to determine whether changes in neurodevelopmental outcomes between 18 and 36 months of age were associated with prenatal exposure to triptan medications, a class of 5-HT receptor agonists used ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Social welfare support runs in families. Recent studies using Nordic registry data have found individual differences in genetic factors to be of substantial importance for medical benefits. However, to date there has been ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Perivascular cells (PC) were recently implied as regulators of metastasis and immune cell activity. Perivascular heterogeneity in clinical samples, and associations with other tumor features and outcome, remain largely ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Membrane vesicles (MVs) are spherical particles naturally released from the membrane of Gram-negative bacteria. Bacterial MV production is associated with a range of phenotypes including biofilm formation, horizontal gene ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2016)
Drug delivery to the oral cavity poses a significant challenge due to the short residence time of the formulations at the site of action. From this point of view, nanoparticulate drug delivery systems with ability to adhere ...
(Journal article / Tidsskriftartikkel / SubmittedVersion, 2016)
Body composition after kidney transplantation is linked to glucose metabolism, and impaired glucose metabolism is associated with increased risk of cardiovascular events and death. One year after transplantation, we examined ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
The use of antibodies in “bottom-up “LC-MS workflows to determine low abundant biological active proteins in complex human samples has increased in recent years: immuno-capture analysis combines the workflow of conventional ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Tacrolimus and sirolimus are important immunosuppressive drugs used in human islet transplantation; however, they are linked to detrimental effects on islets and reduction of long-term graft function. Few studies investigate ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
With increased development of medical technology (MT), new challenges emerge related to education and training of pharmacists and other healthcare specialists. Currently, only a few universities in the EU promote MT education ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
The aim of the present study was to develop a LC-MS/MS-based proteomic analysis method of urinary exosomal proteins that has the potential to discover disease biomarkers. In short, urinary exosomes from healthy subjects ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Objectives Three studies so far have investigated the effect of prenatal non-steroidal anti-inflammatory drug (NSAID) exposure on birth weight and gestational age. The aim in this study was to evaluate the association of ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Bradykinin is an important mediator in blood pressure regulation, ischemic precondition and capillary leakage, allergy, anaphylaxis, inflammation, and nociception, at least partly via the generation of nitric oxide (NO). ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Nature Index analysis 2014 rates India at the 13th place for its high-quality scientific publications. Despite this achievement, several studies have revealed that India is also among the major contrib-utors of articles ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Phage display screening readily allows for the identification of a multitude of antibody specificities, but to identify optimal lead candidates remains a challenge. Here, we direct the antibody-capsid fusion away from the ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2016)
Pharmaceutical formulations intended for treatment of xerostomia (dry mouth) should be able to keep the oral mucosa hydrated for a prolonged period of time. The products already existing on the market contain water-soluble ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Objective To determine pregnant women and new mothers’ perception of risks in pregnancy.
Design, settings and participants This was a large-scale multinational survey including 9113 pregnant women and new mothers from 18 ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Introduction Little is known about medication use among women with eating disorders in relation to pregnancy.
Aims To explore patterns of and associations between use of psychotropic, gastrointestinal and analgesic ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Background and purpose Radiotherapy is used to palliate pelvic symptoms of castration resistant prostate cancer (CRPC). However, magnitude and time course of effects and toxicities are poorly documented. Study aims were ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
HER2-targeted therapy has been shown to have limited efficacy in ovarian cancer despite frequent overexpression of this receptor. Photochemical internalization (PCI) is a modality for cytosolic drug delivery, currently ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
A novel C1-symmetric dinitrogen ligand was synthesized in high yield from commercially available (1R,2R,3R,5S)-(−)-isopinocampheylamine and 1-methyl-2- imidazolecarboxaldehyde. In combination with Cu(OAc)2∙H2O, this new ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Ablation of glycosylated lysosomal membrane protein (GLMP, formerly known as NCU-G1) has been shown to cause chronic liver injury which progresses into liver fibrosis in mice. Both lysosomal dysfunction and chronic liver ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
About 80% of patients with type 2 diabetes are classified as overweight. However, only about 1/3 of severely obese subjects have type 2 diabetes. This indicates that several severely obese individuals may possess certain ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Background
The factors related to the treatment of nausea during pregnancy have not yet been investigated in several countries simultaneously. The present study aimed to describe differences in self-reported ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Background
Zanthoxylum heitzii bark extracts have insecticidal properties and have been reported to be used against malaria in Western Africa. Previously, it has been shown ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Background
Delirium affects 15% of hospitalised patients and is linked with poor outcomes, yet few pharmacological treatment options exist. One hypothesis is that delirium may in part result from exaggerated ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Background
Although, medicinal plants have been important for women’s health historically, the knowledge about such use during pregnancy in developing countries is limited. This is the first quantitative, ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Mucoadhesive drug therapy destined for localized drug treatment is gaining increasing importance in today’s drug development. Chitosan, due to its known biodegradability, bioadhesiveness and excellent safety profile offers ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Background
Chronic Fatigue Syndrome (CFS) is a common and disabling condition in adolescence with few treatment options. A central feature of CFS is orthostatic intolerance and abnormal autonomic cardiovascular ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Background
This work investigates a general method for producing alginate gel matrices using an internal mode of gelation that depends solely on soluble alginate and alginate/gelling ion particles. The ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
The literature compound 3[beta]-hydroxy-bisnor-5-cholenic aldehyde is an important intermediate for the synthesis of new modulators of the nuclear oxysterol receptor Liver X. As part of our ongoing search for new LXR ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Background Polymorphisms of genes encoding the Fcy receptors (Fc fragment of IgG receptor 2A (FCGR2A) and 3A (FCGR3A)), which influence their affinity for the Fc fragment, have been linked to the pharmacodynamics of ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Different non-ionic cellulose ethers (methyl cellulose, MC; hydroxyethyl cellulose, HEC; hydroxypropyl cellulose, HPC; hydroxypropylmethyl cellulose, HPMC) and microcrystalline cellulose (MCC) were investigated as matrix ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
This article summarizes the results of several of our studies on medication safety in pregnancy based on the Norwegian Mother and Child Cohort Study (MoBa). Medications investigated include antidepressants, NSAIDs, codeine, ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Background Delirium is a common complication in patients with hip fractures and is associated with an increased risk of subsequent dementia. The aim of this trial was to evaluate the effect of a pre- and postoperative ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Background: Some women continue smoking during pregnancy despite the extensive information available on the dangers smoking poses to their fetus. This study aimed to examine the prevalence and determinants of smoking before ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
The olon tree, Zanthoxylum heitzii (syn. Fagara heitzii) is commonly found in the central-west African forests. In the Republic of Congo (Congo-Brazzaville) its bark is anecdotally reported to provide human protection ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Human kidney predominant protein, NCU-G1, is a highly conserved protein with an unknown biological function. Initially described as a nuclear protein, it was later shown to be a bona fide lysosomal integral membrane protein. ...
(Journal article / Tidsskriftartikkel / Published version; Peer reviewed, 2014)
Aims The aim was to develop a theory-based population pharmacokinetic model of tacrolimus in adult kidney transplant recipients and to externally evaluate this model and two previous empirical models.
Methods Data were ...
(Journal article / Tidsskriftartikkel / Published version; Peer reviewed, 2014)
Purpose To identify patient characteristics that influence tacrolimus individual dose requirement in kidney transplant recipients.
Methods Data on forty-four 12-h pharmacokinetic profiles from 29 patients and trough ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Objectives: Intercountry comparability between studies on medication use in pregnancy is difficult due to dissimilarities in study design and methodology. This study aimed to examine patterns and factors associated with ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
Microcystins (MCs) are a group of biotoxins (>150) produced by cyanoba cteria, with a worldwide distribution. MCs are hepatotoxic, and acute exposure causes severe liver damage in humans and animals. Rapid and cheap methods ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
Three flavone-C-glycosides—cassiaoccidentalin A (1), isovitexin (2) and isoorientin (3)—were isolated from the ethyl acetate (EtOAc) soluble fraction of the methanol crude extract of the African medicinal plant Biophytum ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
Reliable, sensitive and automatable analytical methodology is of great value in e.g. cancer diagnostics. In this context, an on-line system for enzymatic cleavage of proteins, subsequent peptide separation by liquid ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
Background
Cranberry is one of the most commonly used herbs during pregnancy. The herb has been used traditionally against urinary tract infections. No studies are found that specifically address the risk ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
Background
In the early phases following heart transplantation a main challenge is to reduce the impact of acute rejections. Previous studies indicate that intracellular ciclosporin A (CsA) concentration ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
Background
Despite the widespread use of medicinal plants in Mali, knowledge about how traditional practitioners (TPs) treat pregnant and lactating women is lacking.
...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
Background
Reverse transcription quantitative PCR has become a powerful technique to monitor mRNA transcription in response to different environmental conditions in many bacterial species. However, correct ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
Background
The use of complementary and alternative medicines (CAM) is growing in the general population. Herbal medicines are used in all countries of the world and are included in the top CAM therapies ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
The recently discovered HEAT-like repeat (HLR) DNA glycosylase superfamily is widely distributed in all domains of life. The present bioinformatics and phylogenetic analysis shows that HLR DNA glycosylase superfamily members ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
Several eukaryotic symbioses have shown to host a rich diversity of prokaryotes that interact with their hosts. Here, we study bacterial communities associated with ectomycorrhizal root systems of Bistorta vivipara compared ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
Background
Recent years have shown a marked increase in the use of next-generation sequencing technologies for quantification of gene expression (RNA sequencing, RNA-Seq). The expression level of a gene is ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
Background
Hip fractures mainly affect older people. It is associated with high morbidity and mortality, and in particular a high frequency of delirium. Incident delirium following hip fracture is associated ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
Background
Acute rejection (AR) episodes in renal transplant recipients are suspected when plasma creatinine is elevated and other potential causes out ruled. Graft biopsies are however needed for definite ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
Background
Recent studies have reported associations between a variant allele in a let-7 microRNA complementary site (LCS6) within the 3′untranslated region (3′UTR) of KRAS (rs61764370) and clinical outcome ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
Background
Studies indicate that strength training has beneficial effects on clinical health outcomes in prostate cancer patients during androgen deprivation therapy. However, randomized controlled trials ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
Serum half-life of IgG is controlled by the neonatal Fc receptor (FcRn) that interacts with the IgG Fc region and may be increased or decreased as a function of altered FcRn binding. Preclinical evaluations of modified ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
A positive inotropic responsiveness to serotonin, mediated by 5-HT4 and 5-HT2A receptors, appears in the ventricle of rats with post-infarction congestive heart failure (HF) and pressure overload-induced hypertrophy. A ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
Context: Plasma total cysteine (tCys) independently relates to fat mass in adults. Dietary cyst(e)ine promotes adiposity and decreases glucose tolerance in some rodent models, but alleviates insulin resistance in ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Atlantic cod (Gadus morhua) is a large, cold-adapted teleost that sustains long-standing commercial fisheries and incipient aquaculture. Here we present the genome sequence of Atlantic cod, showing evidence for complex ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background
One important physiological response to environmental stress in animals is change in gene expression. To obtain reliable data from gene expression studies using RT-qPCR it is important to evaluate ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background
Cell lines from Atlantic salmon kidney have made it possible to culture and study infectious salmon anemia virus (ISAV), an aquatic orthomyxovirus affecting farmed Atlantic salmon. However, ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Background
Group II introns are widespread genetic elements endowed with a dual functionality. They are catalytic RNAs (ribozymes) that are able of self-splicing and they are also mobile retroelements that ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
Aims/objective: We aimed to assess the long-term effects of post-transplant glycaemia on long-term survival after renal transplantation.
Methods: Study participants were 1,410 consecutive transplant recipients without ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)
Background
Bacillus cereus and the closely related Bacillus thuringiensis are Gram positive opportunistic pathogens that may cause food poisoning, and the three secreted pore-forming ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)
Background
High activity of cysteine proteases such as legumain and the cathepsins have been shown to facilitate growth and invasion of a variety of tumor types. In breast cancer, several recent studies ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)
The neonatal Fc receptor (FcRn) regulates the serum half-life of both IgG and albumin through a pH-dependent mechanism that involves salvage from intracellular degradation. Therapeutics and diagnostics built on IgG, Fc, ...