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Now showing items 101-200 of 1380
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
(Doctoral thesis / Doktoravhandling, 2020)
Ny forskning har vist at omega-3 fettsyrer, som eikosapentaensyre (EPA), dokosapentaensyre (DPA), og dokosaheksaensyre (DHA), er viktige forløpere til hydroksylerte endogene forbindelser, som dannes i mennesker og dyr. En ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Perfluoroalkyl acids (PFAAs) are persistent man-made chemicals, ubiquitous in nature and present in human samples. Although restrictions are being introduced, they are still used in industrial processes as well as in ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Purpose
Zuclopenthixol is an antipsychotic available as oral and long-acting injectable (LAI) formulations. The aim of this study was to investigate the effect of age on zuclopenthixol exposure during oral and LAI ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background: Many drugs with dose-dependent effects on hemodynamic variables are metabolized by cytochrome P450 2D6 (CYP2D6). The aim of this study was to compare prescribed dosages and hemodynamic responses of such drugs ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Healthcare services such as diabetes risk-assessment are increasingly common in community pharmacies. Knowledge of community pharmacists’ experiences of such services could ease the implementation of a larger-scale ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Abstract
Clozapine (CLZ) is the superior antipsychotic drug for treatment of schizophrenia, but exhibits an extensive interpatient pharmacokinetic variability. Here, we conducted a genome-wide association study ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background
Women with unplanned pregnancies use folic acid less frequently, and more often use potentially teratogenic medications in the first trimester. Yet most studies based on routinely collected data lack information ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The objective of this work was to develop and characterize solid lipid nanoparticle (SLN)-loaded mucoadhesive films to reveal their potential as successful drug formulations. SLNs based on lipid (Lipoid S100) and surfactant ...
The lactate receptor HCAR1 at the brain-cerebrospinal fluid interface and its role in stroke Restricted Access
(Master thesis / Masteroppgave, 2020)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Obesity is associated with comorbidities of which pharmacological treatment is needed. Physiological changes associated with obesity may influence the pharmacokinetics of drugs, but the effect of body weight on drug ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background
Epigenetic clocks have been recognized for their precise prediction of chronological age, age-related diseases, and all-cause mortality. Existing epigenetic clocks are based on CpGs from the ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background
According to previous studies, older patients frequently have serum concentrations of antidepressant medication above the recommended reference range.
Objective
The aim of this study was to investigate ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Abstract
Primary human myotubes represent an alternative system to intact skeletal muscle for the study of human diseases related to changes in muscle energy metabolism. This work aimed to study if fatty acid and glucose ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Mucosal drug delivery accounts for various administration routes (i.e., oral, vaginal, ocular, pulmonary, etc.) and offers a vast surface for the permeation of drugs. However, the mucus layer which shields and lubricates ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Increased exploitation of resources in sensitive marine ecosystems emphasizes the importance of knowledge regarding ecological impacts. However, current bio-monitoring practices are limited in terms of target-organisms and ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Objective To investigate the effect of pharmacist-led medicines management in multimorbid, hospitalised patients on long-term hospital readmissions and survival.
Design Parallel-group, randomised controlled trial.
Setting ...
Maternal characteristics and use of medications in pregnant women that sought medical help due to infertility – a European, cross-sectional web-based study Restricted Access
(Master thesis / Masteroppgave, 2020)
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
The thermal and oxidative degradation behavior and the corrosiveness of imidazole (Im), 2-methylimidazole (2MIm), 2-ethyl-4-methylimidazole (2E4MIm), 2,4,5-trimethylimidazole (2,4,5MIm), and 1,2,4,5-tetramethylimidazole ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Abstract Genes and proteins show variable expression patterns throughout the human body. However, it is not clear whether relative differences in mRNA concentrations are retained on the protein level. Furthermore, ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Needle-free uptake across mucosal barriers is a preferred route for delivery of biologics, but the efficiency of unassisted transmucosal transport is poor. To make administration and therapy efficient and convenient, ...
Uhensiktsmessig legemiddelbruk hos eldre og informasjonsoverføring ved skifte av omsorgsnivå ved en intermediæravdeling Restricted Access
(Master thesis / Masteroppgave, 2020)
Bakgrunn: Mengden legemidler på markedet øker stadig og flere er svært potente. Samtidig kan et økende antall sykdommer behandles eller forebygges og nasjonale retningslinjer angir ofte bruk av flere medikamenter enten for ...
(Master thesis / Masteroppgave, 2020)
Bakgrunn Humant immunsviktvirus (HIV)-infeksjon har gått fra å kunne gi dødelig sykdom, til å kunne gi en kronisk ikke-dødelig sykdom. Takket være legemiddelterapien har HIV- rammede en livslengde tilnærmet normalbefolkningen. ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Purpose The β-1 adrenergic receptor blocker metoprolol is primarily metabolized by the polymorphic enzyme cytochrome P 450 2D6 (CYP2D6), an enzyme with substantial genetic heterogeneity. Our purpose was to investigate the ...
Kvalitetsvurdering av DDD i det islandske reseptregisteret - Innvirkning av DDD feil på vitenskapelige publikasjoner Restricted Access
(Master thesis / Masteroppgave, 2020)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Purpose
Limited research has focused on the association between prenatal thyroid hormone replacement therapy (THRT) and motor function, communication skills, and behavior in preschool children. Here, we estimated the ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Abstract Adequate antipsychotic treatment intensity is required for defining treatment-resistant schizophrenia (TRS) and justifying clozapine treatment. We investigated the occurrence of undetectable or subtherapeutic serum ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background
Concerns have been raised about the use of opioid maintenance treatment (OMT) during pregnancy and negative effects for the offspring. While neonatal outcomes and short-term effects are relatively well ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
A series of 36 dual functionalized N-(poly)ethylen glycol N-allyl-/N-benzyl imidazolium and benzimidazolium ILs were synthesized for extractive desulfurization studies (EDS). The novel ILs were readily prepared from imidazole ...
(Master thesis / Masteroppgave, 2020)
(Master thesis / Masteroppgave, 2020)
Sammendrag Bakgrunn All behandling med antikoagulantia bør gjøres etter individuell vurdering av hver enkelt pasient, særlig for den eldre pasientgruppen. Regionale legemiddelinformasjonssentre (RELIS) mottar mange ...
Håndtering av legemiddelmangel i apotek med fokus på logistikk Restricted Access
(Master thesis / Masteroppgave, 2020)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Objective: To explore the trends in prevalence and incidence of multiple sclerosis (MS) in Telemark, Norway (latitude 58.7-60.3˚N), over the past two decades, with focus on differences between rural and urban areas. Methods: ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Disruption of neurite outgrowth is a marker for neurotoxicity. Persistent organic pollutants (POPs) are potential developmental neurotoxicants. We investigated their effect on neurite outgrowth in PC12 rat pheochromocytoma ...
Fremstilling av kryssbundne kitosanfilmer for mucoadhesjon i tynntarmen Restricted Access
(Master thesis / Masteroppgave, 2020)
Mass Spectrometric Analysis of Peptide- and Protein Doping Agents Restricted Access
(Master thesis / Masteroppgave, 2020)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Abstract Objective: To pinpoint the earliest cellular defects underlying seizure onset (epileptogenic period) during perinatal brain development in a new zebrafish model of Dravet syndrome (DS) and to investigate potential ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Cyclooxygenase-2 and several lipoxygenases convert polyunsaturated fatty acids into a large variety of products. During inflammatory processes, these enzymes form several distinct families of specialized pro-resolving lipid ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background
Studies on medication-related problems (MRPs) among pregnant women are scarce, despite the potential consequences for both mother and child. This study aimed to describe the prevalence, clinical significance, ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Electromembrane extraction (EME) in small, stagnant and chip-like devices has the potential for future in-field operation. Literature briefly discuss such systems, but performance suffered from evaporative losses of sample ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Background: Population-based pharmaco-epidemiologic studies are used to assess postmarketing drug safety and discover beneficial effects of off-label drug use. We conducted a drug-wide association study (DWAS) to screen ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
It is unclear to what extent parental influences on the development of internalizing problems in offspring are explained by indirect genetic effects, reflected in the environment provided by the parent, in addition to the ...
(Master thesis / Masteroppgave, 2020)
Summary of thesis EME is an emerging sample preparation technique and a supported liquid membrane (SLM) is an important part of it. In this literature-based study, organic solvents used as SLM was reviewed. Prior to ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Objective:
To describe epidemiology and antimicrobial susceptibility testing (AST) data of bacteria causing invasive infections in Norwegian children (0–18 years).
Methods:
Population-based observational study ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The volume, composition, and movement of the cerebrospinal fluid (CSF) are important for brain physiology, pathology, and diagnostics. Nevertheless, few studies have focused on the main structure that produces CSF, the ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Flagellar motility is considered an important virulence factor in different pathogenic bacteria. In Listeria monocytogenes the transcriptional repressor MogR regulates motility in a temperature-dependent manner, directly ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
In the present work, we study the photodynamic action of cercosporin (cerco), a naturally occurring photosensitizer, on human cancer multicellular spheroids. U87 spheroids exhibit double the uptake of cerco than T47D and ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Living donors (LDs) are preferred over DDs for renal transplantation in children due to superior GS. Oslo University Hospital has never restricted living donation by upper age. The aim of this study was to investigate ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background
The use of HbA1c ≥6.5% for diagnosis of diabetes has been challenged for post-transplantation diabetes mellitus (PTDM) also known as new onset diabetes after transplantation (NODAT) due to a low ...
Bruk av fluorokinoloner i sykehus – en prospektiv kartleggingsstudie Restricted Access
(Master thesis / Masteroppgave, 2019)
Hensikt: Hensikten med denne studien var å kartlegge behandlings- og forskrivningstrender av fluorokinoloner ved Sykehuset Namsos, og videre kartlegge om valg av fluorokinoloner er i tråd med Nasjonal faglig retningslinje ...
AQP4 Expression and Distribution in Mice With Heterozygous Targeted Deletion of Aqp4 Restricted Access
(Master thesis / Masteroppgave, 2019)
(Journal article / Tidsskriftartikkel; Peer reviewed, 2019)
Puwainaphycins (PUWs) and minutissamides (MINs) are structurally analogous cyclic lipopeptides possessing cytotoxic activity. Both types of compound exhibit high structural variability, particularly in the fatty acid (FA) ...
(Master thesis / Masteroppgave, 2019)
(Master thesis / Masteroppgave, 2019)
Sammendrag Bakgrunn: Antibiotikaresistens er et globalt problem i dag og settes på linje med for eksempel klimaendringsproblemet. Høyt forbruk av antibiotika (inkludert mye feilbruk) både til dyr og mennesker, den omfattende ...
(Doctoral thesis / Doktoravhandling, 2019)
(Doctoral thesis / Doktoravhandling, 2019)
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
An experimental/computational approach has been successfully applied in order to study the effect of solubilizing vehicles (cyclodextrins and liposomes) on the passive diffusion of four active pharmaceutical ingredients ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background
Knowledge of risk factors for drug-related hospitalizations (DRHs) is limited.
Aim
To examine the prevalence of DRHs and the relationships between DRHs and various variables in multimorbid patients admitted ...
(Master thesis / Masteroppgave, 2019)
Tomat (Solanum lycopersicum L.) er en stor bærfrukt som har opprinnelse i Sør-Amerika. Tomatplanten ble innført til Europa på 1500-tallet og bruken av tomat som mat, er i dag verdensomspennende. I denne oppgave ble struktur- ...
(Master thesis / Masteroppgave, 2019)
For centuries, infectious diseases had a huge toll on the global mortality and morbidity rates. Antibiotics emergence was fundamental for the process of controlling, preventing and fighting infectious diseases, regardless ...
(Master thesis / Masteroppgave, 2019)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
In recent years there has been increased attention to child neurodevelopment in studies on medication safety in pregnancy. Neurodevelopment is a multifactorial outcome that can be assessed by various assessors, using ...
Prenatal eksponering for metadon eller buprenorfin og effekt på proteiner viktige for læring og hukommelse. In vivo og ex vivo studier i rotte Restricted Access
(Master thesis / Masteroppgave, 2019)
Legemiddelassistert rehabilitering (LAR) er en behandling som tilbys pasienter med heroinavhengighet. Behandlingen ble tilgjengelig i Norge på 1990-tallet, og består i å erstatte heroin med et langtidsvirkende opioid. ...
(Master thesis / Masteroppgave, 2019)
I dette arbeidet har det blitt utviklet en thiol-ene basert mikrochip for elektromembranekstraksjon (EME) koblet direkte til kapillærelektroforese (CE) og UV-deteksjon. EME-chipen har potensial for framtidige analyser ...
Kort- og langtidseffekt av gastrisk bypass-operasjon på in vivo CYP3A-aktivitet i pasienter med sykelig overvekt Restricted Access
(Master thesis / Masteroppgave, 2019)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background
Kidney transplantation is considered to be the treatment of choice for people with end-stage renal disease (ESRD). However, due to the shortage of available organs and the increase in the ESRD ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Objectives To examine risk perception, beliefs about migraine medications and medical adherence among pregnant and breastfeeding women with migraine.
Design and setting Cross-sectional study conducted in Norway from ...
Nye sink-chelaterende forbindelser som mulige nye legemidler mot antibiotisk resistens (ZinChel) Restricted Access
(Master thesis / Masteroppgave, 2019)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
In this study, self-assembling Soluplus® micelles were examined for inherent properties. Through calorimetric analysis, the critical micelle concentration (CMC) could be determined at 25 and 37 °C, and the influence of ...
Synthetic Studies Towards an Analog of the Specialized Pro-resolving Mediator RvD1n-3 DPA Restricted Access
(Master thesis / Masteroppgave, 2019)
The synthesis of a hitherto unknown fatty acid analog presented in this thesis is based on the initial synthesis of two main fragments, termed the α- and the ω-fragment, respectively. The analog is then to be assembled by ...
(Master thesis / Masteroppgave, 2019)
Bakgrunn: Humane skjelettmuskelceller i kultur dyrkes fra satellittceller isolert fra muskelbiopsier. I hvilken grad type muskel in vivo betyr noe for fenotype av muskelceller in vitro har tidligere vært lite studert. ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
A pivotal matter to aquaculture is the sourcing of sustainable resources as ingredients to aquafeeds. Levels of plant delivered oils as source of fatty acids (FA) in aquafeeds have reached around 70% resulting in reduced ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Anatomical changes in the gastrointestinal tract and subsequent weight loss may influence drug disposition and thus drug dosing following bariatric surgery. This review systematically examines the effects of bariatric ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background
Antibiotic resistance is a global health threat. Public knowledge is considered a prerequisite for appropriate use of antibiotics and limited spread of antibiotic resistance. Our aim was to examine ...
(Doctoral thesis / Doktoravhandling, 2019)
Hypothyroidism is a thyroid dysfunction defined by inadequate production of thyroid hormones. This dysfunction is common (3%) in pregnant women and women of reproductive age. When the condition occurs during pregnancy, the ...
Funksjonen til Plin2 i muskel og lever Restricted Access
(Master thesis / Masteroppgave, 2019)
Adipokine levels are associated with insulin resistance in antipsychotics users independently of BMI
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background
The prevalence of obesity, metabolic syndrome and type 2 diabetes mellitus is increased among patients with severe mental disorders, and particularly use of second generation antipsychotic drugs is associated ...
Kan inhalasjonsveiledning og utskrivningstjeneste for kolspasienter på Lungemedisinsk sengepost bidra til færre reinnleggelser? - En pilotstudie Restricted Access
(Master thesis / Masteroppgave, 2019)
(Doctoral thesis / Doktoravhandling, 2019)
Patients with end-stage renal disease (ESRD) are treated with renal replacement therapy (RRT), which consist of either dialysis or renal transplantation. Pharmacological therapy is essential for these patients, but can be ...
(Master thesis / Masteroppgave, 2019)
(Master thesis / Masteroppgave, 2019)
Sammendrag Bakgrunn: Innføring av e-resept i 2011 har bidratt til en effektiv samhandling mellom pasient, behandlere og apotek. Imidlertid har det blitt identifisert et økende antall doble og uaktuelle resepter i den ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
In this study, gellan gum (GG), a natural polysaccharide, was used to fabricate spherical porous beads suitable as sustained drug delivery systems for oral administration. GG was cross-linked with calcium ions to prepare ...
INHALASJONSVEILEDNING I APOTEK «Er det variasjon i tjenestefarmasøyters bedømmelse av inhalasjonsteknikk?» Restricted Access
(Master thesis / Masteroppgave, 2019)
(Doctoral thesis / Doktoravhandling, 2019)
Heroin is one of the most addictive drugs of abuse, but heroin itself is considered an inactive prodrug which acts mainly through its metabolites. The work of this doctoral thesis highlights the role of heroin’s first ...
(Master thesis / Masteroppgave, 2019)
Bakgrunn Samfunnservervet pneumoni (CAP) er en infeksjon i de nedre luftveiene, ervervet utenfor sykehus eller annen helseinstitusjon, eller innenfor 48 timer etter sykehusinnleggelse. CAP rammer ca. 1 % av den vestlige ...
Formulering og fremstilling av fluorholdige liposomer til potensiell bruk i karies- og erosjonsprofylakse Restricted Access
(Master thesis / Masteroppgave, 2019)
(Master thesis / Masteroppgave, 2019)
INTRODUKSJON: Kronisk obstruktiv lungesykdom (kols) er en alvorlig sykdom forbundet med mange symptomer. Inhalasjonspreparater er førstevalget i behandling av kols. Det er svært viktig med korrekt inhalasjonsteknikk for å ...
(Master thesis / Masteroppgave, 2019)
(Master thesis / Masteroppgave, 2019)
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Albatrellus ovinus, the sheep polypore, is a large, dense mushroom being rich in cell wall material. Polysaccharides were isolated by sequential extraction, enzymatic treatment and analyzed with respect to monosaccharide ...
Investigations in cultured rat neurons of acute oxaliplatin and pregabalin effects on intracellular calcium and role of Transient Receptor Potential cold sensors Restricted Access
(Master thesis / Masteroppgave, 2019)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Many women experience anxiety or sleep disorders during pregnancy and require pharmacological treatment with benzodiazepines (BZDs) or z-hypnotics. Limited information is currently available on how prenatal exposure to ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Often referred to as “the master gland”, the pituitary is a key organ controlling growth, maturation, and homeostasis in vertebrates. The anterior pituitary, which contains several hormone-producing cell types, is highly ...
(Doctoral thesis / Doktoravhandling, 2019)
The NMDA-receptor is a central part of the machinery that enables us to learn, form memories and develop a normal brain. It is expressed all over the central nervous system and is responsible for signalling between nerve ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background
Recent studies have suggested an association between prenatal paracetamol exposure and adverse neurodevelopmental outcomes in children. However, these findings may be confounded by unmeasured factors related ...
(Journal article / Tidsskriftartikkel / SubmittedVersion, 2019)
Background and aims
Intranasal (i.n.) naloxone is an established treatment for opioid overdose. Anyone likely to witness an overdose should have access to the antidote. We aimed to determine whether an i.n. formulation ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Purpose
The purpose of the study is to identify and explore risk factors of serious adverse drug events (SADE) and SADE-related admissions in acutely hospitalized multimorbid older adults and assess whether these could ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Importance: Hypothyroidism during pregnancy is associated with neurodevelopmental delays in the offspring. However, it remains unknown whether prenatal thyroid hormone replacement therapy (THRT) has benefits regarding ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Data-independent acquisition (DIA) is a powerful mass spectrometric technique to perform both protein identification and quantification of complex protein samples. Setting up DIA methods on Orbitrap analyzers requires a ...