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Proteomics‐informed prediction of rosuvastatin plasma profiles in patients with a wide range of body weight 
Wegler, Christine; Garcia, Luna Prieto; Klinting, Signe; Robertsen, Ida; Wisniewski, Jacek R.; Hjelmesæth, Jøran; Åsberg, Anders; Jansson-Löfmark, Rasmus; Andersson, Tommy B.; Artursson, Per (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Synthetic, Biosynthetic and Biological Studies of Specialized Pro-resolving Mediators: Novel Leads in Drug Discovery 
Nesman, Jannicke Irina (Doctoral thesis / Doktoravhandling, 2020)
Ny forskning har vist at omega-3 fettsyrer, som eikosapentaensyre (EPA), dokosapentaensyre (DPA), og dokosaheksaensyre (DHA), er viktige forløpere til hydroksylerte endogene forbindelser, som dannes i mennesker og dyr. En ...
Perfluoroalkyl acids potentiate glutamate excitotoxicity in rat cerebellar granule neurons 
Berntsen, Hanne Friis; Moldes-Anaya, Angel; Bjørklund, Cesilie Granum; Ragazzi, Lorenzo; Haug, Trude M; Strandabø, Rønnaug; Verhaegen, Steven; Paulsen, Ragnhild Elisabeth; Ropstad, Erik; Tasker, Andrew (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Perfluoroalkyl acids (PFAAs) are persistent man-made chemicals, ubiquitous in nature and present in human samples. Although restrictions are being introduced, they are still used in industrial processes as well as in ...
Impact of age and CYP2D6 genotype on exposure of zuclopenthixol in patients using long-acting injectable versus oral formulation-an observational study including 2044 patients 
Tveito, Marit; Smith, Robert Løvsletten; Molden, Espen; Høiseth, Gudrun (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Purpose Zuclopenthixol is an antipsychotic available as oral and long-acting injectable (LAI) formulations. The aim of this study was to investigate the effect of age on zuclopenthixol exposure during oral and LAI ...
Prescribed Doses of CYP2D6-Metabolized Drugs and Hemodynamic Responses in Relation to CYP2D6 Genotype Among Older Patients Exposed to Polypharmacy 
Romskaug, Rita; Wyller, Torgeir Bruun; Straand, Jørund; Kersten, Hege; Molden, Espen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background: Many drugs with dose-dependent effects on hemodynamic variables are metabolized by cytochrome P450 2D6 (CYP2D6). The aim of this study was to compare prescribed dosages and hemodynamic responses of such drugs ...
Pharmacists’ experience of a diabetes risk-assessment service and analytical quality control in community pharmacies : a focus-group study 
Risøy, Aslaug Johanne; Kjome, Reidun Lisbet Skeide; Svensberg, Karin; Råheim, Målfrid; Sølvik, Una Ørvim (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Healthcare services such as diabetes risk-assessment are increasingly common in community pharmacies. Knowledge of community pharmacists’ experiences of such services could ease the implementation of a larger-scale ...
Identification of a novel polymorphism associated with reduced clozapine concentration in schizophrenia patients—a genome-wide association study adjusting for smoking habits 
Smith, Robert Løvsletten; O’Connell, Kevin; Athanasiu, Lavinia; Djurovic, Srdjan; Kringen, Marianne K.; Andreassen, Ole Andreas; Molden, Espen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Abstract Clozapine (CLZ) is the superior antipsychotic drug for treatment of schizophrenia, but exhibits an extensive interpatient pharmacokinetic variability. Here, we conducted a genome-wide association study ...
Fertility treatment and oral contraceptive discontinuation for identification of pregnancy planning in routinely collected health data – an application to analgesic and antibiotic utilisation 
Hjorth, Sarah; Wood, Mollie; Tauqeer, Fatima; Nordeng, Hedvig (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Women with unplanned pregnancies use folic acid less frequently, and more often use potentially teratogenic medications in the first trimester. Yet most studies based on routinely collected data lack information ...
Solid lipid nanoparticle-loaded mucoadhesive buccal films – Critical quality attributes and in vitro safety & efficacy 
Tzanova, Martina; Hagesaether, Ellen; Tho, Ingunn (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The objective of this work was to develop and characterize solid lipid nanoparticle (SLN)-loaded mucoadhesive films to reveal their potential as successful drug formulations. SLNs based on lipid (Lipoid S100) and surfactant ...
The lactate receptor HCAR1 at the brain-cerebrospinal fluid interface and its role in stroke Restricted Access
Nguyen, Teresa Dang (Master thesis / Masteroppgave, 2020)
Correlation of body weight and composition with hepatic activities of cytochrome P450 enzymes 
Krogstad, Veronica; Peric, Alexandra; Robertsen, Ida; Kringen, Marianne K.; Vistnes, Maria; Hjelmesæth, Jøran; Sandbu, Rune; Johnson, Line Kristin; Angeles, Philip Carlo Soriano; Jansson-Löfmark, Rasmus; Karlsson, Cecilia; Andersson, Shalini; Åsberg, Anders; Andersson, Tommy B.; Christensen, Hege Staaland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Obesity is associated with comorbidities of which pharmacological treatment is needed. Physiological changes associated with obesity may influence the pharmacokinetics of drugs, but the effect of body weight on drug ...
Blood-based epigenetic estimators of chronological age in human adults using DNA methylation data from the Illumina MethylationEPIC array 
Lee, Yunsung; Haftorn, Kristine L; Denault, William R P; Nustad, Haakon E; Page, Christian M; Lyle, Robert; Lee-Ødegård, Sindre; Moen, Gunn-Helen; Prasad, Rashmi B; Groop, Leif C; Sletner, Line; Sommer, Christine; Magnus, Maria C; Gjessing, Håkon K; Harris, Jennifer R; Magnus, Per; Håberg, Siri E; Jugessur, Astanand; Bohlin, Jon (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Epigenetic clocks have been recognized for their precise prediction of chronological age, age-related diseases, and all-cause mortality. Existing epigenetic clocks are based on CpGs from the ...
Use of Antidepressants in Older People during a 10-Year Period: An Observational Study on Prescribed Doses and Serum Levels 
Tveit, Kristine; Hermann, Monica; Waade, Ragnhild Birkeland; Nilsen, Roy Miodini; Wallerstedt, Susanna M.; Molden, Espen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background According to previous studies, older patients frequently have serum concentrations of antidepressant medication above the recommended reference range. Objective The aim of this study was to investigate ...
Substrate oxidation in primary human skeletal muscle cells is influenced by donor age 
Aas, Vigdis; Thoresen, G. Hege; Rustan, Arild; Lund, Jenny (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Abstract Primary human myotubes represent an alternative system to intact skeletal muscle for the study of human diseases related to changes in muscle energy metabolism. This work aimed to study if fatty acid and glucose ...
Impact of mucin on drug diffusion: Development of a straightforward in vitro method for the determination of drug diffusivity in the presence of mucin 
Falavigna, Margherita; Stein, Paul C.; Flaten, Gøril Eide; Di Cagno, Massimiliano Pio (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Mucosal drug delivery accounts for various administration routes (i.e., oral, vaginal, ocular, pulmonary, etc.) and offers a vast surface for the permeation of drugs. However, the mucus layer which shields and lubricates ...
Evaluation of a eukaryote phylogenetic microarray for environmental monitoring of marine sediments 
Lekang, Katrine; Lanzén, Anders; Jonassen, Inge; Thompson, Eric; Troedsson, Christofer (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Increased exploitation of resources in sensitive marine ecosystems emphasizes the importance of knowledge regarding ecological impacts. However, current bio-monitoring practices are limited in terms of target-organisms and ...
Effect of medicines management versus standard care on readmissions in multimorbid patients: a randomised controlled trial 
Lea, Marianne; Mowe, Morten; Molden, Espen; Kvernrød, Kristin; Skovlund, Eva; Mathiesen, Liv (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Objective To investigate the effect of pharmacist-led medicines management in multimorbid, hospitalised patients on long-term hospital readmissions and survival. Design Parallel-group, randomised controlled trial. Setting ...
Maternal characteristics and use of medications in pregnant women that sought medical help due to infertility – a European, cross-sectional web-based study Restricted Access
Ilic, Miljana (Master thesis / Masteroppgave, 2020)
Degradative behavior and toxicity of alkylated imidazoles 
Evjen, Sigvart; Åstrand, Ove Alexander Høgmoen; Gaarder, Mona; Paulsen, Ragnhild Elisabeth; Fiksdahl, Anne; Knuutila, Hanna K (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
The thermal and oxidative degradation behavior and the corrosiveness of imidazole (Im), 2-methylimidazole (2MIm), 2-ethyl-4-methylimidazole (2E4MIm), 2,4,5-trimethylimidazole (2,4,5MIm), and 1,2,4,5-tetramethylimidazole ...
Global variability analysis of mRNA and protein concentrations across and within human tissues 
Wegler, Christine; Ölander, Magnus; Wisniewski, JR; Lundquist, Patrick; Zettl, K; Åsberg, Anders; Hjelmesæth, Jøran; Andersson, Tommy B; Artursson, Per (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Abstract Genes and proteins show variable expression patterns throughout the human body. However, it is not clear whether relative differences in mRNA concentrations are retained on the protein level. Furthermore, ...
An engineered human albumin enhances half-life and transmucosal delivery when fused to protein-based biologics 
Bern, Malin C.; Nilsen, Jeannette; Ferrarese, Mattia; Sand, Kine Marita Knudsen; Tollefsrud Gjølberg, Torleif; Lode, Heidrun Elisabeth; Davidson, Robert J.; Camire, Rodney M.; Bækkevold, Espen Sønderaal; Foss, Stian; Grevys, Algirdas; Dalhus, Bjørn; Wilson, John; Høydahl, Lene; Christianson, Gregory J.; Roopenian, Derry C.; Schlothauer, Tilman; Michaelsen, Terje Einar; Moe, Morten Carsten; Lombardi, Silvia; Pinotti, Mirko; Sandlie, Inger; Branchini, Alessio; Andersen, Jan Terje (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Needle-free uptake across mucosal barriers is a preferred route for delivery of biologics, but the efficiency of unassisted transmucosal transport is poor. To make administration and therapy efficient and convenient, ...
Uhensiktsmessig legemiddelbruk hos eldre og informasjonsoverføring ved skifte av omsorgsnivå ved en intermediæravdeling Restricted Access
Müller, Kristin Meisdalen (Master thesis / Masteroppgave, 2020)
Bakgrunn: Mengden legemidler på markedet øker stadig og flere er svært potente. Samtidig kan et økende antall sykdommer behandles eller forebygges og nasjonale retningslinjer angir ofte bruk av flere medikamenter enten for ...
HIV, komedikasjon og komorbiditet En studie basert på data fra Reseptregisteret 
Scherffenberg, Maria (Master thesis / Masteroppgave, 2020)
Bakgrunn Humant immunsviktvirus (HIV)-infeksjon har gått fra å kunne gi dødelig sykdom, til å kunne gi en kronisk ikke-dødelig sykdom. Takket være legemiddelterapien har HIV- rammede en livslengde tilnærmet normalbefolkningen. ...
Impact of genotype-predicted CYP2D6 metabolism on clinical effects and tolerability of metoprolol in patients after myocardial infarction – a prospective observational study 
Anstensrud, Anne Kristine; Molden, Espen; Haug, Hans Jørgen; Qazi, Rehman; Muriq, Hysen; Fosshaug, Linn Elisabeth Lillerud; Spigset, Olav; Øie, Erik (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Purpose The β-1 adrenergic receptor blocker metoprolol is primarily metabolized by the polymorphic enzyme cytochrome P 450 2D6 (CYP2D6), an enzyme with substantial genetic heterogeneity. Our purpose was to investigate the ...
Kvalitetsvurdering av DDD i det islandske reseptregisteret - Innvirkning av DDD feil på vitenskapelige publikasjoner Restricted Access
Korkosh, Fatmeh Bayar (Master thesis / Masteroppgave, 2020)
Thyroid hormone replacement therapy in pregnancy and motor function, communication skills, and behavior of preschool children: The Norwegian Mother, Father, and Child Cohort Study 
van den Broek, Sophie; Lupattelli, Angela; Frank, Anna-Simone; Haug, Line Småstuen; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Purpose Limited research has focused on the association between prenatal thyroid hormone replacement therapy (THRT) and motor function, communication skills, and behavior in preschool children. Here, we estimated the ...
Undetectable or subtherapeutic serum levels of antipsychotic drugs preceding switch to clozapine 
Kyllesø, Lennart; Smith, Robert Løvsletten; Karlstad, Øystein; Andreassen, Ole Andreas; Molden, Espen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Abstract Adequate antipsychotic treatment intensity is required for defining treatment-resistant schizophrenia (TRS) and justifying clozapine treatment. We investigated the occurrence of undetectable or subtherapeutic serum ...
Prenatal exposure to methadone or buprenorphine impairs cognitive performance in young adult rats 
Kongstorp, Mette; Bogen, Inger Lise; Stiris, Tom; Andersen, Jannike Mørch (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Concerns have been raised about the use of opioid maintenance treatment (OMT) during pregnancy and negative effects for the offspring. While neonatal outcomes and short-term effects are relatively well ...
Fuel oil desulfurization with dual functionalized imidazolium based ionic liquids 
Butt, Hussain Shakeel; Chellappan, Lethesh Kallidanthiyil; Fiksdahl, Anne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
A series of 36 dual functionalized N-(poly)ethylen glycol N-allyl-/N-benzyl imidazolium and benzimidazolium ILs were synthesized for extractive desulfurization studies (EDS). The novel ILs were readily prepared from imidazole ...
Disposal of unused medicines in Norway 
Jovic, Dijana (Master thesis / Masteroppgave, 2020)
Henvendelser til RELIS om nye antikoagulasjonsmidler 
Nguyen, Hong Tuyet Na Tina (Master thesis / Masteroppgave, 2020)
Sammendrag Bakgrunn All behandling med antikoagulantia bør gjøres etter individuell vurdering av hver enkelt pasient, særlig for den eldre pasientgruppen. Regionale legemiddelinformasjonssentre (RELIS) mottar mange ...
Håndtering av legemiddelmangel i apotek med fokus på logistikk Restricted Access
Popovic, Milena (Master thesis / Masteroppgave, 2020)
Prevalence of multiple sclerosis in rural and urban districts in Telemark county, Norway 
Flemmen, Heidi Øyen; Simonsen, Cecilia Smith; Berg-Hansen, Pål; Moen, Stine Marit; Kersten, Hege; Heldal, Kristian; Celius, Elisabeth Gulowsen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Objective: To explore the trends in prevalence and incidence of multiple sclerosis (MS) in Telemark, Norway (latitude 58.7-60.3˚N), over the past two decades, with focus on differences between rural and urban areas. Methods: ...
A human relevant mixture of persistent organic pollutants (POPs) and perfluorooctane sulfonic acid (PFOS) enhance nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells 
Yadav, Ajay; Amber, Mazia; Zosen, Denis; Labba, Nils Anders; Huiberts, Eva Henriette Willemijn; Samulin-Erdem, Johanna Maria; Haugen, Fred; Berntsen, Hanne Friis; Zienolddiny, Shanbeh; Paulsen, Ragnhild Elisabeth; Ropstad, Erik; Connolly, Lisa; Verhaegen, Steven (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Disruption of neurite outgrowth is a marker for neurotoxicity. Persistent organic pollutants (POPs) are potential developmental neurotoxicants. We investigated their effect on neurite outgrowth in PC12 rat pheochromocytoma ...
Er det en sammenheng mellom serumkonsentrasjon av DOAK og hemoglobin hos eldre pasienter? En prospektiv observasjonsstudie ved Mottaksklinikken, Haukeland universitetssjukehus 
Mellingsæter, Trude Cecilie (Master thesis / Masteroppgave, 2020)
Fremstilling av kryssbundne kitosanfilmer for mucoadhesjon i tynntarmen Restricted Access
Andelic, Cornelia (Master thesis / Masteroppgave, 2020)
Mass Spectrometric Analysis of Peptide- and Protein Doping Agents Restricted Access
Pavic, Dragan (Master thesis / Masteroppgave, 2020)
New insights into the early mechanisms of epileptogenesis in a zebrafish model of Dravet syndrome 
Tiraboschi, Ettore; Martina, Silvia; van der Ent, Wietske; Grzyb, Kamil; Gawel, Kinga; Cordero-Maldonado, Maria Lorena; Poovathingal, Suresh K.; Heintz, Sarah; Satheesh, Somisetty Venkata; Brattespe, Jarle; Xu, Ju; Suster, Maximiliano; Skupin, Alexander; Esguerra, Camila V. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Abstract Objective: To pinpoint the earliest cellular defects underlying seizure onset (epileptogenic period) during perinatal brain development in a new zebrafish model of Dravet syndrome (DS) and to investigate potential ...
Enzymatic studies with 3-oxa n-3 DPA 
Pangopoulos, Maria Kant; Nolsøe, Jens Mortansson Jelstrup; Antonsen, Simen Gjelseth; Colas, Romain; Dalli, Jesmond; Aursnes, Marius; Stenstrøm, Yngve H.; Hansen, Trond Vidar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Cyclooxygenase-2 and several lipoxygenases convert polyunsaturated fatty acids into a large variety of products. During inflammatory processes, these enzymes form several distinct families of specialized pro-resolving lipid ...
Medication-related problems among hospitalized pregnant women in a tertiary teaching hospital in Ethiopia: a prospective observational study 
Ahmed, Seid M; Sundby, Johanne; Aragaw, Yesuf A; Nordeng, Hedvig (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Studies on medication-related problems (MRPs) among pregnant women are scarce, despite the potential consequences for both mother and child. This study aimed to describe the prevalence, clinical significance, ...
Towards exhaustive electromembrane extraction under stagnant conditions 
Restan, Magnus Saed; Skjærvø, Øystein; Martinsen, Ørjan Grøttem; Pedersen-Bjergaard, Stig (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Electromembrane extraction (EME) in small, stagnant and chip-like devices has the potential for future in-field operation. Literature briefly discuss such systems, but performance suffered from evaporative losses of sample ...
Drug Use and Cancer Risk: A Drug-Wide Association Study (DWAS) in Norway 
Støer, Nathalie Charlotte; Botteri, Edoardo; Thoresen, G. Hege; Karlstad, Øystein; Weiderpass, Elisabete; Friis, Søren; Pottegård, Anton; Kulle, Bettina (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Background: Population-based pharmaco-epidemiologic studies are used to assess postmarketing drug safety and discover beneficial effects of off-label drug use. We conducted a drug-wide association study (DWAS) to screen ...
Maternal and paternal effects on offspring internalizing problems: Results from genetic and family-based analyses 
Jami, Eshim; Eilertsen, Espen Moen; Hammerschlag, Anke R.; Qiao, Zhen; Evans, David M.; Ystrøm, Eivind; Bartels, Meike; Middeldorp, Christel M. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
It is unclear to what extent parental influences on the development of internalizing problems in offspring are explained by indirect genetic effects, reflected in the environment provided by the parent, in addition to the ...
Liquid membrane in Electro Membrane Extraction 
Mehmood, Amir (Master thesis / Masteroppgave, 2020)
Summary of thesis EME is an emerging sample preparation technique and a supported liquid membrane (SLM) is an important part of it. In this literature-based study, organic solvents used as SLM was reviewed. Prior to ...
Epidemiology and Antimicrobial Susceptibility of Invasive Bacterial Infections in Children—A Population-Based Study From Norway 
Thaulow, Christian Magnus; Lindemann, Paul Christoffer; Klingenberg, Claus; Berild, Dag; Blix, Hege Salvesen; Myklebust, Tor Åge; Harthug, Stig (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Objective: To describe epidemiology and antimicrobial susceptibility testing (AST) data of bacteria causing invasive infections in Norwegian children (0–18 years). Methods: Population-based observational study ...
The Lactate Receptor HCA1 Is Present in the Choroid Plexus, the Tela Choroidea, and the Neuroepithelial Lining of the Dorsal Part of the Third Ventricle 
Hadzic, Alena; Nguyen, Teresa Dang; Hosoyamada, Makoto; Tomioka, Naoko H.; Bergersen, Linda Hildegard; Storm-Mathisen, Jon; Morland, Cecilie (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The volume, composition, and movement of the cerebrospinal fluid (CSF) are important for brain physiology, pathology, and diagnostics. Nevertheless, few studies have focused on the main structure that produces CSF, the ...
MogR is a ubiquitous transcriptional repressor affecting motility, biofilm formation and virulence in Bacillus thuringiensis 
Smith, Veronika; Josefsen, Malin; Lindbäck, Toril; Hegna, Ida Kristin; Finke, Sarah; Tourasse, Nicolas Jacques; Nielsen-LeRoux, Christina; Økstad, Ole Andreas; Fagerlund, Annette (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Flagellar motility is considered an important virulence factor in different pathogenic bacteria. In Listeria monocytogenes the transcriptional repressor MogR regulates motility in a temperature-dependent manner, directly ...
Photodynamic Efficacy of Cercosporin in 3D Tumor Cell Cultures 
Grigalavicius, Mantas; Mastrangelopoulou, Maria; Arous, Delmon; Juzeniene, Asta; Ménard, Mathilde; Skarpen, Ellen; Berg, Kristian; Theodossiou, Theodossis (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
In the present work, we study the photodynamic action of cercosporin (cerco), a naturally occurring photosensitizer, on human cancer multicellular spheroids. U87 spheroids exhibit double the uptake of cerco than T47D and ...
Five decades with grandparent donors: The Norwegian strategy and experience 
Bjerre, Anna Kristina; Mjøen, Geir; Line, Pål Dag; Naper, Christian; Reisæter, Anna Varberg; Åsberg, Anders (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Living donors (LDs) are preferred over DDs for renal transplantation in children due to superior GS. Oslo University Hospital has never restricted living donation by upper age. The aim of this study was to investigate ...
Validation of diagnostic utility of fasting plasma glucose and HbA1c in stable renal transplant recipients one year after transplantation 
Ussif, Amin M; Åsberg, Anders; Halden, Thea A S; Nordheim, Espen; Hartmann, Anders; Jenssen, Trond (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background The use of HbA1c ≥6.5% for diagnosis of diabetes has been challenged for post-transplantation diabetes mellitus (PTDM) also known as new onset diabetes after transplantation (NODAT) due to a low ...
Bruk av fluorokinoloner i sykehus – en prospektiv kartleggingsstudie Restricted Access
Andreassen, Vigdis (Master thesis / Masteroppgave, 2019)
Hensikt: Hensikten med denne studien var å kartlegge behandlings- og forskrivningstrender av fluorokinoloner ved Sykehuset Namsos, og videre kartlegge om valg av fluorokinoloner er i tråd med Nasjonal faglig retningslinje ...
AQP4 Expression and Distribution in Mice With Heterozygous Targeted Deletion of Aqp4 Restricted Access
Salameh, Maher Ayman (Master thesis / Masteroppgave, 2019)
Alternative Biosynthetic Starter Units Enhance the Structural Diversity of Cyanobacterial Lipopeptides 
Mareš, Jan; Hájek, Jan; Urajová, Petra; Kust, Andreja; Jokela, Jouni; Saurav, Kumar; Galica, Tomáš; Čapková, Kateřina; Mattila, Antti; Haapaniemi, Esa; Permi, Perttu; Mysterud, Ivar; Skulberg, Olav M.; Karlsen, Jan; Fewer, David P.; Sivonen, Kaarina; Tønnesen, Hanne Hjort; Hrouzek, Pavel (Journal article / Tidsskriftartikkel; Peer reviewed, 2019)
Puwainaphycins (PUWs) and minutissamides (MINs) are structurally analogous cyclic lipopeptides possessing cytotoxic activity. Both types of compound exhibit high structural variability, particularly in the fatty acid (FA) ...
Leger og legemiddelrelaterte oppgaver i akuttmottaket - En "time-motion" studie 
Tran, Therese (Master thesis / Masteroppgave, 2019)
Oslo-farmasøyters holdninger, erfaringer og kunnskaper vedrørende antibiotikabruk 
Hassan, Samya Khalid (Master thesis / Masteroppgave, 2019)
Sammendrag Bakgrunn: Antibiotikaresistens er et globalt problem i dag og settes på linje med for eksempel klimaendringsproblemet. Høyt forbruk av antibiotika (inkludert mye feilbruk) både til dyr og mennesker, den omfattende ...
4ß-Hydroxycholesterol as biomarker for variation in CYP3A activity 
Hole, Kristine (Doctoral thesis / Doktoravhandling, 2019)
Towards safer drug therapy and improved clinical outcomes in elderly and multimorbid patients 
Lea, Marianne (Doctoral thesis / Doktoravhandling, 2019)
Studying the effect of solubilizing agents on drug diffusion through the unstirred water layer (UWL) by localized spectroscopy 
Di Cagno, Massimiliano Pio; Stein, Paul C (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
An experimental/computational approach has been successfully applied in order to study the effect of solubilizing vehicles (cyclodextrins and liposomes) on the passive diffusion of four active pharmaceutical ingredients ...
Prevalence and risk factors of drug-related hospitalizations in multimorbid patients admitted to an internal medicine ward 
Lea, Marianne; Mowe, Morten; Mathiesen, Liv; Kvernrød, Kristin; Skovlund, Eva; Molden, Espen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background Knowledge of risk factors for drug-related hospitalizations (DRHs) is limited. Aim To examine the prevalence of DRHs and the relationships between DRHs and various variables in multimorbid patients admitted ...
Pektiner i tomat ved modning 
Houji, Maryam Jehad Khalil (Master thesis / Masteroppgave, 2019)
Tomat (Solanum lycopersicum L.) er en stor bærfrukt som har opprinnelse i Sør-Amerika. Tomatplanten ble innført til Europa på 1500-tallet og bruken av tomat som mat, er i dag verdensomspennende. I denne oppgave ble struktur- ...
Assessing methods for bioprospecting of marine algae for antimicrobial agents 
Kanaan, Chirine Issam (Master thesis / Masteroppgave, 2019)
For centuries, infectious diseases had a huge toll on the global mortality and morbidity rates. Antibiotics emergence was fundamental for the process of controlling, preventing and fighting infectious diseases, regardless ...
Developing a method to measure tacrolimus-induced tremor in kidney-transplant recipients 
Hovd, Markus Herberg (Master thesis / Masteroppgave, 2019)
Use and validity of child neurodevelopment outcome measures in studies on prenatal exposure to psychotropic and analgesic medications – A systematic review 
Andersen, Sarah Hjorth; Bromley, Rebecca; Ystrøm, Eivind; Lupattelli, Angela; Spigset, Olav; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
In recent years there has been increased attention to child neurodevelopment in studies on medication safety in pregnancy. Neurodevelopment is a multifactorial outcome that can be assessed by various assessors, using ...
Prenatal eksponering for metadon eller buprenorfin og effekt på proteiner viktige for læring og hukommelse. In vivo og ex vivo studier i rotte Restricted Access
Salih, Triske Woshyar (Master thesis / Masteroppgave, 2019)
Legemiddelassistert rehabilitering (LAR) er en behandling som tilbys pasienter med heroinavhengighet. Behandlingen ble tilgjengelig i Norge på 1990-tallet, og består i å erstatte heroin med et langtidsvirkende opioid. ...
Utvikling av elektromembranekstraksjon-chip koblet direkte til kapillærelektroforese 
Li, Marit (Master thesis / Masteroppgave, 2019)
I dette arbeidet har det blitt utviklet en thiol-ene basert mikrochip for elektromembranekstraksjon (EME) koblet direkte til kapillærelektroforese (CE) og UV-deteksjon. EME-chipen har potensial for framtidige analyser ...
Kort- og langtidseffekt av gastrisk bypass-operasjon på in vivo CYP3A-aktivitet i pasienter med sykelig overvekt Restricted Access
Ilyas, Maria (Master thesis / Masteroppgave, 2019)
The EKiTE network (epidemiology in kidney transplantation - a European validated database): an initiative epidemiological and translational European collaborative research 
Lorent, M.; Foucher, Y.; Kerleau, K.; Brouard, S.; Baayen, C.; Lebouter, S.; Naesens, M.; Bestard Matamoros, O.; Åsberg, A.; Giral, M. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background Kidney transplantation is considered to be the treatment of choice for people with end-stage renal disease (ESRD). However, due to the shortage of available organs and the increase in the ESRD ...
Risk perception, beliefs about medicines and medical adherence among pregnant and breastfeeding women with migraine: findings from a cross-sectional study in Norway 
Amundsen, Siri; Øvrebø, Torunn Gudmestad; Amble, Netta Marie Skretteberg; Poole, Anne Christine; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Objectives To examine risk perception, beliefs about migraine medications and medical adherence among pregnant and breastfeeding women with migraine. Design and setting Cross-sectional study conducted in Norway from ...
Nye sink-chelaterende forbindelser som mulige nye legemidler mot antibiotisk resistens (ZinChel) Restricted Access
Mørk, Marie Hermansen (Master thesis / Masteroppgave, 2019)
Micellisation Mechanism and Behaviour of Soluplus®–Furosemide Micelles: Preformulation Studies of an Oral Nanocarrier-Based System 
Alopaeus, Julia Fredrika; Hagesæther, Ellen; Tho, Ingunn (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
In this study, self-assembling Soluplus® micelles were examined for inherent properties. Through calorimetric analysis, the critical micelle concentration (CMC) could be determined at 25 and 37 °C, and the influence of ...
Synthetic Studies Towards an Analog of the Specialized Pro-resolving Mediator RvD1n-3 DPA Restricted Access
Reinertsen, Amalie Føreid (Master thesis / Masteroppgave, 2019)
The synthesis of a hitherto unknown fatty acid analog presented in this thesis is based on the initial synthesis of two main fragments, termed the α- and the ω-fragment, respectively. The analog is then to be assembled by ...
Skjelettmuskelceller isolert fra musculus vastus lateralis og musculi interspinales har ulike egenskaper i kultur 
Spiering, Lisa (Master thesis / Masteroppgave, 2019)
Bakgrunn: Humane skjelettmuskelceller i kultur dyrkes fra satellittceller isolert fra muskelbiopsier. I hvilken grad type muskel in vivo betyr noe for fenotype av muskelceller in vitro har tidligere vært lite studert. ...
Interaction between dietary fatty acids and genotype on immune response in Atlantic salmon (Salmo salar) after vaccination: Atranscriptome study 
Andresen, Adriana Magalhaes Santos; Lutfi Royo, Esmail; Ruyter, Bente; Berge, Gerd Marit; Gjøen, Tor (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
A pivotal matter to aquaculture is the sourcing of sustainable resources as ingredients to aquafeeds. Levels of plant delivered oils as source of fatty acids (FA) in aquafeeds have reached around 70% resulting in reduced ...
The influence of bariatric surgery on oral drug bioavailability in patients with obesity: A systematic review 
Angeles, Philip Carlo Soriano; Robertsen, Ida; Seeberg, Lars Thomas; Krogstad, Veronica; Skattebu, Julie; Sandbu, Rune; Åsberg, Anders; Hjelmesæth, Jøran (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Anatomical changes in the gastrointestinal tract and subsequent weight loss may influence drug disposition and thus drug dosing following bariatric surgery. This review systematically examines the effects of bariatric ...
Knowledge of antibiotics and antibiotic resistance among Norwegian pharmacy customers – a cross-sectional study 
Waaseth, Marit; Adan, Abdifatah; Røen, Ingrid L; Eriksen, Karoline; Stanojevic, Tijana; Halvorsen, Kjell H; Garcia, Beate H; Holst, Lone; Ulshagen, Karen M; Blix, Hege S; Ariansen, Hilde; Nordeng, Hedvig M (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background Antibiotic resistance is a global health threat. Public knowledge is considered a prerequisite for appropriate use of antibiotics and limited spread of antibiotic resistance. Our aim was to examine ...
Thyroid hormone replacement therapy during pregnancy – Quantifying medication patterns and associated outcomes in the offspring 
Frank, Anna-Simone Josefine (Doctoral thesis / Doktoravhandling, 2019)
Hypothyroidism is a thyroid dysfunction defined by inadequate production of thyroid hormones. This dysfunction is common (3%) in pregnant women and women of reproductive age. When the condition occurs during pregnancy, the ...
Funksjonen til Plin2 i muskel og lever Restricted Access
Ali, Jasmin (Master thesis / Masteroppgave, 2019)
Adipokine levels are associated with insulin resistance in antipsychotics users independently of BMI 
Vedal, Trude Seselie Jahr; Steen, Nils Eiel; Birkeland, Kåre I.; Dieset, Ingrid; Reponen, Elina Johanna; Laskemoen, Jannicke F.; Rødevand, Linn; Melle, Ingrid; Andreassen, Ole Andreas; Molden, Espen; Jönsson, Erik Gunnar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background The prevalence of obesity, metabolic syndrome and type 2 diabetes mellitus is increased among patients with severe mental disorders, and particularly use of second generation antipsychotic drugs is associated ...
Kan inhalasjonsveiledning og utskrivningstjeneste for kolspasienter på Lungemedisinsk sengepost bidra til færre reinnleggelser? - En pilotstudie Restricted Access
Kebede, Adyam Tesfamariam (Master thesis / Masteroppgave, 2019)
Pharmacokinetic challenges in renal replacement therapy 
Egeland, Erlend Johannessen (Doctoral thesis / Doktoravhandling, 2019)
Patients with end-stage renal disease (ESRD) are treated with renal replacement therapy (RRT), which consist of either dialysis or renal transplantation. Pharmacological therapy is essential for these patients, but can be ...
Formation and Duration of Pluronic Gels at Different Conditions 
Saxegaard, Embla Marie (Master thesis / Masteroppgave, 2019)
Uaktuelle og doble resepter i Reseptformidleren "Pasientens legemiddelliste" som en mulig fremtidig løsning 
Dimitrijevic, Tijana (Master thesis / Masteroppgave, 2019)
Sammendrag Bakgrunn: Innføring av e-resept i 2011 har bidratt til en effektiv samhandling mellom pasient, behandlere og apotek. Imidlertid har det blitt identifisert et økende antall doble og uaktuelle resepter i den ...
Gellan Gum/Laponite Beads for the Modified Release of Drugs: Experimental and Modeling Study of Gastrointestinal Release 
Adrover, Alessandra; Paolicelli, Patrizia; Petralito, Stefania; Di Muzio, Laura; Trilli, Jordan; Cesa, Stefania; Tho, Ingunn; Casadei, Maria Antonietta (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
In this study, gellan gum (GG), a natural polysaccharide, was used to fabricate spherical porous beads suitable as sustained drug delivery systems for oral administration. GG was cross-linked with calcium ions to prepare ...
INHALASJONSVEILEDNING I APOTEK «Er det variasjon i tjenestefarmasøyters bedømmelse av inhalasjonsteknikk?» Restricted Access
Rosic, Vedrana (Master thesis / Masteroppgave, 2019)
The contribution of 6-acetylmorphine to heroin-induced effects: Studies of pharmacokinetics, behavior and immunotherapeutic intervention using a monoclonal antibody in mice 
Kvello, Anne Marte Sjursen (Doctoral thesis / Doktoravhandling, 2019)
Heroin is one of the most addictive drugs of abuse, but heroin itself is considered an inactive prodrug which acts mainly through its metabolites. The work of this doctoral thesis highlights the role of heroin’s first ...
Samfunnservervet pneumoni ved St. Olavs hospital HF - Kartleggingsstudie for 2018 
Bakkene, Birgitte (Master thesis / Masteroppgave, 2019)
Bakgrunn Samfunnservervet pneumoni (CAP) er en infeksjon i de nedre luftveiene, ervervet utenfor sykehus eller annen helseinstitusjon, eller innenfor 48 timer etter sykehusinnleggelse. CAP rammer ca. 1 % av den vestlige ...
Formulering og fremstilling av fluorholdige liposomer til potensiell bruk i karies- og erosjonsprofylakse Restricted Access
Cuk, Ana (Master thesis / Masteroppgave, 2019)
Kan veiledning i bruk av inhalasjonslegemidler påvirke symptombyrde og inhalasjonsteknikk hos personer med kols innlagt på sengepost? - En randomisert, kontrollert pilotstudie 
Bjørndal, Johanne Sve (Master thesis / Masteroppgave, 2019)
INTRODUKSJON: Kronisk obstruktiv lungesykdom (kols) er en alvorlig sykdom forbundet med mange symptomer. Inhalasjonspreparater er førstevalget i behandling av kols. Det er svært viktig med korrekt inhalasjonsteknikk for å ...
Microsampling i kombinasjon med tryptisk proteolyse og epitopfisking før LC-MS/MS analyse 
Ngo, Huan Bao (Master thesis / Masteroppgave, 2019)
New prodrugs of the natural product myxin as new potential drugs against acute myeloid leukemia (AML) 
Pham, Aina Kristin (Master thesis / Masteroppgave, 2019)
The edible mushroom Albatrellus ovinus contains a α-L-fuco-α-D-galactan, α-D-glucan, a branched (1→6)-β-D-glucan and a branched (1→3)-β-D-glucan 
Samuelsen, Anne Berit C.; Rise, Frode; Wilkins, Alistair L.; Teveleva, Lioubov; Nyman, Anna Armika Tussilago; Aachmann, Finn Lillelund (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Albatrellus ovinus, the sheep polypore, is a large, dense mushroom being rich in cell wall material. Polysaccharides were isolated by sequential extraction, enzymatic treatment and analyzed with respect to monosaccharide ...
Investigations in cultured rat neurons of acute oxaliplatin and pregabalin effects on intracellular calcium and role of Transient Receptor Potential cold sensors Restricted Access
Torihi, Azadeh (Master thesis / Masteroppgave, 2019)
Impact of prenatal exposure to benzodiazepines and z-hypnotics on behavioral problems at 5 years of age: A study from the Norwegian Mother and Child Cohort Study 
Sundbakk, Lene Maria; Wood, Mollie; Gran, Jon Michael; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Many women experience anxiety or sleep disorders during pregnancy and require pharmacological treatment with benzodiazepines (BZDs) or z-hypnotics. Limited information is currently available on how prenatal exposure to ...
Gonadotrope plasticity at cellular, population and structural levels: A comparison between fishes and mammals 
Fontaine, Romain David; Ciani, Elia; Haug, Trude M; Hodne, Kjetil; Ager-Wick, Eirill; Baker, Dianne; Weltzien, Finn-Arne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Often referred to as “the master gland”, the pituitary is a key organ controlling growth, maturation, and homeostasis in vertebrates. The anterior pituitary, which contains several hormone-producing cell types, is highly ...
Properties of glutamate receptor subunit GluN2B antagonists and effects of prenatal opioid exposure: Studies in chicken and rat 
Fjelldal, Marthe Fredheim (Doctoral thesis / Doktoravhandling, 2019)
The NMDA-receptor is a central part of the machinery that enables us to learn, form memories and develop a normal brain. It is expressed all over the central nervous system and is responsible for signalling between nerve ...
Prenatal paracetamol exposure and neurodevelopmental outcomes in preschool-aged children 
Trønnes, Johanne Naper; Wood, Mollie; Lupattelli, Angela; Ystrøm, Eivind; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background Recent studies have suggested an association between prenatal paracetamol exposure and adverse neurodevelopmental outcomes in children. However, these findings may be confounded by unmeasured factors related ...
Pharmacokinetics of a novel, approved, 1.4-mg intranasal naloxone formulation for reversal of opioid overdose—a randomized controlled trial 
Skulberg, Arne Kristian; Åsberg, Anders; Zare, Hasse Khiabani; Røstad, Hilde; Tylleskär, Ida; Dale, Ola (Journal article / Tidsskriftartikkel / SubmittedVersion, 2019)
Background and aims Intranasal (i.n.) naloxone is an established treatment for opioid overdose. Anyone likely to witness an overdose should have access to the antidote. We aimed to determine whether an i.n. formulation ...
Can screening tools for potentially inappropriate prescriptions in older adults prevent serious adverse drug events? 
Wang-Hansen, Marte Sofie; Wyller, Torgeir Bruun; Hvidsten, Lara H. Thomasgaard; Kersten, Hege (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Purpose The purpose of the study is to identify and explore risk factors of serious adverse drug events (SADE) and SADE-related admissions in acutely hospitalized multimorbid older adults and assess whether these could ...
Maternal thyroid hormone replacement therapy exposure and language and communication skills of offspring at 8 years of age 
Frank, Anna-Simone; Lupattelli, Angela; Brandlistuen, Ragnhild Eek; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Importance: Hypothyroidism during pregnancy is associated with neurodevelopmental delays in the offspring. However, it remains unknown whether prenatal thyroid hormone replacement therapy (THRT) has benefits regarding ...
Data-Independent Acquisition for the Orbitrap Q Exactive HF: A Tutorial. 
Reubsaet, Leon; Sweredoski, Michael J.; Moradian, Annie (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Data-independent acquisition (DIA) is a powerful mass spectrometric technique to perform both protein identification and quantification of complex protein samples. Setting up DIA methods on Orbitrap analyzers requires a ...
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