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Exposure to human relevant mixtures of halogenated persistent organic pollutants (POPs) alters neurodevelopmental processes in human neural stem cells undergoing differentiation 
Davidsen, Nichlas; Lauvås, Anna Jacobsen; Myhre, Oddvar; Ropstad, Erik; Carpi, Donatella; Mendoza-de Gyves, Emilio; Berntsen, Hanne Friis; Dirven, Hubert; Paulsen, Ragnhild Elisabeth; Bal-Price, Anna; Pistollato, Francesca (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Halogenated persistent organic pollutants (POPs) like perfluorinated alkylated substances (PFASs), brominated flame retardants (BFRs), organochlorine pesticides and polychlorinated biphenyls (PCBs) are known to cause cancer, ...
A mouth rinse based on a tea solution of Salvia officinalis for oral discomfort in palliative cancer care: A randomized controlled trial 
Monsen, Ragnhild Elisabeth; Herlofson, Bente Brokstad; Gay, Caryl; Fjeld, Katrine Gahre; Hove, Lene Hystad; Malterud, Karl Egil; Saghaug, Elisabeth; Slaaen, Joran; Sundal, Tone; Tollisen, Anita; Lerdal, Anners (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background: Few clinical studies evaluate interventions to reduce oral discomfort among patients in palliative care. Aim: This study examines the efficacy of a Salvia officinalis (SO) based herbal mouth rinse compared to ...
Interactions of natural deep eutectic solvents (NADES) with artificial and natural membranes 
Nystedt, Helene Liepelt; Grønlien, Krister Gjestvang; Tønnesen, Hanne Hjorth (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Natural deep eutectic solvents (NADES) are a third type of liquids, apart from water and lipids. NADES show promise as drug carriers in dermal formulations or formulations for local administration in the oral cavity due ...
Effects of a human-based mixture of persistent organic pollutants on the in vivo exposed cerebellum and cerebellar neuronal cultures exposed in vitro 
Berntsen, Hanne Friis; Duale, Nur; Bjørklund, Cesilie Granum; Rangel-Huerta, Oscar Daniel; Dyrberg, Kine; Hofer, Tim; Rakkestad, Kirsten Eline; Østby, Gunn Charlotte; Halsne, Ruth; Boge, Gudrun Seeberg; Paulsen, Ragnhild Elisabeth; Myhre, Oddvar; Ropstad, Erik (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Exposure to persistent organic pollutants (POPs), encompassing chlorinated (Cl), brominated (Br) and perfluoroalkyl acid (PFAA) compounds is associated with adverse neurobehaviour in humans and animals, and is observed to ...
The effect of a pharmacist consultation on pregnant women’s quality of life with a special focus on nausea and vomiting: an intervention study 
Truong, Maria B; Ngo, Elin; Ariansen, Hilde; Tsuyuki, Ross T; Nordeng, Hedvig (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Maternal wellbeing and quality of life (QOL) are increasingly being recognized as important for healthy pregnancies. The aim of this study was to investigate the impact of a pharmacist consultation ...
Comparison of anticoagulant rodenticide concentrations in liver and feces from apparently healthy red foxes 
Seljetun, Kristin Opdal; Sandvik, Morten; Vindenes, Vigdis; Eliassen, Elin; Øiestad, Elisabeth Leere; Madslien, Knut Ivar Engesæter; Moe, Lars (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Exposure of wildlife and domestic animals to anticoagulant rodenticides (ARs) is a worldwide concern, but few methods exist to determine residue levels in live animals. Traditional liver detection methods preclude determining ...
Thyroid hormone replacement therapy patterns in pregnant women and perinatal outcomes in the offspring 
Frank, Anna-Simone; Lupattelli, Angela; Matteson, David S.; Meltzer, Helle Margrete; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Purpose It remains unknown to what degree thyroid hormone replacement therapy (THRT) during and initiation after pregnancy determines pregnancy outcomes. The present study primarily aimed to quantify the impact of THRT ...
3D cell culture models and organ-on-a-chip: Meet separation science and mass spectrometry 
Lin, Ann; Skottvoll, Frøydis Sved; Rayner, Simon; Pedersen-Bjergaard, Stig; Sullivan, Gareth; Krauss, Stefan; Wilson, Steven Ray Haakon; Harrison, Sean (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
In vitro derived simplified 3D representations of human organs or organ functionalities are predicted to play a major role in disease modeling, drug development, and personalized medicine, as they complement traditional ...
Legumain in Acute Coronary Syndromes: A Substudy of the PLATO (Platelet Inhibition and Patient Outcomes) Trial 
Gregersen, Ida; Michelsen, Annika; Lunde, Ngoc Nguyen; Åkerblom, Axel; Lakic, Tatevik G.; Skjelland, Mona; Skagen, Karolina Ryeng; Becker, Richard C.; Lindbäck, Johan; Himmelmann, Anders; Solberg, Rigmor; Johansen, Harald Thidemann; James, Stefan K.; Siegbahn, Agneta; Storey, Robert F.; Kontny, Frederic; Aukrust, Pål; Ueland, Thor; Wallentin, Lars; Halvorsen, Bente (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background The cysteine protease legumain is increased in patients with atherosclerosis, but its causal role in atherogenesis and cardiovascular disease is still unclear. The aim of the study was to investigate the ...
Sleep problems and depressive symptoms in toddlers and 8-year-old children: A longitudinal study 
Sivertsen, Børge; Harvey, Allison G.; Reichborn-Kjennerud, Ted; Ystrøm, Eivind; Hysing, Mari (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Sleep and depression are interlinked throughout the lifespan, but very few studies have examined the directionality of the sleep–depression link in children. The aim of the current study was to prospectively examine the ...
Diagnostic tests and treatment procedures performed prior to cardiovascular death in individuals with severe mental illness 
Heiberg, Ina Heidi; Nesvåg, Ragnar; Balteskard, Lise; Bramness, Jørgen Gustav; Hultman, Christina M.; Næss, Øyvind; Reichborn-Kjennerud, Ted; Ystrøm, Eivind; Jacobsen, Bjarne K.; Høye, Anne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Objective To examine whether severe mental illnesses (i.e., schizophrenia or bipolar disorder) affected diagnostic testing and treatment for cardiovascular diseases in primary and specialized health care. Methods We ...
Treatment of human skeletal muscle cells with inhibitors of diacylglycerol acyltransferases 1 and 2 to explore isozyme-specific roles on lipid metabolism. 
Thoresen, Hege; Kase, Eili Tranheim; Skagen, Christine (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Diacylglycerol acyltransferases (DGAT) 1 and 2 catalyse the final step in triacylglycerol (TAG) synthesis, the esterification of fatty acyl-CoA to diacylglycerol. Despite catalysing the same reaction and being present in ...
Rheumatoid Arthritis Patients, Both Newly Diagnosed and Methotrexate Treated, Show More DNA Methylation Differences in CD4+ Memory Than in CD4+ Naïve T Cells 
Guderud, Kari; Sunde, Line Hagen; Flåm, Siri Tennebø; Mæhlen, Marthe Thoresen; Mjaavatten, Maria Dahl; Lillegraven, Siri; Aga, Anna-Birgitte; Evenrød, Ida Marie; Norli, Ellen Sauar; Andreassen, Bettina Kulle; Franzenburg, Sören; Franke, Andre; Haavardsholm, Espen Andre; Rayner, Simon; Gervin, Kristina; Lie, Benedicte Alexandra (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background: Differences in DNA methylation have been reported in B and T lymphocyte populations, including CD4+ T cells, isolated from rheumatoid arthritis (RA) patients when compared to healthy controls. CD4+ T cells are ...
Preterm birth and risk for language delays before school entry: A sibling-control study 
Zambrana, Imac Maria; Vollrath, Margarete Erika Maria Torgerse; Jacobsson, Bo; Sengpiel, Verena; Ystrøm, Eivind (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
We investigated whether children born preterm are at risk for language delay using a sibling-control design in the Norwegian Mother and Child Cohort Study (MoBa), conducted by the Norwegian Institute of Public Health. ...
The role of 6-acetylmorphine in heroin-induced reward and locomotor sensitization in mice 
Kvello, Anne Marte Sjursen; Andersen, Jannike Mørch; Boix, Fernando; Mørland, Jørg; Bogen, Inger Lise (Journal article / Tidsskriftartikkel / SubmittedVersion, 2020)
We have previously demonstrated that heroin's first metabolite, 6‐acetylmorphine (6‐AM), is an important mediator of heroin's acute effects. However, the significance of 6‐AM to the rewarding properties of heroin still ...
The cure model in perinatal epidemiology 
Stoltenberg, Emil Aas; Nordeng, Hedvig Marie Egeland; Ystrøm, Eivind; Samuelsen, Sven Ove (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
In the statistical literature, the class of survival analysis models known as cure models has received much attention in recent years. Cure models seem not, however, to be part of the statistical toolbox of perinatal ...
Measured GFR by Utilizing Population Pharmacokinetic Methods to Determine Iohexol Clearance 
Åsberg, Anders; Bjerre, Anna Kristina; Almaas, Runar; Luis-Lima, Sergio; Robertsen, Ida; Salvador, Cathrin Lytomt; Porrini, Esteban; Schwartz, George; Hartmann, Anders; Bergan, Stein (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Introduction There is an increasing demand for accurately measured glomerular filtration rate (GFR). Iohexol serum clearance has become a new gold standard, but it is challenging when GFR is low and 24-hour sampling is ...
Phenotypic Characterization of Larval Zebrafish (Danio rerio) with Partial Knockdown of the cacna1a Gene 
Gawel, Kinga Aurelia; Turski, Waldemar A.; van der Ent, Wietske; Mathai, Benan John; Kirstein-Smardzewska, Karolina Joanna; Simonsen, Anne; Esguerra, Camila V. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The CACNA1A gene encodes the pore-forming α1 subunit of voltage-gated P/Q type Ca2+ channels (Cav2.1). Mutations in this gene, among others, have been described in patients and rodents suffering from absence seizures and ...
Association of coincident self-reported mental health problems and alcohol intake with all-cause and cardiovascular disease mortality: A Norwegian pooled population analysis 
Degerud, Eirik Magnus Meek; Høiseth, Gudrun; Mørland, Jørg Gustav; Ariansen, Inger; Graff-Iversen, Sidsel; Ystrøm, Eivind; Zuccolo, Luisa; Næss, Øyvind (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background The disease burden attributable to mental health problems and to excess or harmful alcohol use is considerable. Despite a strong relationship between these 2 important factors in population health, there are ...
ZN148 Is a Modular Synthetic Metallo-beta-Lactamase Inhibitor That Reverses Carbapenem Resistance in Gram-Negative Pathogens In Vivo 
Samuelsen, Ørjan; Åstrand, Ove Alexander Høgmoen; Frøhlich, Christopher; Heikal, Adam; Skagseth, Susann; Carlsen, Trine Josefine Olsen; Leiros, Hanna-Kirsti S.; Bayer, Annette; Schnaars, Christian; Kildahl-andersen, Geir; Lauksund, Silje; Finke, Sarah; Huber, Sandra; Gjøen, Tor; Andresen, Adriana Magalhaes Santos; Økstad, Ole Andreas; Rongved, Pål (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Carbapenem-resistant Gram-negative pathogens are a critical public health threat and there is an urgent need for new treatments. Carbapenemases (β-lactamases able to inactivate carbapenems) have been identified in both ...
Prenatal exposure to methadone or buprenorphine alters µ-opioid receptor binding and downstream signaling in the rat brain 
Kongstorp, Mette; Bogen, Inger Lise; Steinsland, Synne; Nerem, Elisabeth; Salih, Triske Woshyar; Stiris, Tom; Andersen, Jannike Mørch (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
There is a growing concern related to the use of opioid maintenance treatment during pregnancy. Studies in both humans and animals have reported reduced cognitive functioning in offspring prenatally exposed to methadone ...
Comparing Two Methods of Tablet Manipulation to Adjust the Warfarin Dose in Paediatric Care 
Brustugun, Jørgen; Aas, Elisabeth Birkedal; Tho, Ingunn; Bjerknes, Kathrin (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Tablets containing prescribed doses are not always available, and this is of particular importance in paediatric care where suitable age-appropriate formulations are generally lacking. To obtain a child-adjusted dose, ...
Synthesis and Biological Evaluation of Analogs of Didehydroepiandrosterone as Potential New Anticancer Agents 
J Solum, Eirik; Liekens, Sandra; Hansen, Trond Vidar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The synthesis, cytotoxicity and inhibition of CDK8 by thirteen analogs of cortistatin A are reported. These efforts revealed that the analogs with either a 6- or 7-isoquinoline or 5-indole side chain in the 17-position are ...
Mechanisms linking parental educational attainment with child ADHD, depression, and academic problems: a study of extended families in The Norwegian Mother, Father and Child Cohort Study 
Torvik, Fartein Ask; Eilertsen, Espen Moen; McAdams, Tom A.; Gustavson, Kristin; Zachrisson, Henrik Daae; Brandlistuen, Ragnhild Eek; Gjerde, Line C.; Havdahl, Alexandra; Stoltenberg, Camilla; Ask, Helga; Ystrøm, Eivind (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Low educational attainment in parents is associated with child psychopathology. It is not clear whether the associations are due to risk factors that family members share or due to effects of maternal or ...
Legumain is upregulated in acute cardiovascular events and associated with improved outcome – potentially related to anti-inflammatory effects on macrophages 
Lunde, Ngoc Dieu Nguyen; Gregersen, Ida; Ueland, Thor; Shetelig, Christian; Holm, Sverre; Kong, Xiang Yi; Michelsen, Annika; Otterdal, Kari; Yndestad, Arne; Broch, Kaspar; Gullestad, Lars; Nyman, Tuula Anneli; Bendz, Bjørn; Eritsland, Jan; Hoffmann, Pavel; Skagen, Karolina Ryeng; Gonçalves, Isabel; Nilsson, Jan; Grenegård, Magnus; Poreba, Marcin; Drag, Marcin; Seljeflot, Ingebjørg; Sporsheim, Bjørnar; Espevik, Terje; Skjelland, Mona; Johansen, Harald Thidemann; Solberg, Rigmor; Aukrust, Pål; Björbacka, Harry; Andersen, Geir Øystein; Halvorsen, Bente (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background and aims We have previously found increased levels of the cysteine protease legumain in plasma and plaques from patients with carotid atherosclerosis. This study further investigated legumain during acute ...
Y-site physical compatibility of Numeta G13E with drugs frequently used at Neonatal Intensive Care 
Nezvalova-henriksen, Katerina; Østerberg, Camilla Tomine; Nilsson, Niklas; Staven Berge, Vigdis; Tho, Ingunn (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Preterm neonates require parenteral nutrition (PN) in addition to intravenous drug therapy. Due to limited venous access, drugs are often co-administered with PN via the same lumen. If incompatible, precipitation and ...
How important are parents in the development of child anxiety and depression? A genomic analysis of parent-offspring trios in the Norwegian Mother Father and Child Cohort Study (MoBa) 
Cheesman, Rosa; Eilertsen, Espen M; Ahmadzadeh, Yasmin I; Gjerde, Line C; Hannigan, Laurie J; Havdahl, Alexandra; Young, Alexander I; Eley, Thalia C; Njølstad, Pål R; Magnus, Per; Andreassen, Ole A; Ystrom, Eivind; McAdams, Tom A (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Many studies detect associations between parent behaviour and child symptoms of anxiety and depression. Despite knowledge that anxiety and depression are influenced by a complex interplay of genetic and environmental ...
Determination of anticoagulant rodenticides in faeces of exposed dogs and in a healthy dog population 
Seljetun, Kristin O; Vindenes, Vigdis; Øiestad, Elisabeth L; Brochmann, Gerd-Wenche; Eliassen, Elin; Moe, Lars (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Exposure to anticoagulant rodenticides (ARs) in dogs is among the most common causes of poisoning in small animal practice, but information about toxicokinetic of these rodenticides in dogs is lacking. We ...
Potentially inappropriate prescribing to older patients receiving multidose drug dispensing 
Josendal, Anette V; Bergmo, Trine S; Granas, Anne G (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Multidose drug dispensing (MDD) is an adherence aid that provides patients with machine-dispensed medicines in disposable unit bags, usually for a 14 day period. Previous studies have suggested that the quality ...
Non-prescription purchase of antibiotics during travel abroad among a general adult population in Norway: Findings from the seventh Tromsø Study 
Gravningen, Kirsten Midttun; Field, Nigel; Blix, Hege Salvesen; Asfeldt, anne mette; Småbrekke, Lars (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Non-prescription purchase of antibiotics is undesirable and has not recently been investigated in a representative population in a high-income low-use country during travel abroad. This study examined ...
Pharmacological Validation of the Prepulse Inhibition of Startle Response in Larval Zebrafish using a Commercial Automated System and Software 
Banono, Nancy Saana; Esguerra, Camila (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
While there is an abundance of commercial and standardized automated systems and software for performing the prepulse inhibition (PPI) assay in rodents, to the best of our knowledge, all PPI assays performed in the zebrafish ...
New CDK8 inhibitors as potential anti-leukemic agents – Design, synthesisand biological evaluation 
Solum, Eirik Johansson; Hansen, Trond Vidar; Aesoy, Reidun; Herfindal, Lars (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Cyclin-dependent kinase 8 (CDK8) plays a vital role in regulating cell transcription either through its association with the mediator complex or by the phosphorylation of transcription factors. CDK8-mediated activation of ...
The PPAR Ω Pocket: Renewed Opportunities for Drug Development 
Kaupang, Åsmund; Hansen, Trond Vidar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The past decade of PPARγ research has dramatically improved our understanding of the structural and mechanistic bases for the diverging physiological effects of different classes of PPARγ ligands. The discoveries that lie ...
Identifying targets for antibiotic stewardship interventions through analysis of the antibiotic prescribing process in hospitals - a multicentre observational cohort study 
Wathne, Jannicke S; Skodvin, Brita; Charani, Esmita; Harthug, Stig; Blix, Hege S; Nilsen, Roy M; Kleppe, Lars K S; Vukovic, Marta; Smith, Ingrid (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background In order to change antibiotic prescribing behaviour, we need to understand the prescribing process. The aim of this study was to identify targets for antibiotic stewardship interventions in ...
Extending balance assessment for the generalized propensity score under multiple imputation 
Frank, Anna-Simone; Matteson, David S.; Solvang, Hiroko Kato; Lupattelli, Angela; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
This manuscript extends the definition of the Absolute Standardized Mean Difference (ASMD) for binary exposure (M = 2) to cases for M > 2 on multiple imputed data sets. The Maximal Maximized Standardized Difference (MMSD) ...
Dendritic localization and exocytosis of NAAG in the rat hippocampus 
Nordengen, Kaja; Morland, C; Slusher, B.S.; Gundersen, V (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
While a lot is known about classical, anterograde neurotransmission, less is known about the mechanisms and molecules involved in retrograde neurotransmission. Our hypothesis is that N-acetylaspartylglutamate (NAAG), the ...
Medication-related problems among hospitalized pregnant women in a tertiary teaching hospital in Ethiopia: a prospective observational study 
Ahmed, Seid M; Sundby, Johanne; Aragaw, Yesuf A; Nordeng, Hedvig (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Studies on medication-related problems (MRPs) among pregnant women are scarce, despite the potential consequences for both mother and child. This study aimed to describe the prevalence, clinical significance, ...
Pharmacists’ experience of a diabetes risk-assessment service and analytical quality control in community pharmacies : a focus-group study 
Risøy, Aslaug Johanne; Kjome, Reidun Lisbet Skeide; Svensberg, Karin; Råheim, Målfrid; Sølvik, Una Ørvim (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Healthcare services such as diabetes risk-assessment are increasingly common in community pharmacies. Knowledge of community pharmacists’ experiences of such services could ease the implementation of a larger-scale ...
Use of Antidepressants in Older People during a 10-Year Period: An Observational Study on Prescribed Doses and Serum Levels 
Tveit, Kristine; Hermann, Monica; Waade, Ragnhild Birkeland; Nilsen, Roy Miodini; Wallerstedt, Susanna M.; Molden, Espen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background According to previous studies, older patients frequently have serum concentrations of antidepressant medication above the recommended reference range. Objective The aim of this study was to investigate ...
Substrate oxidation in primary human skeletal muscle cells is influenced by donor age 
Aas, Vigdis; Thoresen, G. Hege; Rustan, Arild; Lund, Jenny (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Abstract Primary human myotubes represent an alternative system to intact skeletal muscle for the study of human diseases related to changes in muscle energy metabolism. This work aimed to study if fatty acid and glucose ...
Impact of age and CYP2D6 genotype on exposure of zuclopenthixol in patients using long-acting injectable versus oral formulation-an observational study including 2044 patients 
Tveito, Marit; Smith, Robert Løvsletten; Molden, Espen; Høiseth, Gudrun (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Purpose Zuclopenthixol is an antipsychotic available as oral and long-acting injectable (LAI) formulations. The aim of this study was to investigate the effect of age on zuclopenthixol exposure during oral and LAI ...
Impact of mucin on drug diffusion: Development of a straightforward in vitro method for the determination of drug diffusivity in the presence of mucin 
Falavigna, Margherita; Stein, Paul C.; Flaten, Gøril Eide; Di Cagno, Massimiliano Pio (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Mucosal drug delivery accounts for various administration routes (i.e., oral, vaginal, ocular, pulmonary, etc.) and offers a vast surface for the permeation of drugs. However, the mucus layer which shields and lubricates ...
Perfluoroalkyl acids potentiate glutamate excitotoxicity in rat cerebellar granule neurons 
Berntsen, Hanne Friis; Moldes-Anaya, Angel; Bjørklund, Cesilie Granum; Ragazzi, Lorenzo; Haug, Trude M; Strandabø, Rønnaug; Verhaegen, Steven; Paulsen, Ragnhild Elisabeth; Ropstad, Erik; Tasker, Andrew (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Perfluoroalkyl acids (PFAAs) are persistent man-made chemicals, ubiquitous in nature and present in human samples. Although restrictions are being introduced, they are still used in industrial processes as well as in ...
Proteomics‐informed prediction of rosuvastatin plasma profiles in patients with a wide range of body weight 
Wegler, Christine; Garcia, Luna Prieto; Klinting, Signe; Robertsen, Ida; Wisniewski, Jacek R.; Hjelmesæth, Jøran; Åsberg, Anders; Jansson-Löfmark, Rasmus; Andersson, Tommy B.; Artursson, Per (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Complex Temperature and Concentration Dependent Self-Assembly of Poly(2-oxazoline) Block Copolymers 
Che, Loan Trinh; Hiorth, Marianne; Hoogenboom, Richard; Kjøniksen, Anna-Lena (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The effect of polymer concentration on the temperature-induced self-association of a block copolymer comprising a poly(2-ethyl-2-oxazoline) block and a random copolymer block consisting of 2-ethyl-2-oxazoline and ...
Fertility treatment and oral contraceptive discontinuation for identification of pregnancy planning in routinely collected health data – an application to analgesic and antibiotic utilisation 
Hjorth, Sarah; Wood, Mollie; Tauqeer, Fatima; Nordeng, Hedvig (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Women with unplanned pregnancies use folic acid less frequently, and more often use potentially teratogenic medications in the first trimester. Yet most studies based on routinely collected data lack information ...
Identification of a novel polymorphism associated with reduced clozapine concentration in schizophrenia patients—a genome-wide association study adjusting for smoking habits 
Smith, Robert Løvsletten; O’Connell, Kevin; Athanasiu, Lavinia; Djurovic, Srdjan; Kringen, Marianne K.; Andreassen, Ole Andreas; Molden, Espen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Abstract Clozapine (CLZ) is the superior antipsychotic drug for treatment of schizophrenia, but exhibits an extensive interpatient pharmacokinetic variability. Here, we conducted a genome-wide association study ...
Solid lipid nanoparticle-loaded mucoadhesive buccal films – Critical quality attributes and in vitro safety & efficacy 
Tzanova, Martina; Hagesaether, Ellen; Tho, Ingunn (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The objective of this work was to develop and characterize solid lipid nanoparticle (SLN)-loaded mucoadhesive films to reveal their potential as successful drug formulations. SLNs based on lipid (Lipoid S100) and surfactant ...
Blood-based epigenetic estimators of chronological age in human adults using DNA methylation data from the Illumina MethylationEPIC array 
Lee, Yunsung; Haftorn, Kristine L; Denault, William R P; Nustad, Haakon E; Page, Christian M; Lyle, Robert; Lee-Ødegård, Sindre; Moen, Gunn-Helen; Prasad, Rashmi B; Groop, Leif C; Sletner, Line; Sommer, Christine; Magnus, Maria C; Gjessing, Håkon K; Harris, Jennifer R; Magnus, Per; Håberg, Siri E; Jugessur, Astanand; Bohlin, Jon (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Epigenetic clocks have been recognized for their precise prediction of chronological age, age-related diseases, and all-cause mortality. Existing epigenetic clocks are based on CpGs from the ...
A natural deep eutectic solvent (NADES) as potential excipient in collagen-based products 
Grønlien, Krister Gjestvang; Pedersen, Mona Elisabeth; Tønnesen, Hanne Hjorth (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Natural deep eutectic solvents (NADES) have previously shown antibacterial properties alone or in combination with photosensitizers and light. In this study, we investigated the behavior of the structural protein collagen ...
Correlation of body weight and composition with hepatic activities of cytochrome P450 enzymes 
Krogstad, Veronica; Peric, Alexandra; Robertsen, Ida; Kringen, Marianne K.; Vistnes, Maria; Hjelmesæth, Jøran; Sandbu, Rune; Johnson, Line Kristin; Angeles, Philip Carlo Soriano; Jansson-Löfmark, Rasmus; Karlsson, Cecilia; Andersson, Shalini; Åsberg, Anders; Andersson, Tommy B.; Christensen, Hege Staaland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Obesity is associated with comorbidities of which pharmacological treatment is needed. Physiological changes associated with obesity may influence the pharmacokinetics of drugs, but the effect of body weight on drug ...
Thyroid hormone replacement therapy in pregnancy and motor function, communication skills, and behavior of preschool children: The Norwegian Mother, Father, and Child Cohort Study 
van den Broek, Sophie; Lupattelli, Angela; Frank, Anna-Simone; Haug, Line Småstuen; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Purpose Limited research has focused on the association between prenatal thyroid hormone replacement therapy (THRT) and motor function, communication skills, and behavior in preschool children. Here, we estimated the ...
An engineered human albumin enhances half-life and transmucosal delivery when fused to protein-based biologics 
Bern, Malin C.; Nilsen, Jeannette; Ferrarese, Mattia; Sand, Kine Marita Knudsen; Tollefsrud Gjølberg, Torleif; Lode, Heidrun Elisabeth; Davidson, Robert J.; Camire, Rodney M.; Bækkevold, Espen Sønderaal; Foss, Stian; Grevys, Algirdas; Dalhus, Bjørn; Wilson, John; Høydahl, Lene; Christianson, Gregory J.; Roopenian, Derry C.; Schlothauer, Tilman; Michaelsen, Terje Einar; Moe, Morten Carsten; Lombardi, Silvia; Pinotti, Mirko; Sandlie, Inger; Branchini, Alessio; Andersen, Jan Terje (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Needle-free uptake across mucosal barriers is a preferred route for delivery of biologics, but the efficiency of unassisted transmucosal transport is poor. To make administration and therapy efficient and convenient, ...
Photodynamic Efficacy of Cercosporin in 3D Tumor Cell Cultures 
Grigalavicius, Mantas; Mastrangelopoulou, Maria; Arous, Delmon; Juzeniene, Asta; Ménard, Mathilde; Skarpen, Ellen; Berg, Kristian; Theodossiou, Theodossis (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
In the present work, we study the photodynamic action of cercosporin (cerco), a naturally occurring photosensitizer, on human cancer multicellular spheroids. U87 spheroids exhibit double the uptake of cerco than T47D and ...
Prevalence of multiple sclerosis in rural and urban districts in Telemark county, Norway 
Flemmen, Heidi Øyen; Simonsen, Cecilia Smith; Berg-Hansen, Pål; Moen, Stine Marit; Kersten, Hege; Heldal, Kristian; Celius, Elisabeth Gulowsen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Objective: To explore the trends in prevalence and incidence of multiple sclerosis (MS) in Telemark, Norway (latitude 58.7-60.3˚N), over the past two decades, with focus on differences between rural and urban areas. Methods: ...
Impact of genotype-predicted CYP2D6 metabolism on clinical effects and tolerability of metoprolol in patients after myocardial infarction – a prospective observational study 
Anstensrud, Anne Kristine; Molden, Espen; Haug, Hans Jørgen; Qazi, Rehman; Muriq, Hysen; Fosshaug, Linn Elisabeth Lillerud; Spigset, Olav; Øie, Erik (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Purpose The β-1 adrenergic receptor blocker metoprolol is primarily metabolized by the polymorphic enzyme cytochrome P 450 2D6 (CYP2D6), an enzyme with substantial genetic heterogeneity. Our purpose was to investigate the ...
Fuel oil desulfurization with dual functionalized imidazolium based ionic liquids 
Butt, Hussain Shakeel; Chellappan, Lethesh Kallidanthiyil; Fiksdahl, Anne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
A series of 36 dual functionalized N-(poly)ethylen glycol N-allyl-/N-benzyl imidazolium and benzimidazolium ILs were synthesized for extractive desulfurization studies (EDS). The novel ILs were readily prepared from imidazole ...
Enzymatic studies with 3-oxa n-3 DPA 
Pangopoulos, Maria Kant; Nolsøe, Jens Mortansson Jelstrup; Antonsen, Simen Gjelseth; Colas, Romain; Dalli, Jesmond; Aursnes, Marius; Stenstrøm, Yngve H.; Hansen, Trond Vidar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Cyclooxygenase-2 and several lipoxygenases convert polyunsaturated fatty acids into a large variety of products. During inflammatory processes, these enzymes form several distinct families of specialized pro-resolving lipid ...
A human relevant mixture of persistent organic pollutants (POPs) and perfluorooctane sulfonic acid (PFOS) enhance nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells 
Yadav, Ajay; Amber, Mazia; Zosen, Denis; Labba, Nils Anders; Huiberts, Eva Henriette Willemijn; Samulin-Erdem, Johanna Maria; Haugen, Fred; Berntsen, Hanne Friis; Zienolddiny, Shanbeh; Paulsen, Ragnhild Elisabeth; Ropstad, Erik; Connolly, Lisa; Verhaegen, Steven (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Disruption of neurite outgrowth is a marker for neurotoxicity. Persistent organic pollutants (POPs) are potential developmental neurotoxicants. We investigated their effect on neurite outgrowth in PC12 rat pheochromocytoma ...
The Lactate Receptor HCA1 Is Present in the Choroid Plexus, the Tela Choroidea, and the Neuroepithelial Lining of the Dorsal Part of the Third Ventricle 
Hadzic, Alena; Nguyen, Teresa Dang; Hosoyamada, Makoto; Tomioka, Naoko H.; Bergersen, Linda Hildegard; Storm-Mathisen, Jon; Morland, Cecilie (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The volume, composition, and movement of the cerebrospinal fluid (CSF) are important for brain physiology, pathology, and diagnostics. Nevertheless, few studies have focused on the main structure that produces CSF, the ...
Evaluation of a eukaryote phylogenetic microarray for environmental monitoring of marine sediments 
Lekang, Katrine; Lanzén, Anders; Jonassen, Inge; Thompson, Eric; Troedsson, Christofer (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Increased exploitation of resources in sensitive marine ecosystems emphasizes the importance of knowledge regarding ecological impacts. However, current bio-monitoring practices are limited in terms of target-organisms and ...
Global variability analysis of mRNA and protein concentrations across and within human tissues 
Wegler, Christine; Ölander, Magnus; Wisniewski, JR; Lundquist, Patrick; Zettl, K; Åsberg, Anders; Hjelmesæth, Jøran; Andersson, Tommy B; Artursson, Per (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Abstract Genes and proteins show variable expression patterns throughout the human body. However, it is not clear whether relative differences in mRNA concentrations are retained on the protein level. Furthermore, ...
Degradative behavior and toxicity of alkylated imidazoles 
Evjen, Sigvart; Åstrand, Ove Alexander Høgmoen; Gaarder, Mona; Paulsen, Ragnhild Elisabeth; Fiksdahl, Anne; Knuutila, Hanna K (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
The thermal and oxidative degradation behavior and the corrosiveness of imidazole (Im), 2-methylimidazole (2MIm), 2-ethyl-4-methylimidazole (2E4MIm), 2,4,5-trimethylimidazole (2,4,5MIm), and 1,2,4,5-tetramethylimidazole ...
Effect of medicines management versus standard care on readmissions in multimorbid patients: a randomised controlled trial 
Lea, Marianne; Mowe, Morten; Molden, Espen; Kvernrød, Kristin; Skovlund, Eva; Mathiesen, Liv (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Objective To investigate the effect of pharmacist-led medicines management in multimorbid, hospitalised patients on long-term hospital readmissions and survival. Design Parallel-group, randomised controlled trial. Setting ...
Prescribed Doses of CYP2D6-Metabolized Drugs and Hemodynamic Responses in Relation to CYP2D6 Genotype Among Older Patients Exposed to Polypharmacy 
Romskaug, Rita; Wyller, Torgeir Bruun; Straand, Jørund; Kersten, Hege; Molden, Espen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background: Many drugs with dose-dependent effects on hemodynamic variables are metabolized by cytochrome P450 2D6 (CYP2D6). The aim of this study was to compare prescribed dosages and hemodynamic responses of such drugs ...
Alternative Biosynthetic Starter Units Enhance the Structural Diversity of Cyanobacterial Lipopeptides 
Mareš, Jan; Hájek, Jan; Urajová, Petra; Kust, Andreja; Jokela, Jouni; Saurav, Kumar; Galica, Tomáš; Čapková, Kateřina; Mattila, Antti; Haapaniemi, Esa; Permi, Perttu; Mysterud, Ivar; Skulberg, Olav M.; Karlsen, Jan; Fewer, David P.; Sivonen, Kaarina; Tønnesen, Hanne Hjort; Hrouzek, Pavel (Journal article / Tidsskriftartikkel; Peer reviewed, 2019)
Puwainaphycins (PUWs) and minutissamides (MINs) are structurally analogous cyclic lipopeptides possessing cytotoxic activity. Both types of compound exhibit high structural variability, particularly in the fatty acid (FA) ...
Validation of diagnostic utility of fasting plasma glucose and HbA1c in stable renal transplant recipients one year after transplantation 
Ussif, Amin M; Åsberg, Anders; Halden, Thea A S; Nordheim, Espen; Hartmann, Anders; Jenssen, Trond (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background The use of HbA1c ≥6.5% for diagnosis of diabetes has been challenged for post-transplantation diabetes mellitus (PTDM) also known as new onset diabetes after transplantation (NODAT) due to a low ...
The hypotonic environmental changes affect liposomal formulations for nose-to-brain targeted drug delivery 
Wu, Iren Yeeling; Nikolaisen, Trygg Einar; Skalko-Basnet, Natasa; Di Cagno, Massimiliano Pio (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Systemic administration of drugs is ineffective in the treatment of central nervous system disorders because of the blood-brain barrier. Nasal administration has been suggested as an alternative administration route as ...
Interventional study to improve adherence to phosphate binder treatment in dialysis patients 
Hjemås, Bodil J; Bøvre, Katrine; Mathiesen, Liv; Lindstrøm, Jonas C; Bjerknes, Kathrin (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background Adherence to phosphate binder treatment is important to prevent high serum phosphate level in chronic dialysis patients. We therefore wanted to investigate patient knowledge, beliefs about and ...
Using a period incidence survey to compare antibiotic use in children between a university hospital and a district hospital in a country with low antimicrobial resistance: a prospective observational study 
Thaulow, Christian Magnus; Blix, Hege Salvesen; Eriksen, Beate Horsberg; Ask, Ingvild; Myklebust, Tor Åge; Berild, Dag (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Objectives To describe and compare antibiotic use in relation to indications, doses, adherence rate to guidelines and rates of broad-spectrum antibiotics (BSA) in two different paediatric departments with different academic ...
Impact of hyperinsulinemia and hyperglycemia on valvular interstitial cells – A link between aortic heart valve degeneration and type 2 diabetes 
Selig, Jessica I; Ouwens, D. Margriet; Raschke, Silja; Thoresen, G. Hege; Fischer, Jens; Lichtenberg, Artur; Akhyari, Payam; Barth, Mareike (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Type 2 diabetes is a known risk factor for cardiovascular diseases and is associated with an increased risk to develop aortic heart valve degeneration. Nevertheless, molecular mechanisms leading to the pathogenesis of valve ...
Adjusting the dose in paediatric care: dispersing four different aspirin tablets and taking a proportion 
Brustugun, Jørgen; Notaker, Nikolai; Paetz, Lasse Holtan; Tho, Ingunn; Bjerknes, Kathrin (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Objectives: When caring for children in a hospital setting, tablets are often manipulated at the ward to obtain the right dose. One example is manipulation of tablets containing the slightly water-soluble substance aspirin, ...
Molecular modelling, synthesis, and biological evaluations of a 3,5-disubstituted isoxazole fatty acid analogue as a PPARα-selective agonist 
Arnesen, Liv Henriette; Haj Yasein, Nadia; Tungen, Jørn Eivind; Soedling, Helen; Matthews, Jason; Paulsen, Steinar M; Nebb, Hilde Irene; Sylte, Ingebrigt; Hansen, Trond Vidar; Sæther, Thomas (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
The peroxisome proliferator activated receptors (PPARs) are important drug targets in treatment of metabolic and inflammatory disorders. Fibrates, acting as PPARα agonists, have been widely used lipid-lowering agents for ...
Quality of Life of Family Carers of Persons with Young-Onset Dementia: A Nordic Two-Year Observational Multicenter 
Hvidsten, Lara H. Thomasgaard; Engedal, Knut; Selbæk, Geir; Wyller, Torgeir Bruun; Saltyte Benth, Jurate; Kersten, Hege (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Objectives To identify factors associated with QOL in carers of persons with young-onset Alzheimer’s (AD) and frontotemporal dementia (FTD) and explore development in QOL over a two-year period. Methods Eighty-eight ...
Systematic evaluation and validation of reference and library selection methods for deconvolution of cord blood DNA methylation data 
Gervin, Kristina; Salas, Lucas A; Bakulski, Kelly M; van Zelm, Menno C; Koestler, Devin C; Wiencke, John K; Duijts, Liesbeth; Moll, Henriëtte A; Kelsey, Karl T; Kobor, Michael S; Lyle, Robert; Christensen, Brock C; Felix, Janine F; Jones, Meaghan J (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background Umbilical cord blood (UCB) is commonly used in epigenome-wide association studies of prenatal exposures. Accounting for cell type composition is critical in such studies as it reduces confounding ...
Early increase of specialized pro-resolving lipid mediators in patients with ST-elevation myocardial infarction 
Fosshaug, Linn Elisabeth Lillerud; Colas, Romain A.; Anstensrud, Anne Kristine; Gregersen, Ida; Nymoen, Ståle H.; Sagen, Ellen; Michelsen, Annika; Vinge, Leif Erik; Øie, Erik; Gullestad, Lars; Halvorsen, Bente; Hansen, Trond Vidar; Aukrust, Pål; Dalli, Jesmond; Yndestad, Arne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background Termination of acute inflammation is an active process orchestrated by lipid mediators (LM) derived from polyunsaturated fatty acids, referred to as specialized pro-resolving mediators (SPM). These mediators ...
Women's perspectives on the management and consequences of hyperemesis gravidarum - a descriptive interview study 
Havnen, Gro Cecilie; Truong, Maria Bich-Thuy; Huynh Do, Mai-Linh; Heitmann, Kristine; Holst, Lone; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Objective: Hyperemesis gravidarum (HG) affects 0.3–3% of pregnant women and is a leading cause of hospitalization in early pregnancy. The aim of the study was to investigate women’s treatment and management of HG, as well ...
Gellan Gum/Laponite Beads for the Modified Release of Drugs: Experimental and Modeling Study of Gastrointestinal Release 
Adrover, Alessandra; Paolicelli, Patrizia; Petralito, Stefania; Di Muzio, Laura; Trilli, Jordan; Cesa, Stefania; Tho, Ingunn; Casadei, Maria Antonietta (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
In this study, gellan gum (GG), a natural polysaccharide, was used to fabricate spherical porous beads suitable as sustained drug delivery systems for oral administration. GG was cross-linked with calcium ions to prepare ...
Maternal fever during pregnancy and offspring attention deficit hyperactivity disorder 
Gustavson, Kristin; Ask, Helga; Ystrøm, Eivind; Stoltenberg, Camilla; Lipkin, W. Ian; Suren, Pål; Håberg, Siri Eldevik; Magnus, Per; Knudsen, Gun Peggy S.; Eilertsen, Espen Moen; Bresnahan, Michaeline; Aase, Heidi; Mjaaland, Siri; Susser, Ezra S.; Hornig, Mady; Reichborn-Kjennerud, Ted (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Maternal fever during pregnancy is associated with several adverse child outcomes. We investigated associations between maternal fever and ADHD among offspring, as well as the sub-dimensions of ADHD - inattention and ...
Association of Maternal Use of Benzodiazepines and Z-Hypnotics During Pregnancy With Motor and Communication Skills and Attention-Deficit/Hyperactivity Disorder Symptoms in Preschoolers 
Lupattelli, Angela; Chambers, Christina D.; Bandoli, Gretchen; Handal, Marte; Skurtveit, Svetlana; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / PublishedVersionAcceptedVersion; Peer reviewed, 2019)
Importance: The reproductive safety of benzodiazepine/z-hypnotic exposure on child longer-term developmental risks remains unresolved. Objective: To quantify the association of motor, communication, and attention-defi ...
Exploring the overlapping binding sites of ifenprodil and EVT‐101 in GluN2B‐containing NMDA receptors using novel chicken embryo forebrain cultures and molecular modeling 
Fjelldal, Marthe Fredheim; Freyd, Thibaud; Evenseth, Linn; Sylte, Ingebrigt; Ring, Avi; Paulsen, Ragnhild Elisabeth (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
N‐methyl‐d‐aspartate receptors (NMDAR) are widely expressed in the brain. GluN2B subunit‐containing NMDARs has recently attracted significant attention as potential pharmacological targets, with emphasis on the functional ...
Can screening tools for potentially inappropriate prescriptions in older adults prevent serious adverse drug events? 
Wang-Hansen, Marte Sofie; Wyller, Torgeir Bruun; Hvidsten, Lara H. Thomasgaard; Kersten, Hege (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Purpose The purpose of the study is to identify and explore risk factors of serious adverse drug events (SADE) and SADE-related admissions in acutely hospitalized multimorbid older adults and assess whether these could ...
Maternal thyroid hormone replacement therapy exposure and language and communication skills of offspring at 8 years of age 
Frank, Anna-Simone; Lupattelli, Angela; Brandlistuen, Ragnhild Eek; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Importance: Hypothyroidism during pregnancy is associated with neurodevelopmental delays in the offspring. However, it remains unknown whether prenatal thyroid hormone replacement therapy (THRT) has benefits regarding ...
Statin-associated muscle symptoms in coronary patients: design of a randomized study 
Munkhaugen, John; Vethe, Nils Tore; Fagerland, Morten; Dammen, Toril; Perk, Joep; Gjertsen, Erik; Otterstad, Jan Erik; Gullestad, Lars; Bergan, Stein; Husebye, Einar (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Objectives. Estimate the effect of atorvastatin on muscular symptom intensity in coronary patients with subjective statin-associated muscle symptoms (SAMS) and to determine the association with blood levels of atorvastatin ...
Community pharmacist counseling in early pregnancy—Results from the SafeStart feasibility study 
Truong, Maria Bich-Thuy; Ngo, Elin Thuy Phuong; Ariansen, Hilde; Tsuyuki, Ross; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background: Community pharmacists are available to counsel women in early pregnancy, but no studies have assessed the feasibility of such a service. Objective: To test the feasibility of a pharmacist consultation in early ...
Is the association between maternal alcohol consumption in pregnancy and pre-school child behavioural and emotional problems causal? Multiple approaches for controlling unmeasured confounding 
Lund, Ingunn Olea; Eilertsen, Espen Moen; Gjerde, Line C.; Røysamb, Espen; Wood, Mollie; Reichborn-Kjennerud, Ted; Ystrøm, Eivind (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Background and aims Hazardous drinking (i.e. alcohol consumption that places drinkers at risk for adverse health outcomes) during pregnancy is associated with adverse child outcomes. To address whether the associations ...
Gonadotrope plasticity at cellular, population and structural levels: A comparison between fishes and mammals 
Fontaine, Romain David; Ciani, Elia; Haug, Trude M; Hodne, Kjetil; Ager-Wick, Eirill; Baker, Dianne; Weltzien, Finn-Arne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Often referred to as “the master gland”, the pituitary is a key organ controlling growth, maturation, and homeostasis in vertebrates. The anterior pituitary, which contains several hormone-producing cell types, is highly ...
NIPSNAP1 and NIPSNAP2 act as “eat-me signal” for mitophagy 
Abudu, Yakubu Princely; Pankiv, Serhiy; Mathai, Benan John; Lystad, Alf Håkon; Bindesbøll, Christian; Brenne, Hanne Britt; Ng, Matthew Yoke Wui; Thiede, Bernd; Yamamoto, Ai; Nthiga, Thaddaeus Mutugi; Lamark, Trond; Esguerra, Camila Vicencio; Johansen, Terje; Simonsen, Anne (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
The clearance of damaged or dysfunctional mitochondria by selective autophagy (mitophagy) is important for cellular homeostasis and prevention of disease. Our understanding of the mitochondrial signals that trigger their ...
Data-Independent Acquisition for the Orbitrap Q Exactive HF: A Tutorial. 
Reubsaet, Leon; Sweredoski, Michael J.; Moradian, Annie (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Data-independent acquisition (DIA) is a powerful mass spectrometric technique to perform both protein identification and quantification of complex protein samples. Setting up DIA methods on Orbitrap analyzers requires a ...
Prenatal paracetamol exposure and neurodevelopmental outcomes in preschool-aged children 
Trønnes, Johanne Naper; Wood, Mollie; Lupattelli, Angela; Ystrøm, Eivind; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background Recent studies have suggested an association between prenatal paracetamol exposure and adverse neurodevelopmental outcomes in children. However, these findings may be confounded by unmeasured factors related ...
Impact of prenatal exposure to benzodiazepines and z-hypnotics on behavioral problems at 5 years of age: A study from the Norwegian Mother and Child Cohort Study 
Sundbakk, Lene Maria; Wood, Mollie; Gran, Jon Michael; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Many women experience anxiety or sleep disorders during pregnancy and require pharmacological treatment with benzodiazepines (BZDs) or z-hypnotics. Limited information is currently available on how prenatal exposure to ...
The edible mushroom Albatrellus ovinus contains a α-L-fuco-α-D-galactan, α-D-glucan, a branched (1→6)-β-D-glucan and a branched (1→3)-β-D-glucan 
Samuelsen, Anne Berit C.; Rise, Frode; Wilkins, Alistair L.; Teveleva, Lioubov; Nyman, Anna Armika Tussilago; Aachmann, Finn Lillelund (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Albatrellus ovinus, the sheep polypore, is a large, dense mushroom being rich in cell wall material. Polysaccharides were isolated by sequential extraction, enzymatic treatment and analyzed with respect to monosaccharide ...
Pharmacokinetics of a novel, approved, 1.4-mg intranasal naloxone formulation for reversal of opioid overdose—a randomized controlled trial 
Skulberg, Arne Kristian; Åsberg, Anders; Zare, Hasse Khiabani; Røstad, Hilde; Tylleskär, Ida; Dale, Ola (Journal article / Tidsskriftartikkel / SubmittedVersion, 2019)
Background and aims Intranasal (i.n.) naloxone is an established treatment for opioid overdose. Anyone likely to witness an overdose should have access to the antidote. We aimed to determine whether an i.n. formulation ...
Design, synthesis and biological evaluation of 6‐substituted quinolines derived from cabozantinib as c‐Met inhibitors 
Lien, Vegard Torp; Pettersen, Solveig; Haugen, Mads Haugland; Olberg, Dag Erlend; Mælandsmo, Gunhild Mari; Klaveness, Jo (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Based on the cabozantinib scaffold, novel c‐Met inhibitors were rationalized from the limited knowledge of structure‐activity relationships for the quinoline 6‐position. Emphasis was given to modifications capable of ...
Identification of potential carcinogenic and chemopreventive effects of prescription drugs: A protocol for a Norwegian registry-based study 
Kulle, Bettina; Støer, Nathalie Charlotte; Martinsen, Jan Ivar; Ursin, Giske; Weiderpass, Elisabete; Thoresen, G. Hege; Debernard, Karen A. Boldingh; Karlstad, Øystein; Pottegard, Anton; Friis, Søren (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Surveillance of unintended effects of pharmaceuticals (pharmacovigilance or drug safety) is crucial, as knowledge of rare or late side effects is limited at the time of the introduction of new medications into the market. ...
Experiences of Kurdish immigrants with the management of type 2 diabetes: a qualitative study from Norway 
Abuelmagd, Walaa Metwally Ali Abdalaah; Osman, Bavi Botan; Håkonsen, Helle; Jenum, Anne Karen; Toverud, Else-Lydia (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Objective: To explore the experiences of immigrant Kurdish patients in Oslo, Norway, related to the management of type 2 diabetes mellitus (T2DM). Design: A qualitative study with focus group interviews. Setting: ...
Cyclopropanation–ring expansion of 3-chloroindoles with α-halodiazoacetates: novel synthesis of 4-quinolone-3-carboxylic acid and norfloxacin 
Peeters, Sara; Berntsen, Linn Neerbye; Rongved, Pål; Bonge-Hansen, Tore (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
We present a short and efficient way of synthesizing two synthetically versatile 4-quinolone-3-carboxylate building blocks by cyclopropanation-ring expansion of 3-chloroindoles with α-halodiazoacetates as the key step. ...
Immunocapture sample clean-up in determination of low abundant protein biomarkers-a feasibility study of peptide capture by anti-protein antibodies 
Levernæs, Maren Christin Stillesby; Farhat, Bassem; Oulie, Inger; Abdullah, Sazan S.; Paus, Elisabeth; Reubsaet, Leon; Halvorsen, Trine Grønhaug (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Immunocapture in mass spectrometry based targeted protein analysis using a bottom-up workflow is nowadays mainly performed by target protein extraction using anti-protein antibodies followed by tryptic digestion. Already ...
Efficacy and Safety of Empagliflozin in Renal Transplant Recipients With Posttransplant Diabetes Mellitus 
Strøm Halden, Thea Anine; Kvitne, Kine Eide; Midtvedt, Karsten; Rajakumar, Laavanyaah; Robertsen, Ida; Brox, Jan; Bollerslev, Jens; Hartmann, Anders; Åsberg, Anders; Jenssen, Trond Geir (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
OBJECTIVE Sodium–glucose cotransporter 2 (SGLT2) inhibitors have lately become the recommended treatment in patients with type 2 diabetes and high cardiovascular risk. Patients with posttransplant diabetes mellitus (PTDM) ...
Increased glycolysis and higher lactate production in hyperglycemic myotubes 
Lund, Jenny; Ouwens, DM; Wettergreen, Marianne; Bakke, Siril Skaret; Thoresen, G. Hege; Aas, Vigdis (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Previous studies have shown that chronic hyperglycemia impairs glucose and fatty acid oxidation in cultured human myotubes. To further study the hyperglycemia-induced suppression of oxidation, lactate oxidation, mitochondrial ...
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