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Effects of a human-based mixture of persistent organic pollutants on the in vivo exposed cerebellum and cerebellar neuronal cultures exposed in vitro 
Berntsen, Hanne Friis; Duale, Nur; Bjørklund, Cesilie Granum; Rangel-Huerta, Oscar Daniel; Dyrberg, Kine; Hofer, Tim; Rakkestad, Kirsten Eline; Østby, Gunn Charlotte; Halsne, Ruth; Boge, Gudrun Seeberg; Paulsen, Ragnhild Elisabeth; Myhre, Oddvar; Ropstad, Erik (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Exposure to persistent organic pollutants (POPs), encompassing chlorinated (Cl), brominated (Br) and perfluoroalkyl acid (PFAA) compounds is associated with adverse neurobehaviour in humans and animals, and is observed to ...
Medication-related problems among hospitalized pregnant women in a tertiary teaching hospital in Ethiopia: a prospective observational study 
Ahmed, Seid M; Sundby, Johanne; Aragaw, Yesuf A; Nordeng, Hedvig (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Studies on medication-related problems (MRPs) among pregnant women are scarce, despite the potential consequences for both mother and child. This study aimed to describe the prevalence, clinical significance, ...
The effect of a pharmacist consultation on pregnant women’s quality of life with a special focus on nausea and vomiting: an intervention study 
Truong, Maria B; Ngo, Elin; Ariansen, Hilde; Tsuyuki, Ross T; Nordeng, Hedvig (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Maternal wellbeing and quality of life (QOL) are increasingly being recognized as important for healthy pregnancies. The aim of this study was to investigate the impact of a pharmacist consultation ...
Identifying targets for antibiotic stewardship interventions through analysis of the antibiotic prescribing process in hospitals - a multicentre observational cohort study 
Wathne, Jannicke S; Skodvin, Brita; Charani, Esmita; Harthug, Stig; Blix, Hege S; Nilsen, Roy M; Kleppe, Lars K S; Vukovic, Marta; Smith, Ingrid (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background In order to change antibiotic prescribing behaviour, we need to understand the prescribing process. The aim of this study was to identify targets for antibiotic stewardship interventions in ...
Extending balance assessment for the generalized propensity score under multiple imputation 
Frank, Anna-Simone; Matteson, David S.; Solvang, Hiroko Kato; Lupattelli, Angela; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
This manuscript extends the definition of the Absolute Standardized Mean Difference (ASMD) for binary exposure (M = 2) to cases for M > 2 on multiple imputed data sets. The Maximal Maximized Standardized Difference (MMSD) ...
Dendritic localization and exocytosis of NAAG in the rat hippocampus 
Nordengen, Kaja; Morland, C; Slusher, B.S.; Gundersen, V (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
While a lot is known about classical, anterograde neurotransmission, less is known about the mechanisms and molecules involved in retrograde neurotransmission. Our hypothesis is that N-acetylaspartylglutamate (NAAG), the ...
How important are parents in the development of child anxiety and depression? A genomic analysis of parent-offspring trios in the Norwegian Mother Father and Child Cohort Study (MoBa) 
Cheesman, Rosa; Eilertsen, Espen M; Ahmadzadeh, Yasmin I; Gjerde, Line C; Hannigan, Laurie J; Havdahl, Alexandra; Young, Alexander I; Eley, Thalia C; Njølstad, Pål R; Magnus, Per; Andreassen, Ole A; Ystrom, Eivind; McAdams, Tom A (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Many studies detect associations between parent behaviour and child symptoms of anxiety and depression. Despite knowledge that anxiety and depression are influenced by a complex interplay of genetic and environmental ...
ZN148 Is a Modular Synthetic Metallo-beta-Lactamase Inhibitor That Reverses Carbapenem Resistance in Gram-Negative Pathogens In Vivo 
Samuelsen, Ørjan; Åstrand, Ove Alexander Høgmoen; Frøhlich, Christopher; Heikal, Adam; Skagseth, Susann; Carlsen, Trine Josefine Olsen; Leiros, Hanna-Kirsti S.; Bayer, Annette; Schnaars, Christian; Kildahl-andersen, Geir; Lauksund, Silje; Finke, Sarah; Huber, Sandra; Gjøen, Tor; Andresen, Adriana Magalhaes Santos; Økstad, Ole Andreas; Rongved, Pål (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Carbapenem-resistant Gram-negative pathogens are a critical public health threat and there is an urgent need for new treatments. Carbapenemases (β-lactamases able to inactivate carbapenems) have been identified in both ...
Legumain is upregulated in acute cardiovascular events and associated with improved outcome – potentially related to anti-inflammatory effects on macrophages 
Lunde, Ngoc Dieu Nguyen; Gregersen, Ida; Ueland, Thor; Shetelig, Christian; Holm, Sverre; Kong, Xiang Yi; Michelsen, Annika; Otterdal, Kari; Yndestad, Arne; Broch, Kaspar; Gullestad, Lars; Nyman, Tuula Anneli; Bendz, Bjørn; Eritsland, Jan; Hoffmann, Pavel; Skagen, Karolina Ryeng; Gonçalves, Isabel; Nilsson, Jan; Grenegård, Magnus; Poreba, Marcin; Drag, Marcin; Seljeflot, Ingebjørg; Sporsheim, Bjørnar; Espevik, Terje; Skjelland, Mona; Johansen, Harald Thidemann; Solberg, Rigmor; Aukrust, Pål; Björbacka, Harry; Andersen, Geir Øystein; Halvorsen, Bente (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background and aims We have previously found increased levels of the cysteine protease legumain in plasma and plaques from patients with carotid atherosclerosis. This study further investigated legumain during acute ...
Mechanisms linking parental educational attainment with child ADHD, depression, and academic problems: a study of extended families in The Norwegian Mother, Father and Child Cohort Study 
Torvik, Fartein Ask; Eilertsen, Espen Moen; McAdams, Tom A.; Gustavson, Kristin; Zachrisson, Henrik Daae; Brandlistuen, Ragnhild Eek; Gjerde, Line C.; Havdahl, Alexandra; Stoltenberg, Camilla; Ask, Helga; Ystrøm, Eivind (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Low educational attainment in parents is associated with child psychopathology. It is not clear whether the associations are due to risk factors that family members share or due to effects of maternal or ...
3D cell culture models and organ-on-a-chip: Meet separation science and mass spectrometry 
Lin, Ann; Skottvoll, Frøydis Sved; Rayner, Simon; Pedersen-Bjergaard, Stig; Sullivan, Gareth; Krauss, Stefan; Wilson, Steven Ray Haakon; Harrison, Sean (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
In vitro derived simplified 3D representations of human organs or organ functionalities are predicted to play a major role in disease modeling, drug development, and personalized medicine, as they complement traditional ...
Pharmacological Validation of the Prepulse Inhibition of Startle Response in Larval Zebrafish using a Commercial Automated System and Software 
Banono, Nancy Saana; Esguerra, Camila (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
While there is an abundance of commercial and standardized automated systems and software for performing the prepulse inhibition (PPI) assay in rodents, to the best of our knowledge, all PPI assays performed in the zebrafish ...
New CDK8 inhibitors as potential anti-leukemic agents – Design, synthesisand biological evaluation 
Solum, Eirik Johansson; Hansen, Trond Vidar; Aesoy, Reidun; Herfindal, Lars (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Cyclin-dependent kinase 8 (CDK8) plays a vital role in regulating cell transcription either through its association with the mediator complex or by the phosphorylation of transcription factors. CDK8-mediated activation of ...
The PPAR Ω Pocket: Renewed Opportunities for Drug Development 
Kaupang, Åsmund; Hansen, Trond Vidar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The past decade of PPARγ research has dramatically improved our understanding of the structural and mechanistic bases for the diverging physiological effects of different classes of PPARγ ligands. The discoveries that lie ...
Determination of anticoagulant rodenticides in faeces of exposed dogs and in a healthy dog population 
Seljetun, Kristin O; Vindenes, Vigdis; Øiestad, Elisabeth L; Brochmann, Gerd-Wenche; Eliassen, Elin; Moe, Lars (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Exposure to anticoagulant rodenticides (ARs) in dogs is among the most common causes of poisoning in small animal practice, but information about toxicokinetic of these rodenticides in dogs is lacking. We ...
Y-site physical compatibility of Numeta G13E with drugs frequently used at Neonatal Intensive Care 
Nezvalova-henriksen, Katerina; Østerberg, Camilla Tomine; Nilsson, Niklas; Staven Berge, Vigdis; Tho, Ingunn (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Preterm neonates require parenteral nutrition (PN) in addition to intravenous drug therapy. Due to limited venous access, drugs are often co-administered with PN via the same lumen. If incompatible, precipitation and ...
Non-prescription purchase of antibiotics during travel abroad among a general adult population in Norway: Findings from the seventh Tromsø Study 
Gravningen, Kirsten Midttun; Field, Nigel; Blix, Hege Salvesen; Asfeldt, anne mette; Småbrekke, Lars (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Non-prescription purchase of antibiotics is undesirable and has not recently been investigated in a representative population in a high-income low-use country during travel abroad. This study examined ...
Potentially inappropriate prescribing to older patients receiving multidose drug dispensing 
Josendal, Anette V; Bergmo, Trine S; Granas, Anne G (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Multidose drug dispensing (MDD) is an adherence aid that provides patients with machine-dispensed medicines in disposable unit bags, usually for a 14 day period. Previous studies have suggested that the quality ...
Comparison of anticoagulant rodenticide concentrations in liver and feces from apparently healthy red foxes 
Seljetun, Kristin Opdal; Sandvik, Morten; Vindenes, Vigdis; Eliassen, Elin; Øiestad, Elisabeth Leere; Madslien, Knut Ivar Engesæter; Moe, Lars (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Exposure of wildlife and domestic animals to anticoagulant rodenticides (ARs) is a worldwide concern, but few methods exist to determine residue levels in live animals. Traditional liver detection methods preclude determining ...
Diagnostic tests and treatment procedures performed prior to cardiovascular death in individuals with severe mental illness 
Heiberg, Ina Heidi; Nesvåg, Ragnar; Balteskard, Lise; Bramness, Jørgen Gustav; Hultman, Christina M.; Næss, Øyvind; Reichborn-Kjennerud, Ted; Ystrøm, Eivind; Jacobsen, Bjarne K.; Høye, Anne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Objective To examine whether severe mental illnesses (i.e., schizophrenia or bipolar disorder) affected diagnostic testing and treatment for cardiovascular diseases in primary and specialized health care. Methods We ...
Sleep problems and depressive symptoms in toddlers and 8-year-old children: A longitudinal study 
Sivertsen, Børge; Harvey, Allison G.; Reichborn-Kjennerud, Ted; Ystrøm, Eivind; Hysing, Mari (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Sleep and depression are interlinked throughout the lifespan, but very few studies have examined the directionality of the sleep–depression link in children. The aim of the current study was to prospectively examine the ...
Legumain in Acute Coronary Syndromes: A Substudy of the PLATO (Platelet Inhibition and Patient Outcomes) Trial 
Gregersen, Ida; Michelsen, Annika; Lunde, Ngoc Nguyen; Åkerblom, Axel; Lakic, Tatevik G.; Skjelland, Mona; Skagen, Karolina Ryeng; Becker, Richard C.; Lindbäck, Johan; Himmelmann, Anders; Solberg, Rigmor; Johansen, Harald Thidemann; James, Stefan K.; Siegbahn, Agneta; Storey, Robert F.; Kontny, Frederic; Aukrust, Pål; Ueland, Thor; Wallentin, Lars; Halvorsen, Bente (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background The cysteine protease legumain is increased in patients with atherosclerosis, but its causal role in atherogenesis and cardiovascular disease is still unclear. The aim of the study was to investigate the ...
Treatment of human skeletal muscle cells with inhibitors of diacylglycerol acyltransferases 1 and 2 to explore isozyme-specific roles on lipid metabolism. 
Thoresen, Hege; Kase, Eili Tranheim; Skagen, Christine (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Diacylglycerol acyltransferases (DGAT) 1 and 2 catalyse the final step in triacylglycerol (TAG) synthesis, the esterification of fatty acyl-CoA to diacylglycerol. Despite catalysing the same reaction and being present in ...
Thyroid hormone replacement therapy patterns in pregnant women and perinatal outcomes in the offspring 
Frank, Anna-Simone; Lupattelli, Angela; Matteson, David S.; Meltzer, Helle Margrete; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Purpose It remains unknown to what degree thyroid hormone replacement therapy (THRT) during and initiation after pregnancy determines pregnancy outcomes. The present study primarily aimed to quantify the impact of THRT ...
Rheumatoid Arthritis Patients, Both Newly Diagnosed and Methotrexate Treated, Show More DNA Methylation Differences in CD4+ Memory Than in CD4+ Naïve T Cells 
Guderud, Kari; Sunde, Line Hagen; Flåm, Siri Tennebø; Mæhlen, Marthe Thoresen; Mjaavatten, Maria Dahl; Lillegraven, Siri; Aga, Anna-Birgitte; Evenrød, Ida Marie; Norli, Ellen Sauar; Andreassen, Bettina Kulle; Franzenburg, Sören; Franke, Andre; Haavardsholm, Espen Andre; Rayner, Simon; Gervin, Kristina; Lie, Benedicte Alexandra (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background: Differences in DNA methylation have been reported in B and T lymphocyte populations, including CD4+ T cells, isolated from rheumatoid arthritis (RA) patients when compared to healthy controls. CD4+ T cells are ...
Complex Temperature and Concentration Dependent Self-Assembly of Poly(2-oxazoline) Block Copolymers 
Che, Loan Trinh; Hiorth, Marianne; Hoogenboom, Richard; Kjøniksen, Anna-Lena (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The effect of polymer concentration on the temperature-induced self-association of a block copolymer comprising a poly(2-ethyl-2-oxazoline) block and a random copolymer block consisting of 2-ethyl-2-oxazoline and ...
Measured GFR by Utilizing Population Pharmacokinetic Methods to Determine Iohexol Clearance 
Åsberg, Anders; Bjerre, Anna Kristina; Almaas, Runar; Luis-Lima, Sergio; Robertsen, Ida; Salvador, Cathrin Lytomt; Porrini, Esteban; Schwartz, George; Hartmann, Anders; Bergan, Stein (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Introduction There is an increasing demand for accurately measured glomerular filtration rate (GFR). Iohexol serum clearance has become a new gold standard, but it is challenging when GFR is low and 24-hour sampling is ...
The cure model in perinatal epidemiology 
Stoltenberg, Emil Aas; Nordeng, Hedvig Marie Egeland; Ystrøm, Eivind; Samuelsen, Sven Ove (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
In the statistical literature, the class of survival analysis models known as cure models has received much attention in recent years. Cure models seem not, however, to be part of the statistical toolbox of perinatal ...
The role of 6-acetylmorphine in heroin-induced reward and locomotor sensitization in mice 
Kvello, Anne Marte Sjursen; Andersen, Jannike Mørch; Boix, Fernando; Mørland, Jørg; Bogen, Inger Lise (Journal article / Tidsskriftartikkel / SubmittedVersion, 2020)
We have previously demonstrated that heroin's first metabolite, 6‐acetylmorphine (6‐AM), is an important mediator of heroin's acute effects. However, the significance of 6‐AM to the rewarding properties of heroin still ...
Blood-based epigenetic estimators of chronological age in human adults using DNA methylation data from the Illumina MethylationEPIC array 
Lee, Yunsung; Haftorn, Kristine L; Denault, William R P; Nustad, Haakon E; Page, Christian M; Lyle, Robert; Lee-Ødegård, Sindre; Moen, Gunn-Helen; Prasad, Rashmi B; Groop, Leif C; Sletner, Line; Sommer, Christine; Magnus, Maria C; Gjessing, Håkon K; Harris, Jennifer R; Magnus, Per; Håberg, Siri E; Jugessur, Astanand; Bohlin, Jon (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Epigenetic clocks have been recognized for their precise prediction of chronological age, age-related diseases, and all-cause mortality. Existing epigenetic clocks are based on CpGs from the ...
Solid lipid nanoparticle-loaded mucoadhesive buccal films – Critical quality attributes and in vitro safety & efficacy 
Tzanova, Martina; Hagesaether, Ellen; Tho, Ingunn (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The objective of this work was to develop and characterize solid lipid nanoparticle (SLN)-loaded mucoadhesive films to reveal their potential as successful drug formulations. SLNs based on lipid (Lipoid S100) and surfactant ...
Pharmacists’ experience of a diabetes risk-assessment service and analytical quality control in community pharmacies : a focus-group study 
Risøy, Aslaug Johanne; Kjome, Reidun Lisbet Skeide; Svensberg, Karin; Råheim, Målfrid; Sølvik, Una Ørvim (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Healthcare services such as diabetes risk-assessment are increasingly common in community pharmacies. Knowledge of community pharmacists’ experiences of such services could ease the implementation of a larger-scale ...
Use of Antidepressants in Older People during a 10-Year Period: An Observational Study on Prescribed Doses and Serum Levels 
Tveit, Kristine; Hermann, Monica; Waade, Ragnhild Birkeland; Nilsen, Roy Miodini; Wallerstedt, Susanna M.; Molden, Espen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background According to previous studies, older patients frequently have serum concentrations of antidepressant medication above the recommended reference range. Objective The aim of this study was to investigate ...
Substrate oxidation in primary human skeletal muscle cells is influenced by donor age 
Aas, Vigdis; Thoresen, G. Hege; Rustan, Arild; Lund, Jenny (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Abstract Primary human myotubes represent an alternative system to intact skeletal muscle for the study of human diseases related to changes in muscle energy metabolism. This work aimed to study if fatty acid and glucose ...
Prescribed Doses of CYP2D6-Metabolized Drugs and Hemodynamic Responses in Relation to CYP2D6 Genotype Among Older Patients Exposed to Polypharmacy 
Romskaug, Rita; Wyller, Torgeir Bruun; Straand, Jørund; Kersten, Hege; Molden, Espen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background: Many drugs with dose-dependent effects on hemodynamic variables are metabolized by cytochrome P450 2D6 (CYP2D6). The aim of this study was to compare prescribed dosages and hemodynamic responses of such drugs ...
Perfluoroalkyl acids potentiate glutamate excitotoxicity in rat cerebellar granule neurons 
Berntsen, Hanne Friis; Moldes-Anaya, Angel; Bjørklund, Cesilie Granum; Ragazzi, Lorenzo; Haug, Trude M; Strandabø, Rønnaug; Verhaegen, Steven; Paulsen, Ragnhild Elisabeth; Ropstad, Erik; Tasker, Andrew (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Perfluoroalkyl acids (PFAAs) are persistent man-made chemicals, ubiquitous in nature and present in human samples. Although restrictions are being introduced, they are still used in industrial processes as well as in ...
A natural deep eutectic solvent (NADES) as potential excipient in collagen-based products 
Grønlien, Krister Gjestvang; Pedersen, Mona Elisabeth; Tønnesen, Hanne Hjorth (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Natural deep eutectic solvents (NADES) have previously shown antibacterial properties alone or in combination with photosensitizers and light. In this study, we investigated the behavior of the structural protein collagen ...
Impact of mucin on drug diffusion: Development of a straightforward in vitro method for the determination of drug diffusivity in the presence of mucin 
Falavigna, Margherita; Stein, Paul C.; Flaten, Gøril Eide; Di Cagno, Massimiliano Pio (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Mucosal drug delivery accounts for various administration routes (i.e., oral, vaginal, ocular, pulmonary, etc.) and offers a vast surface for the permeation of drugs. However, the mucus layer which shields and lubricates ...
Fertility treatment and oral contraceptive discontinuation for identification of pregnancy planning in routinely collected health data – an application to analgesic and antibiotic utilisation 
Hjorth, Sarah; Wood, Mollie; Tauqeer, Fatima; Nordeng, Hedvig (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Women with unplanned pregnancies use folic acid less frequently, and more often use potentially teratogenic medications in the first trimester. Yet most studies based on routinely collected data lack information ...
Proteomics‐informed prediction of rosuvastatin plasma profiles in patients with a wide range of body weight 
Wegler, Christine; Garcia, Luna Prieto; Klinting, Signe; Robertsen, Ida; Wisniewski, Jacek R.; Hjelmesæth, Jøran; Åsberg, Anders; Jansson-Löfmark, Rasmus; Andersson, Tommy B.; Artursson, Per (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Correlation of body weight and composition with hepatic activities of cytochrome P450 enzymes 
Krogstad, Veronica; Peric, Alexandra; Robertsen, Ida; Kringen, Marianne K.; Vistnes, Maria; Hjelmesæth, Jøran; Sandbu, Rune; Johnson, Line Kristin; Angeles, Philip Carlo Soriano; Jansson-Löfmark, Rasmus; Karlsson, Cecilia; Andersson, Shalini; Åsberg, Anders; Andersson, Tommy B.; Christensen, Hege Staaland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Obesity is associated with comorbidities of which pharmacological treatment is needed. Physiological changes associated with obesity may influence the pharmacokinetics of drugs, but the effect of body weight on drug ...
Impact of age and CYP2D6 genotype on exposure of zuclopenthixol in patients using long-acting injectable versus oral formulation-an observational study including 2044 patients 
Tveito, Marit; Smith, Robert Løvsletten; Molden, Espen; Høiseth, Gudrun (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Purpose Zuclopenthixol is an antipsychotic available as oral and long-acting injectable (LAI) formulations. The aim of this study was to investigate the effect of age on zuclopenthixol exposure during oral and LAI ...
Preterm birth and risk for language delays before school entry: A sibling-control study 
Zambrana, Imac Maria; Vollrath, Margarete Erika Maria Torgerse; Jacobsson, Bo; Sengpiel, Verena; Ystrøm, Eivind (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
We investigated whether children born preterm are at risk for language delay using a sibling-control design in the Norwegian Mother and Child Cohort Study (MoBa), conducted by the Norwegian Institute of Public Health. ...
Association of coincident self-reported mental health problems and alcohol intake with all-cause and cardiovascular disease mortality: A Norwegian pooled population analysis 
Degerud, Eirik Magnus Meek; Høiseth, Gudrun; Mørland, Jørg Gustav; Ariansen, Inger; Graff-Iversen, Sidsel; Ystrøm, Eivind; Zuccolo, Luisa; Næss, Øyvind (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background The disease burden attributable to mental health problems and to excess or harmful alcohol use is considerable. Despite a strong relationship between these 2 important factors in population health, there are ...
Phenotypic Characterization of Larval Zebrafish (Danio rerio) with Partial Knockdown of the cacna1a Gene 
Gawel, Kinga Aurelia; Turski, Waldemar A.; van der Ent, Wietske; Mathai, Benan John; Kirstein-Smardzewska, Karolina Joanna; Simonsen, Anne; Esguerra, Camila V. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The CACNA1A gene encodes the pore-forming α1 subunit of voltage-gated P/Q type Ca2+ channels (Cav2.1). Mutations in this gene, among others, have been described in patients and rodents suffering from absence seizures and ...
Prenatal exposure to methadone or buprenorphine alters µ-opioid receptor binding and downstream signaling in the rat brain 
Kongstorp, Mette; Bogen, Inger Lise; Steinsland, Synne; Nerem, Elisabeth; Salih, Triske Woshyar; Stiris, Tom; Andersen, Jannike Mørch (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
There is a growing concern related to the use of opioid maintenance treatment during pregnancy. Studies in both humans and animals have reported reduced cognitive functioning in offspring prenatally exposed to methadone ...
Comparing Two Methods of Tablet Manipulation to Adjust the Warfarin Dose in Paediatric Care 
Brustugun, Jørgen; Aas, Elisabeth Birkedal; Tho, Ingunn; Bjerknes, Kathrin (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Tablets containing prescribed doses are not always available, and this is of particular importance in paediatric care where suitable age-appropriate formulations are generally lacking. To obtain a child-adjusted dose, ...
Synthesis and Biological Evaluation of Analogs of Didehydroepiandrosterone as Potential New Anticancer Agents 
J Solum, Eirik; Liekens, Sandra; Hansen, Trond Vidar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The synthesis, cytotoxicity and inhibition of CDK8 by thirteen analogs of cortistatin A are reported. These efforts revealed that the analogs with either a 6- or 7-isoquinoline or 5-indole side chain in the 17-position are ...
Identification of a novel polymorphism associated with reduced clozapine concentration in schizophrenia patients—a genome-wide association study adjusting for smoking habits 
Smith, Robert Løvsletten; O’Connell, Kevin; Athanasiu, Lavinia; Djurovic, Srdjan; Kringen, Marianne K.; Andreassen, Ole Andreas; Molden, Espen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Abstract Clozapine (CLZ) is the superior antipsychotic drug for treatment of schizophrenia, but exhibits an extensive interpatient pharmacokinetic variability. Here, we conducted a genome-wide association study ...
Evaluation of a eukaryote phylogenetic microarray for environmental monitoring of marine sediments 
Lekang, Katrine; Lanzén, Anders; Jonassen, Inge; Thompson, Eric; Troedsson, Christofer (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Increased exploitation of resources in sensitive marine ecosystems emphasizes the importance of knowledge regarding ecological impacts. However, current bio-monitoring practices are limited in terms of target-organisms and ...
Fuel oil desulfurization with dual functionalized imidazolium based ionic liquids 
Butt, Hussain Shakeel; Chellappan, Lethesh Kallidanthiyil; Fiksdahl, Anne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
A series of 36 dual functionalized N-(poly)ethylen glycol N-allyl-/N-benzyl imidazolium and benzimidazolium ILs were synthesized for extractive desulfurization studies (EDS). The novel ILs were readily prepared from imidazole ...
Degradative behavior and toxicity of alkylated imidazoles 
Evjen, Sigvart; Åstrand, Ove Alexander Høgmoen; Gaarder, Mona; Paulsen, Ragnhild Elisabeth; Fiksdahl, Anne; Knuutila, Hanna K (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
The thermal and oxidative degradation behavior and the corrosiveness of imidazole (Im), 2-methylimidazole (2MIm), 2-ethyl-4-methylimidazole (2E4MIm), 2,4,5-trimethylimidazole (2,4,5MIm), and 1,2,4,5-tetramethylimidazole ...
A human relevant mixture of persistent organic pollutants (POPs) and perfluorooctane sulfonic acid (PFOS) enhance nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells 
Yadav, Ajay; Amber, Mazia; Zosen, Denis; Labba, Nils Anders; Huiberts, Eva Henriette Willemijn; Samulin-Erdem, Johanna Maria; Haugen, Fred; Berntsen, Hanne Friis; Zienolddiny, Shanbeh; Paulsen, Ragnhild Elisabeth; Ropstad, Erik; Connolly, Lisa; Verhaegen, Steven (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Disruption of neurite outgrowth is a marker for neurotoxicity. Persistent organic pollutants (POPs) are potential developmental neurotoxicants. We investigated their effect on neurite outgrowth in PC12 rat pheochromocytoma ...
Alternative Biosynthetic Starter Units Enhance the Structural Diversity of Cyanobacterial Lipopeptides 
Mareš, Jan; Hájek, Jan; Urajová, Petra; Kust, Andreja; Jokela, Jouni; Saurav, Kumar; Galica, Tomáš; Čapková, Kateřina; Mattila, Antti; Haapaniemi, Esa; Permi, Perttu; Mysterud, Ivar; Skulberg, Olav M.; Karlsen, Jan; Fewer, David P.; Sivonen, Kaarina; Tønnesen, Hanne Hjort; Hrouzek, Pavel (Journal article / Tidsskriftartikkel; Peer reviewed, 2019)
Puwainaphycins (PUWs) and minutissamides (MINs) are structurally analogous cyclic lipopeptides possessing cytotoxic activity. Both types of compound exhibit high structural variability, particularly in the fatty acid (FA) ...
Validation of diagnostic utility of fasting plasma glucose and HbA1c in stable renal transplant recipients one year after transplantation 
Ussif, Amin M; Åsberg, Anders; Halden, Thea A S; Nordheim, Espen; Hartmann, Anders; Jenssen, Trond (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background The use of HbA1c ≥6.5% for diagnosis of diabetes has been challenged for post-transplantation diabetes mellitus (PTDM) also known as new onset diabetes after transplantation (NODAT) due to a low ...
Association of Maternal Use of Benzodiazepines and Z-Hypnotics During Pregnancy With Motor and Communication Skills and Attention-Deficit/Hyperactivity Disorder Symptoms in Preschoolers 
Lupattelli, Angela; Chambers, Christina D.; Bandoli, Gretchen; Handal, Marte; Skurtveit, Svetlana; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Importance The reproductive safety of benzodiazepine/z-hypnotic exposure on child longer-term developmental risks remains unresolved. Objective To quantify the association of motor, communication, and attention-defi ...
The hypotonic environmental changes affect liposomal formulations for nose-to-brain targeted drug delivery 
Wu, Iren Yeeling; Nikolaisen, Trygg Einar; Skalko-Basnet, Natasa; Di Cagno, Massimiliano Pio (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Systemic administration of drugs is ineffective in the treatment of central nervous system disorders because of the blood-brain barrier. Nasal administration has been suggested as an alternative administration route as ...
Climate change and epilepsy: Time to take action 
Sisodiya, Sanjay M.; Fowler, Hayley J.; Lake, Iain; Nanji, Rosemary O.; Gawel, Kinga Aurelia; Esguerra, Camila Vicencio; Newton, Charles; Foley, Aideen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Climate change is the biggest challenge facing humanity today. The associated global warming and humidification, increases in the severity and frequency of extreme climate events, extension of the ranges of vector‐borne ...
Interpreting non-linear drug diffusion data: Utilizing Korsmeyer-Peppas model to study drug release from liposomes 
Wu, Iren Yeeling; Bala, Sonali; Skalko-Basnet, Natasa; Di Cagno, Massimiliano Pio (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
The aim of this work was to clarify the dynamics behind the influence of ionic strength on the changes in drug release from large unilamellar vesicles (LUVs). For this purpose, we have investigated the transport of two ...
Studying the effect of solubilizing agents on drug diffusion through the unstirred water layer (UWL) by localized spectroscopy 
Di Cagno, Massimiliano Pio; Stein, Paul C (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
An experimental/computational approach has been successfully applied in order to study the effect of solubilizing vehicles (cyclodextrins and liposomes) on the passive diffusion of four active pharmaceutical ingredients ...
Prevalence and risk factors of drug-related hospitalizations in multimorbid patients admitted to an internal medicine ward 
Lea, Marianne; Mowe, Morten; Mathiesen, Liv; Kvernrød, Kristin; Skovlund, Eva; Molden, Espen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background Knowledge of risk factors for drug-related hospitalizations (DRHs) is limited. Aim To examine the prevalence of DRHs and the relationships between DRHs and various variables in multimorbid patients admitted ...
Use and validity of child neurodevelopment outcome measures in studies on prenatal exposure to psychotropic and analgesic medications – A systematic review 
Andersen, Sarah Hjorth; Bromley, Rebecca; Ystrøm, Eivind; Lupattelli, Angela; Spigset, Olav; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
In recent years there has been increased attention to child neurodevelopment in studies on medication safety in pregnancy. Neurodevelopment is a multifactorial outcome that can be assessed by various assessors, using ...
The influence of bariatric surgery on oral drug bioavailability in patients with obesity: A systematic review 
Angeles, Philip Carlo Soriano; Robertsen, Ida; Seeberg, Lars Thomas; Krogstad, Veronica; Skattebu, Julie; Sandbu, Rune; Åsberg, Anders; Hjelmesæth, Jøran (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Anatomical changes in the gastrointestinal tract and subsequent weight loss may influence drug disposition and thus drug dosing following bariatric surgery. This review systematically examines the effects of bariatric ...
Knowledge of antibiotics and antibiotic resistance among Norwegian pharmacy customers – a cross-sectional study 
Waaseth, Marit; Adan, Abdifatah; Røen, Ingrid L; Eriksen, Karoline; Stanojevic, Tijana; Halvorsen, Kjell H; Garcia, Beate H; Holst, Lone; Ulshagen, Karen M; Blix, Hege S; Ariansen, Hilde; Nordeng, Hedvig M (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background Antibiotic resistance is a global health threat. Public knowledge is considered a prerequisite for appropriate use of antibiotics and limited spread of antibiotic resistance. Our aim was to examine ...
Adipokine levels are associated with insulin resistance in antipsychotics users independently of BMI 
Vedal, Trude Seselie Jahr; Steen, Nils Eiel; Birkeland, Kåre I.; Dieset, Ingrid; Reponen, Elina Johanna; Laskemoen, Jannicke F.; Rødevand, Linn; Melle, Ingrid; Andreassen, Ole Andreas; Molden, Espen; Jönsson, Erik Gunnar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background The prevalence of obesity, metabolic syndrome and type 2 diabetes mellitus is increased among patients with severe mental disorders, and particularly use of second generation antipsychotic drugs is associated ...
Interaction between dietary fatty acids and genotype on immune response in Atlantic salmon (Salmo salar) after vaccination: Atranscriptome study 
Andresen, Adriana Magalhaes Santos; Lutfi Royo, Esmail; Ruyter, Bente; Berge, Gerd Marit; Gjøen, Tor (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
A pivotal matter to aquaculture is the sourcing of sustainable resources as ingredients to aquafeeds. Levels of plant delivered oils as source of fatty acids (FA) in aquafeeds have reached around 70% resulting in reduced ...
Micellisation Mechanism and Behaviour of Soluplus®–Furosemide Micelles: Preformulation Studies of an Oral Nanocarrier-Based System 
Alopaeus, Julia Fredrika; Hagesæther, Ellen; Tho, Ingunn (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
In this study, self-assembling Soluplus® micelles were examined for inherent properties. Through calorimetric analysis, the critical micelle concentration (CMC) could be determined at 25 and 37 °C, and the influence of ...
Association of Maternal Use of Benzodiazepines and Z-Hypnotics During Pregnancy With Motor and Communication Skills and Attention-Deficit/Hyperactivity Disorder Symptoms in Preschoolers 
Lupattelli, Angela; Chambers, Christina D.; Bandoli, Gretchen; Handal, Marte; Skurtveit, Svetlana; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / PublishedVersionAcceptedVersion; Peer reviewed, 2019)
Importance: The reproductive safety of benzodiazepine/z-hypnotic exposure on child longer-term developmental risks remains unresolved. Objective: To quantify the association of motor, communication, and attention-defi ...
Risk perception, beliefs about medicines and medical adherence among pregnant and breastfeeding women with migraine: findings from a cross-sectional study in Norway 
Amundsen, Siri; Øvrebø, Torunn Gudmestad; Amble, Netta Marie Skretteberg; Poole, Anne Christine; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Objectives To examine risk perception, beliefs about migraine medications and medical adherence among pregnant and breastfeeding women with migraine. Design and setting Cross-sectional study conducted in Norway from ...
The EKiTE network (epidemiology in kidney transplantation - a European validated database): an initiative epidemiological and translational European collaborative research 
Lorent, M.; Foucher, Y.; Kerleau, K.; Brouard, S.; Baayen, C.; Lebouter, S.; Naesens, M.; Bestard Matamoros, O.; Åsberg, A.; Giral, M. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background Kidney transplantation is considered to be the treatment of choice for people with end-stage renal disease (ESRD). However, due to the shortage of available organs and the increase in the ESRD ...
Gellan Gum/Laponite Beads for the Modified Release of Drugs: Experimental and Modeling Study of Gastrointestinal Release 
Adrover, Alessandra; Paolicelli, Patrizia; Petralito, Stefania; Di Muzio, Laura; Trilli, Jordan; Cesa, Stefania; Tho, Ingunn; Casadei, Maria Antonietta (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
In this study, gellan gum (GG), a natural polysaccharide, was used to fabricate spherical porous beads suitable as sustained drug delivery systems for oral administration. GG was cross-linked with calcium ions to prepare ...
Vitamin D as a risk factor for patient survival after kidney transplantation: A prospective observational cohort study 
Thorsen, Inga Strand; Bleskestad, Inger Hjørdis; Åsberg, Anders; Hartmann, Anders; Skadberg, Øyvind; Brede, Cato; Ueland, Thor; Pasch, Andreas; Reisæter, Anna Varberg; Gøransson, Lasse (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Background Short‐term survival after kidney transplantation is excellent, but long‐term survival remains low and is equivalent to non‐end‐stage renal disease patients with many invasive malignancies. The aim of the study ...
Maternal fever during pregnancy and offspring attention deficit hyperactivity disorder 
Gustavson, Kristin; Ask, Helga; Ystrøm, Eivind; Stoltenberg, Camilla; Lipkin, W. Ian; Suren, Pål; Håberg, Siri Eldevik; Magnus, Per; Knudsen, Gun Peggy S.; Eilertsen, Espen Moen; Bresnahan, Michaeline; Aase, Heidi; Mjaaland, Siri; Susser, Ezra S.; Hornig, Mady; Reichborn-Kjennerud, Ted (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Maternal fever during pregnancy is associated with several adverse child outcomes. We investigated associations between maternal fever and ADHD among offspring, as well as the sub-dimensions of ADHD - inattention and ...
Women's perspectives on the management and consequences of hyperemesis gravidarum - a descriptive interview study 
Havnen, Gro Cecilie; Truong, Maria Bich-Thuy; Huynh Do, Mai-Linh; Heitmann, Kristine; Holst, Lone; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Objective: Hyperemesis gravidarum (HG) affects 0.3–3% of pregnant women and is a leading cause of hospitalization in early pregnancy. The aim of the study was to investigate women’s treatment and management of HG, as well ...
Interventional study to improve adherence to phosphate binder treatment in dialysis patients 
Hjemås, Bodil J; Bøvre, Katrine; Mathiesen, Liv; Lindstrøm, Jonas C; Bjerknes, Kathrin (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background Adherence to phosphate binder treatment is important to prevent high serum phosphate level in chronic dialysis patients. We therefore wanted to investigate patient knowledge, beliefs about and ...
Exploring the overlapping binding sites of ifenprodil and EVT‐101 in GluN2B‐containing NMDA receptors using novel chicken embryo forebrain cultures and molecular modeling 
Fjelldal, Marthe Fredheim; Freyd, Thibaud; Evenseth, Linn; Sylte, Ingebrigt; Ring, Avi; Paulsen, Ragnhild Elisabeth (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
N‐methyl‐d‐aspartate receptors (NMDAR) are widely expressed in the brain. GluN2B subunit‐containing NMDARs has recently attracted significant attention as potential pharmacological targets, with emphasis on the functional ...
Associations between maternal depressive symptoms and risk for offspring early-life psychopathology: the role of genetic and non-genetic mechanisms 
Gjerde, Line C.; Eilertsen, Espen Moen; Hannigan, Laurie; Eley, Thalia C.; Røysamb, Espen; Reichborn-Kjennerud, Ted; Rijsdijk, Frühling V.; McAdams, Tom A.; Ystrøm, Eivind (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Background Although maternal depressive symptoms are robustly associated with offspring early-life psychopathology symptoms, it is not clear which potential mechanisms are at play. We aimed to estimate the relative ...
High intensity interval training ameliorates mitochondrial dysfunction in the left ventricle of mice with type 2 diabetes 
Bækkerud, Fredrik Hjulstad; Salerno, Simona; Ceriotti, Paola; Morland, Cecilie; Storm-Mathisen, Jon; Bergersen, Linda Hildegard; Høydal, Morten; Catalucci, Daniele; Stølen, Tomas (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Both human and animal studies have shown mitochondrial and contractile dysfunction in hearts of type 2 diabetes mellitus (T2DM). Exercise training has shown positive effects on cardiac function, but its effect on the ...
Characterization of Inulin-Type Fructan from Platycodon grandiflorus and Study on Its Prebiotic and Immunomodulating Activity 
Pang, Di-Jiang; Huang, Chao; Chen, Mei-Ling; Chen, Yu-Long; Fu, Yu-Ping; Paulsen, Berit Smestad; Rise, Frode; Zhang, Bing-Zhao; Chen, Zheng-Li; Jia, Ren-Yong; Li, Li-Xia; Song, Xu; Feng, Bin; Ni, Xue-Qin; Yin, Zhong-Qiong; Zou, Yuan-Feng (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Platycodon grandiflorus is a plant widely used in traditional Chinese medicine, of which polysaccharides are reported to be the main components responsible for its bio-functions. In this work, the inulin-type fructan (PGF) ...
A Method for Direct Monitoring of Atorvastatin Adherence in Cardiovascular Disease Prevention: Quantification of the Total Exposure to Parent Drug and Major Metabolites Using 2-Channel Chromatography and Tandem Mass Spectrometry 
Vethe, Nils Tore; Munkhaugen, John; Andersen, Anders Mikal; Husebye, Einar; Bergan, Stein (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Background: Low adherence to statin therapy remains a public health concern associated with poor prognosis in cardiovascular disease patients. A feasible method for statin adherence monitoring in clinical practice has ...
Impact of hyperinsulinemia and hyperglycemia on valvular interstitial cells – A link between aortic heart valve degeneration and type 2 diabetes 
Selig, Jessica I; Ouwens, D. Margriet; Raschke, Silja; Thoresen, G. Hege; Fischer, Jens; Lichtenberg, Artur; Akhyari, Payam; Barth, Mareike (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Type 2 diabetes is a known risk factor for cardiovascular diseases and is associated with an increased risk to develop aortic heart valve degeneration. Nevertheless, molecular mechanisms leading to the pathogenesis of valve ...
Molecular modelling, synthesis, and biological evaluations of a 3,5-disubstituted isoxazole fatty acid analogue as a PPARα-selective agonist 
Arnesen, Liv Henriette; Haj Yasein, Nadia; Tungen, Jørn Eivind; Soedling, Helen; Matthews, Jason; Paulsen, Steinar M; Nebb, Hilde Irene; Sylte, Ingebrigt; Hansen, Trond Vidar; Sæther, Thomas (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
The peroxisome proliferator activated receptors (PPARs) are important drug targets in treatment of metabolic and inflammatory disorders. Fibrates, acting as PPARα agonists, have been widely used lipid-lowering agents for ...
Quality of Life of Family Carers of Persons with Young-Onset Dementia: A Nordic Two-Year Observational Multicenter 
Hvidsten, Lara H. Thomasgaard; Engedal, Knut; Selbæk, Geir; Wyller, Torgeir Bruun; Saltyte Benth, Jurate; Kersten, Hege (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Objectives To identify factors associated with QOL in carers of persons with young-onset Alzheimer’s (AD) and frontotemporal dementia (FTD) and explore development in QOL over a two-year period. Methods Eighty-eight ...
Identification and Assessment of Drug-User Groups Among Nightlife Attendees: Self-Reports, Breathalyzer-Tests and Oral Fluid Drug Tests 
Bretteville-Jensen, Anne Line; Burdzovic, Jasmina; Gjersing, Linn; Øiestad, Elisabeth Leere; Gjerde, Halvard (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Background and Objectives: Even though nightlife studies with potentially intoxicated participants provide the much needed information on drug use, they face additional methodological challenges. This study aimed to explore ...
A novel direct method to determine adherence to atorvastatin therapy in patients with coronary heart disease 
Kristiansen, Oscar; Vethe, Nils Tore; Fagerland, Morten; Bergan, Stein; Munkhaugen, John; Husebye, Einar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Aims Objective methods to monitor statin adherence are needed. We have established a liquid chromatography–tandem mass spectrometry assay for quantification of atorvastatin and its metabolites in blood. This study aimed ...
Women’s Beliefs About Medicines and Adherence to Pharmacotherapy in Pregnancy: Opportunities for Community Pharmacists 
Ceulemans, Michael; Lupattelli, Angela; Nordeng, Hedvig Marie Egeland; Odalovic, Marina; Twigg, Michael J.; Foulon, Veerle (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Background: During pregnancy, women might weigh the benefits of treatment against potential risks to the unborn child. However, non-adherence to necessary treatment can adversely affect both mother and child. To optimize ...
Vesicles From Vibrio cholerae Contain AT-Rich DNA and Shorter mRNAs That Do Not Correlate With Their Protein Products 
Langlete, Petter; Krabberød, Anders Kristian; Winther-Larsen, Hanne Cecilie (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Extracellular vesicles secreted by Gram-negative bacteria have proven to be important in bacterial defense, communication and host-pathogen relationships. They resemble smaller versions of the bacterial mother cell, with ...
Adjusting the dose in paediatric care: dispersing four different aspirin tablets and taking a proportion 
Brustugun, Jørgen; Notaker, Nikolai; Paetz, Lasse Holtan; Tho, Ingunn; Bjerknes, Kathrin (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Objectives: When caring for children in a hospital setting, tablets are often manipulated at the ward to obtain the right dose. One example is manipulation of tablets containing the slightly water-soluble substance aspirin, ...
Using a period incidence survey to compare antibiotic use in children between a university hospital and a district hospital in a country with low antimicrobial resistance: a prospective observational study 
Thaulow, Christian Magnus; Blix, Hege Salvesen; Eriksen, Beate Horsberg; Ask, Ingvild; Myklebust, Tor Åge; Berild, Dag (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Objectives To describe and compare antibiotic use in relation to indications, doses, adherence rate to guidelines and rates of broad-spectrum antibiotics (BSA) in two different paediatric departments with different academic ...
Statin-associated muscle symptoms in coronary patients: design of a randomized study 
Munkhaugen, John; Vethe, Nils Tore; Fagerland, Morten; Dammen, Toril; Perk, Joep; Gjertsen, Erik; Otterstad, Jan Erik; Gullestad, Lars; Bergan, Stein; Husebye, Einar (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Objectives. Estimate the effect of atorvastatin on muscular symptom intensity in coronary patients with subjective statin-associated muscle symptoms (SAMS) and to determine the association with blood levels of atorvastatin ...
Early increase of specialized pro-resolving lipid mediators in patients with ST-elevation myocardial infarction 
Fosshaug, Linn Elisabeth Lillerud; Colas, Romain A.; Anstensrud, Anne Kristine; Gregersen, Ida; Nymoen, Ståle H.; Sagen, Ellen; Michelsen, Annika; Vinge, Leif Erik; Øie, Erik; Gullestad, Lars; Halvorsen, Bente; Hansen, Trond Vidar; Aukrust, Pål; Dalli, Jesmond; Yndestad, Arne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background Termination of acute inflammation is an active process orchestrated by lipid mediators (LM) derived from polyunsaturated fatty acids, referred to as specialized pro-resolving mediators (SPM). These mediators ...
Community pharmacist counseling in early pregnancy—Results from the SafeStart feasibility study 
Truong, Maria Bich-Thuy; Ngo, Elin Thuy Phuong; Ariansen, Hilde; Tsuyuki, Ross; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background: Community pharmacists are available to counsel women in early pregnancy, but no studies have assessed the feasibility of such a service. Objective: To test the feasibility of a pharmacist consultation in early ...
Can screening tools for potentially inappropriate prescriptions in older adults prevent serious adverse drug events? 
Wang-Hansen, Marte Sofie; Wyller, Torgeir Bruun; Hvidsten, Lara H. Thomasgaard; Kersten, Hege (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Purpose The purpose of the study is to identify and explore risk factors of serious adverse drug events (SADE) and SADE-related admissions in acutely hospitalized multimorbid older adults and assess whether these could ...
Systematic evaluation and validation of reference and library selection methods for deconvolution of cord blood DNA methylation data 
Gervin, Kristina; Salas, Lucas A; Bakulski, Kelly M; van Zelm, Menno C; Koestler, Devin C; Wiencke, John K; Duijts, Liesbeth; Moll, Henriëtte A; Kelsey, Karl T; Kobor, Michael S; Lyle, Robert; Christensen, Brock C; Felix, Janine F; Jones, Meaghan J (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background Umbilical cord blood (UCB) is commonly used in epigenome-wide association studies of prenatal exposures. Accounting for cell type composition is critical in such studies as it reduces confounding ...
Data-Independent Acquisition for the Orbitrap Q Exactive HF: A Tutorial. 
Reubsaet, Leon; Sweredoski, Michael J.; Moradian, Annie (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Data-independent acquisition (DIA) is a powerful mass spectrometric technique to perform both protein identification and quantification of complex protein samples. Setting up DIA methods on Orbitrap analyzers requires a ...
Is the association between maternal alcohol consumption in pregnancy and pre-school child behavioural and emotional problems causal? Multiple approaches for controlling unmeasured confounding 
Lund, Ingunn Olea; Eilertsen, Espen Moen; Gjerde, Line C.; Røysamb, Espen; Wood, Mollie; Reichborn-Kjennerud, Ted; Ystrøm, Eivind (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Background and aims Hazardous drinking (i.e. alcohol consumption that places drinkers at risk for adverse health outcomes) during pregnancy is associated with adverse child outcomes. To address whether the associations ...
NIPSNAP1 and NIPSNAP2 act as “eat-me signal” for mitophagy 
Abudu, Yakubu Princely; Pankiv, Serhiy; Mathai, Benan John; Lystad, Alf Håkon; Bindesbøll, Christian; Brenne, Hanne Britt; Ng, Matthew Yoke Wui; Thiede, Bernd; Yamamoto, Ai; Nthiga, Thaddaeus Mutugi; Lamark, Trond; Esguerra, Camila Vicencio; Johansen, Terje; Simonsen, Anne (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
The clearance of damaged or dysfunctional mitochondria by selective autophagy (mitophagy) is important for cellular homeostasis and prevention of disease. Our understanding of the mitochondrial signals that trigger their ...
Maternal thyroid hormone replacement therapy exposure and language and communication skills of offspring at 8 years of age 
Frank, Anna-Simone; Lupattelli, Angela; Brandlistuen, Ragnhild Eek; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Importance: Hypothyroidism during pregnancy is associated with neurodevelopmental delays in the offspring. However, it remains unknown whether prenatal thyroid hormone replacement therapy (THRT) has benefits regarding ...
Gonadotrope plasticity at cellular, population and structural levels: A comparison between fishes and mammals 
Fontaine, Romain David; Ciani, Elia; Haug, Trude M; Hodne, Kjetil; Ager-Wick, Eirill; Baker, Dianne; Weltzien, Finn-Arne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Often referred to as “the master gland”, the pituitary is a key organ controlling growth, maturation, and homeostasis in vertebrates. The anterior pituitary, which contains several hormone-producing cell types, is highly ...
Prenatal paracetamol exposure and neurodevelopmental outcomes in preschool-aged children 
Trønnes, Johanne Naper; Wood, Mollie; Lupattelli, Angela; Ystrøm, Eivind; Nordeng, Hedvig Marie Egeland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Background Recent studies have suggested an association between prenatal paracetamol exposure and adverse neurodevelopmental outcomes in children. However, these findings may be confounded by unmeasured factors related ...
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