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IN VITRO STUDIES SUGGEST INVOLVEMENT OF CYP2D6 IN THE METABOLISM OF SIMVASTATIN AND ACTIVE METABOLITES
(Master thesis / Hovedoppgave, 2003)
ABSTRACT Aim: The HMG-CoA reductase inhibitor, simvastatin (SV), is known to be extensively metabolised by CYP3A4 in humans. However, clinical studies have suggested a possible involvement of the polymorphic enzyme CYP2D6 ...