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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
It remains uncertain whether pharmacokinetic changes following Roux-en-Y gastric bypass (RYGB) can be attributed to surgery-induced gastrointestinal alterations per se and/or the subsequent weight loss. The aim was to ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Obesity is associated with comorbidities of which pharmacological treatment is needed. Physiological changes associated with obesity may influence the pharmacokinetics of drugs, but the effect of body weight on drug ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Introduction
Rosuvastatin pharmacokinetics is mainly dependent on the activity of hepatic uptake transporter OATP1B1. In this study, we aimed to investigate and disentangle the effect of Roux-en-Y gastric bypass (RYGB) ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Human liver tissue is composed of heterogeneous mixtures of different cell types and their cellular stoichiometry can provide information on hepatic physiology and disease progression. Deconvolution algorithms for the ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
Background and Objective
Several drugs on the market are substrates for P-glycoprotein (P-gp), an efflux transporter highly expressed in barrier tissues such as the intestine. Body weight, weight loss, and a Roux-en-Y ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Previous studies have not accounted for the close link between type 2 diabetes mellitus (T2DM) and obesity when investigating the impact of T2DM on cytochrome P450 (CYP) activities. The aim was to investigate the effect ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Aim
Roux-en-Y gastric bypass (RYGB) may influence drug disposition due to surgery-induced gastrointestinal alterations and/or subsequent weight loss. The objective was to compare short- and long-term effects of RYGB and ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Abstract
Purpose
Variability in cytochrome P450 3A4 (CYP3A4) metabolism is mainly caused by non-genetic factors, hence providing a need for accurate phenotype biomarkers. Although 4β-hydroxycholesterol ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
Mathematical models, such as physiologically based pharmacokinetic (PBPK) models, are used to predict e.g., drug disposition and toxicity. However, populations differ in the abundance of proteins involved in these processes. ...