Browsing Farmasøytisk institutt by Author "Rustan, Arild"

Now showing items 1-12 of 12

  • Exercise in vivo marks human myotubes in vitro: Training-induced increase in lipid metabolism 
    Lund, Jenny; Rustan, Arild; Løvsletten, Nils Gunnar; Mudry, Jonathan M.; Langleite, Torgrim Mikal; Feng, Yuan Zeng; Stensrud, Camilla; Brubak, Mari G; Drevon, Christian A; Birkeland, Kåre I.; Kolnes, Kristoffer Jensen; Johansen, Egil Ivar; Tangen, Daniel S.; Stadheim, Hans Kristian; Gulseth, Hanne Løvdal; Krook, Anna; Kase, Eili Tranheim; Jensen, Jørgen; Thoresen, G. Hege (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Background and aims Physical activity has preventive as well as therapeutic benefits for overweight subjects. In this study we aimed to examine effects of in vivo exercise on in vitro metabolic adaptations by studying ...
  • Glucose metabolism and metabolic flexibility in cultured skeletal muscle cells is related to exercise status in young male subjects 
    Lund, Jenny; Tangen, Daniel S.; Wiig, Håvard; Stadheim, Hans Kristian; Siw, Anette Helle; Birk, Jesper B.; Ingemann-Hansen, Thorsten; Rustan, Arild; Thoresen, G. Hege; Wojtaszewski, Jørgen F.P.; Kase, Eili Tranheim; Jensen, Jørgen (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
    We hypothesised that skeletal muscles of healthy young people have a large variation in oxidative capacity and fibre-type composition, and aimed therefore to investigate glucose metabolism in biopsies and myotubes isolated ...
  • Higher lipid turnover and oxidation in cultured human myotubes from athletic versus sedentary young male subjects 
    Lund, Jenny; Helle, Siw A.; Li, Yuchuan; Løvsletten, Nils Gunnar; Stadheim, Hans Kristian; Jensen, Jørgen; Kase, Eili Tranheim; Thoresen, G. Hege; Rustan, Arild (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    In this study we compared fatty acid (FA) metabolism in myotubes established from athletic and sedentary young subjects. Six healthy sedentary (maximal oxygen uptake (VO2max)≤ 46 ml/kg/min) and six healthy athletic ...
  • Increased triacylglycerol - Fatty acid substrate cycling in human skeletal muscle cells exposed to eicosapentaenoic acid. 
    Løvsletten, Nils Gunnar; Bakke, Siril Skaret; Kase, Eili Tranheim; Ouwens, D. Margriet; Thoresen, G. Hege; Rustan, Arild (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    It has previously been shown that pretreatment of differentiated human skeletal muscle cells (myotubes) with eicosapentaenoic acid (EPA) promoted increased uptake of fatty acids and increased triacylglycerol accumulation, ...
  • Lack of the lysosomal membrane protein, GLMP, in mice results in metabolic dysregulation in liver 
    Kong, Xiang Yi; Kase, Eili Tranheim; Herskedal, Anette; Schjalm, Camilla; Damme, Markus; Nesset, Cecilie Kåsi; Thoresen, G. Hege; Rustan, Arild; Eskild, Winnie (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    Ablation of glycosylated lysosomal membrane protein (GLMP, formerly known as NCU-G1) has been shown to cause chronic liver injury which progresses into liver fibrosis in mice. Both lysosomal dysfunction and chronic liver ...
  • Loss of lysosomal membrane protein NCU-G1 in mice results in spontaneous liver fibrosis with accumulation of lipofuscin and iron in Kupffer cells 
    Kong, Xiang Yi; Nesset, Cecilie Kåsi; Damme, Markus; Løberg, Else Marit; Lübke, Torben; Mæhlen, Jan; Andersson, Kristin Brevik; Lorenzo, Petra Isabel O.; Roos, Norbert; Thoresen, G. Hege; Rustan, Arild; Kase, Eili Tranheim; Eskild, Winnie (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
    Human kidney predominant protein, NCU-G1, is a highly conserved protein with an unknown biological function. Initially described as a nuclear protein, it was later shown to be a bona fide lysosomal integral membrane protein. ...
  • Loss of perilipin 2 in cultured myotubes enhances lipolysis and redirects the metabolic energy balance from glucose oxidation towards fatty acid oxidation 
    Feng, Yuan Zeng; Lund, Jenny; Li, Yuchuan; Knabenes, Irlin K; Bakke, Siril Skaret; Kase, Eili Tranheim; Lee, Yun K; Kimmel, Alan R; Thoresen, G. Hege; Rustan, Arild; Dalen, Knut Tomas (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Lipid droplet (LD) coating proteins are essential for the formation and stability of intracellular LDs. Plin2 is an abundant LD coating protein in skeletal muscle, but its importance for muscle function is unclear. We show ...
  • A mitochondria-targeted fatty acid analogue influences hepatic glucose metabolism and reduces the plasma insulin/glucose ratio in male Wistar rats 
    Lindquist, Carine; Bjørndal, Bodil; Bakke, Hege Gilbø; Slettom, Grete; Karoliussen, Marie; Rustan, Arild; Thoresen, G. Hege; Skorve, Jon; Nygård, Ottar; Berge, Rolf Kristian (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    A fatty acid analogue, 2-(tridec-12-yn-1-ylthio)acetic acid (1-triple TTA), was previously shown to have hypolipidemic effects in rats by targeting mitochondrial activity predominantly in liver. This study aimed to determine ...
  • Myotubes from Severely Obese Type 2 Diabetic Subjects Accumulate Less Lipids and Show Higher Lipolytic Rate than Myotubes from Severely Obese Non-Diabetic Subjects 
    Bakke, Siril Skaret; Feng, Yuan Zeng; Nikolic, Natasa; Kase, Eili Tranheim; Moro, Cedric; Stensrud, Camilla; Damlien, Lisbeth; Ludahl, Marianne Odnakk; Sandbu, Rune; Solheim, Brita Marie; Rustan, Arild; Hjelmesæth, Jøran; Thoresen, G. Hege; Aas, Vigdis (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    About 80% of patients with type 2 diabetes are classified as overweight. However, only about 1/3 of severely obese subjects have type 2 diabetes. This indicates that several severely obese individuals may possess certain ...
  • Substrate oxidation in primary human skeletal muscle cells is influenced by donor age 
    Aas, Vigdis; Thoresen, G. Hege; Rustan, Arild; Lund, Jenny (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Abstract Primary human myotubes represent an alternative system to intact skeletal muscle for the study of human diseases related to changes in muscle energy metabolism. This work aimed to study if fatty acid and glucose ...
  • Uncovering human METTL12 as a mitochondrial methyltransferase that modulates citrate synthase activity through metabolite-sensitive lysine methylation 
    Malecki, Jedrzej Mieczyslaw; Jakobsson, Magnus; Ho, Angela Yeuan Yen; Moen, Anders; Rustan, Arild; Falnes, Pål (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Lysine methylation is an important and much-studied posttranslational modification of nuclear and cytosolic proteins but is present also in mitochondria. However, the responsible mitochondrial lysine-specific methyltransferases ...
  • Upregulated PDK4 expression is a sensitive marker of increased fatty acid oxidation 
    Pettersen, Ina Katrine Nitschke; Tusubira, Deusdedit; Ashrafi, Hanan; Dyrstad, Sissel Elisabeth; Hansen, Lena; Liu, Xiao-Zheng; Hodneland, Linn I.; Løvsletten, Nils Gunnar; Berge, Kjetil; Wergedahl, Hege; Bjørndal, Bodil; Fluge, Øystein; Bruland, Ove; Rustan, Arild; Halberg, Nils; Røsland, Gro Vatne; Berge, Rolf Kristian; Tronstad, Karl Johan (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Fatty acid oxidation is a central fueling pathway for mitochondrial ATP production. Regulation occurs through multiple nutrient- and energy-sensitive molecular mechanisms. We explored if upregulated mRNA expression of the ...