Browsing Farmasøytisk institutt by Author "Paulsen, Steinar M"

Now showing items 1-2 of 2

Molecular modelling, synthesis, and biological evaluations of a 3,5-disubstituted isoxazole fatty acid analogue as a PPARα-selective agonist

Arnesen, Liv Henriette; Haj Yasein, Nadia; Tungen, Jørn Eivind; Soedling, Helen; Matthews, Jason; Paulsen, Steinar M; Nebb, Hilde Irene; Sylte, Ingebrigt; Hansen, Trond Vidar; Sæther, Thomas (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)

The peroxisome proliferator activated receptors (PPARs) are important drug targets in treatment of metabolic and inflammatory disorders. Fibrates, acting as PPARα agonists, have been widely used lipid-lowering agents for ...
Synthesis and biological evaluations of marine oxohexadecenoic acids: PPARα/γ dual agonism and anti-diabetic target gene effects

Sæther, Thomas; Paulsen, Steinar M; Tungen, Jørn Eivind; Vik, Anders; Aursnes, Marius; Holen, Torgeir; Hansen, Trond Vidar; Nebb, Hilde Irene (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)

Obesity and associated disorders such as metabolic syndrome and type 2 diabetes (T2D) have reached epidemic proportions. Several natural products have been reported as Peroxisome Proliferator-Activated Receptor (PPAR) ...

Browse