Browsing Farmasøytisk institutt by Author "Jansson-Löfmark, Rasmus"

Now showing items 1-10 of 10

  • Correlation of body weight and composition with hepatic activities of cytochrome P450 enzymes 
    Krogstad, Veronica; Peric, Alexandra; Robertsen, Ida; Kringen, Marianne K.; Vistnes, Maria; Hjelmesæth, Jøran; Sandbu, Rune; Johnson, Line Kristin; Angeles, Philip Carlo Soriano; Jansson-Löfmark, Rasmus; Karlsson, Cecilia; Andersson, Shalini; Åsberg, Anders; Andersson, Tommy B.; Christensen, Hege Staaland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Obesity is associated with comorbidities of which pharmacological treatment is needed. Physiological changes associated with obesity may influence the pharmacokinetics of drugs, but the effect of body weight on drug ...
  • Correlations between 4β-hydroxycholesterol and hepatic and intestinal CYP3A4: protein expression, microsomal ex vivo activity, and in vivo activity in patients with a wide body weight range 
    Kvitne, Kine Eide; Hole, Kristine; Krogstad, Veronica; Wollmann, Birgit Malene Tovik; Wegler, Christine; Johnson, Line Kristin; Hertel, Jens Kristoffer; Artursson, Per; Karlsson, Cecilia; Andersson, Shalini; Andersson, Tommy B.; Sandbu, Rune; Hjelmesæth, Jøran Sture; Skovlund, Eva; Christensen, Hege; Jansson-Löfmark, Rasmus; Åsberg, Anders; Molden, Espen; Robertsen, Ida (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Abstract Purpose Variability in cytochrome P450 3A4 (CYP3A4) metabolism is mainly caused by non-genetic factors, hence providing a need for accurate phenotype biomarkers. Although 4β-hydroxycholesterol ...
  • Digoxin Pharmacokinetics in Patients with Obesity Before and After a Gastric Bypass or a Strict Diet Compared with Normal Weight Individuals 
    Kvitne, Kine Eide; Hovd, Markus; Johnsen, Line Kristin; Wegler, Christine; Karlsson, Cecilia; Artursson, Per; Andersson, Shalini; Sandbu, Rune; Hjelmesæth, Jøran Sture; Skovlund, Eva; Jansson-Löfmark, Rasmus; Christensen, Hege; Åsberg, Anders; Robertsen, Ida (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Background and Objective Several drugs on the market are substrates for P-glycoprotein (P-gp), an efflux transporter highly expressed in barrier tissues such as the intestine. Body weight, weight loss, and a Roux-en-Y ...
  • Drug disposition protein quantification in matched human jejunum and liver from donors with obesity 
    Wegler, Christine; Wisniewski, Jacek R.; Robertsen, Ida; Christensen, Hege; Hertel, Jens Kristoffer; Hjelmesæth, Jøran Sture; Jansson-Löfmark, Rasmus; Åsberg, Anders; Andersson, Tommy B; Artursson, Per (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Mathematical models, such as physiologically based pharmacokinetic (PBPK) models, are used to predict e.g., drug disposition and toxicity. However, populations differ in the abundance of proteins involved in these processes. ...
  • Impact of type 2 diabetes on in vivo activities and protein expressions of cytochrome P450 in patients with obesity 
    Kvitne, Kine Eide; Åsberg, Anders; Johnson, Line Kristin; Wegler, Christine; Hertel, Jens Kristoffer; Artursson, Per; Karlsson, Cecilia Elisabeth; Andersson, Shalini; Sandbu, Rune; Skovlund, Eva; Christensen, Hege; Jansson-Löfmark, Rasmus; Hjelmesæth, Jøran Sture; Robertsen, Ida (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Previous studies have not accounted for the close link between type 2 diabetes mellitus (T2DM) and obesity when investigating the impact of T2DM on cytochrome P450 (CYP) activities. The aim was to investigate the effect ...
  • Neither Gastric Bypass Surgery Nor Diet-Induced Weight-Loss Affect OATP1B1 Activity as Measured by Rosuvastatin Oral Clearance 
    Hovd, Markus Herberg; Robertsen, Ida; Johnson, Line Kristin; Krogstad, Veronica; Wegler, Christine; Kvitne, Kine Eide; Kringen, Marianne K.; Skovlund, Eva; Karlsson, Cecilia; Andersson, Shalini; Artursson, Per; Sandbu, Rune; Hjelmesæth, Jøran Sture; Åsberg, Anders; Jansson-Löfmark, Rasmus; Christensen, Hege (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Introduction Rosuvastatin pharmacokinetics is mainly dependent on the activity of hepatic uptake transporter OATP1B1. In this study, we aimed to investigate and disentangle the effect of Roux-en-Y gastric bypass (RYGB) ...
  • Proteome deconvolution of liver biopsies reveals hepatic cell composition as an important marker of fibrosis 
    Handin, Niklas; Yuan, Di; Ölander, Magnus; Wegler, Christine; Karlsson, Cecilia; Jansson-Löfmark, Rasmus; Hjelmesæth, Jøran Sture; Åsberg, Anders; Lauschke, Volker M.; Artursson, Per (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Human liver tissue is composed of heterogeneous mixtures of different cell types and their cellular stoichiometry can provide information on hepatic physiology and disease progression. Deconvolution algorithms for the ...
  • Proteomics‐informed prediction of rosuvastatin plasma profiles in patients with a wide range of body weight 
    Wegler, Christine; Garcia, Luna Prieto; Klinting, Signe; Robertsen, Ida; Wisniewski, Jacek R.; Hjelmesæth, Jøran; Åsberg, Anders; Jansson-Löfmark, Rasmus; Andersson, Tommy B.; Artursson, Per (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
  • Short- and long-term effects of body weight loss following calorie restriction and gastric bypass on CYP3A-activity – a non-randomized three-armed controlled trial 
    Kvitne, Kine Eide; Robertsen, Ida; Skovlund, Eva; Christensen, Hege Staaland; Krogstad, Veronica; Wegler, Christine; Angeles, Philip Carlo Soriano; Wollmann, Birgit Malene Tovik; Hole, Kristine; Sandbu, Rune; Artursson, Per; Karlsson, Cecilia; Andersson, Shalini; Andersson, Tommy B.; Hjelmesæth, Jøran; Jansson-Löfmark, Rasmus; Åsberg, Anders (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    It remains uncertain whether pharmacokinetic changes following Roux-en-Y gastric bypass (RYGB) can be attributed to surgery-induced gastrointestinal alterations per se and/or the subsequent weight loss. The aim was to ...
  • Short- and long-term effects of body weight, calorie restriction and gastric bypass on CYP1A2, CYP2C19 and CYP2C9 activity 
    Kvitne, Kine Eide; Krogstad, Veronica; Wegler, Christine; Johnson, Line Kristin; Kringen, Marianne K.; Hovd, Markus Herberg; Hertel, Jens Kristoffer; Heijer, Maria; Sandbu, Rune; Skovlund, Eva; Artursson, Per; Karlsson, Cecilia; Andersson, Shalini; Andersson, Tommy B.; Hjelmesæth, Jøran Sture; Åsberg, Anders; Jansson-Löfmark, Rasmus; Christensen, Hege; Robertsen, Ida (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Aim Roux-en-Y gastric bypass (RYGB) may influence drug disposition due to surgery-induced gastrointestinal alterations and/or subsequent weight loss. The objective was to compare short- and long-term effects of RYGB and ...