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(Doctoral thesis / Doktoravhandling, 2019)
Heroin is one of the most addictive drugs of abuse, but heroin itself is considered an inactive prodrug which acts mainly through its metabolites. The work of this doctoral thesis highlights the role of heroin’s first ...
(Doctoral thesis / Doktoravhandling, 2019)
There is extensive interindividual variability in drug response and tolerability. One of the major reasons for this is differences in drug metabolism, which may reflect pharmacogenetic variability and/or environmental ...
(Doctoral thesis / Doktoravhandling, 2019)
In this thesis, focus was on further developing EME and PALME as bioanalytical sample preparation techniques. EME and PALME differ in the fundamental principles for extraction, and they may therefore be advantageous for ...
(Doctoral thesis / Doktoravhandling, 2019)
The cysteine protease legumain is reported to be involved in the pathologies of several inflammatory conditions. The subcellular localization of legumain is thought to be mainly lysosomal. However, translocation to other ...
(Doctoral thesis / Doktoravhandling, 2019)
Medicinal plants form the basis of traditional medicine health systems and play an important role in meeting primary healthcare needs around the world. At the same time, traditional knowledge on medicinal plants is eroding ...
(Doctoral thesis / Doktoravhandling, 2022)
The prevalence of obesity and related metabolic illnesses have rapidly increased over the last decades. One of these diseases is type 2 diabetes (T2D), characterized by chronic hyperglycaemia and insulin resistance in ...
(Doctoral thesis / Doktoravhandling, 2019)
The prevalence of metabolic disorders such as obesity and type 2 diabetes (T2D) has increased dramatically worldwide the last decades. Lifestyle factors such as diet and physical activity have preventive as well as therapeutic ...
(Doctoral thesis / Doktoravhandling, 2021)
Small cell lung cancer is an aggressive disease that requires early diagnosis to reduce patient mortality. Presently, there are two known biomarkers that are widely used for the detection and monitoring of small cell lung ...
(Doctoral thesis / Doktoravhandling, 2021)
The bacterium Bacillus cereus is increasingly recognized as a major source of food-borne disease, as well as other severe infections. Biofilms are a common multicellular mode of growth, where bacteria can be protected ...
(Doctoral thesis / Doktoravhandling, 2022)
Multidose drug dispensing (MDD) is machine dispensed medications into unit bags, a system commonly used in home care services. Currently, an electronic prescribing system for MDD is being piloted. We find that MDD patients ...