Sambucus nigra L. or black elder has a long history of use in traditional European medicine for treatment of inflammations, infections, diabetes and for boosting the immune system. The aim of this thesis was to investigate ...

Glutamate is the major excitatory neurotransmitter in the mammalian CNS. Excitotoxicity refers to the ability of glutamate to destroy neurons, and this pathological condition may occur e.g. during stroke. In this thesis, ...

The prevalence of type 2 diabetes (T2D) has increased worldwide during the last decades. Obesity and accumulation of lipids in skeletal muscles are strongly associated with T2D. Much focus has been on the possibility of ...

Mobile genetic elements have had, and still have an impact on the evolution of the genomes providing means for adaptation and structural organization. These elements are one of the major driving forces for the general ...

Non-living antigens are often poorly immunogenic and require addition of adjuvants to elicit protective immunity. Due to the immunostimulatory potential of Toll-like receptor (TLR) ligands, they are explored as vaccine ...

The work presented in this thesis employed knowledge in medicinal chemistry to discover new compounds aiming to reduce resistance in infections caused by virulent Gram-negative bacteria, resistant to antibiotics. The general ...

Escitalopram and sertraline are among the most widely used drugs in the treatment of depression in Norway. Both drugs show substantial pharmacokinetic variability. Previous studies have indicated that the drug metabolising ...

Electromembrane extraction (EME) was described for the first time in 2006 and demonstrated electrokinetic migration of charged substances from an aqueous sample solution through a supported liquid membrane (SLM) and into ...