Sambucus nigra L. or black elder has a long history of use in traditional European medicine for treatment of inflammations, infections, diabetes and for boosting the immune system. The aim of this thesis was to investigate ...

Glutamate is the major excitatory neurotransmitter in the mammalian CNS. Excitotoxicity refers to the ability of glutamate to destroy neurons, and this pathological condition may occur e.g. during stroke. In this thesis, ...

Legumain is an enzyme present in most cells but its dysregulation is associated with several diseases. During stem cell differentiation, legumain stimulates fat cell and inhibits osteoblast differentiation. This thesis ...

The prevalence of type 2 diabetes (T2D) has increased worldwide during the last decades. Obesity and accumulation of lipids in skeletal muscles are strongly associated with T2D. Much focus has been on the possibility of ...

Mobile genetic elements have had, and still have an impact on the evolution of the genomes providing means for adaptation and structural organization. These elements are one of the major driving forces for the general ...

CACNA1C and CACNA1D are voltage-gated calcium channel genes that have been repeatedly associated with psychiatric disorders by various genomic studies. These genes are involved in gene expression regulation, neurotransmitter ...

Non-living antigens are often poorly immunogenic and require addition of adjuvants to elicit protective immunity. Due to the immunostimulatory potential of Toll-like receptor (TLR) ligands, they are explored as vaccine ...

Main research findings In the field of bioanalysis, drug molecules and endogenous compounds can be determined and quantified from biological samples such as blood and urine. However, the complexity of such biological ...

The work presented in this thesis employed knowledge in medicinal chemistry to discover new compounds aiming to reduce resistance in infections caused by virulent Gram-negative bacteria, resistant to antibiotics. The general ...