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dc.date.accessioned2013-03-12T12:48:58Z
dc.date.available2013-03-12T12:48:58Z
dc.date.issued2002en_US
dc.date.submitted2004-05-19en_US
dc.identifier.citationAli, Muna Obied. Determination of the prevalence of tuberculosis with drug-resistant strains of Mycobacterium tuberculosis in Khartoum, Gazira and camps for displaced people, Sudan. Masteroppgave, University of Oslo, 2002en_US
dc.identifier.urihttp://hdl.handle.net/10852/30070
dc.description.abstractSETTING: Khartoum, Gazira and camps for displaced people OBJECTIVES: To find the extent of anti-tuberculosis drug resistance in Sudan and to estimate the association between drug resistance-TB and proportion of new cases and previously treated cases. And to identify medical, social and demographic factors associated with the development of drug-resistant TB DESIGN: Strains isolated from 144 patients with pulmonary tuberculosis were studied for susceptibility to anti-tuberculosis drugs by the BACTEC method. Data collection forms were filled, to identify factors associated with drug resistance. RESULTS: Twenty-seven strains (50%) were resistant to at least one anti-tuberculosis drugs. Thirty-one (22%) were multi-drug resistant. With exception of only 2 cases, all MDR were found among previously treated cases. The highest rate of mono-drug resistance was observed for streptomycin in both groups of patients (new and previously treated patients). 22 (23.6%) strains collected from new and 8 (15.6%) of strains collected from previously treated patients were resistant to streptomycin respectively. Resistance to ethambutol was only seen in multi-drug resistance strains. With the exception of only one strain, all strains resistant to rifampicin were multi-drug resistant. In Khartoum 24 (26.4%) were multi-drug resistant, in Gazira 4 (16%) and in the camps for displaced people 3 (10.7%) were multi-drug resistant. A history of previous treatment for tuberculosis, being more than 40 years of age, having long duration of symptoms, low weight and household contact of a TB patient were significantly associated with resistance to at least one anti-tuberculosis drug and multidrug resistance. CONCULUSIONS: There is a high prevalence of M. tuberculosis strains resistant to streptomycin also in new patients; drug resistance except for streptomycin among new cases is a rare phenomenon in Sudan, which indicates a low rate of transmission of resistant strains. Drug resistance among previously treated patients is present at an alarming level.nor
dc.language.isoengen_US
dc.titleDetermination of the prevalence of tuberculosis with drug-resistant strains of Mycobacterium tuberculosis in Khartoum, Gazira and camps for displaced people, Sudanen_US
dc.typeMaster thesisen_US
dc.date.updated2006-12-18en_US
dc.creator.authorAli, Muna Obieden_US
dc.subject.nsiVDP::751en_US
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft.au=Ali, Muna Obied&rft.title=Determination of the prevalence of tuberculosis with drug-resistant strains of Mycobacterium tuberculosis in Khartoum, Gazira and camps for displaced people, Sudan&rft.inst=University of Oslo&rft.date=2002&rft.degree=Masteroppgaveen_US
dc.identifier.urnURN:NBN:no-8952en_US
dc.type.documentMasteroppgaveen_US
dc.identifier.duo18916en_US
dc.contributor.supervisorGunnar Bjune, Per Sandvenen_US
dc.identifier.bibsys041256549en_US
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/30070/1/ali.pdf


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