Background: Recent large-scale undertakings such as ENCODE and Roadmap Epigenomics have generated experimental data mapped to the human reference genome (as genomic tracks) representing a variety of functional elements ...

Cross-domain information exchange is an increasingly important capability for conducting efficient and secure operations, both within coalitions and within single nations. A data guard is a common cross-domain sharing ...

The final publication is available at IOS Press through http://dx.doi.org/10.3233/COM-170081

Objective: Patients with chronic obstructive pulmonary disease (COPD) often have abnormal ECGs. Our aim was to separate the effects on ECG by airway obstruction, emphysema and right ventricular (RV) afterload in patients ...

Computational models of cardiac mechanics, personalized to a patient, offer access to mechanical information above and beyond direct medical imaging. Additionally, such models can be used to optimize and plan therapies ...

Cardiac computational models, individually personalized, can provide clinicians with useful diagnosticinformation and aid in treatment planning. A major bottleneck in this process can be determining modelparameters to fit ...

In this paper we extend previous work on using bintrees as an efficient representation for qualitative information about spatial objects. Our approach represents each spatial object as a bintree satisfying the exact same ...

Distributional semantic models learn vector representations of words through the contexts they occur in. Although the choice of context (which often takes the form of a sliding window) has a direct influence on the resulting ...

The final publication is available at IOS Press.

In this paper we study the evolution of ontologybased data access (OBDA) specifications, and focus on the case in which the ontology and/or the data source schema change, which may require a modification to the mapping ...

Purpose: Chemotherapy-induced alterations to gene expression are due to transcriptional reprogramming of tumor cells or subclonal adaptations to treatment. The effect on whole-transcriptome mRNA expression was investigated ...

Background Copeptin is a novel biomarker that predicts mortality in lower respiratory tract infections and heart failure (HF), but the diagnostic value of copeptin in acute dyspnea and the prognostic ...

The book aims to be a resource for those interested in planning and implementing large-scale information infrastructures for novel electronic services in health care. The focus of this book is on the pivotal role of the ...

Background Breast cancer is a heterogeneous disease at the clinical and molecular level. In this study we integrate classifications extracted from five different molecular levels in order to identify ...

Reliable CCS monitoring is vital in order to confirm that injected CO2 stays in the reservoir as intended, and that any occurring leakage is promptly detected allowing corrective actions to be initiated. Motivations for ...

This paper describes an emerging shared repository of large-text resources for creating word vectors, including pre-processed corpora and pre-trained vectors for a range of frameworks and configurations. This will facilitate ...

Background The disease and phenotype track was designed to evaluate the relative performance of ontology matching systems that generate mappings between source ontologies. Disease and phenotype ontologies ...

Background and Objective: For more than a decade, computer-assisted surgical systems have been helping surgeons to plan liver resections. The most widespread strategies to plan liver resections are: drawing traces in ...

This paper presents a method of automatic construction extraction from a large corpus of Russian. The term ‘construction’ here means a multi-word expression in which a variable can be replaced with an- other word from the ...

Background: Studies on medication safety in pregnancy often rely on an oversimplification of medication use into exposed or non-exposed, without considering intensity and timing of use in pregnancy, or concomitant medication ...

I denne artikkelen viser vi et nytt system for å kunne gi delvis automatisk og formativ tilbakemelding til studenter på skriftlig eksamen. Vi vil belyse en ny måte å gi individuell tilbakemelding rettet mot hver enkelt ...

Two mathematical models are part of the foundation of Computational neurophysiology; (a) the Cable equation is used to compute the membrane potential of neurons, and, (b) volume-conductor theory describes the extracellular ...

With the latest development in the design and fabrication of high-density Multi-Electrode Arrays (MEA) for in-vivo neural recordings, the spatiotemporal information in the recorded signals allows for refined estimation of ...

Background speckle can often obscure objects of interest in an ultrasound image. The probability of detection and classification of point scatterers is highly affected by background speckle. The proposed algorithm uses a ...

Epistemic logic plays an important role in artificial intelligence for reasoning about multi-agent systems. Current approaches for modelling multi-agent systems with epistemic logic use Kripke semantics where the knowledge ...

The sockets API has become the standard way that applications access the transport services offered by the IP stack. This article presents NEAT, a user space library that can provide an alternate transport API. NEAT allows ...

Digitalisation is usually about process innovation with the use of IT, i.e. automating or informating organisational processes. However, redesigned processes are often misaligned with the underlying digital infrastructure. ...

Lung cancer is the leading cause of cancer related death, and the past years’ improved insight into underlying molecular events has significantly improved outcome for specific subsets of patients. In particular, several ...

It is widely recognized that the Internet transport layer has become ossified, where further evolution has become hard or even impossible. This is a direct consequence of the ubiquitous deployment of middleboxes that hamper ...

The daily stand-up meeting is a widely used practice. However, what is more uncertain is how valuable the practice is to team members. We invited professional developers of a programming forum to a survey and obtained 221 ...

This paper proposes a simple terminology for understanding and dealing with two current phenomena; we suggest calling them heavyweight and lightweight IT. Heavyweight IT denotes the well-established knowledge regime of ...

This paper proposes a fractional biharmonic operator equation model in the time-space domain to describe scattering attenuation of acoustic waves in heterogeneous media. Compared with the existing models, the proposed ...

Middleboxes in private networks have been known to change packets in many ways, making it hard to design protocol extensions that work for the large majority of Internet users. Addressing the need to know what such middleboxes ...

Popular media and public health care discourses describe an increasing number of mobile health technologies. These applications tend to be presented as a means of achieving patient empowerment, patient-centered care, and ...

Touch-screen musical performance has become commonplace since the widespread adoption of mobile devices such as smartphones and tablets. However, mobile digital musical instruments are rarely designed to emphasise collaborative ...

Background We have previously reported a high incidence of colorectal cancer (CRC) in carriers of pathogenic MLH1 variants (path_MLH1) despite follow-up with colonoscopy including polypectomy. ...

Recent studies have shown that word embedding models can be used to trace time-related (diachronic) semantic shifts for particular words. In this paper, we evaluate some of these approaches on the new task of predicting ...

Background Comparing sets of sequences is a situation frequently encountered in bioinformatics, examples being comparing an assembly to a reference genome, or two genomes to each other. The purpose of the ...

This paper describes the process of automatically adding synsets and hypernymy relations to an existing wordnet based on word embeddings computed for POStagged lemmas in a large news corpus, achieving exact match attachment ...

This paper reports on a suite of experiments that evaluates how the linguistic granularity of part-of-speech tagsets impacts the performance of tagging and syntactic dependency parsing. Our results show that parsing accuracy ...

Both a DNA lesion and an intermediate for antibody maturation, uracil is primarily processed by base excision repair (BER), either initiated by uracil-DNA glycosylase (UNG) or by single-strand selective monofunctional ...

This paper investigates interactions in parser performance for the two official standards for written Norwegian: Bokmål and Nynorsk. We demonstrate that while applying models across standards yields poor performance, ...

We present the UltraSound ToolBox (USTB), a processing framework for ultrasound signals. USTB aims to facilitate the comparison of imaging techniques and the dissemination of research results. It fills the void of tools ...

Abstract: Distributed systems modelling often involves a set of heterogeneous models where each model specifies a set of local constraints capturing a specific view of the system. In real life, distributed systems are often ...

A memory model dictates which values may be returned when reading from memory. In a parallel computing setting, the memory model affects how processes communicate through shared memory. The design of a proper memory model ...

This paper deals with using word embedding models to trace the temporal dynamics of semantic relations between pairs of words. The set-up is similar to the well-known analogies task, but expanded with a time dimension. To ...

Evolving robot morphologies implies the need for lifetime learning so that newborn robots can learn to manipulate their bodies. An individual’s morphology will obviously combine traits of all its parents; it must adapt its ...

Biometric systems have to address many requirements, such as large population coverage, demographic diversity, varied deployment environment, as well as practical aspects like performance and spoofing attacks. Traditional ...

Bézier surfaces are mathematical tools employed in a wide variety of applications. Some works in the literature propose parallelization strategies to improve performance for the computation of Bézier surfaces. These ...

Percutaneous image-guided tumor ablation is a minimally invasive surgical procedure for the treatment of malignant tumors using a needle-shaped ablation probe. Automating the insertion of a needle by using a robot could ...

The 3’,5’-cyclic adenosine monophosphate (cAMP)-dependent protein kinase, or protein kinase A (PKA), pathway is one of the most versatile and best studied signaling pathways in eukaryotic cells. The two paralogous PKA ...

Co-evolution of robot morphologies and control systems is a new and interesting approach for robotic design. However, the increased size and ruggedness of the search space becomes a challenge, often leading to early ...

The widespread introduction of lightweight IT—smartphones, tablets, the Internet of Things, and the growth of third-party app developers—has become a challenge for many organizations. Local units and end-users increasingly ...

Our cities, landscapes, institutions, and homes are increasingly being equipped with sensors that glean information that is being processed by algorithms and visualized to serve as a basis for decision making. Such Internet ...

The common-reflection-surface (CRS) method offers a stack with higher signal-to-noise ratio at the cost of a time-consuming semblance search to obtain the stacking parameters. We have developed a fast method for extracting ...

Reasonable Ontology Templates, OTTRs for short, are OWL ontology macros capable of representing ontology design patterns (ODPs) and closely integrating their use into ontology engineering. An OTTR is itself an OWL ontology ...

Exascale computing systems are being built with thousands of nodes. The high number of components of these systems significantly increases the probability of failure. A key component for them is the interconnection network. ...

Designs of railway infrastructure (tracks, signalling and control systems, etc.) need to comply with comprehensive sets of regulations describing safety requirements, engineering conventions, and design heuristics. We have ...

Understanding the way information systems grow and change over time and the role of different contributors in these processes is central to current research on software development and innovation. In relation to this, there ...

We give the first non-interleaving early operational semantics for the pi-calculus which generalizes the standard interleaving semantics and unfolds to the stable model of prime event structures. Our starting point is the ...

Copyright (2017) Acoustical Society of America. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the Acoustical Society of America. The following article ...

Objective Through the conduct of an individual-based intervention study, the main purpose of this project was to build and evaluate the required infrastructure that may enable routine practice of precision cancer medicine ...

Background The first Atlantic cod (Gadus morhua) genome assembly published in 2011 was one of the early genome assemblies exclusively based on high-throughput 454 pyrosequencing. Since then, rapid advances ...

In recent years, it has come to attention that governments have been doing mass surveillance of personal communications without the consent of the citizens. As a consequence of these revelations, developers have begun ...

Sensitive and specific genotyping of human papillomaviruses (HPVs) is important for population-based surveillance of carcinogenic HPV types and for monitoring vaccine effectiveness. Here we compare HPV genotyping by Next ...

In this paper, we examine infrastructuring in the context of developing national, public eHealth services in Norway. Specifically, we analyze the work of a project team engaged in the design and development of new web-based ...

Information integration and workflow technologies for data analysis have always been major fields of investigation in bioinformatics. A range of popular workflow suites are available to support analyses in computational ...

Purpose: T cells infiltrating follicular lymphoma (FL) tumors are considered dysfunctional, yet the optimal target for immune checkpoint blockade is unknown. Characterizing coinhibitory receptor expression patterns and ...

Objective: Today most patients with Lynch syndrome (LS) survive their first cancer. There is limited information on the incidences and outcome of subsequent cancers. The present study addresses three questions: (i) what ...

This paper explores openness and its role and relevance in creating an opportunity for sustained innovation through design thinking in organizations such as libraries. There is a growing recognition of design thinking as ...

Background A visualization referred to as rainfall plot has recently gained popularity in genome data analysis. The plot is mostly used for illustrating the distribution of somatic cancer mutations along a ...

Background It has been proposed that future reference genomes should be graph structures in order to better represent the sequence diversity present in a species. However, there is currently no standard ...

MicroJam is a mobile app for sharing tiny touch-screen performances. Mobile applications that streamline creativity and social interaction have enabled a very broad audience to develop their own creative practices. While ...

In designing safety-critical infrastructures s.a. railway systems, engineers often have to deal with complex and large-scale designs. Formal methods can play an important role in helping automate various tasks. For railway ...

The present report proposes a methodology for Smart Grid Security Classification (SGSC) having as target usage the complex systems in the smart grids and particularly Advanced Metering Infrastructures (AMI). Our methodology ...

Perineuronal nets (PNNs) are specialized extracellular matrix (ECM) structures that condense around the soma and proximal dendrites of subpopulations of neurons. Emerging evidence suggests that they are involved in regulating ...

While much research emphasizes design-before-use, we here study design-in-use. The notion of participatory continuing design is introduced to draw attention to the ongoing work of incorporating information and communication ...

The two-dimensional quick response (QR) codes can be misleading due to the difficulty in differentiating a genuine QR code from a malicious one. Since the vulnerability is practically part of their design, scanning a ...

Threat intelligence is the provision of evidence-based knowledge about existing or potential threats. Benefits of threat intelligence include improved efficiency and effectiveness in security operations in terms of detective ...

In this paper, we present the results of preliminary experiments on finding the link between the surface forms of Russian nouns (as represented by their graphic forms) and their meanings (as represented by vectors in a ...

Falls in homes of the elderly, in residential care facilities and in hospitals commonly occur in close proximity to the bed. Most approaches for recognizing falls use cameras, which challenge privacy, or sensor devices ...

This paper draws from the literature on collective action and the governance of the commons to address the governance of genetic data on variants of specific genes. Specifically, the data arrangements under study relate ...

Distributed Complex Event Processing (CEP) is gaining increasing interest for two reasons: (1) to scale system performance to handle higher workloads in real-time, and (2) to perform in-network processing, e.g., in mobile ...

It is important to include accessibility testing in software development to ensure that the software developed is usable by as many people as possible, independent of their capabilities. Few guidelines exist on how to ...