Background Recent epidemiological evidence shows that colorectal cancer (CRC) continues to occur in carriers of pathogenic mismatch repair (path_MMR) variants despite frequent colonoscopy surveillance in ...

Background Information technology has transformed the way healthcare is conducted. There is a deluge of patient data dispersed in different systems that are commonly not interoperable. As a result, access ...

Background Chemotherapeutic agents such as anthracyclines and taxanes are commonly used in the neoadjuvant setting. Bevacizumab is an antibody which binds to vascular endothelial growth factor A (VEGFA) ...

Background In kindreds carrying path_BRCA1/2 variants, some women in these families will develop cancer despite testing negative for the family’s pathogenic variant. These families may have additional ...

Background The consequences of lifestyle-related disease represent a major burden for the individual as well as for society at large. Individual preventive health checks to the general population have been ...

Background Pathogenesis of inflammatory diseases can be tracked by studying the causality relationships among the factors contributing to its development. We could, for instance, hypothesize on the connections ...

Background Mammography screening is used to detect breast cancer at an early treatable stage, reducing breast cancer mortality. Traditionally, breast cancer has been seen as a disease with only progressive ...

Background Increased availability of genome assemblies for non-model organisms has resulted in invaluable biological and genomic insight into numerous vertebrates, including teleosts. Sequencing of the ...

RoboJam is a machine-learning system for generating music that assists users of a touchscreen music app by performing responses to their short improvisations. This system uses a recurrent artificial neural network to ...

Background The ballan wrasse (Labrus bergylta) belongs to a large teleost family containing more than 600 species showing several unique evolutionary traits such as lack of stomach and hermaphroditism. ...

The rapidly increasing pervasiveness and integration of computers in human society calls for a broad discipline under which this development can be studied. We argue that to design and use technology one needs to develop ...

Background The genetic mechanisms for families who meet the clinical criteria for Lynch syndrome (LS) but do not carry pathogenic variants in the mismatch repair (MMR) genes are still undetermined. We aimed ...

Background Although chemo-immunotherapy has led to an improved overall survival for most B-cell lymphoma types, relapsed and refractory disease remains a challenge. The malaria drug artesunate has previously ...

© 2018 IEEE. Translations and content mining are permitted for academic research only. Personal use is also permitted, but republication/redistribution requires IEEE permission. See http://www.ieee.org/publications_stand ...

Background In laparoscopic surgery, image quality can be severely degraded by surgical smoke, which not only introduces errors for the image processing algorithms (used in image guided surgery), but also ...

Background The current versions of reference genome assemblies still contain gaps represented by stretches of Ns. Since high throughput sequencing reads cannot be mapped to those gap regions, the regions ...

The paper reports our participation in the shared task on word sense induction and disambiguation for the Russian language (RUSSE’2018). Our team was ranked 2nd for the wiki-wiki dataset (containing mostly homonyms) and ...

Objective: A major goal in systems neuroscience is to determine the causal relationship between neural activity and behavior. To this end, methods that combine monitoring neural activity, behavioral tracking, and targeted ...

Background: Digital innovations have evolved over the last 15 years to support health activities, and their introduction in low- and middle-income countries has shown the potential to catalyze gains in health systems and ...

This paper focuses on the process of translating insights from a Computer Supported Cooperative Work (CSCW)-based study, conducted on a vessel at sea, into a model that can assist systems developers working with simulators, ...

The filtered delay multiply and sum (F-DMAS) beamformer has recently been presented in the context of medical ultrasound image formation. This nonlinear beamformer produces images with improved contrast resolution and noise ...

Sample pooling enabled by dedicated indexes is a common strategy for cost-effective and robust high-throughput sequencing. Index misassignment leading to mutual contamination between pooled samples has however been described ...

Background Chromatin organisation affects gene expression and regional mutation frequencies and contributes to carcinogenesis. Aberrant organisation of DNA has been correlated with cancer prognosis in analyses of the ...

This article presents the results of observations and analyses of students’ learning model-driven system development from two related courses taught at a university in Norway and at a university in the United States in ...

Purpose: Circulating chromogranin B (CgB) levels are increased in situations characterized by systemic and myocardial stress, but whether CgB provides prognostic information in patients with acute respiratory failure (ARF) ...

Objective: Patients with chronic obstructive pulmonary disease (COPD) often have abnormal ECGs. Our aim was to separate the effects on ECG by airway obstruction, emphysema and right ventricular (RV) afterload in patients ...

Cardiac computational models, individually personalized, can provide clinicians with useful diagnosticinformation and aid in treatment planning. A major bottleneck in this process can be determining modelparameters to fit ...

The final publication is available at IOS Press through http://dx.doi.org/10.3233/COM-170081

Computational models of cardiac mechanics, personalized to a patient, offer access to mechanical information above and beyond direct medical imaging. Additionally, such models can be used to optimize and plan therapies ...

Genomic locations are represented as coordinates on a specific genome build version, but the build information is frequently missing when coordinates are provided. We show that this information is essential to correctly ...

In this paper we extend previous work on using bintrees as an efficient representation for qualitative information about spatial objects. Our approach represents each spatial object as a bintree satisfying the exact same ...

The final publication is available at IOS Press.

Reliable CCS monitoring is vital in order to confirm that injected CO2 stays in the reservoir as intended, and that any occurring leakage is promptly detected allowing corrective actions to be initiated. Motivations for ...

Background Breast cancer is a heterogeneous disease at the clinical and molecular level. In this study we integrate classifications extracted from five different molecular levels in order to identify ...

Background The disease and phenotype track was designed to evaluate the relative performance of ontology matching systems that generate mappings between source ontologies. Disease and phenotype ontologies ...

An important open problem in robotic planning is the autonomous generation of 3D inspection paths – that is, planning the best path to move a robot along in order to inspect a target structure. We recently suggested a new ...

Percutaneous image-guided tumor ablation is a minimally invasive surgical procedure for the treatment of malignant tumors using a needle-shaped ablation probe. Automating the insertion of a needle by using a robot could ...

Bézier surfaces are mathematical tools employed in a wide variety of applications. Some works in the literature propose parallelization strategies to improve performance for the computation of Bézier surfaces. These ...

Biometric systems have to address many requirements, such as large population coverage, demographic diversity, varied deployment environment, as well as practical aspects like performance and spoofing attacks. Traditional ...

This paper explores openness and its role and relevance in creating an opportunity for sustained innovation through design thinking in organizations such as libraries. There is a growing recognition of design thinking as ...

Background: Studies on medication safety in pregnancy often rely on an oversimplification of medication use into exposed or non-exposed, without considering intensity and timing of use in pregnancy, or concomitant medication ...

Background and Objective: For more than a decade, computer-assisted surgical systems have been helping surgeons to plan liver resections. The most widespread strategies to plan liver resections are: drawing traces in ...

Background A visualization referred to as rainfall plot has recently gained popularity in genome data analysis. The plot is mostly used for illustrating the distribution of somatic cancer mutations along a ...

In this paper, we present the results of preliminary experiments on finding the link between the surface forms of Russian nouns (as represented by their graphic forms) and their meanings (as represented by vectors in a ...

Falls in homes of the elderly, in residential care facilities and in hospitals commonly occur in close proximity to the bed. Most approaches for recognizing falls use cameras, which challenge privacy, or sensor devices ...

Background It has been proposed that future reference genomes should be graph structures in order to better represent the sequence diversity present in a species. However, there is currently no standard ...

The two-dimensional quick response (QR) codes can be misleading due to the difficulty in differentiating a genuine QR code from a malicious one. Since the vulnerability is practically part of their design, scanning a ...

Threat intelligence is the provision of evidence-based knowledge about existing or potential threats. Benefits of threat intelligence include improved efficiency and effectiveness in security operations in terms of detective ...

Popular media and public health care discourses describe an increasing number of mobile health technologies. These applications tend to be presented as a means of achieving patient empowerment, patient-centered care, and ...

Background Comparing sets of sequences is a situation frequently encountered in bioinformatics, examples being comparing an assembly to a reference genome, or two genomes to each other. The purpose of the ...

Perineuronal nets (PNNs) are specialized extracellular matrix (ECM) structures that condense around the soma and proximal dendrites of subpopulations of neurons. Emerging evidence suggests that they are involved in regulating ...

In designing safety-critical infrastructures s.a. railway systems, engineers often have to deal with complex and large-scale designs. Formal methods can play an important role in helping automate various tasks. For railway ...

Background We have previously reported a high incidence of colorectal cancer (CRC) in carriers of pathogenic MLH1 variants (path_MLH1) despite follow-up with colonoscopy including polypectomy. ...

Background Copeptin is a novel biomarker that predicts mortality in lower respiratory tract infections and heart failure (HF), but the diagnostic value of copeptin in acute dyspnea and the prognostic ...

Background The first Atlantic cod (Gadus morhua) genome assembly published in 2011 was one of the early genome assemblies exclusively based on high-throughput 454 pyrosequencing. Since then, rapid advances ...

Background: Recent large-scale undertakings such as ENCODE and Roadmap Epigenomics have generated experimental data mapped to the human reference genome (as genomic tracks) representing a variety of functional elements ...

We report on our experience in ontology-based data access to the Slegge database at Statoil and share the resources employed in this use case: end-user information needs (in natural language), their translations into SPARQL, ...

Cross-domain information exchange is an increasingly important capability for conducting efficient and secure operations, both within coalitions and within single nations. A data guard is a common cross-domain sharing ...

Purpose: Chemotherapy-induced alterations to gene expression are due to transcriptional reprogramming of tumor cells or subclonal adaptations to treatment. The effect on whole-transcriptome mRNA expression was investigated ...

Optimisation is a basic principle of nature and has a vast variety of applications in research and industry. There is a plurality of different optimisation procedures which exhibit different strengths and weaknesses in ...

Acoustic waves propagating in anisotropic media are important for various applications. Even though these wave phenomena do not generally occur in nature, they can be used to approximate wave motion in various physical ...

The 3’,5’-cyclic adenosine monophosphate (cAMP)-dependent protein kinase, or protein kinase A (PKA), pathway is one of the most versatile and best studied signaling pathways in eukaryotic cells. The two paralogous PKA ...

Exascale computing systems are being built with thousands of nodes. The high number of components of these systems significantly increases the probability of failure. A key component for them is the interconnection network. ...

Designs of railway infrastructure (tracks, signalling and control systems, etc.) need to comply with comprehensive sets of regulations describing safety requirements, engineering conventions, and design heuristics. We have ...

Automated verification of security protocols based on dynamic root of trust, typically relying on protected hardware such as TPM, involves several challenges that we address in this paper. We model the semantics of trusted ...

Reasonable Ontology Templates, OTTRs for short, are OWL ontology macros capable of representing ontology design patterns (ODPs) and closely integrating their use into ontology engineering. An OTTR is itself an OWL ontology ...

We give the first non-interleaving early operational semantics for the pi-calculus which generalizes the standard interleaving semantics and unfolds to the stable model of prime event structures. Our starting point is the ...

The widespread introduction of lightweight IT—smartphones, tablets, the Internet of Things, and the growth of third-party app developers—has become a challenge for many organizations. Local units and end-users increasingly ...

Our cities, landscapes, institutions, and homes are increasingly being equipped with sensors that glean information that is being processed by algorithms and visualized to serve as a basis for decision making. Such Internet ...

I denne artikkelen viser vi et nytt system for å kunne gi delvis automatisk og formativ tilbakemelding til studenter på skriftlig eksamen. Vi vil belyse en ny måte å gi individuell tilbakemelding rettet mot hver enkelt ...

The sockets API has become the standard way that applications access the transport services offered by the IP stack. This article presents NEAT, a user space library that can provide an alternate transport API. NEAT allows ...

This paper draws from the literature on collective action and the governance of the commons to address the governance of genetic data on variants of specific genes. Specifically, the data arrangements under study relate ...

Understanding the way information systems grow and change over time and the role of different contributors in these processes is central to current research on software development and innovation. In relation to this, there ...

Co-evolution of robot morphologies and control systems is a new and interesting approach for robotic design. However, the increased size and ruggedness of the search space becomes a challenge, often leading to early ...

The common-reflection-surface (CRS) method offers a stack with higher signal-to-noise ratio at the cost of a time-consuming semblance search to obtain the stacking parameters. We have developed a fast method for extracting ...

Copyright (2017) Acoustical Society of America. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the Acoustical Society of America. The following article ...

Objective Through the conduct of an individual-based intervention study, the main purpose of this project was to build and evaluate the required infrastructure that may enable routine practice of precision cancer medicine ...

It is widely recognized that the Internet transport layer has become ossified, where further evolution has become hard or even impossible. This is a direct consequence of the ubiquitous deployment of middleboxes that hamper ...

Two mathematical models are part of the foundation of Computational neurophysiology; (a) the Cable equation is used to compute the membrane potential of neurons, and, (b) volume-conductor theory describes the extracellular ...

Adaptive beamformers aim for improved resolution and contrast in the ultrasound images, and their performance is typically benchmarked using metrics such as contrast ratio (CR) and contrast-to-noise ratio (CNR). Using ...

Background speckle can often obscure objects of interest in an ultrasound image. The probability of detection and classification of point scatterers is highly affected by background speckle. The proposed algorithm uses a ...

This paper proposes a fractional biharmonic operator equation model in the time-space domain to describe scattering attenuation of acoustic waves in heterogeneous media. Compared with the existing models, the proposed ...

With the latest development in the design and fabrication of high-density Multi-Electrode Arrays (MEA) for in-vivo neural recordings, the spatiotemporal information in the recorded signals allows for refined estimation of ...

This paper proposes a simple terminology for understanding and dealing with two current phenomena; we suggest calling them heavyweight and lightweight IT. Heavyweight IT denotes the well-established knowledge regime of ...

Digital transformation can be seen as the mutual reinforcement of process redesign and innovative use of IT. The literature on digital transformation focuses on digital business strategy and the transformational CIO. ...

Epistemic logic plays an important role in artificial intelligence for reasoning about multi-agent systems. Current approaches for modelling multi-agent systems with epistemic logic use Kripke semantics where the knowledge ...

Lung cancer is the leading cause of cancer related death, and the past years’ improved insight into underlying molecular events has significantly improved outcome for specific subsets of patients. In particular, several ...

Objective: Today most patients with Lynch syndrome (LS) survive their first cancer. There is limited information on the incidences and outcome of subsequent cancers. The present study addresses three questions: (i) what ...

Information integration and workflow technologies for data analysis have always been major fields of investigation in bioinformatics. A range of popular workflow suites are available to support analyses in computational ...

Purpose: T cells infiltrating follicular lymphoma (FL) tumors are considered dysfunctional, yet the optimal target for immune checkpoint blockade is unknown. Characterizing coinhibitory receptor expression patterns and ...

We present the UltraSound ToolBox (USTB), a processing framework for ultrasound signals. USTB aims to facilitate the comparison of imaging techniques and the dissemination of research results. It fills the void of tools ...

An undesired effect, the dark region artifact (DRA), has been under-communicated in our research community. The DRA appear next to acoustically strong targets for some of the many adaptive beamformers introduced in the ...

Both a DNA lesion and an intermediate for antibody maturation, uracil is primarily processed by base excision repair (BER), either initiated by uracil-DNA glycosylase (UNG) or by single-strand selective monofunctional ...

Sensitive and specific genotyping of human papillomaviruses (HPVs) is important for population-based surveillance of carcinogenic HPV types and for monitoring vaccine effectiveness. Here we compare HPV genotyping by Next ...

Background The mucosal changes associated with female genital schistosomiasis (FGS) encompass abnormal blood vessels. These have been described as circular, reticular, branched, convoluted and having uneven calibre. ...

With the emergence of the Web of Data, there is a need of tools for searching and exploring the growing amount of semantic data. Unfortunately, such tools are scarce and typically require knowledge of SPARQL/RDF. We propose ...

The european higher education area (EHEA) aims to create a more comparable, compatible and coherent space of Higher Education in Europe. After a decade of reforms, most of the required instruments are already in place, so ...

Background. VSEARCH is an open source and free of charge multithreaded 64-bit tool for processing and preparing metagenomics, genomics and population genomics nucleotide sequence data. It is designed as an alternative to ...

Background The limited availability of maternal and child health data has limited progress in reducing mortality and morbidity among pregnant women and children. Global health agencies, leaders, and funders ...