Sixty years have passed since neurosurgeon Nils Lundberg presented his thesis about intracranial pressure (ICP) monitoring, which represents a milestone for its clinical introduction. Monitoring of ICP has since become a ...

Background Targeted client communication (TCC) using text messages can inform, motivate and remind pregnant and postpartum women of timely utilization of care. The mixed results of the effectiveness of TCC interventions ...

Background Graph-based reference genomes have become popular as they allow read mapping and follow-up analyses in settings where the exact haplotypes underlying a high-throughput sequencing experiment are ...

The structure and performance of neural networks are intimately connected, and by use of evolutionary algorithms, neural network structures optimally adapted to a given task can be explored. Guiding such neuroevolution ...

Background Advances in whole genome sequencing strategies have provided the opportunity for genomic and comparative genomic analysis of a vast variety of organisms. The analysis results are highly dependent on the quality ...

While coordination is assumed to contribute to distributed self-managing work team performance, our knowledge about the factors influencing coordination in such team settings is limited. In the present study, we investigate ...

Background We previously reported that in pathogenic mismatch repair (path_MMR) variant carriers, the incidence of colorectal cancer (CRC) was not reduced when colonoscopy was undertaken more frequently ...

Background Cisplatin-based chemotherapy (CBCT) is part of standard treatment of several cancers. In testicular cancer (TC) survivors, an increased risk of developing metabolic syndrome (MetS) is observed. ...

In the oil and gas industry, during exploration prospect assessment, explorationists rely on ad hoc manual work practices and tools for developing and communicating multiple hypothetical geological scenarios of the prospect. ...

Background: Stroke and coronary heart disease share the same risk factors, and a multifactorial intervention after stroke may potentially result in the same reduction in cardiovascular mortality as seen after coronary ...

Accessibility has become an important focus in software development; the goal is to allow as many people as possible, regardless of their capabilities, to use software. We have investigated the methods that software teams ...

The digitization of newspapers has opened up new possibilities for user involvement, yet established practices in the media industry hinder news organisations from fully exploiting the many new opportunities that exist in ...

The latest technical and interaction advancements within the virtual reality (VR) field have marked a new era, not only for VR, but also for VR locomotion. In this era, well-established, prevalent VR locomotion techniques ...

The drum-like virtual reality (VR) keyboard is a contemporary, controller-based interface for text input in VR that uses a drum set metaphor. The controllers are used as sticks which, through downward movements, “press” ...

The Unified Parallel C (UPC) programming language offers parallelism via logically partitioned shared memory, which typically spans physically disjoint memory subsystems. One convenient feature of UPC is its ability to ...

Empirical studies of information and communication technology (ICT) is often done by researchers who work closely with practitioners. Acquiring a role as an insider researcher gives the researcher performative knowledge ...

In recent years, deep learning algorithms have become increasingly more prominent for their unparalleled ability to automatically learn discriminant features from large amounts of data. However, within the field of ...

Pituitary endocrine cells fire action potentials (APs) to regulate their cytosolic Ca2+ concentration and hormone secretion rate. Depending on animal species, cell type, and biological conditions, pituitary APs are generated ...

Existing consumer VR systems support text input using handheld controllers in combination with virtual keyboards and many designers have attempted to build on these widely used techniques. However, information on current ...

One of the hallmarks of cancer is sustained angiogenesis. Favorable results have been reported in some breast cancer (BC) patients receiving antiangiogenic therapy with bevacizumab (Bev) in combination with chemotherapy, ...

Combining HLA-DQ–gluten tetramers with mass cytometry and RNA sequencing analysis, we find that gluten-specific CD4+ T cells in the blood and intestines of patients with celiac disease display a surprisingly rare phenotype. ...

Collaborative robots are becoming more common on factory floors as well as regular environments, however, their safety still is not a fully solved issue. Collision detection does not always perform as expected and collision ...

If robots are to become ubiquitous, they will need to be able to adapt to complex and dynamic environments. Robots that can adapt their bodies while deployed might be flexible and robust enough to meet this challenge. ...

Activation of endoplasmic reticulum (ER) stress/the unfolded protein response (UPR) has been linked to cancer, but the molecular mechanisms are poorly understood and there is a paucity of reagents to translate this for ...

Sentiment analysis benefits from large, hand-annotated resources in order to train and test machine learning models, which are often data hungry. While some languages, e.g., English, have a vast arrayof these resources, ...

Prevention enthusiasts show great optimism about the potential of health apps to modify peoples’ lifestyles through the tracking and quantification of behaviours and bodily signs. Critical sociologists warn for the ...

This paper describes the development of a parallel simulator of a multicore memory system from a model formalized as a structural operational semantics (SOS). Our implementation uses the Abstract Behavioral Specification ...

The impact of the tumor immune microenvironment on overall survival in non‐small cell lung cancer (NSCLC) has been studied, but there is little information on its relevance for risk of relapse after surgery. Understanding ...

In this article, we examine work with communal data in the context of clinical genetic testing. Drawing from prior research on digital research infrastructures and from the analysis of our empirical data on genetic testing, ...

The complexity of a legged robot’s environment or task can inform how specialised its gait must be to ensure success. Evolving specialised robotic gaits demands many evaluations—acceptable for computer simulations, but not ...

Genome-wide association studies have implicated many ion channels in schizophrenia pathophysiology. Although the functions of these channels are relatively well characterized by single-cell studies, the contributions of ...

In speech and music, the acoustic and perceptual onset(s) of a sound are usually not congruent with its perceived temporal location. Rather, these "P-centers" are heard some milliseconds after the acoustic onset, and a ...

Background In breast cancer, activation of bone morphogenetic protein (BMP) signaling and elevated levels of BMP-antagonists have been linked to tumor progression and metastasis. However, the simultaneous ...

In recent years, researchers have explored human body posture and motion to control robots in more natural ways. These interfaces require the ability to track the body movements of the user in three dimensions. Deploying ...

In minimally invasive surgery, smoke generated by such as electrocautery and laser ablation deteriorates image quality severely. This creates discomfortable view for the surgeon which may increase surgical risk and degrade ...

In this paper we explore the application of methods for classical judgment aggregation in pooling probabilistic opinions on logically related issues. For this reason, we first modify the Boolean judgment aggregation framework ...

Data sampling has an important role in the majority of local explanation methods. Generating neighborhood samples using either the Gaussian distribution or the distribution of training data is a widely-used procedure in ...

Background Intratumoural T-cell infiltrate intensity cortes wrelaith clinical outcome in stage II/III colorectal cancer (CRC). We aimed to determine whether this association varies across this heterogeneous group. Me ...

Objective. Mechanistic modeling of neurons is an essential component of computational neuroscience that enables scientists to simulate, explain, and explore neural activity. The conventional approach to simulation of ...

Interoperability is accepted as a fundamental necessity for the successful realization of Healthcare Information Systems. It can be achieved by utilizing consistent standards defining syntactic and semantic meaning of the ...

Prostate cancer is a highly heterogeneous disease and typically multiple distinct cancer foci are present at primary diagnosis. Molecular classification of prostate cancer can potentially aid the precision of diagnosis and ...

In agile software development, a core responsibility of the product owner (PO) is to communicate business needs to the development team. In large-scale agile software development projects, many teams work toward an overall ...

International policy and law have long sought to ensure that states regulate the negative impacts of production processes on people and the planet. Sustainable Development Goal (SDG) 12 targets sustainable production and ...

Linked Data exploration is an essential task in the process of understanding, assessing, and using datasets made available in the Resource Description Framework (RDF) format. Current solutions for exploration of RDF data ...

Automatic polyp detection and segmentation are highly desirable for colon screening due to polyp miss rate by physicians during colonoscopy, which is about 25%. However, this computerization is still an unsolved problem ...

Most patients whose large bowel cancer has spread to other organs do not respond to immune therapy. We detected a rare gene mutation, termed 9p24.1 copy-number gain (CNG), in an otherwise incurable colorectal cancer that ...

Cancer cells exploit many of the cellular adaptive responses to support their survival needs. One such critical pathway in eukaryotic cells is the unfolded protein response (UPR) that is important in normal physiology as ...

Ontology-based visual query formulation is a viable alternative to textual query editors in the Semantic Web domain for extracting data from structured data sources in terms of the skills and knowledge required. A visual ...

We present a comprehensive study of state-of-the-art algorithms for the prediction of sensor events and activities of daily living in smart homes. Data have been collected from eight smart homes with real users and 13-17 ...

The interaction designer plays an important role in facilitating high-quality interactions and accessible user experiences. Currently, interaction designers have diverse and often interdisciplinary backgrounds, in which ...

We study evolutionary robot systems where not only the robot brains but also the robot bodies are evolvable. Such systems need to include a learning period right after ‘birth’ to acquire a controller that fits the newly ...

Recent developments in the field of indoor RealTime Locating Systems (RTLS) using mobile devices stimulate decision support for users. For instance, smartphone-based navigation in shops can enable location-aware recommendations ...

DiffServ was designed to implement service provider quality of service (QoS) policies, where routers change and react upon the DiffServ Code Point (DSCP) in the IP header. However, nowadays, applications are beginning to ...

XTRA (XFSM for Transport) aims at providing a first attempt towards a “code-once-port-everywhere” platform-agnostic programming abstraction tailored to the deployment of transport layer functions. XTRA's programming ...

A microfluidic laminar flow cell (LFC) forms an indispensable component in single-molecule experiments, enabling different substances to be delivered directly to the point under observation and thereby tightly controlling ...

Left ventricular (LV) dilatation is a key step in transition to heart failure (HF) in response to pressure overload. Cardiac extracellular matrix (ECM) contains fibrillar collagens and proteoglycans, important for maintaining ...

The brain is the most complex of human organs, and the pathophysiology underlying abnormal brain function in psychiatric disorders is largely unknown. Despite the rapid development of diagnostic tools and treatments in ...

Data preprocessing is a crucial step in data analysis. A substantial amount of time is spent on data transformation tasks such as data formatting, modification, extraction, and enrichment, typically making it more convenient ...

To meet the demands of communication‐intensive workloads in the cloud, virtual machines (VMs) should utilize low overhead network communication paradigms. In general, such paradigms enable VMs to directly communicate with ...

Exploring the effects of a chemical compound on a species takes a considerable experimental effort. Appropriate methods for estimating and suggesting new effects can dramatically reduce the work needed to be done by a ...

In this paper, we present a preliminary study to compute embeddings for OWL 2 ontologies by projecting the ontology axioms into a graph and performing (random) walks over the ontology graph to create a corpus of sentences. ...

Introduction: In liver surgery, medical images from pre-operative computed tomography and magnetic resonance imaging are the basis for the decision-making process. These images are used in surgery planning and guidance, ...

Conventional surgical navigation systems rely on preoperative imaging to provide guidance. In laparoscopic liver surgery, insufflation of the abdomen (pneumoperitoneum) can cause deformations on the liver, introducing ...

Previous studies have shown that miniaturised accelerometers can be used to monitor cardiac function and automatically detect ischemic events. However, accelerometers cannot differentiate between acceleration due to motion ...

Background Recent epidemiological evidence shows that colorectal cancer (CRC) continues to occur in carriers of pathogenic mismatch repair (path_MMR) variants despite frequent colonoscopy surveillance in ...

Background Information technology has transformed the way healthcare is conducted. There is a deluge of patient data dispersed in different systems that are commonly not interoperable. As a result, access ...

Thanks to the popularity of mobile devices numerous location-based services (LBS) have emerged. While several privacy-preserving solutions for LBS have been proposed, most of these solutions do not consider the fact that ...

Background In laparoscopic surgery, image quality can be severely degraded by surgical smoke, which not only introduces errors for the image processing algorithms (used in image guided surgery), but also ...

Background The current versions of reference genome assemblies still contain gaps represented by stretches of Ns. Since high throughput sequencing reads cannot be mapped to those gap regions, the regions ...

Background The ballan wrasse (Labrus bergylta) belongs to a large teleost family containing more than 600 species showing several unique evolutionary traits such as lack of stomach and hermaphroditism. ...

The rapidly increasing pervasiveness and integration of computers in human society calls for a broad discipline under which this development can be studied. We argue that to design and use technology one needs to develop ...

Background The genetic mechanisms for families who meet the clinical criteria for Lynch syndrome (LS) but do not carry pathogenic variants in the mismatch repair (MMR) genes are still undetermined. We aimed ...

Background Although chemo-immunotherapy has led to an improved overall survival for most B-cell lymphoma types, relapsed and refractory disease remains a challenge. The malaria drug artesunate has previously ...

Background Increased availability of genome assemblies for non-model organisms has resulted in invaluable biological and genomic insight into numerous vertebrates, including teleosts. Sequencing of the ...

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RoboJam is a machine-learning system for generating music that assists users of a touchscreen music app by performing responses to their short improvisations. This system uses a recurrent artificial neural network to ...

Background In kindreds carrying path_BRCA1/2 variants, some women in these families will develop cancer despite testing negative for the family’s pathogenic variant. These families may have additional ...

Background Pathogenesis of inflammatory diseases can be tracked by studying the causality relationships among the factors contributing to its development. We could, for instance, hypothesize on the connections ...

Background Chemotherapeutic agents such as anthracyclines and taxanes are commonly used in the neoadjuvant setting. Bevacizumab is an antibody which binds to vascular endothelial growth factor A (VEGFA) ...

Background The consequences of lifestyle-related disease represent a major burden for the individual as well as for society at large. Individual preventive health checks to the general population have been ...

Background Mammography screening is used to detect breast cancer at an early treatable stage, reducing breast cancer mortality. Traditionally, breast cancer has been seen as a disease with only progressive ...

This paper focuses on the process of translating insights from a Computer Supported Cooperative Work (CSCW)-based study, conducted on a vessel at sea, into a model that can assist systems developers working with simulators, ...

This paper studies the secure transmission rate issue between sensors and the remote controller to defend the jamming and eavesdropping attacks in green cyber-physical transportation systems. In this system, the traffic ...

Targeted therapy for patients with HER2‐positive (HER2+) breast cancer has improved overall survival, but many patients still suffer relapse and death from the disease. Intratumor heterogeneity of both estrogen receptor ...

Background: Chemotherapeutic agents such as anthracyclines and taxanes are commonly used in the neoadjuvant setting. Bevacizumab is an antibody which binds to vascular endothelial growth factor A (VEGFA) and inhibits its ...

Summary Individual tumor genomes pose a major challenge for clinical interpretation due to their unique sets of acquired mutations. There is a general scarcity of tools that can (i) systematically interrogate cancer ...

One of the major obstacles in automatic polyp detection during colonoscopy is the lack of labeled polyp training images. In this paper, we propose a framework of conditional adversarial networks to increase the number of ...

Driven by the evolutionary development of automobile industry and cellular technologies, dependable vehicular connectivity has become essential to realize future intelligent transportation systems (ITS). In this paper, we ...

Objective: A major goal in systems neuroscience is to determine the causal relationship between neural activity and behavior. To this end, methods that combine monitoring neural activity, behavioral tracking, and targeted ...

It is essential to focus on universal design in agile software development to ensure that the software developed is usable by as many people as possible. This work studies how members of agile teams regard universal design, ...

In this paper, we study how to efficiently integrate multiple relational databases using an ontology-based approach. In ontology-based data integration (OBDI) an ontology provides a coherent view of multiple databases, and ...

To enable elderly people to live independently in their homes, the government aims to de-institutionalize elderly care services by upscaling home care services and care housing and downscaling long-term stays at nursing ...

Background Most patients with path_MMR gene variants (Lynch syndrome (LS)) now survive both their first and subsequent cancers, resulting in a growing number of older patients with LS for whom limited information exists ...

The genomes of ancient humans can reveal patterns of early human migration (see the Perspective by Achilli et al.). Iceland has a genetically distinct population, despite relatively recent settlement (∼1100 years ago). ...

Malicious attacks in the power system can eventually result in a large-scale cascade failure if not rectified in a timely manner. These attacks, which are traditionally classified into physical and cyber attacks, can be ...

Genomic alterations occurring during melanoma progression and the resulting genomic heterogeneity between metastatic deposits remain incompletely understood. Analyzing 86 metastatic melanoma deposits from 53 patients with ...

In this work we present the Talk of Norway (ToN) data set, a collection of Norwegian Parliament speeches from 1998 to 2016. Every speech is richly annotated with metadata harvested from different sources, and augmented ...

Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is the most popular assay to identify genomic regions, called ChIP-seq peaks, that are bound in vivo by transcription factors (TFs). These regions are derived ...

The pathophysiology of atrial fibrillation (AF) is broad, with components related to the unique and diverse cellular electrophysiology of atrial myocytes, structural complexity, and heterogeneity of atrial tissue, and ...