Abstracts:The project is based on Dohans Hypothesis from 1966, where he suggests a possible relationship between food intolerance and Schizophrenia. We wanted to find out whether the concentration of peptides is elevated in urine from untreated Schizophrenic patients compared to the normal population. And if that is correct, is there any correlation between the peptide-concentration in the urine or individual peaks and severity of the disease. We also want to find out if there are some specific peptides which are elevated that would correlate with symptoms. We used data from 96 presumed healthy persons as standard of reference, and data from ten patients. Nine were Schizophrenic, and one was Schizoaffective. To analyse the urines, High Pressure Liquid Chromatography (HPLC) was performed. This first result was that the urine sample from the schizoaffective patient differed visible from rest of the samples; it had noticeable late peptide-peaks which were not found neither among the Schizophrenic, nor the normal samples. The total concentration of peptides is elevated in urine samples from the drug free Schizophrenic patients. A tendency for a correlation between the total concentration and severity of the disease was found. The different peptide-peaks gave different results. Some of the peaks are not significantly different from controls. Other peaks are present in both groups, but are much larger in the patient group. Yet another type of peaks is only present among the patients. It turns out that it is difficult to compare peptide-peaks with symptoms because the number of patients is too low, and both peptide-peaks and symptoms appear to be overlapping among the patients.