Pancreatic cancer is more often chemoresistent than most other gastrointestinal carcinoma, and surgery is therefore the only treatment with curative potential. A general goal is therefore to increase the percentage of patient candidates for curative resection. One part of this discussion is whether or not a vascular resection should be performed in patients with tumor infiltration of PV or SMV. I wanted to find out if this is an acceptable procedure when considering morbidity, mortality and long term survival. Which criteria should be used to select patient that should be considered for a more radical procedure and how to increase this number further, is also an unresolved issue. To answer these questions I did a literature study. This is a review of articles about the topic published the last 5 years. Generally this seems to be an accepted procedure with morbidity and mortality, as well as long term survival, being comparable to standard treatments. Neoadjuvant treatments have several advantages, but there is no standard definition of which patients belong in this group. After reviewing the literature I make some suggestion as to how these patients should be selected.