Polyphenols, and particularly flavanoids, have been in the scientific spotlight for many years due to their beneficial qualities in human health. These qualities have been grossly attributed to the antioxidant properties of polyphenolic compounds, but recent studies indicates another apparent cause to the advantageous effect – direct modification of intracellular signaling systems, specifically the cyclic aminomonophosphate (cAMP) second messenger system, could play a major role when it comes to the innate immune response and events leading up to chronic inflammation.
This paper intends to test this hypothesis with a clinical trial of cecal ligation and puncture (CLP) followed by administration of either resveratrol or genistein, two important polyphenols previously shown to convey major beneficial effects when ingested through diet.
Due to the preliminary results, or lack thereof, this paper does not establish a valid connection between polyphenols and attenuated immune responses in septic rats; this largely believed to be due to human and methodical flaw.
The results show that we still have a long way to go when ascertaining the true cause of the apparent longevity seen in consumers of wine, fruits and vegetables.