Background and aims:
Several studies describe an association between vitamin D and glucose metabolism, however data are ambiguous. We aimed to study the relationship between serum levels of 25(OH) vitamin D and insulin action in subjects with type 2 diabetes and hypovitaminosis D.
Twenty-six subjects with type 2 diabetes and hypovitaminosis D, recruited from the DIVINE study (Diabetes Intervention Trial with Vitamin D in Subjects of Sub-Indian and Nordic Ethnicity), were included in the present analysis. Insulin action was measured as homeostasis model assessment of insulin resistance (HOMAIR) and with the hyperinsulinemic euglycemic glucose clamp method.
Results: Subjects had a mean age of 57 years, a mean BMI of 31,1 kg/m2 and a median S-25(OH) vitamin D of 39 nmol/l. S -25(OH) vitamin D did not correlate with measures of insulin action and was not significantly different between subjects of Nordic and South-Asian ethnicity.
S-25(OH) vitamin D did not correlate significantly with any measures of insulin action in subjects with hypovitaminosis D and type 2 diabetes. Possibly, a study including more subjects can detect such a relationship.