AbstractObjective: The Aim of this study was to evaluate whether lifestyle intervention and optimized medication at an out-patient clinic had the potential of reversing diabetic cardiomyopathy and improve metabolism in DM2 patients. With tissue Doppler and wave Doppler we analyzed left systolic and diastolic atrial function.Patients and Methods: In this sub-study of the ABCD-study, we examined atrial function in 29 patients with DM2. With waveDoppler we got transmitral blood flow values for E, DT and A. With tissue Doppler, early velocity (E’), atrial velocity (A’), their ratio (E’/A’) and systolic velocity (S’) were measured at the septal and lateral corner of mitral annulus. We also measured metabolic changes.Results: The intervention group had significant metabolic improvements in HbA1c and total-cholesterol. We got borderline significant results for triglycerides. The intervention group had a significant improvement in systolic and diastolic blood pressure. But between the groups the improvement in blood pressure was only borderline significant. For atrial function the results were less conclusive. Conclusion: Close follow-up in outpatient clinic has the potential to improve metabolic values in patients with DM2. The lack of cardiac results might be due to the short period of follow-up (2 years), and because there were too few patients.